Compounds > bicalutamide

bicalutamide and hydroxyflutamide

bicalutamide has been researched along with hydroxyflutamide in 49 studies

Research

Studies (49)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's12 (24.49)18.2507
2000's25 (51.02)29.6817
2010's11 (22.45)24.3611
2020's1 (2.04)2.80

Authors

AuthorsStudies
Batzold, FH; Bell, MR; Juniewicz, PE; Kowalczyk, PJ; Kullnig, RK; Luss, HR; Mallamo, JP; Pilling, GM; Wetzel, JR; Winneker, RC1
Ackerman, JH; Bell, MR; Christiansen, RG; D'Ambra, TE; Herrmann, JL; Kullnig, RK; Mallamo, JP; Opalka, CJ; Snyder, BW; Winneker, RC1
Edwards, JP; Farmer, LJ; Hamann, LG; Higuchi, RI; Jones, TK; Kong, JW; Marschke, KB; Wang, XN; Zhi, L1
Edwards, JP; Hamann, LG; Jones, TK; Kong, JW; Marschke, KB; Ruppar, DA1
An, Y; Attar, RM; Balog, A; Geng, J; Gottardis, MM; Kish, K; Krystek, SR; Pickering, D; Rizzo, CA; Sack, J; Salvati, ME; Shan, W; Wei, DD; Weinmann, R1
Attar, RM; Balog, A; Geng, J; Gottardis, MM; Hunt, JT; Martinez, R; Pickering, D; Rizzo, CA; Salvati, ME; Wei, DD; Weinmann, R1
Emura, T; Furuta, Y; Imaoka, I; Ishikura, N; Kato, N; Kodama, H; Nagamuta, M; Nakamura, M; Ohta, M; Onuma, E; Sato, H; Tachibana, K; Taniguchi, K; Yoshino, H1
Dence, CS; Jenks, C; Katzenellenbogen, JA; Parent, EE; Sharp, TL; Welch, MJ1
Imaoka, I; Ishikura, N; Kato, N; Kawata, H; Nagamuta, M; Nakamura, M; Ohta, M; Onuma, E; Sato, H; Tachibana, K; Taniguchi, K; Yoshino, H1
Attar, RM; Balog, A; Chandrasena, G; Fura, A; Furch, JA; Galella, MA; Geng, J; Giese, S; Gottardis, MM; Gougoutas, J; Jure-Kunkel, M; Krystek, SR; Mitt, T; Obermeier, M; Rampulla, R; Rizzo, CA; Salvati, ME; Shan, W; Vite, GD1
Arnold, LA; Connelly, M; Féau, C; Guy, RK; Kosinski, A; Zhu, F1
Geng, G; Sauriol, F; Shi, Q; Wu, JH; Zhou, J1
Hashimoto, Y; Makishima, M; Nakamura, M1
Fujii, S; Kagechika, H; Mori, S; Yamada, A1
Cen, S; He, Y; Hu, L; Li, Q; Li, X; Liu, Y; Wu, M; Zhou, J1
Wang, S; Xiang, W1
Berrevoets, CA; Mulder, E; Veldscholte, J1
Kemppainen, JA; Wilson, EM1
Jimenez, J; Luizzi, MF; Sonnenschein, C; Soto, AM; Szelei, J1
Labrie, F; Simard, J; Singh, SM1
Bartsch, G; Cronauer, MV; Culig, Z; Hittmair, A; Hobisch, A; Klocker, H; Radmayr, C; Zhang, J1
Chang, C; Miyamoto, H; Wilding, G; Yeh, S1
Chang, C; Lardy, H; Messing, E; Miyamoto, H; Yeh, S1
Budman, DR; Kreis, W; Liu, XM; Wang, LG1
Hackenberg, R; Loos, S; Schulz, KD1
Lumbroso, S; Moras, D; Nicolas, JC; Poujol, N; Sultan, C; Tahiri, B; Wurtz, JM1
Baniahmad, A; Cato, AC; Dotzlaw, H; Iñiguez Lluhí, JA; Mink, S; Moehren, U1
Furutani, T; Hashimoto, T; Kato, S; Koutoku, H; Kudoh, M; Shikama, H; Shimizu, Y; Tanimoto, K; Watanabe, T1
Bartsch, G; Culig, Z; Godoy-Tundidor, S; Hobisch, A; Pfeil, K1
Jänne, OA; Karvonen, U; Palvimo, JJ1
Lou, YR; Nazarova, N; Pennanen, P; Qiao, S; Tuohimaa, P1
Bevan, CL; Cato, AC; Gamble, SC; Hanrahan, S; Hurst, HC; Totty, N; Waxman, J; Whitaker, HC1
Lou, YR; Nazarova, N; Talonpoika, R; Tuohimaa, P1
Farla, P; Hersmus, R; Houtsmuller, AB; Trapman, J1
Asim, M; Baniahmad, A; Dotzlaw, H; Papaioannou, M; Reeb, C1
Chang, CY; Elbi, C; Hager, GL; Hendarwanto, A; Klokk, TI; Kurys, P; Nagaich, AK; Saatcioglu, F; Slagsvold, T1
De Rosier, T; Eliason, HC; Ervin, KM; Gowda, K; Kupcho, KR; Marks, BD; Ozers, MS; Qadir, N; Riddle, SM; Shekhani, MS1
Fuse, H; Hiyama, T; Ito, T; Kato, S; Kimura, K; Korenaga, S; Sakari, M1
Hara, S; Hyochi, N; Isaacs, JT; Ishioka, J; Kageyama, Y; Kihara, K; Singh, P; Urushibara, M1
Baniahmad, A; Eskelinen, H; Lehtovuori, PT; Nyrönen, TH; Roell, D; Söderholm, AA; Viiliäinen, J1
Lenie, S; Smitz, J1
Dubbink, HJ; Hersmus, R; Jenster, G; Lusher, SJ; Molier, M; Trapman, J; van de Wijngaart, DJ1
Itoh, K; Kanayama, H; Kawabata, R; Oie, S; Oka, T; Takahashi, M1
Culig, Z1
Begum, S; Bevan, CL; Brooke, GN; Bryan, RA; Dart, DA; Fioretti, FM; Gamble, SC; Hough, MA; Odontiadis, M; Powell, SM; Wait, R; Waxman, J1
Awrey, S; Azad, AA; Cherkasov, A; Chi, KN; Collins, CC; Gleave, ME; Lallous, N; LeBihan, S; Leblanc, E; Murillo, J; Rennie, PS; Singh, K; Tse, R; Volik, SV; Wyatt, AW1
Hara, N; Ishizaki, F; Nishiyama, T; Takeda, K; Tasaki, M; Tomita, Y1
El-Shishtawy, KA; Ide, H; Kashiwagi, E; Kawahara, T; Li, Y; Miyamoto, H; Reis, LO; Zheng, Y1
Azhagiya Singam, ER; Durkin, KA; La Merrill, MA; Smith, MT; Tachachartvanich, P1

