bicuculline has been researched along with diazepam in 272 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 123 (45.22) | 18.7374 |
| 1990's | 80 (29.41) | 18.2507 |
| 2000's | 50 (18.38) | 29.6817 |
| 2010's | 16 (5.88) | 24.3611 |
| 2020's | 3 (1.10) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Dodd, RH; Furtmüller, R; Jursky, F; Razet, R; Sieghart, W; Sigel, E; Thomet, U | 1 |
| Chou, WH; McMahon, T; Messing, RO; Newton, PM; Qi, ZH; Shokat, KM; Song, M; Wallace, MJ; Wang, D; Zhang, C | 1 |
| Haefely, W; Polc, P | 2 |
| Gallager, DW; Tallman, JF; Thomas, JW | 1 |
| Javid, MJ; Stone, WE | 1 |
| Dudai, Y | 1 |
| Fukushima, H; Nakamura, M | 1 |
| Altier, H; D'Angelo, L; Monti, JM | 1 |
| Chiu, TH; Rosenberg, HC | 1 |
| Karobath, M; Sperk, G | 1 |
| Pletscher, A; Saner, A | 1 |
| Brickley, JJ; Englander, RN; Hanna, GR; Johnson, RN | 1 |
| Risley, EA; Williams, M | 1 |
| Barnes, CD; Polzin, RL | 1 |
| Braestrup, C; Falch, E; Krogsgaard-Larsen, P; Nielsen, M | 2 |
| Marusov, IV; Val'dman, AV | 1 |
| Barnes, CD; Strahlendorf, H; Strahlendorf, J | 1 |
| Krsiak, M; Masek, K; Ostrovskaya, RU; Sulcová, A | 1 |
| Lippa, AS; Regan, B | 1 |
| Greenlee, D; Olsen, RW; Ticku, MK; Van Ness, PC | 1 |
| Fukushima, H; Tsuchiya, T | 1 |
| Antonaccio, MJ; Kerwin, L; Taylor, DG | 1 |
| Briley, MS; Langer, SZ | 1 |
| Molodavkin, GM; Ostrovskaia, RU | 2 |
| Ostrovskaia, RU; Voronina, TA | 1 |
| Curtis, DR; Game, CJ; Lodge, D | 1 |
| Amabeoku, GJ; Chikuni, O | 2 |
| Hales, TG; Kim, H; Longoni, B; Olsen, RW; Tobin, AJ | 1 |
| Biscardi, R; Wilson, MA | 1 |
| Golovko, AI; Sofronov, GA | 2 |
| Rochford, J; Stewart, J | 1 |
| Lin, WC; Watanabe, K; Yano, S | 2 |
| Wilson, MA | 1 |
| Gale, K; Pazos, A; Peterson, CJ; Vinayak, S | 1 |
| Agmo, A; Fernández, H | 1 |
| Bitran, D; Kellogg, CK; Primus, RJ | 1 |
| Diamantis, W; Gels, M; Gordon, R; Sofia, RD | 1 |
| Araki, Y; Gomita, Y; Ichimaru, Y; Moriyama, M | 1 |
| Engel, JA; Söderpalm, B | 1 |
| Satoh, T; Shimada, K; Wakabayashi, H | 1 |
| Blakeman, DP; Im, WB | 1 |
| De Luca, C; De Medici, D; Massotti, M | 1 |
| Hicks, TP; Oka, JI | 1 |
| Luhmann, HJ; Prince, DA | 1 |
| Albers, HE; Liou, SY; Shibata, S; Ueki, S | 1 |
| Elgoyhen, AB; Kazanietz, MG | 1 |
| Albertson, TE; Joy, RM | 1 |
| Elsworth, JD; Gruen, RJ; Roth, RH | 1 |
| Huang, JH; Johnston, GA | 1 |
| Kim, KH; Takeuchi, H | 1 |
| Pericić, D; Tvrdeić, A | 1 |
| Beletskaia, IO; Devoĭno, LV; Idova, GV | 1 |
| Alford, S; Sigvardt, KA; Williams, TL | 1 |
| Biggio, G; Concas, A; Mascia, MP; Sanna, E; Serra, M | 1 |
| Chernevskaia, NI; Valeev, AE; Vrublevskiĭ, SV | 1 |
| Akagi, H; Yanagisawa, M | 1 |
| Barker, JL; Dufy, B; Harrison, NL; MacDonald, JF; Owen, DG | 1 |
| Smith, GK; Suzuki, SS | 1 |
| Fukuda, H; Matsumoto, K; Ono, H; Yamazaki, J | 1 |
| Chiu, TH; Rosenberg, HC; Tietz, EI | 1 |
| Gallager, DW; Heninger, C; Hernandez, TD; Wilson, MA | 1 |
| Abel, MS; Blume, AJ; Garrett, KM | 1 |
| Luo, ZP; Yang, XM; Zhou, JH | 2 |
| Chen, CF; Fang, ZB; Guo, XQ; Su, HL; Zhang, JF | 1 |
| Fukuda, H; Ishikawa, M; Miyazaki, H | 1 |
| Lister, RG; Nutt, DJ | 1 |
| Daval, JL; Sarfati, A | 1 |
| Cox, DH; Guidotti, A; Santi, MR | 1 |
| Gobbi, M; Mennini, T; Perin, L; Salmona, M | 1 |
| De Medici, D; Gatta, F; Longo, VG; Massotti, M | 1 |
| Golovenko, NIa; Zhuk, OV; Zin'kovskiĭ, VG | 1 |
| Mehta, AK; Ticku, MK | 1 |
| Gallager, DW; Heninger, C | 1 |
| Byberg, JR; Curtis, DR; Falch, E; Gynther, BD; Hjeds, H; Krogsgaard-Larsen, P; Labouta, IM | 1 |
| Burov, IuV; Orekhov, SN; Vedernikova, NN | 1 |
| Gross, RA; Macdonald, RL; Weddle, MG | 1 |
| Bollen, EL; Bruinvels, J; Ketelaars, CE; Rigter, H | 1 |
| McGarrick, JD; Stone, TW; Thexton, AJ | 1 |
| Iversen, LL; Wong, EH | 1 |
| Humphrey, SJ; McCall, RB | 1 |
| Anderson, SA; Gallager, DW; Gonsalves, SF; Malcolm, AB | 1 |
| Lee, RJ; Lomax, P; McCabe, RT; Olsen, RW; Wamsley, JK | 1 |
| Iasnetsov, VS; Sizov, PI | 1 |
| Curtis, DR; Falch, E; Krogsgaard-Larsen, P; Nielsen, L | 1 |
| Otero Losada, ME; Pérez, C; Rubio, MC | 1 |
| Menaker, M; Ralph, MR | 1 |
| Biggio, G; Corda, MG | 1 |
| Astier, H; Roussel, JP; Tapia-Arancibia, L | 1 |
| Ferrario, P; Hafner, B; Mantegazza, P; Tammiso, R; Zambotti, F; Zonta, N | 1 |
| Laporte, AM; Soubrié, P; Thiébot, MH | 1 |
| Idemudia, SO; Lal, H; Mathis, DA | 1 |
| Cherubini, E; North, RA | 1 |
| Kruszewska, A | 1 |
| Fehér, O; Toldi, J | 1 |
| Conte, B; Furio, M; Maggi, CA; Meli, A; Santicioli, P | 1 |
| Gallager, DW; Gonsalves, SF | 1 |
| Lakić, N; Manev, H; Pericić, D | 1 |
| Goddard, GV; Morimoto, K | 1 |
| Chweh, AY; Coleman, JC; Shenoy, AK; Swinyard, EA | 1 |
| Huang, CJ; Xiang, JZ | 1 |
| Gallo, V; Guidotti, A; Vaccarino, F; Wise, BC | 1 |
| Higashio, T; Inukai, T; Nakao, K | 1 |
| Furukawa, T; Katsuragi, T; Ushijima, I | 1 |
| Blaskó, G; Kardos, J; Simonyi, M; Szántay, C | 1 |
| Langwiński, R; Matla, J | 1 |
| Andreev, BV; Ignatov, IuD | 1 |
| Mantegazza, P; Parenti, M; Tammiso, R; Vita, P; Zambotti, F; Zonta, N | 1 |
| Goldstein, JM; Knobloch, LC; Malick, JB | 1 |
| Allikmets, LKh; Riago, LK; Sarv, KhA | 1 |
| Miyamoto, M; Nagawa, Y; Saji, Y; Shintani, M | 1 |
| Engel, JA; Liljequist, S | 1 |
| Overstreet, D; Pilotto, R; Singer, G | 1 |
| Classen, K; Göthert, M; Schlicker, E | 1 |
| Zetler, G | 1 |
| Paul, SM; Skolnick, P; Zatz, M | 1 |
| Persson, B; Rubenson, A; Sillén, U | 1 |
| Davis, WC; Ticku, MK | 1 |
| Olsen, RW | 1 |
| Braestrup, C; Nielsen, M | 1 |
| Cavagnini, F; Grandison, L; Guidotti, A; Invitti, SC; Schmid, R | 1 |
| Allikmets, LKh; Nurk, AM; Riago, LK | 1 |
| Morgan, PF; Stone, TW | 1 |
| Massotti, M; Sagratella, S | 1 |
| Buldakova, SL; Glushankov, PG; Saakian, SA; Skrebitskiĭ, VG | 1 |
| Leeb-Lundberg, LM; Olsen, RW | 1 |
| Brinton, RE; Gee, KW; Yamamura, HI | 1 |
| Janiszewski, W; Schwarz, M; Sontag, KH; Turski, L | 1 |
| Vellucci, SV; Webster, RA | 1 |
| Burnham, WM; Livingston, KE; Madras, BK; Okazaki, MM; Spero, L | 1 |
| Barnes, CD; Strahlendorf, HK | 1 |
| Ashton, D | 1 |
| Di Chiara, G; Diana, M; Imperato, A; Nicoletti, F; Scapagnini, U | 1 |
| Buu, NT; Duhaime, J; Kuchel, O | 1 |
| Acs, Z; Makara, GB; Stark, E | 1 |
| Lee, EK; Ross, RJ; Walters, JR; Waszczak, BL | 1 |
| Burnham, WM; Madras, BK; Okazaki, MM; Spero, L | 1 |
| Birk, J; Noble, RG | 1 |
| Alger, BE; Nicoll, RA | 1 |
| Artaud, F; Bourgoin, S; Cesselin, F; Glowinski, J; Hamon, M | 1 |
| Cortese, I; Cuomo, V; Siro-Brigiani, G | 1 |
| Czuczwar, SJ; Kleinrok, Z; Turski, L | 1 |
| Fukuda, H; Kaneko, T; Ono, H | 1 |
| Duka, T; Herz, A; Wüster, M | 1 |
| Guidotti, A; Massotti, M | 1 |
| Gan'shina, TS | 1 |
| Forchetti, CM; Meek, JL | 1 |
| Adamec, RE; Livingston, KE; McNaughton, B; Racine, R | 1 |
| Bourn, WM; Reigel, CE | 1 |
| Kaneto, H; Rahman, AF; Takahashi, M | 1 |
| Iwasaki, T; Nakagawa, Y | 1 |
| Dirksen, R; Maksay, G; van Rijn, CM; Willems-van Bree, E | 1 |
| Angelides, KJ; Duffy, S; Fraser, DD; Kettenmann, H; MacVicar, BA; Perez-Velazquez, JL | 1 |
| Biggio, G; Concas, A; Marino, G; Minei, R; Mostallino, MC; Pannaccione, A; Pierobon, P; Santoro, G | 1 |
| Amabeoku, G; Chikuni, O | 1 |
| Morel, E; Perrault, G; Sanger, DJ; Zivkovic, B | 1 |
| Parkman, HP; Stapelfeldt, WH; Szurszewski, JH | 1 |
| Cancedda, E; Corda, MG; Giorgi, O; Lecca, D; Orlandi, M | 1 |
| Biggio, G; Concas, A; Dazzi, L; Maciocco, E; Mascia, MP; Santoro, G | 1 |
| Hammond, DL; McGowan, MK | 1 |
| Lennon, VA; Parkman, HP; Stapelfeldt, WH; Szurszewski, JH; Williams, CL | 1 |
| Cancedda, E; Corda, MG; Giorgi, O | 1 |
| Aguayo, LG; Alarcón, JM | 1 |
| Stringer, JL | 1 |
| Amico-Roxas, M; Caruso, A; Cutuli, VM; de Bernardis, E; Lucenti, A; Villari, L | 1 |
| Colwell, CS; Kaufman, CM; Menaker, M | 1 |
| Liljequist, S; Tabakoff, B | 1 |
| el Manira, A; Grillner, S; Matsushima, T; Tegnér, J | 1 |
| Ishima, T; Iwasaki, T; Kimura, K; Nakagawa, Y | 1 |
| Pericić, D; Pivac, N | 1 |
| Misawa, M; Motegi, H; Suzuki, T | 1 |
| Dowling, JE; Qian, H | 1 |
| Fordyce, WE; Kanter, RK; Paskanik, AM; Terndrup, TE | 1 |
| Costa, E; Mocchetti, I; Sun, FY | 1 |
| Krůsek, J; Vanĕcek, J; Zemková, H | 1 |
| Chang, YF; Gao, XM | 1 |
| Contarino, A; Giusti, P; Lipartiti, M; Mariot, R; Zanotti, A | 1 |
| Akaike, N; Harata, N; Shimura, M; Tamai, M | 1 |
| Hansen, HC; Jackson, HC; Judge, ME; Klitgaard, H; Kristiansen, M; Suzdak, PD; Swedberg, MD | 1 |
| Contarino, A; Giusti, P; Lipartiti, M; Natolino, F; Zanotti, A | 2 |
| Dalvi, A; Rodgers, RJ | 1 |
| Biggio, G; Casula, A; Maciocco, E; Murgia, A; Sanna, E; Tuligi, G; Usala, M | 1 |
| Obata, K | 1 |
| Bujas, M; Pericić, D | 1 |
| Belachew, S; Coucke, P; Goffin, F; Lefebvre, PP; Malgrange, B; Moonen, G; Rigo, JM; Van de Water, TR; Xhauflaire, G | 1 |
| Eder, HG; Fisher, RS; Jones, DB | 1 |
| Fernández-Guasti, A; López-Rubalcava, C | 1 |
| Greenfield, LJ; Macdonald, RL; Neelands, TR; Turner, RS; Zhang, J | 1 |
| Biggio, G; Concas, A; Marino, G; Minei, R; Mostallino, MC; Pierobon, P; Porcu, P | 1 |
| Devaud, LL; Fritschy, JM; Morrow, AL | 1 |
| Kuribara, H; Maruyama, Y; Stavinoha, WB | 2 |
| Hu, HZ; Li, ZW; Shao, M | 1 |
| Ben-Ari, Y; Dzhala, V; Khalilov, I; Khazipov, R | 2 |
| Flemström, G; Säfsten, B | 1 |
| Chen, CL; Chiu, TH; Yang, YR | 1 |
| Qian, H; Ripps, H | 1 |
| Crowe, SF; Farkas, L | 1 |
| Birnir, B; Everitt, AB; Gage, PW; Lim, MS | 1 |
| DeFord, SM; Gibson, CJ; Hamm, RJ; O'Dell, DM; Wilson, MS | 1 |
| Sapp, DW; Yeh, HH | 1 |
| Chen, Z; Fujii, Y; Ishizawa, K; Kamei, C; Okuma, C; Sugimoto, Y | 1 |
| Signore, AP; Yeh, HH | 1 |
| Ansaldo, MA; Fedele, E; Raiteri, M; Varnier, G | 1 |
| Jacob, MK; White, RE | 1 |
| Birnir, B; Eghbali, M; Everitt, AB; Gage, PW | 1 |
| Antkowiak, B; Hentschke, H | 1 |
| Wada, E; Wada, K; Yamada, K | 1 |
| Germane, S; Klusa, V; Opmane, B; Svirskis, S; Wikberg, JE | 1 |
| Birnir, B; Cox, GB; Eghbali, M; Gage, PW | 1 |
| Baufreton, J; Bioulac, B; Dovero, S; Dufy, B; Garret, M; Taupignon, A | 1 |
| Kim, SU; Krieger, C; Puil, E; Yokogawa, T | 1 |
| Aoyagi, Y; Ohta, A; Watanabe, Y; Yamada, K | 1 |
| Hevers, W; Lüddens, H | 1 |
| Attwell, D; Hamann, M; Rossi, DJ | 1 |
| Nemmani, KV; Ramarao, P | 1 |
| Altobelli, D; Cannizzaro, C; Martire, M; Maurizi, S; Preziosi, P | 1 |
