Compounds > bifendate
Page last updated: 2024-09-02

bifendate and verapamil

bifendate has been researched along with verapamil in 3 studies

Compound Research Comparison

Studies
(bifendate)		Trials
(bifendate)		Recent Studies (post-2010)
(bifendate)		Studies
(verapamil)		Trials
(verapamil)		Recent Studies (post-2010) (verapamil)
12484317,6211,5272,067

Protein Interaction Comparison

ProteinTaxonomybifendate (IC50)verapamil (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)6.8
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.297
ATP-dependent translocase ABCB1Mus musculus (house mouse)2
ATP-dependent translocase ABCB1Homo sapiens (human)2.2346
Cytochrome P450 3A4Homo sapiens (human)3.8008
Alpha-2A adrenergic receptorHomo sapiens (human)0.579
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)3.02
ATP-dependent translocase ABCB1Mus musculus (house mouse)10
Catechol O-methyltransferaseHomo sapiens (human)0.2
Potassium voltage-gated channel subfamily A member 3Homo sapiens (human)8
Histamine H2 receptorHomo sapiens (human)2.59
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.442
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.297
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)3.02
Sodium-dependent serotonin transporterHomo sapiens (human)0.24
Multidrug resistance-associated protein 1 Homo sapiens (human)5.598
D(3) dopamine receptorHomo sapiens (human)0.186
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.165
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)6.8
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.2
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.3945
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.2
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.175
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)1.1934

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gu, X; Lai, Y; Peng, H; Peng, S; Ren, Z; Tang, X; Zhang, Y; Zhao, Q1
Gu, X; Lai, Y; Ma, Y; Peng, H; Peng, S; Ren, Z; Tang, X; Zhang, Y1
Gu, X; Huang, Z; Lu, B; Luo, X; Peng, H; Peng, S; Ren, Z; Tang, X; Tian, J; Xue, R; Zhang, Y1

Other Studies

3 other study(ies) available for bifendate and verapamil

ArticleYear
Synthesis and biological evaluation of novel bifendate derivatives bearing 6,7-dihydro-dibenzo[c,e]azepine scaffold as potent P-glycoprotein inhibitors.
    European journal of medicinal chemistry, 2012, Volume: 51

    Topics: Adenosine Triphosphatases; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azepines; Biphenyl Compounds; Chemistry Techniques, Synthetic; Doxorubicin; Gene Expression Regulation; Humans; K562 Cells; Rhodamine 123; RNA, Messenger; Structure-Activity Relationship

2012
Synthesis and biological evaluation of bifendate-chalcone hybrids as a new class of potential P-glycoprotein inhibitors.
    Bioorganic & medicinal chemistry, 2012, Apr-15, Volume: 20, Issue:8

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Chalcone; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; K562 Cells; Structure-Activity Relationship

2012
Potent Inhibition of Nitric Oxide-Releasing Bifendate Derivatives against Drug-Resistant K562/A02 Cells in Vitro and in Vivo.
    Journal of medicinal chemistry, 2017, 02-09, Volume: 60, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biphenyl Compounds; Cell Proliferation; Drug Resistance, Neoplasm; Heterografts; Humans; In Vitro Techniques; K562 Cells; Mice; Mice, Nude; Nitric Oxide

2017