Reviews

2 review(s) available for bicalutamide and hydroxyflutamide

ArticleYear
Therapeutic Strategies to Target the Androgen Receptor.
    Journal of medicinal chemistry, 2022, 07-14, Volume: 65, Issue:13

    Topics: Androgen Antagonists; Androgen Receptor Antagonists; Humans; Male; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen

2022
Targeting the androgen receptor in prostate cancer.
    Expert opinion on pharmacotherapy, 2014, Volume: 15, Issue:10

    Topics: Androgen Antagonists; Anilides; Antibodies, Neutralizing; Anticarcinogenic Agents; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Curcumin; Flutamide; Histone Deacetylase Inhibitors; HSP90 Heat-Shock Proteins; Humans; Male; Molecular Targeted Therapy; Nitriles; Oligonucleotides, Antisense; Phenylthiohydantoin; Phosphatidylinositol 3-Kinases; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Steroid 17-alpha-Hydroxylase; Tosyl Compounds

2014

Other Studies

47 other study(ies) available for bicalutamide and hydroxyflutamide

ArticleYear
Antiandrogenic steroidal sulfonyl heterocycles. Utility of electrostatic complementarity in defining bioisosteric sulfonyl heterocycles.
    Journal of medicinal chemistry, 1992, May-15, Volume: 35, Issue:10