| Chaichantipyuth, C; Matsumoto, K; Murakami, Y; Sukma, M; Tohda, M; Watanabe, H | 1 |
| Mogil, JS; Nemmani, KV | 1 |
| Klitgaard, H; Margineanu, DG | 1 |
| Birnir, B; Eghbali, M; Gage, PW | 1 |
| Epstein, OI; Molodavkin, GM; Sergeeva, SA; Voronina, TA | 1 |
| Baur, R; Sigel, E | 1 |
| Chopde, CT; Khisti, RT; Kokare, DM; Rao, TL; Sarkar, S; Subhedar, N | 1 |
| Kang-Park, MH; Moore, SD; Wilson, WA | 1 |
| Hansen, SL; Sánchez, C; Sperling, BB | 1 |
| Bhatia, J; Katyal, V; Mahajan, P; Mediratta, PK; Sharma, KK; Tewary, S | 1 |
| Cardin, JA; Schmidt, MF | 1 |
| Anschel, DJ; Fisher, RS; Ortega, E | 1 |
| Feigenspan, A; Weiler, R | 1 |
| Fritschy, JM; Marowsky, A; Vogt, KE | 1 |
| Andreeva, N; Garret, M; Haas, HL; Scherer, A; Sergeeva, OA | 1 |
| Choi, KB; Jeong, JH; Moon, NJ; Park, ES; Sohn, UD | 1 |
| Chopde, CT; Hirani, K; Jain, NS | 1 |
| Auta, J; Costa, E; Davis, JM; Guidotti, A | 1 |
| Liu, QS; Poo, MM; Pu, L | 1 |
| Hirano, S; Kamei, J; Miyata, S | 1 |
| Beleboni, Rde O; Coutinho-Netto, J; Cunha, AO; dos Santos, WF; Gelfuso, EA; Liberato, JL; Mortari, MR | 1 |
| Addae, JI; Ali, N; Stone, TW; Youssef, FF | 1 |
| Cho, YW; Jang, CG; Jin, C; Jung, JW; Lee, JJ; Oh, TH; Ryu, JH; Yoon, BH | 1 |
| Dambrova, M; Dzirkale, Z; Klusa, V; Krigere, L; Kviesis, J; Mekss, P; Mezhapuke, R; Muceniece, R; Rumaks, J; Saleniece, K; Schiöth, HB | 1 |
| Auta, J; Costa, E; Guidotti, A; Impagnatiello, F; Kadriu, B | 1 |
| Dickson, CT; Engin, E; Stellbrink, J; Treit, D | 1 |
| Miao, QL; Poo, MM; Xu, M; Zhang, SY; Zhang, XH | 1 |
| Kawaguchi, M; Okubo, M | 1 |
| Brandão, ML; Cabral, A; Nobre, MJ | 1 |
| Duburs, G; Dzirkale, Z; Fernandes, MA; Klusa, V; Mezhapuke, R; Pupure, J; Rumaks, J; Sile, V; Svirskis, S; Vanina, M | 1 |
| Cao, J; Hu, XD; Li, S; Liu, YN; Shi, L; Suo, ZW; Yang, HB; Yang, X; Zheng, CR | 1 |
| Akaike, N; Iwata, S; Shin, MC; Wakita, M; Xie, DJ | 1 |
| Hashimoto, K; Kano, M; Kitamura, K; Miyazaki, T; Nakayama, H; Obata, K; Sakimura, K; Watanabe, M; Yanagawa, Y | 1 |
| Arnold, LA; Chen, Q; Cook, JM; Emala, CW; Ionescu-Zanetti, C; Johnson, J; Smith, S; Wang, ZJ; Yim, PD; Yuan, N | 1 |
| Cao, Z; Hammock, BD; Lein, PJ; McCoy, M; Pessah, IN; Rogawski, MA | 1 |
| Bailey, CP; Dewey, WL; Gabra, BH; Henderson, G; Hull, LC | 1 |
| Bhutada, P; Deshmukh, P; Dixit, P; Kaulaskar, S; Thakur, K | 1 |
| Grauer, M; Jabs, R; Passlick, S; Schäfer, C; Seifert, G; Steinhäuser, C | 1 |
| Jeon, BH; Jeong, JA; Jo, JY; Kim, HW; Kim, YJ; Lee, GS; Lee, JU; Pandit, S; Park, JB; Song, JG | 1 |
| Denman, RB; Merz, G; Sung, YJ; Xie, W | 1 |
| Jang, HJ; Joo, K; Kim, MJ; Lee, C; Rhie, DJ | 1 |
| Aguilar, BL; Forcelli, PA; Malkova, L; Wellman, LL | 1 |
| Aricescu, AR; Desai, R; Karia, D; Kotecha, A; Laverty, D; Malinauskas, T; Masiulis, S; Miller, KW; Pardon, E; Serna Martin, I; Steyaert, J; Uchański, T; Zivanov, J | 1 |
| Gharpure, A; Hibbs, RE; Howard, RJ; Kim, JJ; Lindahl, E; Noviello, CM; Teng, J; Walsh, RM; Zhu, S; Zhuang, Y | 1 |
| Esumi, S; Izushi, Y; Kitamura, Y; Matsumoto, D; Noda, Y; Sendo, T; Ushio, S; Wada, Y | 1 |
| Gold, MS; Loeza-Alcocer, E | 1 |
2 review(s) available for bicuculline and diazepam
| Article | Year |
|---|---|
Signal transduction mechanisms in cultured CNS neurons and clonal pituitary cells.
Topics: Amino Acids; Animals; Bicuculline; Cell Line; Central Nervous System; Diazepam; Electric Conductivity; Electrophysiology; Glycine; Ion Channels; Neurons; Pituitary Gland; Protein Kinases; Thyrotropin-Releasing Hormone | 1987 |
The GABA postsynaptic membrane receptor-ionophore complex. Site of action of convulsant and anticonvulsant drugs.
Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Bicuculline; Brain; Chlorides; Convulsants; Diazepam; GABA Antagonists; gamma-Aminobutyric Acid; Ion Channels; Picrotoxin; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Seizures; Synaptic Membranes | 1981 |
270 other study(ies) available for bicuculline and diazepam
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Use of bicuculline, a GABA antagonist, as a template for the development of a new class of ligands showing positive allosteric modulation of the GABA(A) receptor.
Topics: Allosteric Regulation; Bicuculline; GABA Antagonists; Ligands; Receptors, GABA-A | 2000 |
Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits.
Topics: Adenosine Triphosphate; Allosteric Regulation; Animals; Benzodiazepines; Cells, Cultured; Enzyme Activation; Ethanol; Hippocampus; Humans; Mice; Mice, Knockout; Mutation; Phosphorylation; Protein Kinase C-epsilon; Protein Kinase Inhibitors; Protein Subunits; Pyridines; Receptors, GABA-A; Sensitivity and Specificity; Serine; Zolpidem | 2007 |
Effects of two benzodiazepines, phenobarbitone, and baclofen on synaptic transmission in the cat cuneate nucleus.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Anti-Anxiety Agents; Baclofen; Bicuculline; Cats; Diazepam; Drug Interactions; Evoked Potentials; Flunitrazepam; Glutamate Decarboxylase; Medulla Oblongata; Neural Inhibition; Phenobarbital; Picrotoxin; Propionates; Semicarbazides; Synapses; Synaptic Transmission | 1976 |
GABAergic modulation of benzodiazepine binding site sensitivity.
Topics: Amanita; Aminobutyrates; Animals; Bicuculline; Cerebral Cortex; Diazepam; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Ligands; Neurotransmitter Agents; Rats; Receptors, Drug; Receptors, Neurotransmitter | 1978 |
Benzodiazepines and phenobarbital as antagonists of dissimilar chemical convulsants.
Topics: 3-Mercaptopropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Chlordiazepoxide; Convulsants; Diazepam; gamma-Aminobutyric Acid; Isoniazid; Male; Mice; Nitrazepam; Pentylenetetrazole; Phenobarbital; Picrotoxin; Therapeutic Equivalency | 1978 |
Modulation of benzodiazepine binding sites in calf cortex by an endogenous factor and GABAergic ligands.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Cattle; Cerebral Cortex; Cycloleucine; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Nerve Tissue Proteins; Receptors, Drug | 1979 |
Effect of benzodiazepines on central serotonergic neuron systems.
Topics: Animals; Anticonvulsants; Bicuculline; Brain; Cyproheptadine; Diazepam; Drug Interactions; In Vitro Techniques; Male; Mescaline; Mice; Muscle Contraction; Neurons; Pentylenetetrazole; Postural Balance; Rats; Serotonin; Synaptic Transmission; Synaptosomes; Time Factors | 1977 |
The effects of the combined administration of gamma-hydroxybutyrate and diazepam on sleep parameters in the rat.
Topics: Animals; Bicuculline; Diazepam; Dose-Response Relationship, Drug; Hydroxybutyrates; Male; Rats; Sleep; Sleep, REM; Wakefulness | 1979 |
GABA receptor-mediated modulation of 3H-diazepam binding in rat cortex.
Topics: Animals; Bicuculline; Cerebral Cortex; Diazepam; Freezing; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Male; Rats; Receptors, Cell Surface; Synaptosomes | 1979 |
Stimulation of benzodiazepine receptor binding by gamma-aminobutyric acid.
Topics: Animals; Bicuculline; Brain; Cerebral Cortex; Diazepam; gamma-Aminobutyric Acid; Kinetics; Membranes; Muscimol; Rats; Receptors, Drug | 1979 |
Effect of diazepam on cerebral 5-hydroxytryptamine synthesis.
Topics: 5-Hydroxytryptophan; Aminooxyacetic Acid; Animals; Bicuculline; Brain; Diazepam; Drug Interactions; gamma-Aminobutyric Acid; Male; Picrotoxin; Rats; Reserpine; Serotonin | 1979 |
Effects of antiepileptic drugs on thalamocortical excitability.
Topics: Animals; Bicuculline; Cats; Computers; Diazepam; Electric Stimulation; Electroencephalography; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Ethosuximide; Motor Cortex; Phenytoin; Thalamus; Time Factors | 1977 |
Enhancement of the binding of 3H-diazepam to rat brain membranes in vitro by SQ 20009, A novel anxiolytic, gamma-aminobutyric acid (GABA) and muscimol.
Topics: Animals; Bicuculline; Brain; Diazepam; Etazolate; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Membranes; Muscimol; Nicotinic Acids; Oxazoles; Picrotoxin; Rats; Stimulation, Chemical | 1979 |
Effect of diazepam on GABAergic cuneate neurons.
Topics: Animals; Bicuculline; Cats; Diazepam; gamma-Aminobutyric Acid; Glutamates; Medulla Oblongata; Neurons; Picrotoxin | 1979 |
Partial agonists for brain GABA/benzodiazepine receptor complex.
Topics: Animals; Benzodiazepines; Bicuculline; Brain; Crotonates; Diazepam; GABA Antagonists; gamma-Aminobutyric Acid; Imidazoles; Isoxazoles; Muscimol; Piperidines; Rats; Receptors, Drug; Sulfonic Acids | 1979 |
[Role of the GABA-ergic systems of the brain in manifesting the activating effect of diazepam].
Topics: Animals; Bicuculline; Brain; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Motor Activity; Muscimol; Rats; Receptors, Drug; Self Stimulation | 1979 |
A possible interplay of GABA with serotonergic and noradrenergic systems in the cerebellum.
Topics: Animals; Bicuculline; Cats; Cerebellum; Diazepam; Drug Interactions; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Norepinephrine; Serotonin | 1979 |
Bicuculline antagonizes effects of diazepam on aggresive and timid behaviour in mice.
Topics: Aggression; Animals; Bicuculline; Diazepam; Humans; Male; Mice | 1979 |
Additional studies on the importance of glycine and GABA in mediating the actions of benzodiazepines.
Topics: Aminobutyrates; Animals; Bicuculline; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glycine; Male; Mice; Pentylenetetrazole; Seizures; Strychnine | 1977 |
Effects of drugs on gamma-aminobutyric acid receptors, uptake, release and synthesis in vitro.
Topics: Aminobutyrates; Animals; Astacoidea; Bicuculline; Brain; Diazepam; gamma-Aminobutyric Acid; Haloperidol; Imipramine; In Vitro Techniques; Male; Mice; Penicillin G; Pentylenetetrazole; Picrotoxin; Receptors, Drug; Synaptosomes | 1978 |
Effects of benzodiazepines and pentobarbitone on the gaba-ergic recurrent inhibition of hippocampal neurons.
Topics: Action Potentials; Aminobutyrates; Animals; Benzodiazepines; Bicuculline; Cats; Diazepam; Drug Synergism; Female; gamma-Aminobutyric Acid; Hippocampus; Male; Neural Inhibition; Neurons; Pentobarbital | 1978 |
Effects of central GABA receptor agonism and antagonism on evoked diencephalic cardiovascular responses.
