bidisomide has been researched along with piperidines in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (9.52) | 18.7374 |
| 1990's | 17 (80.95) | 18.2507 |
| 2000's | 2 (9.52) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Frederick, LG; Garthwaite, SM; Schmidt, JJ | 1 |
| Claypool, WD; Friedman, IM; Gardiner, P; Karim, A; Kowalski, KG; McDonald, SJ; Page, RL; Pritchett, EL; Wharton, JM; Wilkinson, WE | 1 |
| Hoffman, BF; Spinelli, W | 1 |
| Frederick, LG; Garthwaite, SM; McDonald, SJ | 1 |
| Ijiri, H; Ishihara, T; Komori, S; Li, BH; Matsumura, K; Mochizuki, S; Naitoh, A; Sano, S; Umetani, K; Watanabe, A | 1 |
| Gardiner, P; Garthwaite, SM; Hackett, AM | 1 |
| Ames, GB; Cook, CS; Karim, A; Kowalski, KG; Smith, ME | 1 |
| Cook, CS; Karim, A; McDonald, SJ | 1 |
| Awaji, T; Hashimoto, K; Hirasawa, A; Motomura, S; Zhenjiu, W | 1 |
| Kacew, S; Rorig, KJ; Ruben, Z | 1 |
| Ames, GB; Cook, CS; Hribar, JD; Karim, A; Liu, NW; Schoenhard, GL; Sweeney, DL | 1 |
| Masson, M; Palate, B; Roba, J; Vandenberghe, Y | 1 |
| Martin, CL; Mcmahon, EG; Palomo, MA | 1 |
| Karim, A; Kowalski, KG | 1 |
| Cook, CS; Lee, KH; Schoenhard, GL; Xu, GX | 1 |
| Cook, C; Fleisher, D; Kararli, T; Karim, A; Kirchhoff, C; Pao, LH; Truelove, J; Zhou, SY | 1 |
| Cook, CS; Karim, A; Osis, J; Schoenhard, GL; Zhang, L | 1 |
| Demarest, C; Luna, E; Skanchy, DJ; Stobaugh, JF; Tait, RJ; Xie, GH | 1 |
| Cook, CS; Hribar, J; Lonien, M | 1 |
| Hashimoto, K; Homma, N; Tsujimoto, G | 1 |
1 review(s) available for bidisomide and piperidines
| Article | Year |
|---|---|
Perspectives on intracellular storage and transport of cationic-lipophilic drugs.
Topics: Animals; Anti-Arrhythmia Agents; Biological Transport; Carbohydrate Metabolism; Cations; Chemical Phenomena; Chemistry, Physical; Drug-Related Side Effects and Adverse Reactions; Organelles; Pharmaceutical Preparations; Phospholipids; Piperidines | 1993 |
5 trial(s) available for bidisomide and piperidines
| Article | Year |
|---|---|
Bidisomide (SC-40230), a new antiarrhythmic agent: initial study of tolerability and pharmacokinetics.
Topics: Administration, Oral; Adult; Anti-Arrhythmia Agents; Biological Availability; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Humans; Injections, Intravenous; Male; Piperidines; Random Allocation | 1992 |
Importance of pharmacokinetic and physicochemical data in the discovery and development of novel anti-arrhythmic drugs.
Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Drug Design; Humans; Middle Aged; Octanols; Piperidines; Water | 1993 |
A semicompartmental modeling approach for pharmacodynamic data assessment.
Topics: Anti-Arrhythmia Agents; Humans; Infusions, Intravenous; Models, Biological; Monte Carlo Method; Nonlinear Dynamics; Pharmacokinetics; Piperidines; Regression Analysis; Software | 1995 |
Treatment of atrial fibrillation and paroxysmal supraventricular tachycardia with bidisomide. The Atrial Fibrillation Investigation with Bidisomide (AFIB) Investigators.
Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Double-Blind Method; Electrocardiography; Humans; Middle Aged; Piperidines; Tachycardia, Supraventricular | 1997 |
Reduced systemic availability of an antiarrhythmic drug, bidisomide, with meal co-administration: relationship with region-dependent intestinal absorption.
Topics: Animals; Anti-Arrhythmia Agents; Area Under Curve; Biological Availability; Dogs; Female; Food-Drug Interactions; Humans; Infusions, Intravenous; Intestinal Absorption; Male; Piperidines; Viscosity | 1998 |
15 other study(ies) available for bidisomide and piperidines
| Article | Year |
|---|---|
Rapid infusions of bidisomide or disopyramide in conscious dogs: effect of myocardial infarction on acute tolerability.
Topics: Animals; Anti-Arrhythmia Agents; Disopyramide; Dogs; Dose-Response Relationship, Drug; Drug Tolerance; Electrocardiography; Female; Infusions, Intravenous; Male; Myocardial Infarction; Piperidines | 1992 |
Mechanisms of termination of reentrant atrial arrhythmias by class I and class III antiarrhythmic agents.