    Topics: Androgen Antagonists; Androgen Receptor Antagonists; Electrochemistry; Heterocyclic Compounds; Receptors, Androgen; Substrate Specificity; X-Ray Diffraction

1992
Antiandrogenic steroidal sulfonylpyrazoles.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:8

    Topics: Androgen Antagonists; Animals; Male; Molecular Structure; Orchiectomy; Organ Size; Pregnanes; Prostate; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, Androgen; Structure-Activity Relationship; Testosterone; X-Ray Diffraction

1990
Synthesis and biological activity of a novel series of nonsteroidal, peripherally selective androgen receptor antagonists derived from 1,2-dihydropyridono[5,6-g]quinolines.
    Journal of medicinal chemistry, 1998, Feb-12, Volume: 41, Issue:4

    Topics: Androgen Antagonists; Androgen Receptor Antagonists; Animals; Cell Line; COS Cells; Dihydropyridines; Dihydrotestosterone; Gonadotropins; Heterocyclic Compounds; Humans; Indicators and Reagents; Male; Molecular Structure; Orchiectomy; Prostate; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Androgen; Receptors, Progesterone; Recombinant Proteins; Seminal Vesicles; Structure-Activity Relationship; Testosterone; Transfection

1998
Effects of isosteric pyridone replacements in androgen receptor antagonists based on 1,2-dihydro- and 1,2,3,4-tetrahydro-2,2-dimethyl-6-trifluoromethyl-8-pyridono[5,6-g]quin olines.
    Bioorganic & medicinal chemistry letters, 2000, Mar-06, Volume: 10, Issue:5

    Topics: Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Animals; COS Cells; Humans; Pyridones; Quinolines; Transcription, Genetic

2000
Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgen receptor antagonists.
    Bioorganic & medicinal chemistry letters, 2005, Jan-17, Volume: 15, Issue:2

    Topics: Androgen Antagonists; Bridged Bicyclo Compounds, Heterocyclic; Indoles; Protein Isoforms; Receptors, Androgen; Structure-Activity Relationship; Tumor Cells, Cultured

2005
Identification of a novel class of androgen receptor antagonists based on the bicyclic-1H-isoindole-1,3(2H)-dione nucleus.
    Bioorganic & medicinal chemistry letters, 2005, Jan-17, Volume: 15, Issue:2

    Topics: Androgen Antagonists; Androgen Receptor Antagonists; Animals; Bridged Bicyclo Compounds, Heterocyclic; Humans; Indoles; Inhibitory Concentration 50; Male; Mutation; Prostatic Neoplasms; Receptors, Androgen; Structure-Activity Relationship; Tumor Cells, Cultured

2005
Discovery of 7alpha-substituted dihydrotestosterones as androgen receptor pure antagonists and their structure-activity relationships.
    Bioorganic & medicinal chemistry, 2007, Jan-01, Volume: 15, Issue:1

    Topics: Androgen Receptor Antagonists; Animals; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; HeLa Cells; Humans; Molecular Structure; Stereoisomerism; Structure-Activity Relationship

2007
Synthesis and biological evaluation of [18F]bicalutamide, 4-[76Br]bromobicalutamide, and 4-[76Br]bromo-thiobicalutamide as non-steroidal androgens for prostate cancer imaging.
    Journal of medicinal chemistry, 2007, Mar-08, Volume: 50, Issue:5

    Topics: Androgen Antagonists; Anilides; Animals; Bromine Radioisotopes; Fluorine Radioisotopes; Isotope Labeling; Ligands; Male; Mice; Neoplasm Transplantation; Nitriles; Prostatic Neoplasms; Radioligand Assay; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Androgen; Stereoisomerism; Structure-Activity Relationship; Tissue Distribution; Tosyl Compounds

2007
Discovery and structure-activity relationships of new steroidal compounds bearing a carboxy-terminal side chain as androgen receptor pure antagonists.
    Bioorganic & medicinal chemistry letters, 2007, Oct-15, Volume: 17, Issue:20