Topics: Animals; Bicuculline; Cats; Diazepam; Diencephalon; Electric Stimulation; gamma-Aminobutyric Acid; Hemodynamics; Muscimol; Receptors, Drug; Sympathetic Nervous System | 1978 |
Influence of GABA receptor agonists and antagonists on the binding of 3H-diazepam to the benzodiazepine receptor.
Topics: Animals; Benzodiazepines; Bicuculline; Brain; Diazepam; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Muscimol; Rats; Receptors, Drug | 1978 |
[GABA-ergic mechanism of action of diazepam on cerebral cortex neurons].
Topics: Aminobutyrates; Animals; Bicuculline; Brain Chemistry; Diazepam; Evoked Potentials; GABA Antagonists; Male; Neurons; Rats; Semicarbazides; Somatosensory Cortex; Valproic Acid | 1976 |
[Antagonistic effect of bicuculline and thiosemicarbazide on the tranquilizing effects of diazepam].
Topics: Animals; Bicuculline; Conflict, Psychological; Diazepam; gamma-Aminobutyric Acid; Isoquinolines; Male; Rats; Receptors, Drug; Semicarbazides | 1977 |
Benzodiazepines and central glycine receptors.
Topics: Action Potentials; Animals; Bicuculline; Cats; Chlordiazepoxide; Diazepam; Glycine; Mice; Receptors, Drug; Seizures; Species Specificity; Spinal Cord; Strychnine; Time Factors | 1976 |
Effects of some GABAergic agents on quinine-induced seizures in mice.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Diazepam; Male; Mice; Mice, Inbred Strains; Muscimol; Phenobarbital; Phenytoin; Quinine; Receptors, GABA-A; Seizures | 1992 |
Immortalized hypothalamic GT1-7 neurons express functional gamma-aminobutyric acid type A receptors.
Topics: Anesthetics; Animals; Barbiturates; Base Sequence; Bicuculline; Cell Line, Transformed; Cell Membrane; Chloride Channels; Diazepam; Electrophysiology; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation; Hypothalamus; Membrane Proteins; Mice; Molecular Sequence Data; Muscimol; Neurons; Peptides; Polymerase Chain Reaction; Receptors, GABA-A; RNA, Messenger; Sensitivity and Specificity; Steroids; Tritium; Tumor Cells, Cultured; Zinc | 1992 |
Effects of gender and gonadectomy on responses to chronic benzodiazepine receptor agonist exposure in rats.
Topics: Animals; Benzodiazepines; Bicuculline; Brain; Diazepam; Drug Implants; Drug Tolerance; Female; Hormones; Male; Orchiectomy; Ovariectomy; Ovary; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sex Factors; Silicone Elastomers; Testis; Time Factors; Tritium | 1992 |
[Effects of GABA antagonist-induced seizures on 3H-muscimol and 3H-diazepam binding in the rat striatum].
Topics: Animals; Bicuculline; Binding Sites; Corpus Striatum; Diazepam; GABA Antagonists; Male; Muscimol; Picrotoxin; Rats; Receptors, GABA-A; Seizures; Tritium | 1992 |
Naloxone-induced hypoalgesia: lack of involvement of the GABA-benzodiazepine receptor complex.
Topics: Analgesia; Animals; Baclofen; Bicuculline; Diazepam; Male; Muscimol; Naloxone; Pain Measurement; Rats; Rats, Wistar; Receptors, GABA-A | 1992 |
Involvement of central GABAA receptor complex in controlling the basal gastric secretory activity in pylorus-ligated rats.
Topics: Analysis of Variance; Anesthesia; Animals; Bicuculline; Diazepam; Gastric Acid; Male; Pentobarbital; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A | 1992 |
Influences of gender, gonadectomy, and estrous cycle on GABA/BZ receptors and benzodiazepine responses in rats.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Brain; Brain Chemistry; Diazepam; Estrus; Female; Flunitrazepam; Male; Orchiectomy; Ovariectomy; Radioimmunoassay; Radioligand Assay; Rats; Receptors, GABA-A; Sex Characteristics | 1992 |
A rodent model of focally evoked self-sustaining status epilepticus.
Topics: Animals; Bicuculline; Diazepam; Disease Models, Animal; Electroencephalography; Lithium; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus | 1992 |
Benzodiazepine receptor ligands and sexual behavior in the male rat: the role of GABAergic mechanisms.
Topics: Animals; Bicuculline; Carbolines; Chlordiazepoxide; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Male; Motor Activity; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sexual Behavior, Animal | 1991 |
Gestational exposure to diazepam increases sensitivity to convulsants that act at the GABA/benzodiazepine receptor complex.
Topics: Animals; Bicuculline; Caffeine; Carbolines; Cerebral Cortex; Chlorides; Convulsants; Diazepam; Female; GABA-A Receptor Antagonists; Male; Picrotoxin; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptors, GABA-A; Seizures; Strychnine; Synaptosomes | 1991 |
Interaction of felbamate and diazepam against maximal electroshock seizures and chemoconvulsants in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Diazepam; Drug Interactions; Electroshock; Felbamate; GABA-A Receptor Antagonists; Isoniazid; Male; Mice; Pentylenetetrazole; Phenylcarbamates; Propylene Glycols; Seizures | 1991 |
Effects of anxiolytic drugs on escape behavior induced by dorsal central gray stimulation in rats.
Topics: Animals; Anti-Anxiety Agents; Arousal; Avoidance Learning; Bicuculline; Brain Mapping; Bromazepam; Chlordiazepoxide; Diazepam; Electric Stimulation; Escape Reaction; GABA Antagonists; Male; Meprobamate; Pentobarbital; Periaqueductal Gray; Picrotoxin; Rats; Rats, Inbred Strains; Sensory Thresholds | 1991 |
Involvement of the GABAA/benzodiazepine chloride ionophore receptor complex in the 5,7-DHT Induced anticonflict effect.
Topics: 5,7-Dihydroxytryptamine; Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Bicuculline; Diazepam; Drinking Behavior; Electroshock; Flumazenil; Hippocampus; Injections, Intraventricular; Limbic System; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Serotonin | 1991 |
Effects of adrenergic blockers or bicuculline on diazepam induced changes in rat pineal melatonin synthesis in vivo and in vitro.
Topics: Acetylserotonin O-Methyltransferase; Animals; Bicuculline; Diazepam; Drug Interactions; gamma-Aminobutyric Acid; Male; Melatonin; Phenoxybenzamine; Pineal Gland; Propranolol; Rats; Rats, Inbred Strains; Serotonin | 1991 |
Correlation between gamma-aminobutyric acidA receptor ligand-induced changes in t-butylbicyclophosphoro[35S]thionate binding and 36Cl- uptake in rat cerebrocortical membranes.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cerebral Cortex; Chloride Channels; Chlorides; Desoxycorticosterone; Diazepam; Ethanol; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Ligands; Membrane Proteins; Pentobarbital; Pregnanolone; Rats; Receptors, GABA-A; Synaptosomes | 1991 |
Relative efficacies of benzodiazepine receptor agonists in affecting red nucleus electrical activity in rabbits.
Topics: Animals; Bicuculline; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; Imidazoles; Isoquinolines; Male; Pentylenetetrazole; Pyridazines; Pyridines; Rabbits; Receptors, GABA-A; Red Nucleus; Zolpidem | 1990 |
Benzodiazepines and synaptic processing in the spatial domain within the cat's primary somatosensory cortex.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Cats; Diazepam; Electric Stimulation; Electrophysiology; Female; Flumazenil; Fluphenazine; gamma-Aminobutyric Acid; Male; Midazolam; Physical Stimulation; Somatosensory Cortex; Space Perception; Synapses | 1990 |
Control of NMDA receptor-mediated activity by GABAergic mechanisms in mature and developing rat neocortex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Diazepam; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Somatosensory Cortex | 1990 |
Effects of GABA and anxiolytics on the single unit discharge of suprachiasmatic neurons in rat hypothalamic slices.
Topics: Animals; Anti-Anxiety Agents; Azabicyclo Compounds; Baclofen; Bicuculline; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Hypothalamus; In Vitro Techniques; Muscimol; Neurons; Piperazines; Rats; Receptors, GABA-A; Suprachiasmatic Nucleus | 1990 |
Relaxant effect of benzodiazepines on uterine rings isolated from estrogen-treated rats.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Bicuculline; Clonazepam; Convulsants; Diazepam; Estradiol; Estrogens; Female; Flumazenil; In Vitro Techniques; Isoquinolines; Muscle, Smooth; Potassium Chloride; Propranolol; Rats; Rats, Inbred Strains; Uterine Contraction | 1990 |
Interactions of GABAA antagonists with deltamethrin, diazepam, pentobarbital, and SKF100330A in the rat dentate gyrus.
Topics: Action Potentials; Animals; Anticonvulsants; Bicuculline; Diazepam; Drug Interactions; Female; GABA Antagonists; Hippocampus; Insecticides; Male; Membrane Potentials; Nicotinic Acids; Nitriles; Pentobarbital; Picrotoxin; Pyrethrins; Rats; Rats, Inbred Strains | 1991 |
Regionally specific alterations in the low-affinity GABAA receptor following perinatal exposure to diazepam.
Topics: Animals; Bicuculline; Binding, Competitive; Brain; Diazepam; Female; gamma-Aminobutyric Acid; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1990 |
(+)-Hydrastine, a potent competitive antagonist at mammalian GABAA receptors.
Topics: Acetylcholine; Alkaloids; Animals; Baclofen; Benzylisoquinolines; Bicuculline; Binding, Competitive; Brain Chemistry; Convulsants; Diazepam; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Membranes; Muscimol; Muscle, Smooth; Muscle, Smooth, Vascular; Rats; Receptors, GABA-A; Stereoisomerism | 1990 |
Pharmacological characteristics of two different types of inhibitory GABA receptors on Achatina fulica neurones.
Topics: Animals; Baclofen; Bicuculline; Crotonates; Diazepam; Dibenzazepines; Electrophysiology; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Muscimol; Neurons; Pentobarbital; Picrotoxin; Receptors, GABA-A; Snails | 1990 |
Species dependent dual modulation of the benzodiazepine/GABA receptor chloride channel by dihydroergosine.
Topics: Animals; Bicuculline; Brain; Chloride Channels; Diazepam; Ergotamines; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Membrane Proteins; Mice; Mice, Inbred CBA; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Species Specificity | 1990 |
[The role of the hypophysis in the immunomodulating influence of the GABA-ergic system].
Topics: Animals; Bicuculline; Diazepam; Hypophysectomy; Immunization; Mice; Mice, Inbred CBA; Neuroimmunomodulation; Phenotype; Pituitary Gland; Receptors, GABA-A; Rosette Formation; Spleen; T-Lymphocytes | 1990 |
GABAergic control of rhythmic activity in the presence of strychnine in the lamprey spinal cord.
Topics: Action Potentials; Animals; Bicuculline; Diazepam; Fishes; gamma-Aminobutyric Acid; In Vitro Techniques; Lampreys; Spinal Cord; Strychnine | 1990 |
Diazepam enhances bicuculline-induced increase of t-[35S]butylbicyclophosphorothionate binding in unwashed membrane preparations from rat cerebral cortex.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cerebral Cortex; Convulsants; Diazepam; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Subcellular Fractions | 1990 |
[GABA-activated conductance of mammalian cerebellar neurons].
Topics: Animals; Bicuculline; Chlorides; Diazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channels; Membrane Potentials; Pentobarbital; Potassium; Purkinje Cells; Rats; Receptors, GABA-A | 1986 |
GABAergic modulation of a substance P-mediated reflex of slow time course in the isolated rat spinal cord.
Topics: Animals; Baclofen; Bicuculline; Diazepam; Electrophysiology; gamma-Aminobutyric Acid; In Vitro Techniques; Muscimol; Rats; Rats, Inbred Strains; Reflex; Spinal Cord; Substance P | 1987 |
Spontaneous EEG spikes in the normal hippocampus. V. Effects of ether, urethane, pentobarbital, atropine, diazepam and bicuculline.
Topics: Anesthetics; Animals; Atropine; Behavior, Animal; Bicuculline; Diazepam; Electroencephalography; Ether; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Pentobarbital; Rats; Reference Values; Seizures; Urethane | 1988 |
Macrolide compounds, ivermectin and milbemycin D, stimulate chloride channels sensitive to GABAergic drugs in cultured chick spinal neurons.
Topics: Animals; Anti-Bacterial Agents; Bicuculline; Cells, Cultured; Chick Embryo; Chlorides; Diazepam; gamma-Aminobutyric Acid; Ion Channels; Ivermectin; Lactones; Macrolides; Membrane Potentials; Muscimol; Neurons; Picrotoxin; Sesterterpenes; Spinal Cord | 1989 |
Regional GABA/benzodiazepine receptor/chloride channel coupling after acute and chronic benzodiazepine treatment.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Bicuculline; Brain; Chlorides; Diazepam; Flunitrazepam; Flurazepam; gamma-Aminobutyric Acid; Ion Channels; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stimulation, Chemical | 1989 |
Relationship of agonist efficacy to changes in GABA sensitivity and anticonvulsant tolerance following chronic benzodiazepine ligand exposure.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Bicuculline; Brain Chemistry; Diazepam; Drug Tolerance; Electrophysiology; Flumazenil; gamma-Aminobutyric Acid; Male; Raphe Nuclei; Rats; Rats, Inbred Strains; Seizures | 1989 |
Differential effects of iodide and chloride on allosteric interactions of the GABAA receptor.
Topics: Allosteric Regulation; Animals; Anions; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Carbolines; Chlorides; Diazepam; gamma-Aminobutyric Acid; Iodides; Male; Pentobarbital; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1989 |
[Effect of clonidine on the schedule-controlled performance action of two benzodiazepine receptor agonists].
Topics: Animals; Bicuculline; Clonidine; Conditioning, Operant; Diazepam; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reinforcement Schedule; Yohimbine | 1989 |
[Influence of microinjection of bicuculline into ventrolateral medulla on the suppression of cardiac function induced by diazepam in rabbits].
Topics: Animals; Bicuculline; Cardiotonic Agents; Diazepam; Female; Heart; Male; Medulla Oblongata; Microinjections; Rabbits | 1989 |
Modulatory roles of GABAergic mechanisms in post-rotatory nystagmus in the rabbit.
Topics: Animals; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Nystagmus, Pathologic; Picrotoxin; Rabbits; Rotation; Semicarbazides; Strychnine; Time Factors | 1989 |
3-(Methoxycarbonyl)-amino-beta-carboline reduces both the sedative and anticonvulsant effects of diazepam.
Topics: Animals; Anticonvulsants; Bicuculline; Carbolines; Diazepam; Hypnotics and Sedatives; Male; Mice; Seizures; Time Factors | 1989 |
Effects of bicuculline-induced seizures on benzodiazepine and adenosine receptors in developing rat brain.