Topics: Animals; Anti-Arrhythmia Agents; Disopyramide; Dogs; Electrocardiography; Flecainide; Heart Conduction System; Heart Rate; Lidocaine; Piperidines; Propafenone; Sotalol | 1989 |
Cardiovascular profile of a new anti-arrhythmic agent, SC-40230.
Topics: Animals; Anti-Arrhythmia Agents; Cats; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Female; Hemodynamics; Male; Myocardial Contraction; Piperidines | 1989 |
Effects of bidisomide (SC-40230), a new class I antiarrhythmic agent, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats; comparison with mexiletine and disopyramide.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiac Complexes, Premature; Coronary Disease; Disopyramide; Heart Rate; Male; Mexiletine; Myocardial Reperfusion Injury; Piperidines; Rats; Rats, Sprague-Dawley; Tachycardia, Ventricular; Ventricular Fibrillation | 1995 |
The effect of bidisomide (SC-40230), a new class Ia/Ib antiarrhythmic agent, on defibrillation energy requirements in dogs with healed myocardial infarctions.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Dogs; Electric Countershock; Electrocardiography; Heart Rate; Myocardial Infarction; Piperidines; Ventricular Fibrillation | 1993 |
Absorption and disposition of a new antiarrhythmic agent bidisomide in man.
Topics: Absorption; Adult; Anti-Arrhythmia Agents; Erythrocytes; Humans; Male; Piperidines; Saliva; Stereoisomerism | 1993 |
Effects of a new class I antiarrhythmic drug bidisomide on canine ventricular arrhythmia models.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Digitalis Glycosides; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Epinephrine; Female; Myocardial Contraction; Piperidines; Sinoatrial Node | 1993 |
Metabolism of a novel antiarrhythmic agent, bidisomide, in man: use of high resolution mass spectrometry to distinguish desisopropyl bidisomide from desacetyl bidisomide.
Topics: Administration, Oral; Anti-Arrhythmia Agents; Humans; Injections, Intravenous; Mass Spectrometry; Piperidines | 1995 |
Effect of folate supplementation on clinical chemistry and hematologic changes related to bidisomide administration in the rat.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Antidotes; Aspartate Aminotransferases; Body Weight; Bone Marrow; Bone Marrow Cells; Deoxyuridine; Diet; DNA; Eating; Femur; Food Deprivation; Formiminoglutamic Acid; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Leucovorin; Male; Methylmalonic Acid; Piperidines; Rats; Rats, Sprague-Dawley; Taurine; Vitamin B Complex; Weight Gain | 1995 |
Comparison of bidisomide, flecainide and dofetilide on action potential duration in isolated canine atria: effect of isoproterenol.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Dose-Response Relationship, Drug; Flecainide; Guinea Pigs; Heart Atria; Isoproterenol; Male; Phenethylamines; Piperidines; Sulfonamides | 1996 |
Mechanisms of food effects of structurally related antiarrhythmic drugs, disopyramide and bidisomide in the rat.
Topics: Animals; Anti-Arrhythmia Agents; Bile; Colon; Disopyramide; Fasting; Food-Drug Interactions; Gastrointestinal Transit; Hydrogen-Ion Concentration; Ileum; Intestinal Absorption; Jejunum; Male; Permeability; Piperidines; Rats; Sodium Chloride | 1997 |
Mechanism of compound- and species-specific food effects of structurally related antiarrhythmic drugs, disopyramide and bidisomide.
Topics: Adult; Animals; Anti-Arrhythmia Agents; Area Under Curve; Biological Availability; Cross-Over Studies; Dietary Fats; Disopyramide; Dogs; Female; Food-Drug Interactions; Humans; Intestinal Absorption; Liver; Male; Piperidines; Species Specificity; Structure-Activity Relationship | 1998 |
Application of sulfobutylether-beta-cyclodextrin with specific degrees of substitution for the enantioseparation of pharmaceutical mixtures by capillary electrophoresis.
Topics: Anti-Arrhythmia Agents; beta-Cyclodextrins; Cyclodextrins; Electrophoresis, Capillary; Ethers; Osmolar Concentration; Piperidines; Stereoisomerism | 1999 |
Effect of diet and gavage on the dose- and dose-mode-dependent absorption and metabolism of bidisomide in rat.
Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Diet; Dogs; Dose-Response Relationship, Drug; Feces; Female; Humans; Liver; Male; Models, Biological; Piperidines; Rats; Rats, Sprague-Dawley; Scintillation Counting; Sex Factors | 2000 |
Electrophysiologic effects of an antiarrhythmic agent, bidisomide, on sodium current in isolated rat ventricular myocytes: comparison with mexiletine and disopyramide.
Topics: Animals; Anti-Arrhythmia Agents; Disopyramide; Electrophysiology; Heart; Heart Ventricles; In Vitro Techniques; Kinetics; Mexiletine; Myocardium; Patch-Clamp Techniques; Piperidines; Rats; Sodium Channel Blockers; Sodium Channels | 2001 |