    Topics: Androgen Receptor Antagonists; Animals; Mice; Models, Molecular; Molecular Structure; Protein Binding; Receptors, Androgen; Steroids; Structure-Activity Relationship

2007
Identification and optimization of a novel series of [2.2.1]-oxabicyclo imide-based androgen receptor antagonists.
    Bioorganic & medicinal chemistry letters, 2008, Mar-15, Volume: 18, Issue:6

    Topics: Administration, Oral; Androgen Antagonists; Androgen Receptor Antagonists; Anilides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, High Pressure Liquid; Drug Design; Humans; Isoindoles; Male; Mice; Mice, Inbred BALB C; Models, Molecular; Molecular Structure; Nitriles; Prostatic Neoplasms; Protein Binding; Receptors, Androgen; Structure-Activity Relationship; Tosyl Compounds; Tumor Cells, Cultured

2008
Novel flufenamic acid analogues as inhibitors of androgen receptor mediated transcription.
    ACS chemical biology, 2009, Oct-16, Volume: 4, Issue:10

    Topics: Androgen Receptor Antagonists; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Cell Line, Tumor; Flufenamic Acid; Gene Expression Regulation, Neoplastic; Humans; Male; Prostatic Neoplasms; Receptors, Androgen; Structure-Activity Relationship; Tacrolimus Binding Proteins; Transcriptional Activation

2009
Design and synthesis of androgen receptor antagonists with bulky side chains for overcoming antiandrogen resistance.
    Journal of medicinal chemistry, 2009, Sep-10, Volume: 52, Issue:17

    Topics: Androgen Antagonists; Androgen Receptor Antagonists; Binding, Competitive; Cell Line, Tumor; Cell Proliferation; Curcumin; Dihydrotestosterone; Drug Design; Drug Resistance; Humans; Hydrogen Bonding; Ligands; Models, Molecular; Molecular Conformation; Mutation; Norisoprenoids; Protein Structure, Tertiary; Receptors, Androgen; Transcriptional Activation

2009
Development of silicon-containing bis-phenol derivatives as androgen receptor antagonists: selectivity switching by C/Si exchange.
    Bioorganic & medicinal chemistry, 2013, Apr-01, Volume: 21, Issue:7

    Topics: Androgen Receptor Antagonists; Cell Line, Tumor; Cell Proliferation; HEK293 Cells; Humans; Phenol; Receptors, Androgen; Receptors, Calcitriol; Silicon

2013
Design and Synthesis of 4-(4-Benzoylaminophenoxy)phenol Derivatives As Androgen Receptor Antagonists.
    ACS medicinal chemistry letters, 2013, Oct-10, Volume: 4, Issue:10

    Topics:

2013
Identification of Triptophenolide from
    ACS medicinal chemistry letters, 2016, Dec-08, Volume: 7, Issue:12

    Topics:

2016
Effects of antiandrogens on transformation and transcription activation of wild-type and mutated (LNCaP) androgen receptors.
    The Journal of steroid biochemistry and molecular biology, 1993, Volume: 46, Issue:6

    Topics: Adenocarcinoma; Alanine; Amino Acid Sequence; Androgen Antagonists; Anilides; Animals; Blotting, Western; Cell Line; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Cyproterone Acetate; Dose-Response Relationship, Drug; Flutamide; Humans; Male; Metribolone; Mutagenesis, Site-Directed; Nitriles; Point Mutation; Prostatic Neoplasms; Receptors, Androgen; Recombinant Proteins; Threonine; Tosyl Compounds; Transcription, Genetic; Transfection; Transformation, Genetic; Tumor Cells, Cultured

1993
Agonist and antagonist activities of hydroxyflutamide and Casodex relate to androgen receptor stabilization.
    Urology, 1996, Volume: 48, Issue:1

    Topics: Androgen Antagonists; Anilides; Binding, Competitive; Cells, Cultured; Flutamide; Nitriles; Receptors, Androgen; Tosyl Compounds

1996
Androgen-induced inhibition of proliferation in human breast cancer MCF7 cells transfected with androgen receptor.
    Endocrinology, 1997, Volume: 138, Issue:4