Topics: Animals; Bicuculline; Brain; Diazepam; Female; Male; Rats; Receptors, GABA-A; Receptors, Purinergic; Seizures | 1987 |
Heterogeneity of gamma-aminobutyric acid/benzodiazepine/beta-carboline receptor complex in rat spinal cord.
Topics: Animals; Bicuculline; Binding, Competitive; Carbolines; Cerebellum; Diazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Male; Muscimol; Rats; Receptors, GABA-A; Spinal Cord; Synaptic Membranes | 1988 |
Rapid internalization of benzodiazepine receptors in the rat cortex induced by handling.
Topics: Animals; Bicuculline; Carbolines; Cerebral Cortex; Corticosterone; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Ligands; Male; Rats; Receptors, GABA-A; Stress, Physiological; Synaptic Membranes; Viscosity | 1988 |
Effects of drugs on the electrical activity of the red nucleus in the rabbit. Activation of benzodiazepine and barbiturate receptors.
Topics: Animals; Bicuculline; Carbolines; Diazepam; Drug Interactions; Electroencephalography; Flumazenil; Muscle Relaxation; Pentobarbital; Pyridazines; Rabbits; Receptors, GABA-A; Receptors, Neurotransmitter; Red Nucleus | 1988 |
[Effector modeling of the effect of ligands of GABA receptor complex. Modification of conformation states of the complex by combined administration of benzodiazepines and barbiturates].
Topics: Animals; Anti-Anxiety Agents; Barbital; Barbiturates; Benzodiazepines; Benzodiazepinones; Bicuculline; Diazepam; Drug Antagonism; Female; Ligands; Mice; Models, Biological; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A | 1988 |
Interactions of pentobarbital and phenobarbital with GABAergic drugs against chemoconvulsants in rats.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Convulsants; Diazepam; Drug Interactions; Isoxazoles; Male; Pentobarbital; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Strychnine | 1988 |
Altered gamma-aminobutyric acid/benzodiazepine interaction after chronic diazepam exposure.
Topics: Animals; Benzodiazepines; Bicuculline; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Diazepam; gamma-Aminobutyric Acid; Ionophores; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Time Factors | 1988 |
Synthesis and biological activity of a GABAA agonist which has no effect on benzodiazepine binding and of structurally related glycine antagonists.
Topics: Animals; Bicuculline; Brain Chemistry; Chemical Phenomena; Chemistry; Diazepam; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Isoxazoles; Oxazoles; Piperidines; Pyrrolidines; Rats; Receptors, GABA-A; Synaptic Membranes | 1987 |
[Anxiolytic action of beta-carbolines in rats].
Topics: Alcoholism; Animals; Anti-Anxiety Agents; Bicuculline; Carbolines; Diazepam; Drug Evaluation, Preclinical; Escape Reaction; Humans; Indoles; Male; Rats; Receptors, GABA-A | 1985 |
Benzodiazepine, beta-carboline, and barbiturate actions on GABA responses.
Topics: Animals; Anti-Anxiety Agents; Barbiturates; Bicuculline; Carbolines; Cells, Cultured; Clonazepam; Diazepam; gamma-Aminobutyric Acid; Membrane Potentials; Mice; Neurons; Nitrazepam; Pentobarbital; Phenobarbital; Picrotoxin; Receptors, GABA-A; Spinal Cord | 1986 |
GABA-B receptor activation and conflict behaviour.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Baclofen; Behavior, Animal; Bicuculline; Cell Membrane; Cerebellum; Cerebral Cortex; Conflict, Psychological; Diazepam; Male; Oxazepam; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
Pharmacologically induced changes in the latency of digastric reflexes in 1-7 day old rabbits.
Topics: Animals; Animals, Newborn; Bicuculline; Decerebrate State; Diazepam; Electromyography; gamma-Aminobutyric Acid; Pentobarbital; Picrotoxin; Rabbits; Reflex; Stomach; Strychnine; Synaptic Transmission | 1988 |
Behavioral evidence for the role of noradrenaline in putative anxiolytic and sedative effects of benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Bicuculline; Clonidine; Conditioning, Operant; Diazepam; Dose-Response Relationship, Drug; Hypnotics and Sedatives; Male; Norepinephrine; Rats; Rats, Inbred Strains; Reinforcement Schedule; Yohimbine | 1988 |
Modulation of [3H]diazepam binding in rat cortical membranes by GABAA agonists.
Topics: Androstanes; Animals; Azasteroids; Bicuculline; Cell Membrane; Cerebral Cortex; Diazepam; GABA Antagonists; gamma-Aminobutyric Acid; Imidazoles; Isonicotinic Acids; Isoxazoles; Muscimol; Piperidines; Rats; Receptors, GABA-A; Taurine | 1985 |
Evidence for gamma-aminobutyric acid mediation of the sympathetic nerve inhibitory response to vagal afferent stimulation.
Topics: Afferent Pathways; Animals; Bicuculline; Blood Pressure; Cats; Diazepam; Female; gamma-Aminobutyric Acid; Heart; Male; Neural Inhibition; Picrotoxin; Receptors, GABA-A; Reflex; Sympathetic Nervous System; Urethane; Vagus Nerve | 1985 |
Continuous release of diazepam: electrophysiological, biochemical and behavioral consequences.
Topics: Animals; Bicuculline; Brain; Delayed-Action Preparations; Diazepam; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Serotonin | 1985 |
Benzodiazepine/gamma-aminobutyric acid receptor deficit in the midbrain of the seizure-susceptible gerbil.
Topics: Animals; Bicuculline; Diazepam; Disease Models, Animal; Flunitrazepam; Gerbillinae; Mesencephalon; Muscimol; Pentobarbital; Receptors, GABA-A; Seizures | 1985 |
[Effect of gamma-aminobutyric acid, its agonists and antagonists on uterine smooth muscle].
Topics: Animals; Bicuculline; Convulsants; Diazepam; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Rabbits; Receptors, GABA-A; Uterus | 1985 |
GABA agonists. Resolution, absolute stereochemistry, and enantioselectivity of (S)-(+)- and (R)-(-)-dihydromuscimol.
Topics: Animals; Bicuculline; Brain; Cats; Chemical Phenomena; Chemistry; Diazepam; gamma-Aminobutyric Acid; Isoxazoles; Molecular Conformation; Muscimol; Neurons; Oxazolidinones; Piperidines; Rats; Receptors, GABA-A; Spinal Cord; Stereoisomerism; Structure-Activity Relationship; Synaptic Membranes | 1985 |
Changes in GABAergic system parameters after chronic administration of bicuculline.
Topics: Animals; Bicuculline; Brain; Cerebellum; Cerebral Cortex; Diazepam; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Injections, Intraperitoneal; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Membranes | 1985 |
Effects of diazepam on circadian phase advances and delays.
Topics: Animals; Bicuculline; Circadian Rhythm; Cricetinae; Diazepam; gamma-Aminobutyric Acid; Light; Male; Mesocricetus; Motor Activity; Synaptic Transmission | 1986 |
Proconflict effect of GABA receptor complex antagonists. Reversal by diazepam.
Topics: Animals; Benzodiazepinones; Bicuculline; Conflict, Psychological; Diazepam; Flumazenil; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1986 |
Benzodiazepines inhibit thyrotropin (TSH)-releasing hormone-induced TSH and growth hormone release from perifused rat pituitaries.
Topics: Animals; Benzodiazepines; Bicuculline; Diazepam; Flumazenil; Growth Hormone; Growth Hormone-Releasing Hormone; In Vitro Techniques; Isoquinolines; Male; Picrotoxin; Pituitary Gland, Anterior; Rats; Receptors, GABA-A; Secretory Rate; Thyrotropin; Thyrotropin-Releasing Hormone | 1986 |
Reversal of the effect of centrally-administered diazepam on morphine antinociception by specific (Ro 15-1788 and Ro 15-3505) and non-specific (bicuculline and caffeine) benzodiazepine antagonists.
Topics: Animals; Benzodiazepinones; Bicuculline; Caffeine; Diazepam; Flumazenil; Injections, Intraventricular; Male; Morphine; Pain; Rats; Rats, Inbred Strains | 1986 |
Microgram doses of diazepam do not induce proconvulsant or proconflict effects in rodents.
Topics: Animals; Bicuculline; Conditioning, Operant; Diazepam; Isoniazid; Mice; Pentylenetetrazole; Picrotoxin; Punishment; Seizures | 1987 |
Enhancement of a diazepam withdrawal symptom by bicuculline and yohimbine.
Topics: Animals; Bicuculline; Diazepam; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Flumazenil; Male; Rats; Substance Withdrawal Syndrome; Yohimbine | 1987 |
Benzodiazepines both enhance gamma-aminobutyrate responses and decrease calcium action potentials in guinea-pig myenteric neurones.
Topics: Action Potentials; Animals; Benzodiazepines; Bicuculline; Calcium; Cell Membrane; Diazepam; Drug Interactions; Electric Conductivity; gamma-Aminobutyric Acid; Guinea Pigs; Midazolam; Myenteric Plexus | 1985 |
The role of GABA in morphine abstinence in rats.
Topics: Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Male; Morphine; Rats; Rats, Inbred Strains; Serotonin; Substance Withdrawal Syndrome | 1988 |
Possible involvement of the central GABAergic system in pentobarbital-stimulated gastric acid secretion in the perfused rat stomach preparation.
Topics: 3-Mercaptopropionic Acid; Anesthesia; Animals; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Gastric Acid; Gastric Mucosa; In Vitro Techniques; Male; Pentobarbital; Pentylenetetrazole; Perfusion; Picrotoxin; Rats; Rats, Inbred Strains; Urethane | 1988 |
Interactions of acoustic and somatosensory evoked responses in a polysensory cortex of the cat.
Topics: Acoustic Stimulation; Amphetamine; Animals; Baclofen; Bicuculline; Cats; Diazepam; Electric Stimulation; Evoked Potentials, Auditory; Evoked Potentials, Somatosensory; Glutamine; Haloperidol; Microelectrodes; Neurons; Parathyroid Hormone; Picrotoxin; Reserpine; Somatosensory Cortex; Taurine | 1987 |
Spinal and supraspinal components of GABAergic inhibition of the micturition reflex in rats.
Topics: Aminooxyacetic Acid; Animals; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Kinetics; Male; Picrotoxin; Rats; Rats, Inbred Strains; Reflex; Spinal Cord; Taurine; Urination | 1987 |
Time course for development of anticonvulsant tolerance and GABAergic subsensitivity after chronic diazepam.
Topics: Animals; Anticonvulsants; Bicuculline; Brain; Diazepam; Drug Interactions; Drug Tolerance; gamma-Aminobutyric Acid; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin | 1987 |
Mechanisms by which picrotoxin and a high dose of diazepam elevate plasma corticosterone level.
Topics: Animals; Apomorphine; Atropine; Bicuculline; Clonidine; Corticosterone; Dexamethasone; Diazepam; Drug Interactions; Female; Haloperidol; Picrotoxin; Rats; Rats, Inbred Strains; Yohimbine | 1986 |
Kindling induced changes in EEG recorded during stimulation from the site of stimulation: collapse of GABA-mediated inhibition and onset of rhythmic synchronous burst.
Topics: Action Potentials; Amygdala; Animals; Bicuculline; Carbolines; Cerebral Cortex; Diazepam; Electroencephalography; gamma-Aminobutyric Acid; Hippocampus; Kindling, Neurologic; Male; Neural Inhibition; Picrotoxin; Rats; Rats, Inbred Strains | 1986 |
An analysis of the in vivo interactions between chemical convulsants and anticonvulsants.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Valproic Acid | 1985 |
Respiratory depression produced by injection of GABA into the fourth ventricle of the rabbit.
Topics: Animals; Bicuculline; Depression, Chemical; Diazepam; Female; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Picrotoxin; Rabbits; Respiration | 1985 |
gamma-Aminobutyric acid- and benzodiazepine-induced modulation of [35S]-t-butylbicyclophosphorothionate binding to cerebellar granule cells.
Topics: Animals; Benzodiazepines; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Carbolines; Cerebellum; Diazepam; gamma-Aminobutyric Acid; Granulocytes; Muscimol; Picrotoxin; Rats; Sulfur Radioisotopes; Temperature | 1985 |
Antagonism of picrotoxin against the taming effect of carbamazepine on footshock induced fighting behavior in mice.
Topics: Aggression; Animals; Bicuculline; Carbamazepine; Diazepam; Electroshock; gamma-Aminobutyric Acid; Haloperidol; Lithium; Male; Mice; Pentylenetetrazole; Picrotoxin | 1985 |
Involvement of adenosine receptor activities in aggressive responses produced by clonidine in mice.
Topics: Adenosine; Aggression; Animals; Apomorphine; Bicuculline; Clonidine; Diazepam; Dipyridamole; Humans; Male; Mice; Receptors, Cell Surface; Receptors, Purinergic; Theophylline | 1984 |
Pharmacodynamic investigation of (+/-)-salutaridine.
Topics: Animals; Bicuculline; Diazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Morphinans; Rats; Receptors, GABA-A; Synaptic Membranes; Synaptosomes | 1984 |
[Effect of diazepam on various effects of morphine use in mice and rats].
Topics: Animals; Bicuculline; Diazepam; Drug Interactions; Etorphine; Male; Mice; Morphine; Motor Activity; Picrotoxin; Rats; Rats, Inbred Strains; Respiration; Synaptic Transmission | 1984 |
[Effect of GABA-negative preparations on the anxiolytic and sedative effects of diazepam].
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Picrotoxin; Rats | 1981 |
Modification of the antinociceptive effect of morphine by centrally administered diazepam and midazolam.
Topics: Analgesics; Animals; Anti-Anxiety Agents; Benzodiazepines; Bicuculline; Diazepam; Injections, Intraventricular; Male; Midazolam; Morphine; Rats; Rats, Inbred Strains; Time Factors | 1982 |
Gabamimetic properties of anxiolytic drugs.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Caudate Nucleus; Diazepam; Electric Stimulation; gamma-Aminobutyric Acid; Male; Movement; Picrotoxin; Pyrazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
[Effect of multiple daily administration of fenibut and diazepam on GABA and benzodiazepine receptors in the mouse brain].
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Brain; Diazepam; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Male; Mice; Receptors, Drug; Receptors, Neurotransmitter | 1983 |
[Effects of pentylenetetrazol on conflict behavior and interactions with anxiolytics in rats].
