bicyclo(2.2.1)heptene and 6-chloropurine

bicyclo(2.2.1)heptene has been researched along with 6-chloropurine* in 1 studies

Other Studies

1 other study(ies) available for bicyclo(2.2.1)heptene and 6-chloropurine

Article	Year
Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors. Bioorganic & medicinal chemistry, 2010, Jun-15, Volume: 18, Issue:12 The synthesis and SAR study of a novel class of coxsackievirus B3 (CVB3) inhibitors are reported. These compounds could be considered as the 6-chloropurines substituted at position 9 with variously substituted bicyclic scaffolds (bicyclo[2.2.1]heptane/ene-norbornane or norbornene). The synthesis and biological evaluation of 31 target compounds are described. Several of the analogues inhibited CVB3 in the low micromolar range (0.66-2muM). Minimal or no cytotoxicity was observed. Topics: Animals; Antiviral Agents; Bridged Bicyclo Compounds; Chlorocebus aethiops; Drug Design; Enterovirus B, Human; Humans; Purines; Structure-Activity Relationship; Vero Cells	2010

Article

Year

Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors.

Bioorganic & medicinal chemistry, 2010, Jun-15, Volume: 18, Issue:12

The synthesis and SAR study of a novel class of coxsackievirus B3 (CVB3) inhibitors are reported. These compounds could be considered as the 6-chloropurines substituted at position 9 with variously substituted bicyclic scaffolds (bicyclo[2.2.1]heptane/ene-norbornane or norbornene). The synthesis and biological evaluation of 31 target compounds are described. Several of the analogues inhibited CVB3 in the low micromolar range (0.66-2muM). Minimal or no cytotoxicity was observed.

Topics: Animals; Antiviral Agents; Bridged Bicyclo Compounds; Chlorocebus aethiops; Drug Design; Enterovirus B, Human; Humans; Purines; Structure-Activity Relationship; Vero Cells

2010