    Topics: Androgen Antagonists; Androgens; Anilides; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Division; Dihydrotestosterone; Dose-Response Relationship, Drug; Female; Flutamide; Humans; In Vitro Techniques; Metribolone; Nandrolone; Nitriles; Receptors, Androgen; Testosterone; Testosterone Congeners; Tosyl Compounds; Transfection; Tumor Cells, Cultured

1997
Comparison of in vitro effects of the pure antiandrogens OH-flutamide, Casodex, and nilutamide on androgen-sensitive parameters.
    Urology, 1997, Volume: 49, Issue:4

    Topics: Androgen Antagonists; Anilides; Animals; Apolipoproteins; Apolipoproteins D; Breast Neoplasms; Carrier Proteins; Cell Division; Dose-Response Relationship, Drug; Flutamide; Glycoproteins; Humans; Imidazoles; Imidazolidines; Membrane Transport Proteins; Mice; Neoplasm Proteins; Nitriles; Tosyl Compounds; Tumor Cells, Cultured

1997
Synergistic activation of androgen receptor by androgen and luteinizing hormone-releasing hormone in prostatic carcinoma cells.
    The Prostate, 1997, Jul-01, Volume: 32, Issue:2

    Topics: Androgen Antagonists; Anilides; Bucladesine; Cell Line; Chloramphenicol O-Acetyltransferase; Cyclic AMP; Flutamide; Genes, Reporter; Gonadotropin-Releasing Hormone; Humans; Kinetics; Male; Metribolone; Nitriles; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Recombinant Fusion Proteins; Testosterone Congeners; Tosyl Compounds; Transcriptional Activation; Transfection; Tumor Cells, Cultured

1997
Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1998, Jun-23, Volume: 95, Issue:13

    Topics: Androgen Antagonists; Androgens; Anilides; Cyproterone Acetate; Drug Interactions; Flutamide; Humans; Imidazoles; Male; Mifepristone; Nitriles; Nuclear Receptor Coactivators; Oncogene Proteins; Prostatic Neoplasms; Protein Binding; Protein Conformation; Tosyl Compounds; Trans-Activators; Transcription Factors; Transcriptional Activation; Tumor Cells, Cultured

1998
Delta5-androstenediol is a natural hormone with androgenic activity in human prostate cancer cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1998, Sep-15, Volume: 95, Issue:19

    Topics: Androgens; Androstane-3,17-diol; Androstenediol; Anilides; Flutamide; Humans; Male; Mutation; Nitriles; Nuclear Receptor Coactivators; Oncogene Proteins; Prostatic Neoplasms; Protein Conformation; Receptors, Androgen; Steroids; Testosterone; Tosyl Compounds; Trans-Activators; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured

1998
Phosphorylation/dephosphorylation of androgen receptor as a determinant of androgen agonistic or antagonistic activity.
    Biochemical and biophysical research communications, 1999, May-27, Volume: 259, Issue:1

    Topics: Androgen Antagonists; Androgens; Anilides; Animals; Base Sequence; Dihydrotestosterone; Estradiol; Estramustine; Flutamide; Humans; Ligands; Male; Molecular Sequence Data; Nitriles; Phosphorylation; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; RNA, Messenger; Tosyl Compounds; Tumor Cells, Cultured

1999
Regulation of GCDFP-15 expression in human mammary cancer cells.
    International journal of molecular medicine, 1999, Volume: 4, Issue:2

    Topics: Androgen Antagonists; Anilides; Apolipoproteins; Apolipoproteins D; Breast Neoplasms; Carrier Proteins; Cell Division; Dihydrotestosterone; Flutamide; Gene Expression Regulation, Neoplastic; Glycoproteins; Humans; Membrane Transport Proteins; Nitriles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tosyl Compounds; Tumor Cells, Cultured

1999
Specific recognition of androgens by their nuclear receptor. A structure-function study.
    The Journal of biological chemistry, 2000, Aug-04, Volume: 275, Issue:31