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains | 1983 |
The effects of GABA and benzodiazepine receptor antagonists on the anti-conflict actions of diazepam or ethanol.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Bicuculline; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Ethanol; Flumazenil; Male; Picrotoxin; Punishment; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1984 |
Self-injection of diazepam in naive rats: effects of dose, schedule and blockade of different receptors.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Bicuculline; Diazepam; Dose-Response Relationship, Drug; Extinction, Psychological; Flumazenil; Haloperidol; Male; Naloxone; Rats; Receptors, Drug; Reinforcement Schedule; Self Administration | 1984 |
GABAB receptor-mediated inhibition of serotonin release in the rat brain.
Topics: Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Brain Chemistry; Cerebral Cortex; Diazepam; Electric Stimulation; gamma-Aminobutyric Acid; Hydroxyindoleacetic Acid; In Vitro Techniques; Male; Nipecotic Acids; Phentolamine; Picrotoxin; Proline; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Serotonin | 1984 |
Two or more conformations of benzodiazepine receptors depending on GABA receptors and other variables.
Topics: Animals; Benzodiazepines; Bicuculline; Brain; Diazepam; gamma-Aminobutyric Acid; Macromolecular Substances; Male; Muscimol; Piperidines; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Receptors, Neurotransmitter; Structure-Activity Relationship; Synaptic Membranes | 1980 |
[Participation of GABA-ergic structures in producing the effects of haloperidol].
Topics: Animals; Bicuculline; Chlorpromazine; Diazepam; gamma-Aminobutyric Acid; Haloperidol; Male; Mice; Rats; Receptors, Neurotransmitter; Seizures; Semicarbazides; Sulfhydryl Compounds | 1980 |
Anticonvulsant effects of careulein and cholecystokinin octapeptide, compared with those of diazepam.
Topics: Animals; Anticonvulsants; Bicuculline; Ceruletide; Cholecystokinin; Diazepam; Kinetics; Male; Mice; Pentylenetetrazole; Seizures; Sincalide; Strychnine; Time Factors | 1980 |
Avermectin B1a: an irreversible activator of the gamma-aminobutyric acid-benzodiazepine-chloride-ionophore receptor complex.
Topics: Animals; Anthelmintics; Bicuculline; Cell Membrane; Chlorides; Diazepam; Disaccharides; In Vitro Techniques; Ivermectin; Lactones; Male; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A | 1980 |
Involvement of central GABA receptors in the regulation of the urinary bladder function of anaesthetized rats.
Topics: Animals; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Glycine; Levodopa; Male; Muscimol; Muscle Contraction; Rats; Receptors, Cell Surface; Urinary Bladder | 1980 |
Pentobarbital enhances [3H]diazepam binding to soluble receptors at the benzodiazepine--GABA-receptor-ionophore complex.
Topics: Animals; Bicuculline; Diazepam; Dose-Response Relationship, Drug; In Vitro Techniques; Ionophores; Pentobarbital; Picrotoxin; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Tritium | 1981 |
GABA reduces binding of 3H-methyl beta-carboline-3-carboxylate to brain benzodiazepine receptors.
Topics: Animals; Bicuculline; Brain; Carbolines; Cerebellum; Cerebral Cortex; Diazepam; gamma-Aminobutyric Acid; Indoles; Muscimol; Rats; Receptors, Drug; Receptors, GABA-A; Structure-Activity Relationship | 1981 |
gamma-Aminobutyric acid- and benzodiazepine-binding sites in human anterior pituitary tissue.
Topics: Adult; Aged; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Humans; Isonicotinic Acids; Isoxazoles; Middle Aged; Muscimol; Pituitary Gland, Anterior; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A | 1982 |
Benzodiazepines enhance the bicuculline-sensitive part of recurrent Renshaw inhibition in the cat spinal cord.
Topics: Animals; Benzodiazepines; Bicuculline; Cats; Diazepam; Drug Synergism; Evoked Potentials; gamma-Aminobutyric Acid; Midazolam; Motor Neurons; Neural Inhibition; Receptors, Cell Surface; Receptors, GABA-A; Spinal Cord; Strychnine | 1982 |
[Effect of the GABA receptor blockader bicuculline on the action of fenibut and diazepam].
Topics: Animals; Behavior, Animal; Bicuculline; Diazepam; Drug Interactions; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
Ethylenediamine and GABA potentiation of [3H]diazepam binding to benzodiazepine receptors in rat cerebral cortex.
Topics: Animals; Bicuculline; Buffers; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Ethylenediamines; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A | 1982 |
Convulsant and anticonvulsant effects of opioids: relationship to GABA-mediated transmission.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Bicuculline; Brain; Convulsants; Diazepam; Electroencephalography; gamma-Aminobutyric Acid; Morphine; Naloxone; Narcotics; Picrotoxin; Rabbits; Receptors, Cell Surface; Receptors, GABA-A; Synaptic Transmission | 1982 |
[Effect of diazepam on reactivity of hippocampal neurons during blocking of GABA-ergic system].
Topics: Action Potentials; Animals; Bicuculline; Depression, Chemical; Diazepam; Drug Antagonism; Evoked Potentials; GABA Antagonists; Hippocampus; In Vitro Techniques; Mice; Mice, Inbred C57BL; Neurons; Picrotoxin; Receptors, Neurotransmitter | 1982 |
Heterogeneity of benzodiazepine receptor interactions with gamma-aminobutyric acid and barbiturate receptor sites.
Topics: Animals; Bicuculline; Binding Sites; Brain; Diazepam; gamma-Aminobutyric Acid; Kinetics; Pentobarbital; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Neurotransmitter; Tissue Distribution | 1983 |
PK 8165 and PK 9084, two quinoline derivatives with anxiolytic properties, antagonize the anticonvulsant effects of diazepam.
Topics: Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Brain; Diazepam; Drug Antagonism; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Quinolines; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1983 |
Is the muscle relaxant effect of diazepam in spastic mutant rats mediated through GABA-independent benzodiazepine receptors?
Topics: Animals; Benzodiazepinones; Bicuculline; Diazepam; Electromyography; Female; Flumazenil; Male; Muscle Contraction; Muscle Relaxation; Picrotoxin; Rats; Rats, Mutant Strains; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Is Ro15-1788 a partial agonist at benzodiazepine receptors?
Topics: Animals; Benzodiazepinones; Bicuculline; Convulsants; Diazepam; Flumazenil; Male; Mice; Mice, Inbred C3H; Phenobarbital; Pyridazines; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Enhancement of 3H-phenytoin binding by diazepam and (+)bicuculline.
Topics: Animals; Bicuculline; Brain; Diazepam; gamma-Aminobutyric Acid; Kinetics; Male; Phenytoin; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Control of substantia nigra pars reticulata neurons by the nucleus accumbens.
Topics: Animals; Bicuculline; Brain Mapping; Cats; Diazepam; Electric Stimulation; Female; gamma-Aminobutyric Acid; Male; Neural Pathways; Nucleus Accumbens; Septal Nuclei; Strychnine; Substantia Nigra; Synaptic Transmission | 1983 |
Diazepam, pentobarbital and D-etomidate produced increases in bicuculline seizure threshold; selective antagonism by RO15-1788, picrotoxin and (+/-)-DMBB.
Topics: Animals; Barbiturates; Benzodiazepinones; Bicuculline; Diazepam; Etomidate; Flumazenil; Imidazoles; Male; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1983 |
Fastigial influences on postural tonus as studied by kainate lesions and by local infusion of GABAergic drugs in the rat.
Topics: Animals; Bicuculline; Cerebellar Nuclei; Diazepam; Functional Laterality; gamma-Aminobutyric Acid; Kainic Acid; Male; Motor Activity; Muscle Tonus; Picrotoxin; Posture; Pyrrolidines; Rats; Rats, Inbred Strains; Stereotaxic Techniques | 1984 |
The bicuculline-like properties of dopamine sulfate in rat brain.
Topics: Animals; Bicuculline; Brain; Diazepam; Dopamine; Drug Interactions; gamma-Aminobutyric Acid; Male; Muscimol; Rats; Rats, Inbred Strains; Seizures; Strychnine; Synaptic Membranes | 1984 |
Growth hormone secretion of the neonatal rat pituitaries is stimulated by gamma-aminobutyric acid in vitro.
Topics: Aging; Animals; Animals, Newborn; Baclofen; Bicuculline; Diazepam; Female; GABA Antagonists; gamma-Aminobutyric Acid; Growth Hormone; In Vitro Techniques; Muscimol; Picrotoxin; Rats; Rats, Inbred Strains; Strychnine | 1984 |
Effects of benzodiazepines on single unit activity in the substantia nigra pars reticulata.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Bicuculline; Caffeine; Diazepam; Dose-Response Relationship, Drug; Electric Conductivity; Flumazenil; Flurazepam; Male; Neurons; Picrotoxin; Rats; Rats, Inbred Strains; Substantia Nigra; Theophylline | 1982 |
Saturable binding of [3H]phenytoin to rat brain membrane fraction.
Topics: Animals; Bicuculline; Binding Sites; Brain; Diazepam; In Vitro Techniques; Male; Membranes; Peptide Hydrolases; Phenytoin; Radioligand Assay; Rats; Tritium | 1981 |
Bicuculline blocks diazepam-induced feeding in Syrian hamsters.
Topics: Animals; Bicuculline; Cricetinae; Diazepam; Feeding Behavior; Male; Mesocricetus; Motor Activity | 1982 |
Pharmacological evidence for two kinds of GABA receptor on rat hippocampal pyramidal cells studied in vitro.
Topics: Animals; Bicuculline; Dendrites; Diazepam; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Membrane Potentials; Penicillins; Pentobarbital; Pyramidal Tracts; Rats; Receptors, Drug | 1982 |
In vivo modulations by GABA-related drugs of met-enkephalin release in basal ganglia of the cat brain.
Topics: Animals; Bicuculline; Cats; Caudate Nucleus; Diazepam; Drug Interactions; Enkephalin, Methionine; Female; gamma-Aminobutyric Acid; Globus Pallidus; Male; Muscimol; Picrotoxin | 1982 |
Effects of muscimol alone and in combination with diazepam on shuttle-box performance in rats.
Topics: Animals; Avoidance Learning; Bicuculline; Diazepam; Drug Interactions; Male; Muscimol; Oxazoles; Rats; Rats, Inbred Strains | 1981 |
Diphenylhydantoin potentiates the protective effect of diazepam against pentylenetetrazol but not against bicuculline and isoniazid-induced seizures in mice.
Topics: Animals; Bicuculline; Diazepam; Drug Synergism; Isoniazid; Male; Mice; Pentylenetetrazole; Phenytoin; Seizures | 1981 |
Decrease in effects of muscimol on the dorsal root after repeated administration of diazepam in rats.
Topics: Animals; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Male; Membrane Potentials; Muscimol; Oxazoles; Rats; Rats, Inbred Strains; Spinal Nerve Roots; Time Factors | 1981 |
Benzodiazepines modulate striatal enkephalin levels via a GABAergic mechanism.
Topics: Aminooxyacetic Acid; Animals; Bicuculline; Corpus Striatum; Diazepam; Endorphins; Enkephalin, Methionine; Enkephalins; Fentanyl; gamma-Aminobutyric Acid; Hypothalamus; Male; Muscimol; Radioimmunoassay; Rats | 1980 |
Endogenous regulators of benzodiazepine recognition sites.
Topics: Animals; Bicuculline; Binding, Competitive; Cerebral Cortex; Diazepam; gamma-Aminobutyric Acid; Kinetics; Rats; Receptors, Drug; Synaptic Membranes | 1980 |
[GABA-ergic mechanisms of the cerebrovascular effects of fenazepam and diazepam].
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Bicuculline; Blood Pressure; Cats; Cerebrovascular Circulation; Diazepam; gamma-Aminobutyric Acid; Reflex; Vasomotor System | 1980 |
Evidence for a tonic GABAergic control of serotonin neurons in the median raphe nucleus.
Topics: Animals; Bicuculline; Brain Stem; Diazepam; gamma-Aminobutyric Acid; Male; Muscimol; Neurons; Picrotoxin; Probenecid; Raphe Nuclei; Rats; Serotonin | 1981 |
Effects of diazepam on hippocampal excitability in the rat: action in the dentate area.
Topics: Animals; Bicuculline; Diazepam; Drug Interactions; Electroshock; Evoked Potentials; Hippocampus; Male; Rats; Time Factors | 1981 |
Effects of barbital or diazepam withdrawal on seizure thresholds to bicuculline, picrotoxin and flurazepam.
Topics: Animals; Barbital; Bicuculline; Convulsants; Diazepam; Flurazepam; Male; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Substance Withdrawal Syndrome | 1995 |
Role of GABAergic systems in the development of morphine tolerance in formalin-treated mice.
Topics: Analgesics, Opioid; Animals; Baclofen; Bicuculline; Diazepam; Drug Tolerance; Flumazenil; Formaldehyde; GABA Agonists; GABA Antagonists; Male; Mice; Mice, Inbred Strains; Morphine; Muscimol; Pain; Pain Measurement; Receptors, GABA | 1995 |
Involvement of benzodiazepine/GABA-A receptor complex in ethanol-induced state-dependent learning in rats.
Topics: Animals; Avoidance Learning; Azides; Benzodiazepines; Bicuculline; Diazepam; Ethanol; Evaluation Studies as Topic; Flumazenil; Male; Muscimol; Picrotoxin; Rats; Rats, Wistar; Reaction Time; Receptors, GABA-A | 1995 |
Diazepam biphasically modulates [3H]TBOB binding to the convulsant site of the GABAA receptor complex.
Topics: Animals; Bicuculline; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Diazepam; Female; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Prosencephalon; Rats; Rats, Wistar; Receptors, GABA-A | 1995 |
GABAA/benzodiazepine receptors in acutely isolated hippocampal astrocytes.
Topics: Amino Acid Sequence; Animals; Antibody Specificity; Astrocytes; Bicuculline; Brain; Calcium; Calcium Channels; Carbolines; Cell Separation; Chlorides; Diazepam; Evoked Potentials; gamma-Aminobutyric Acid; Gene Expression; Glial Fibrillary Acidic Protein; Hippocampus; Immunoblotting; In Vitro Techniques; Macromolecular Substances; Membrane Potentials; Molecular Sequence Data; Muscimol; Patch-Clamp Techniques; Peptide Fragments; Picrotoxin; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1995 |
Biochemical and functional identification of GABA receptors in Hydra vulgaris.
Topics: Animals; Baclofen; Bicuculline; Binding, Competitive; Diazepam; Feeding Behavior; gamma-Aminobutyric Acid; Glutathione; Hydra; Kinetics; Membranes; Receptors, GABA; Sensitivity and Specificity; Stimulation, Chemical; Tritium | 1995 |
GABAergic and dopaminergic systems may be involved in seizures induced by pyrimethamine in mice.
Topics: Animals; Bicuculline; Diazepam; Dopamine; Drug Interactions; gamma-Aminobutyric Acid; Levodopa; Mice; Mice, Inbred Strains; Muscimol; Phenobarbital; Pyrimethamine; Seizures | 1994 |
Repeated treatment with alpidem, a new anxiolytic, does not induce tolerance or physical dependence.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Carbolines; Convulsants; Diazepam; Drug Tolerance; Flumazenil; Imidazoles; Isoniazid; Male; Mice; Pentylenetetrazole; Pyridines; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
The electrophysiological effects of endogenous GABA in the guinea-pig inferior mesenteric ganglion.
Topics: Acetylcholine; Afferent Pathways; Animals; Bicuculline; Colon; Diazepam; Efferent Pathways; Electric Stimulation; Electrophysiology; Evoked Potentials; gamma-Aminobutyric Acid; Ganglia, Sympathetic; Guinea Pigs; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Male; Mesentery; Physical Stimulation; Picrotoxin; Receptors, GABA | 1993 |
Allosteric modulation of [35S]TBPS-binding in the cerebral cortex of the rat during postnatal development.
Topics: Aging; Allosteric Regulation; Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; Convulsants; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stereoisomerism; Sulfur Radioisotopes | 1994 |
[Effect of preliminary administration of phenobarbital on the toxicity of GABA-lytics in mice].
Topics: 3-Mercaptopropionic Acid; Animals; Antidotes; Barbiturates; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Male; Mice; Phenobarbital; Picrotoxin; Time Factors | 1993 |
Effects of propofol, pentobarbital and alphaxalone on t-[35S]butylbicyclophosphorothionate binding in rat cerebral cortex.
Topics: Anesthetics; Animals; Bicuculline; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; Diazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channel Gating; Male; Membranes; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Sulfur Radioisotopes | 1994 |
Antinociception produced by microinjection of L-glutamate into the ventromedial medulla of the rat: mediation by spinal GABAA receptors.
Topics: Animals; Behavior, Animal; Bicuculline; Diazepam; GABA Antagonists; Glutamates; Glutamic Acid; Injections, Spinal; Isonicotinic Acids; Male; Medulla Oblongata; Microinjections; Nociceptors; Pyridazines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, GABA; Skin Temperature; Spinal Cord | 1993 |
Enteric GABA-containing nerves projecting to the guinea-pig inferior mesenteric ganglion modulate acetylcholine release.
Topics: Acetylcholine; Animals; Baclofen; Bicuculline; Colon; Diazepam; Electric Stimulation; gamma-Aminobutyric Acid; Ganglia, Sympathetic; Guinea Pigs; In Vitro Techniques; Male; Mesentery; Muscimol; Neural Pathways; Receptors, GABA-A; Receptors, GABA-B; Splanchnic Nerves; Synaptic Transmission | 1993 |
Modulation of 35S-TBPS binding by GABAergic drugs in the cerebral cortex of newborn and adult rats.
Topics: Aging; Animals; Animals, Newborn; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cell Membrane; Cerebral Cortex; Convulsants; Diazepam; gamma-Aminobutyric Acid; Kinetics; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sulfur Radioisotopes | 1993 |
Modulation of the developing rat sympathetic GABAA receptor by Zn++, benzodiazepines, barbiturates and ethanol.
Topics: Aging; Animals; Barbiturates; Benzodiazepines; Bicuculline; Diazepam; Ethanol; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Neurons; Pentobarbital; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sensitivity and Specificity; Superior Cervical Ganglion; Zinc | 1993 |
Alterations in both excitation and inhibition occur before the onset of seizure activity in the hippocampus.
Topics: Animals; Baclofen; Bicuculline; Diazepam; Electric Stimulation; Evoked Potentials; Hippocampus; Ketamine; Kindling, Neurologic; Limbic System; Male; Neurons; Phenobarbital; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Seizures; Stereotaxic Techniques; Synapses | 1993 |
Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Cimetidine; Diazepam; Female; Mice; Muscimol; Phenobarbital; Phenytoin; Picrotoxin; Receptors, GABA; Seizures; Strychnine | 1993 |
Effects of GABAergic drugs on ethanol-induced gastric lesions.
Topics: Animals; Baclofen; Bicuculline; Diazepam; Ethanol; GABA Antagonists; gamma-Aminobutyric Acid; Gastrointestinal Hemorrhage; Indomethacin; Male; Muscimol; Rats; Rats, Sprague-Dawley; Receptors, GABA; Valproic Acid | 1993 |
Photic induction of Fos in the hamster suprachiasmatic nucleus is inhibited by baclofen but not by diazepam or bicucullin.
Topics: Animals; Baclofen; Bicuculline; Cricetinae; Diazepam; Genes, fos; Light; Male; Mesocricetus; Proto-Oncogene Proteins c-fos; Suprachiasmatic Nucleus | 1993 |
Bicuculline-produced regional differences in the modulation of 35S-TBPS binding by GABA, pentobarbital and diazepam in mouse cerebellum and cortex.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Phenobarbital; Receptors, GABA-A | 1993 |
The spinal GABA system modulates burst frequency and intersegmental coordination in the lamprey: differential effects of GABAA and GABAB receptors.
Topics: Animals; Baclofen; Bicuculline; Culture Techniques; Diazepam; Evoked Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Lampreys; Locomotion; Motor Neurons; Muscimol; Muscles; N-Methylaspartate; Nerve Net; Neurons; Nipecotic Acids; Proline; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Spinal Nerve Roots; Synaptic Transmission | 1993 |
Interaction between benzodiazepine and GABA-A receptors in state-dependent learning.
Topics: Animals; Avoidance Learning; Baclofen; Bicuculline; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Muscimol; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A; Reference Values | 1993 |
Inhibitory effect of diazepam on the activity of the hypothalamic-pituitary-adrenal axis in female rats.
Topics: Adrenocorticotropic Hormone; Animals; Bicuculline; Corticosterone; Depression, Chemical; Diazepam; Female; Flumazenil; GABA-A Receptor Antagonists; Hypothalamo-Hypophyseal System; Isoquinolines; Picrotoxin; Pituitary-Adrenal System; Rats; Receptors, GABA-A | 1993 |
Attenuation of anticonvulsant effects of diazepam after chronic treatment with bicuculline.
Topics: Animals; Anticonvulsants; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Muscimol; Pentobarbital; Rats; Rats, Inbred F344; Rats, Inbred Lew; Receptors, GABA; Sleep | 1993 |
Novel GABA responses from rod-driven retinal horizontal cells.
Topics: Animals; Bicuculline; Chlorides; Crotonates; Diazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Membrane Potentials; Muscimol; Pentobarbital; Perches; Photoreceptor Cells; Receptors, GABA; Retina | 1993 |
Development of a piglet model of status epilepticus: preliminary results.
Topics: Animals; Bicuculline; Diazepam; Hemodynamics; Lorazepam; Models, Biological; Pilot Projects; Respiration; Status Epilepticus; Swine | 1993 |
Adrenal steroids mediate the increase of hippocampal nerve growth factor biosynthesis following bicuculline convulsions.
Topics: Adrenal Cortex Hormones; Adrenalectomy; Animals; Bicuculline; Blotting, Northern; Corticosterone; Dexamethasone; Diazepam; Hippocampus; Immunoenzyme Techniques; Male; Nerve Growth Factors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures | 1993 |
Electrophysiological characterization of GABAA receptors in anterior pituitary cells of newborn rats.
Topics: Animals; Animals, Newborn; Bicuculline; Cells, Cultured; Diazepam; Drug Tolerance; Electric Conductivity; Electrophysiology; Female; GABA Antagonists; gamma-Aminobutyric Acid; Kinetics; Membrane Potentials; Patch-Clamp Techniques; Pentobarbital; Picrotoxin; Pituitary Gland, Anterior; Rats; Receptors, GABA; Zinc | 1995 |
L-lysine is a barbiturate-like anticonvulsant and modulator of the benzodiazepine receptor.
Topics: Animals; Anions; Anticonvulsants; Barbiturates; Bicuculline; Brain Chemistry; Cattle; Central Nervous System Depressants; Diazepam; gamma-Aminobutyric Acid; Lysine; Male; Mice; Pentobarbital; Picrotoxin; Radioligand Assay; Receptors, GABA-A; Stimulation, Chemical | 1995 |
Lack of anticonvulsant tolerance and benzodiazepine receptor down regulation with imidazenil in rats.
Topics: Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Diazepam; Down-Regulation; Drug Tolerance; Flumazenil; GABA Modulators; Imidazoles; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Tritium | 1996 |
Allosteric modulation of GABAA receptors in acutely dissociated neurons of the suprachiasmatic nucleus.
Topics: Allosteric Regulation; Animals; Bicuculline; Chlorides; Diazepam; Electric Conductivity; Female; GABA Antagonists; GABA-A Receptor Agonists; Intracellular Membranes; Male; Neurons; Pentobarbital; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Suprachiasmatic Nucleus | 1996 |
Anticonvulsant profile of the imidazoquinazolines NNC 14-0185 and NNC 14-0189 in rats and mice.
Topics: Acoustic Stimulation; Amygdala; Animals; Anticonvulsants; Bicuculline; Carbolines; Clonazepam; Diazepam; Electroshock; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Kindling, Neurologic; Male; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Pentylenetetrazole; Quinazolines; Rats; Rats, Wistar; Seizures | 1996 |
Abecarnil, a beta-carboline derivative, does not exhibit anticonvulsant tolerance or withdrawal effects in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Binding Sites; Carbolines; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Seizures; Substance Withdrawal Syndrome | 1996 |
GABAergic influences on plus-maze behaviour in mice.
Topics: Animals; Baclofen; Behavior, Animal; Bicuculline; Diazepam; GABA Modulators; Male; Mice; Mice, Inbred DBA; Muscimol; Nipecotic Acids; Oximes; Picrotoxin; Valproic Acid | 1996 |
Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit.
Topics: Animals; Anticonvulsants; Bicuculline; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebral Cortex; Chloride Channels; Convulsants; Diazepam; DNA, Complementary; Female; gamma-Aminobutyric Acid; Humans; Kinetics; Macromolecular Substances; Male; Membrane Potentials; Oocytes; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins; Triazoles; Xenopus laevis | 1996 |
Excitatory and trophic action of GABA and related substances in newborn mice and organotypic cerebellar culture.
Topics: Aging; Animals; Animals, Newborn; Bicuculline; Calcium; Cell Count; Cerebellum; Diazepam; GABA Agents; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Intracellular Membranes; Mice; Mice, Inbred ICR; Motor Activity; Muscimol; Organ Culture Techniques; Purkinje Cells | 1997 |
Sex differences in bicuculline-induced convulsions: interaction with stress and ligands of benzodiazepine binding sites.
Topics: Animals; Benzodiazepines; Bicuculline; Binding Sites; Cold Temperature; Diazepam; Differential Threshold; Dose-Response Relationship, Drug; Female; Flumazenil; Handling, Psychological; Ligands; Male; Rats; Rats, Wistar; Seizures; Sex Characteristics; Stress, Physiological; Swimming | 1997 |
Diazepam-insensitive GABAA receptors on postnatal spiral ganglion neurones in culture.
Topics: Animals; Animals, Newborn; Baclofen; Bicuculline; Carbolines; Cells, Cultured; Convulsants; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pentobarbital; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A; Spiral Ganglion; Zinc | 1997 |
Local perfusion of diazepam attenuates interictal and ictal events in the bicuculline model of epilepsy in rats.
Topics: Administration, Topical; Animals; Bicuculline; Cerebral Cortex; Diazepam; Disease Models, Animal; Double-Blind Method; Drug Delivery Systems; Electroencephalography; Epidural Space; Epilepsies, Partial; Epilepsy; Functional Laterality; Hippocampus; Male; Motor Cortex; Random Allocation; Rats | 1997 |
Modification of the anxiolytic action of 5-HT1A compounds by GABA-benzodiazepine agents in rats.
Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Bicuculline; Buspirone; Diazepam; Drug Interactions; Flumazenil; GABA Agonists; Male; Psychomotor Performance; Pyrimidines; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1 | 1998 |
GABAA receptor pharmacology and subtype mRNA expression in human neuronal NT2-N cells.
Topics: Anticonvulsants; Bicuculline; Carbolines; Convulsants; Diazepam; Diuretics; DNA Primers; Furosemide; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Hypnotics and Sedatives; Lanthanum; Neurons; Patch-Clamp Techniques; Pentobarbital; Phenobarbital; Picrotoxin; Polymerase Chain Reaction; Pregnanediones; Pregnenolone; Pyridines; Receptors, GABA-A; RNA, Messenger; Teratocarcinoma; Triazoles; Tumor Cells, Cultured; Zinc; Zolpidem | 1998 |
Modulation of gamma-aminobutyric acid (GABA) receptors and the feeding response by neurosteroids in Hydra vulgaris.
Topics: Anesthetics; Animals; Anti-Anxiety Agents; Bicuculline; Carbolines; Cerebral Cortex; Chemoreceptor Cells; Clonazepam; Desoxycorticosterone; Diazepam; Feeding Behavior; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Glutathione; Hydra; Neurotransmitter Agents; Pregnanolone; Progesterone; Pyridazines; Radioligand Assay; Rats; Receptors, GABA-A; Tritium | 1998 |
Influence of gender on chronic ethanol-induced alterations in GABAA receptors in rats.
Topics: Animals; Anticonvulsants; Bicuculline; Cerebral Cortex; Convulsants; Desoxycorticosterone; Diazepam; Differential Threshold; Drug Resistance; Ethanol; Female; Gene Expression; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Sex Characteristics; Substance Withdrawal Syndrome; Time Factors | 1998 |
Behavioural pharmacological characteristics of honokiol, an anxiolytic agent present in extracts of Magnolia bark, evaluated by an elevated plus-maze test in mice.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Bicuculline; Biphenyl Compounds; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Antagonists; GABA Modulators; Injections, Subcutaneous; Lignans; Male; Maze Learning; Mice; Mice, Inbred BALB C; Motor Activity; Tetragastrin; Therapeutic Equivalency | 1998 |
Honokiol, a putative anxiolytic agent extracted from magnolia bark, has no diazepam-like side-effects in mice.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Bicuculline; Biphenyl Compounds; Diazepam; Hexobarbital; Learning; Lignans; Male; Memory; Mice; Mice, Inbred BALB C; Sleep; Substance-Related Disorders | 1999 |
Enhancement of GABA-activated current by muscarine in rat dorsal root ganglion neurons.
Topics: Acetylcholine; Action Potentials; Animals; Atropine; Bicuculline; Carbachol; Carbolines; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Female; GABA Agonists; GABA Modulators; Gallamine Triethiodide; gamma-Aminobutyric Acid; Ganglia, Spinal; Ion Channel Gating; Ion Channels; Male; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Nerve Tissue Proteins; Nicotinic Antagonists; Patch-Clamp Techniques; Pentobarbital; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Muscarinic | 1999 |
Abecarnil enhances recovery from diazepam tolerance.
Topics: Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Carbolines; Cell Membrane; Cerebral Cortex; Clonazepam; Diazepam; Drug Interactions; Drug Tolerance; Flumazenil; Imidazoles; Ligands; Male; Mice; Receptors, GABA-A; Seizures; Tritium | 1999 |
Dual role of GABA in the neonatal rat hippocampus.
Topics: Animals; Animals, Newborn; Bicuculline; Diazepam; Electrophysiology; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isonicotinic Acids; Nerve Net; Rats; Rats, Wistar | 1999 |
Effects of gamma-aminobutyric acid and peripheral benzodiazepine ligands on duodenal bicarbonate secretion.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Benzodiazepines; Bicarbonates; Bicuculline; Diazepam; Duodenum; Female; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Intestinal Mucosa; Isoquinolines; Ligands; Male; Muscimol; Rats; Rats, Inbred Lew | 1999 |
Activation of rat locus coeruleus neuron GABA(A) receptors by propofol and its potentiation by pentobarbital or alphaxalone.
Topics: Anesthetics; Anesthetics, Intravenous; Animals; Baclofen; Barium Compounds; Bicuculline; Chlorides; Diazepam; Drug Synergism; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Ionophores; Locus Coeruleus; Male; Neurons; Pentobarbital; Picrotoxin; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Zinc Compounds | 1999 |
Response kinetics and pharmacological properties of heteromeric receptors formed by coassembly of GABA rho- and gamma 2-subunits.
Topics: Animals; Bass; Bicuculline; Diazepam; Dose-Response Relationship, Drug; GABA Antagonists; GABA Modulators; Humans; Neurons; Oocytes; Perches; Picrotoxin; Receptors, GABA; Retina; Xenopus; Zinc | 1999 |
The role of the benzodiazepine-GABA system in the memory processes of the day-old chick.
Topics: Animals; Animals, Newborn; Bicuculline; Chickens; Diazepam; Discrimination, Psychological; Flumazenil; GABA Antagonists; GABA Modulators; Male; Memory; Receptors, GABA-A; Reinforcement, Psychology | 2000 |
Spontaneously opening GABA(A) channels in CA1 pyramidal neurones of rat hippocampus.
Topics: Animals; Bicuculline; Chloride Channels; Diazepam; Electric Conductivity; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Ion Channel Gating; Kinetics; Membrane Potentials; Patch-Clamp Techniques; Pyramidal Cells; Rats; Receptors, GABA-A | 2000 |
Positive and negative modulation of the GABA(A) receptor and outcome after traumatic brain injury in rats.
Topics: Animals; Bicuculline; Brain Injuries; Cognition; Diazepam; GABA Antagonists; GABA Modulators; Male; Maze Learning; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2000 |
Heterogeneity of GABA(A) receptor-mediated responses in the human IMR-32 neuroblastoma cell line.
Topics: Anticonvulsants; Bicuculline; Diazepam; Dose-Response Relationship, Drug; GABA Modulators; gamma-Aminobutyric Acid; Humans; Neuroblastoma; Patch-Clamp Techniques; Pentobarbital; Pregnanolone; Protein Isoforms; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triazoles; Tumor Cells, Cultured; Zinc | 2000 |
Participation of GABAergic and histaminergic systems in inhibiting amygdaloid kindled seizures.
Topics: Amygdala; Animals; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Histamine; Imidazoles; Kindling, Neurologic; Male; Muscimol; Rats; Rats, Wistar; Seizures; Thiourea; Valproic Acid | 2000 |
Chronic exposure to ethanol alters GABA(A) receptor-mediated responses of layer II pyramidal cells in adult rat piriform cortex.
Topics: Age Factors; Alcoholism; Animals; Bicuculline; Central Nervous System Depressants; Cerebral Cortex; Diazepam; Drug Tolerance; Ethanol; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Male; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2000 |
Benzodiazepine-sensitive GABA(A) receptors limit the activity of the NMDA/NO/cyclic GMP pathway: a microdialysis study in the cerebellum of freely moving rats.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Cerebellum; Cyclic GMP; Diazepam; Flumazenil; Infusions, Parenteral; Kinetics; Male; Microdialysis; Muscimol; N-Methylaspartate; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Zolpidem | 2000 |
Diazepam, gamma-aminobutyric acid, and progesterone open K(+) channels in myocytes from coronary arteries.
Topics: Animals; Bicuculline; Calcium; Coronary Vessels; Cyclic AMP; Diazepam; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; In Vitro Techniques; Myocardium; Patch-Clamp Techniques; Potassium Channels; Progesterone; Swine | 2000 |
Bicuculline, pentobarbital and diazepam modulate spontaneous GABA(A) channels in rat hippocampal neurons.
Topics: Animals; Bicuculline; Cells, Cultured; Diazepam; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Ion Channels; Pentobarbital; Rats; Receptors, GABA-A | 2000 |
[Effects of benzodiazepines and general anesthetics on the GABA A receptor: where are the differences?].
Topics: Anesthetics, General; Anesthetics, Inhalation; Animals; Anti-Anxiety Agents; Benzodiazepines; Bicuculline; Diazepam; Enflurane; Halothane; Isoflurane; Neocortex; Propofol; Rats; Receptors, GABA-A | 2000 |
Female gastrin-releasing peptide receptor (GRP-R)-deficient mice exhibit altered social preference for male conspecifics: implications for GRP/GRP-R modulation of GABAergic function.
Topics: Anesthesia; Animals; Bicuculline; Brain Chemistry; Diazepam; Exploratory Behavior; Feeding Behavior; Female; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Gastrin-Releasing Peptide; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Bombesin; Sexual Behavior, Animal; Smell; Social Desirability; Social Dominance | 2001 |
The gamma(2)-MSH peptide mediates a central analgesic effect via a GABA-ergic mechanism that is independent from activation of melanocortin receptors.
Topics: alpha-MSH; Analgesics; Animals; Bicuculline; Catalepsy; Central Nervous System Depressants; Diazepam; Drug Interactions; Ethanol; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; gamma-MSH; Male; Mice; Mice, Inbred BALB C; Muscimol; Naloxone; Narcotic Antagonists; Nociceptors; Pain Threshold; Peptides, Cyclic; Receptors, Corticotropin; Receptors, Melanocortin; Tail | 2001 |
GABA concentration sets the conductance of delayed GABAA channels in outside-out patches from rat hippocampal neurons.
Topics: Animals; Animals, Newborn; Bicuculline; Cells, Cultured; Diazepam; Dose-Response Relationship, Drug; Electric Conductivity; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Ion Channel Gating; Neurons; Patch-Clamp Techniques; Rats; Receptors, GABA-A | 2001 |
Activation of GABA(A) receptors in subthalamic neurons in vitro: properties of native receptors and inhibition mechanisms.
Topics: Animals; Bicarbonates; Bicuculline; Chlorides; Diazepam; Electrophysiology; Flunitrazepam; GABA Agonists; GABA Antagonists; GABA Modulators; Membrane Potentials; Muscimol; Neural Inhibition; Neurons; Organ Culture Techniques; Pentobarbital; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A; Sesterterpenes; Subthalamic Nucleus | 2001 |
Analysis of GABA(A)- and GABA(B)-receptor mediated effects on intracellular Ca(2+) in DRG hybrid neurones.
Topics: Acrylates; Adenosine Triphosphate; Animals; Bicuculline; Caffeine; Calcium; Capsaicin; Cell Line; Diazepam; Dihydropyridines; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Ganglia, Spinal; Hybrid Cells; Mice; Mice, Inbred BALB C; Neurons; Potassium Chloride; Receptors, GABA-A; Receptors, GABA-B; Thapsigargin; Time Factors | 2001 |
Effect of alkylpyrazine derivatives on the duration of pentobarbital-induced sleep, picrotoxicin-induced convulsion and gamma-aminobutyric acid (GABA) levels in the mouse brain.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Bicuculline; Brain Chemistry; Convulsants; Diazepam; GABA Agents; GABA Antagonists; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Injections, Intraventricular; Male; Mice; Pentobarbital; Picrotoxin; Pyrazines; Seizures; Sleep; Time Factors; Valproic Acid | 2001 |
Neuronal mechanisms of the anoxia-induced network oscillations in the rat hippocampus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine; Anesthetics, Local; Animals; Bicuculline; Diazepam; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Periodicity; Potassium; Rats; Rats, Wistar; Tetrodotoxin; Xanthines | 2001 |
Pharmacological heterogeneity of gamma-aminobutyric acid receptors during development suggests distinct classes of rat cerebellar granule cells in situ.
Topics: Aging; Algorithms; Animals; Bicuculline; Carbolines; Cerebellum; Convulsants; Diazepam; Diuretics; Electrophysiology; Furosemide; GABA Antagonists; GABA Modulators; In Vitro Techniques; Membrane Potentials; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2002 |
Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex.
Topics: Action Potentials; Animals; Bicuculline; Bumetanide; Cerebellar Cortex; Diazepam; Electric Stimulation; Furosemide; gamma-Aminobutyric Acid; K Cl- Cotransporters; Nerve Fibers; Neural Inhibition; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Steroids; Symporters; Synapses; Synaptic Transmission | 2002 |
Role of benzodiazepine-GABAA receptor complex in attenuation of U-50,488H-induced analgesia and inhibition of tolerance to its analgesia by ginseng total saponin in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Bicuculline; Diazepam; Dose-Response Relationship, Drug; Drug Antagonism; Drug Tolerance; Drugs, Chinese Herbal; Flumazenil; Ginsenosides; Injections, Intraperitoneal; Male; Mice; Pain; Pain Threshold; Panax; Picrotoxin; Receptors, GABA-A; Receptors, Opioid, kappa; Saponins; Tail | 2002 |
Prenatal diazepam exposure functionally alters the GABA(A) receptor that modulates [3H]noradrenaline release from rat hippocampal synaptosomes.
Topics: Allosteric Regulation; Animals; Baclofen; Bicuculline; Diazepam; Female; Fetal Proteins; GABA Agonists; GABA Antagonists; Hippocampus; Male; Mental Disorders; Nerve Tissue Proteins; Norepinephrine; Picrotoxin; Pregnancy; Pregnanolone; Prenatal Exposure Delayed Effects; Protein Subunits; Rats; Rats, Wistar; Receptors, GABA-A; Synaptosomes | 2002 |
CNS inhibitory effects of barakol, a constituent of Cassia siamia Lamk.
Topics: Animals; Anticonvulsants; Benzopyrans; Bicuculline; Cassia; Diazepam; Dopamine; Dose-Response Relationship, Drug; Male; Maze Learning; Methamphetamine; Pentylenetetrazole; Phenalenes; Phytotherapy; Picrotoxin; Plant Extracts; Rats; Rats, Wistar; Seizures; Sleep; Strychnine; Thiopental | 2002 |
Serotonin-GABA interactions in the modulation of mu- and kappa-opioid analgesia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Bicuculline; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Fenclonine; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Morphine; Pain Threshold; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin; Serotonin Agents; Serotonin Antagonists | 2003 |
Levetiracetam has no significant gamma-aminobutyric acid-related effect on paired-pulse interaction in the dentate gyrus of rats.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Clonazepam; Convulsants; Dentate Gyrus; Diazepam; Electric Stimulation; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Levetiracetam; Male; Phenobarbital; Piracetam; Rats; Rats, Sprague-Dawley; Receptors, GABA; Synaptic Transmission; Time Factors | 2003 |
Conductance of GABAA channels activated by pentobarbitone in hippocampal neurons from newborn rats.
Topics: Animals; Animals, Newborn; Bicuculline; Cells, Cultured; Diazepam; Electric Conductivity; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Ion Channel Gating; Neurons; Patch-Clamp Techniques; Pentobarbital; Rats; Receptors, GABA-A | 2003 |
GABAergic system in the anxiolytic effect of Proproten: experimental study.
Topics: Animals; Anti-Anxiety Agents; Antibodies; Behavior, Animal; Bicuculline; Diazepam; GABA-A Receptor Antagonists; Male; Picrotoxin; Rats; Receptors, GABA-A; S100 Proteins | 2003 |
On high- and low-affinity agonist sites in GABAA receptors.
Topics: Animals; Bicuculline; Binding Sites; Binding, Competitive; Cells, Cultured; Diazepam; GABA Agonists; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Kidney; Ligands; Muscimol; Mutagenesis, Site-Directed; Oocytes; Patch-Clamp Techniques; Radioligand Assay; Rats; Receptors, GABA-A; Structure-Activity Relationship; Transfection; Xenopus | 2003 |
GABAergic agents prevent alpha-melanocyte stimulating hormone induced anxiety and anorexia in rats.
Topics: alpha-MSH; Animals; Anorexia; Anxiety; Bicuculline; Darkness; Diazepam; Eating; GABA Agents; GABA Antagonists; GABA Modulators; Injections, Intraventricular; Light; Male; Rats; Rats, Sprague-Dawley | 2003 |
Differential actions of diazepam and zolpidem in basolateral and central amygdala nuclei.
Topics: Amygdala; Animals; Animals, Newborn; Bicuculline; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; GABA Modulators; In Vitro Techniques; Male; Neural Inhibition; Patch-Clamp Techniques; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Valine; Zolpidem | 2004 |
Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Dehydroepiandrosterone Sulfate; Diazepam; Dose-Response Relationship, Drug; Epilepsy; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Isoxazoles; Kindling, Neurologic; Ligands; Mice; Pentylenetetrazole; Pregnanediones; Receptors, GABA-A | 2004 |
Attenuation of the effect of progesterone and 4'-chlordiazepam on stress-induced immune responses by bicuculline.
Topics: Animals; Antibody Formation; Bicuculline; Cell Migration Inhibition; Diazepam; Diazepam Binding Inhibitor; Dose-Response Relationship, Drug; Edema; GABA Antagonists; Hypnotics and Sedatives; Immunity, Cellular; Male; Mice; Progesterone; Rats; Rats, Wistar; Restraint, Physical; Stress, Psychological | 2003 |
Auditory responses in multiple sensorimotor song system nuclei are co-modulated by behavioral state.
Topics: Acoustic Stimulation; Animals; Arousal; Auditory Pathways; Behavior, Animal; Bicuculline; Brain; Conscious Sedation; Diazepam; Electrodes, Implanted; Evoked Potentials, Auditory; Excitatory Postsynaptic Potentials; Functional Laterality; GABA Agonists; GABA Antagonists; Hypnotics and Sedatives; Male; Muscimol; Songbirds; Vocalization, Animal; Wakefulness | 2004 |
Diazepam prophylaxis for bicuculline-induced seizures: a rat dose-response model.
Topics: Action Potentials; Animals; Bicuculline; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Hippocampus; Male; Rats; Rats, Sprague-Dawley; Seizures | 2004 |
Electrophysiological properties of mouse horizontal cell GABAA receptors.
Topics: Animals; Bicuculline; Carbolines; Diazepam; Electrophysiology; GABA Agonists; GABA Antagonists; GABA Modulators; In Vitro Techniques; Interneurons; Mice; Mice, Inbred C57BL; Patch-Clamp Techniques; Picrotoxin; Pyridines; Receptors, GABA-A; Retina; Zolpidem | 2004 |
Functional mapping of GABA A receptor subtypes in the amygdala.
Topics: Amygdala; Animals; Bicuculline; Diazepam; Female; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Male; Mice; Mice, Mutant Strains; Point Mutation; Protein Binding; Protein Subunits; Receptors, GABA-A; Synaptic Transmission | 2004 |
Pharmacological properties of GABAA receptors in rat hypothalamic neurons expressing the epsilon-subunit.
Topics: Anesthetics, Intravenous; Animals; Bicuculline; Cells, Cultured; Diazepam; Electrophysiology; Fluorescent Antibody Technique; gamma-Aminobutyric Acid; Hypothalamic Area, Lateral; Hypothalamus; Intracellular Signaling Peptides and Proteins; Male; Neurons; Neuropeptides; Orexin Receptors; Orexins; Propofol; Pyridazines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, GABA-A; Receptors, Neuropeptide | 2005 |
Benzodiazepine system is involved in hyperalgesia in rats induced by the exposure to extremely low frequency magnetic fields.
Topics: Animals; Anti-Anxiety Agents; Baclofen; Bicuculline; Diazepam; Electromagnetic Fields; Flumazenil; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Hot Temperature; Hyperalgesia; Injections, Intraventricular; Male; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, GABA-A | 2005 |
Reversal of caffeine-induced anxiety by neurosteroid 3-alpha-hydroxy-5-alpha-pregnane-20-one in rats.
Topics: Adrenalectomy; Analysis of Variance; Anesthetics; Animals; Anxiety; Bicuculline; Caffeine; Central Nervous System Stimulants; Corticotropin-Releasing Hormone; Diazepam; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; GABA Agonists; GABA Antagonists; Hormone Antagonists; Injections, Intraventricular; Male; Maze Learning; Muscimol; Peptide Fragments; Pregnanolone; Progestins; Rats; Rats, Sprague-Dawley; Reaction Time | 2005 |
Imidazenil: an antagonist of the sedative but not the anticonvulsant action of diazepam.
Topics: Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Convulsants; Diazepam; Dose-Response Relationship, Drug; GABA Antagonists; GABA Modulators; Hypnotics and Sedatives; Imidazoles; Male; Motor Activity; Rats; Rats, Inbred F344 | 2005 |
Repeated cocaine exposure in vivo facilitates LTP induction in midbrain dopamine neurons.
Topics: Animals; Bicuculline; Cocaine; Diazepam; Dopamine; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Long-Term Potentiation; Male; Memory; Mesencephalon; Neuronal Plasticity; Neurons; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synapses | 2005 |
Involvement of diazepam-insensitive benzodiazepine receptors in the suppression of DOI-induced head-twitch responses in diabetic mice.
Topics: Amphetamines; Animals; Azides; Behavior, Animal; Benzodiazepines; Bicuculline; Diabetes Mellitus, Experimental; Diazepam; Flumazenil; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Male; Mice; Mice, Inbred ICR; Receptors, GABA-A; Serotonin Receptor Agonists | 2006 |
Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae).
Topics: Analysis of Variance; Animals; Anticonvulsants; Anxiety; Behavior, Animal; Bicuculline; Choice Behavior; Diazepam; Disease Models, Animal; Drug Interactions; Hippocampus; Male; Maze Learning; Neuroprotective Agents; Nipecotic Acids; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Spider Venoms; Spiders; Substantia Nigra; Urea | 2006 |
AMPA receptor activation reduces epileptiform activity in the rat neocortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Benzothiadiazines; Bicuculline; Chlormethiazole; Diazepam; Electroencephalography; Epilepsy; Evoked Potentials, Somatosensory; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Male; Neocortex; Neurons; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 2007 |
Anxiolytic-like effects of sinapic acid in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Bicuculline; Cerebral Cortex; Chloride Channels; Coumaric Acids; Diazepam; Electrophysiology; Flumazenil; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred ICR; Motor Activity; Muscle Relaxation; Muscle, Smooth; Neurons; Neurotransmitter Agents; Piperazines; Postural Balance; Pyridines; Serotonin Antagonists | 2007 |
Potato (Solanum tuberosum) juice exerts an anticonvulsant effect in mice through binding to GABA receptors.
Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Chromatography, High Pressure Liquid; Diazepam; Male; Mass Spectrometry; Mice; Mice, Inbred ICR; Plant Extracts; Receptors, GABA; Solanum tuberosum | 2008 |
Imidazenil: a low efficacy agonist at alpha1- but high efficacy at alpha5-GABAA receptors fail to show anticonvulsant cross tolerance to diazepam or zolpidem.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Bicuculline; Diazepam; Differential Threshold; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; GABA Modulators; Imidazoles; Male; Pyridines; Rats; Rats, Inbred F344; Seizures; Zolpidem | 2008 |
Anxiolytic and antidepressant effects of intracerebroventricularly administered somatostatin: behavioral and neurophysiological evidence.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Bicuculline; Diazepam; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Hippocampus; Injections, Intraventricular; Male; Maze Learning; Rats; Rats, Sprague-Dawley; Somatostatin; Spectrum Analysis; Swimming; Theta Rhythm | 2008 |
Endocannabinoid-dependent homeostatic regulation of inhibitory synapses by miniature excitatory synaptic activities.
Topics: Anesthetics, Local; Animals; Animals, Newborn; Arachidonic Acids; Auditory Cortex; Bicuculline; Biophysics; Cannabinoid Receptor Modulators; Diazepam; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Eukaryotic Initiation Factor-2; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA Modulators; Glycerides; Homeostasis; In Vitro Techniques; Miniature Postsynaptic Potentials; Patch-Clamp Techniques; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Synapses; Tetrodotoxin | 2009 |
Co-operative effect between gamma-aminobutyric acid A receptors and central-type benzodiazepine receptors on amylase release in rat parotid acinar cells.
Topics: Amylases; Animals; Bicuculline; Clonazepam; Diazepam; Isoproterenol; Male; Muscimol; Parotid Gland; Rats; Rats, Wistar; Receptors, GABA-A | 2010 |
GABAergic regulation of auditory sensory gating in low- and high-anxiety rats submitted to a fear conditioning procedure.
Topics: Acoustic Stimulation; Animals; Anxiety; Behavior, Animal; Benzodiazepines; Bicuculline; Clonixin; Conditioning, Classical; Diazepam; Disease Models, Animal; Electroencephalography; Evoked Potentials, Auditory; Fear; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Inferior Colliculi; Male; Maze Learning; Microinjections; Muscimol; Neurons; Prostaglandin Antagonists; Rats; Rats, Wistar; Sensory Gating; Statistics as Topic | 2010 |
Comparative study of taurine and tauropyrone: GABA receptor binding, mitochondrial processes and behaviour.
Topics: Animals; Behavior, Animal; Bicuculline; Diazepam; Dihydropyridines; Energy Metabolism; Ethanol; Hydrophobic and Hydrophilic Interactions; Male; Mice; Mice, Inbred ICR; Mitochondria; Motor Activity; Muscle Tonus; Protein Binding; Rats; Rats, Wistar; Receptors, GABA-A; Rotarod Performance Test; Seizures; Structure-Activity Relationship; Taurine | 2011 |
GABAergic disinhibition induced pain hypersensitivity by upregulating NMDA receptor functions in spinal dorsal horn.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Diazepam; Drug Interactions; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; Hyperalgesia; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Neural Inhibition; Phosphorylation; Posterior Horn Cells; Protein Kinase Inhibitors; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Sulfonamides | 2011 |
Synergic effect of diazepam and muscimol via presynaptic GABA(A) receptors on glutamatergic evoked EPSCs.
Topics: Animals; Bicuculline; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Excitatory Postsynaptic Potentials; GABA Modulators; GABA-A Receptor Agonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Ion Channels; Muscimol; Neural Inhibition; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, GABA-A | 2011 |
GABAergic inhibition regulates developmental synapse elimination in the cerebellum.
Topics: Agatoxins; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Bicuculline; Biophysical Phenomena; Biophysics; Calbindins; Calcium; Calcium Channels; Cerebellum; Chromones; Cytochromes c; Dendrites; Diazepam; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Modulators; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation, Developmental; Glutamate Decarboxylase; Green Fluorescent Proteins; In Vitro Techniques; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Confocal; Microscopy, Electron, Transmission; Nerve Tissue Proteins; Neurotoxins; Patch-Clamp Techniques; Phospholipase C beta; Protein Kinase C; Purkinje Cells; Quinoxalines; Receptors, Glutamate; Receptors, Metabotropic Glutamate; S100 Calcium Binding Protein G; Synapses; Vesicular Inhibitory Amino Acid Transport Proteins | 2012 |
Comparison of cell expression formats for the characterization of GABA(A) channels using a microfluidic patch clamp system.
Topics: Benzodiazepines; Bicuculline; Diazepam; GABA Agents; GABA Agonists; GABA Antagonists; GABA Modulators; Gene Expression; HEK293 Cells; High-Throughput Screening Assays; Humans; Imidazoles; Ion Channel Gating; Microfluidic Analytical Techniques; Muscimol; Patch-Clamp Techniques; Picrotoxin; Receptors, GABA-A; Recombinant Proteins; Transfection | 2012 |
Tetramethylenedisulfotetramine alters Ca²⁺ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation.
Topics: Action Potentials; Animals; Animals, Newborn; Anticonvulsants; Bicuculline; Bridged-Ring Compounds; Calcium Channel Blockers; Calcium Signaling; Cells, Cultured; Convulsants; Diazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; High-Throughput Screening Assays; Hippocampus; Mice; Mice, Inbred C57BL; Microelectrodes; Neurons; Picrotoxin; Pregnanolone; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Spectrometry, Fluorescence; Time Factors | 2012 |
Reversal of morphine analgesic tolerance by ethanol in the mouse.
Topics: Analgesics, Opioid; Animals; Baclofen; Bicuculline; Central Nervous System Depressants; Diazepam; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ethanol; GABA Antagonists; Hypnotics and Sedatives; Immersion; Injections, Intraventricular; Male; Mice; Morphine; Pain Measurement; Receptors, GABA-A; Receptors, GABA-B | 2013 |
Effects of agomelatine in a murine model of obsessive-compulsive disorder: interaction with meta-chlorophenylpiperazine, bicuculline, and diazepam.
Topics: Acetamides; Animals; Antidepressive Agents; Behavior, Animal; Bicuculline; Diazepam; Disease Models, Animal; Drug Interactions; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Male; Mice; Mice, Inbred C57BL; Motor Activity; Obsessive-Compulsive Disorder; Piperazines; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists | 2013 |
Expression of the γ2-subunit distinguishes synaptic and extrasynaptic GABA(A) receptors in NG2 cells of the hippocampus.
Topics: Animals; Benzodiazepines; Bicuculline; Diazepam; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Muscimol; Neuroglia; Neurons; Patch-Clamp Techniques; Pentobarbital; Protein Subunits; Receptors, GABA-A; Synapses | 2013 |
Attenuated benzodiazepine-sensitive tonic GABAA currents of supraoptic magnocellular neuroendocrine cells in 24-h water-deprived rats.
Topics: Animals; Bicuculline; Diazepam; GABA Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Imidazoles; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Neuroendocrine Cells; Propofol; Protein Subunits; Rats; Receptors, GABA-A; Supraoptic Nucleus; Water Deprivation | 2014 |
GABAAergic stimulation modulates intracellular protein arginine methylation.
Topics: Animals; Arginine; Bicuculline; Cell Differentiation; Cell Line; Diazepam; Drug Synergism; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hydrogen-Ion Concentration; Intracellular Space; Methylation; Mice, Knockout; Muscimol; Neurons; Protein-Arginine N-Methyltransferases; Receptors, GABA-A; Signal Transduction | 2014 |
GluN2B-containing N-methyl-D-aspartate receptors compensate for the inhibitory control of synaptic plasticity during the early critical period in the rat visual cortex.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Animals, Newborn; Bicuculline; Diazepam; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; GABA Modulators; GABA-A Receptor Antagonists; Gene Expression Regulation, Developmental; Long-Term Potentiation; Male; Neural Inhibition; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Visual Cortex | 2015 |
Bidirectional Control of Social Behavior by Activity within Basolateral and Central Amygdala of Primates.
Topics: Animals; Basolateral Nuclear Complex; Bicuculline; Central Amygdaloid Nucleus; Diazepam; Dose-Response Relationship, Drug; Female; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Macaca nemestrina; Magnetic Resonance Imaging; Male; Microinjections; Muscimol; Neural Inhibition; Social Behavior; Statistics, Nonparametric | 2016 |
GABA
Topics: Allosteric Regulation; Alprazolam; Benzodiazepines; Bicuculline; Binding, Competitive; Cryoelectron Microscopy; Diazepam; GABA Modulators; Humans; Ligands; Models, Molecular; Nanostructures; Picrotoxin; Receptors, GABA-A; Signal Transduction | 2019 |
Shared structural mechanisms of general anaesthetics and benzodiazepines.
Topics: Allosteric Regulation; Anesthetics, General; Barbiturates; Benzodiazepines; Bicuculline; Binding Sites; Binding, Competitive; Cryoelectron Microscopy; Diazepam; Electrophysiology; Etomidate; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Ligands; Models, Molecular; Molecular Conformation; Molecular Dynamics Simulation; Phenobarbital; Picrotoxin; Propofol; Receptors, GABA-A | 2020 |
Bumetanide prevents diazepam-modified anxiety-like behavior in lipopolysaccharide-treated mice.
Topics: Animals; Anti-Anxiety Agents; Anti-Bacterial Agents; Anxiety; Behavior, Animal; Bicuculline; Bumetanide; Diazepam; Emotions; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Inflammation; Lipopolysaccharides; Male; Mice, Inbred ICR; Minocycline; Motor Activity; Sodium Potassium Chloride Symporter Inhibitors | 2021 |
Peripheral GABAA receptor signaling contributes to visceral hypersensitivity in a mouse model of colitis.
Topics: Animals; Bicuculline; Colitis; Colon; Dextran Sulfate; Diazepam; Disease Models, Animal; Inflammatory Bowel Diseases; Mice; Mice, Inbred C57BL; Muscimol; Pain; Receptors, GABA-A | 2022 |