    Topics: Amino Acid Sequence; Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Anilides; Binding Sites; Computer Simulation; Cyproterone Acetate; Dose-Response Relationship, Drug; Flutamide; Humans; Ligands; Metribolone; Models, Molecular; Molecular Sequence Data; Nitriles; Progesterone; Promegestone; Receptors, Androgen; Sequence Alignment; Tosyl Compounds; Transcriptional Activation

2000
The amino terminus of the human AR is target for corepressor action and antihormone agonism.
    Molecular endocrinology (Baltimore, Md.), 2002, Volume: 16, Issue:4

    Topics: Androgen Antagonists; Anilides; Animals; Catalytic Domain; Cell Line; Cyclic AMP-Dependent Protein Kinases; Cyproterone Acetate; DNA-Binding Proteins; Flutamide; Haplorhini; Humans; Ligands; Male; Nitriles; Nuclear Receptor Co-Repressor 2; Point Mutation; Protein Conformation; Receptors, Androgen; Repressor Proteins; Tosyl Compounds; Transcriptional Activation; Transfection

2002
Stabilization of androgen receptor protein is induced by agonist, not by antagonists.
    Biochemical and biophysical research communications, 2002, Jun-21, Volume: 294, Issue:4

    Topics: Androgen Receptor Antagonists; Androgens; Anilides; Animals; Blotting, Northern; Blotting, Western; CHO Cells; Cricetinae; Dihydrotestosterone; Dose-Response Relationship, Drug; Flutamide; Humans; Ligands; Luciferases; Nitriles; Plasmids; Receptors, Androgen; RNA Processing, Post-Transcriptional; Time Factors; Tosyl Compounds; Transcriptional Activation; Transfection; Tumor Cells, Cultured

2002
Acquisition of agonistic properties of nonsteroidal antiandrogens after treatment with oncostatin M in prostate cancer cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:7

    Topics: Androgen Antagonists; Anilides; Antineoplastic Agents; Calcium-Calmodulin-Dependent Protein Kinases; Chloramphenicol; Cyclic AMP-Dependent Protein Kinases; DNA Primers; Enzyme Inhibitors; Flavonoids; Flutamide; Growth Inhibitors; Humans; Interleukin-6; Male; Nitriles; Oncostatin M; Peptides; Prostatic Neoplasms; Receptors, Androgen; Receptors, Cytokine; Receptors, Oncostatin M; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tosyl Compounds; Transfection; Tumor Cells, Cultured

2002
Pure antiandrogens disrupt the recruitment of coactivator GRIP1 to colocalize with androgen receptor in nuclei.
    FEBS letters, 2002, Jul-17, Volume: 523, Issue:1-3

    Topics: Active Transport, Cell Nucleus; Androgen Antagonists; Androgens; Anilides; Animals; Cell Nucleus; Chlorocebus aethiops; COS Cells; Cyproterone Acetate; Flutamide; Nitriles; Nuclear Receptor Coactivator 2; Receptors, Androgen; Subcellular Fractions; Tosyl Compounds; Transcription Factors; Transcriptional Activation

2002
Inhibition of fatty acid synthase expression by 1alpha,25-dihydroxyvitamin D3 in prostate cancer cells.
    The Journal of steroid biochemistry and molecular biology, 2003, Volume: 85, Issue:1

    Topics: Androgen Antagonists; Anilides; Calcitriol; Cerulenin; Cycloheximide; Down-Regulation; Enzyme Inhibitors; Fatty Acid Synthases; Flutamide; Gene Expression Regulation, Neoplastic; Humans; Male; Nitriles; Oligonucleotide Array Sequence Analysis; Prostatic Neoplasms; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tosyl Compounds; Tumor Cells, Cultured

2003
Androgen receptor is targeted to distinct subcellular compartments in response to different therapeutic antiandrogens.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Nov-01, Volume: 10, Issue:21

    Topics: Adenosine Triphosphate; Androgen Antagonists; Androgens; Anilides; Animals; Cell Line, Tumor; Cell Nucleus; COS Cells; Cytoplasm; Cytoskeleton; Electrophoresis, Gel, Two-Dimensional; Flutamide; Humans; Immunoblotting; Male; Mass Spectrometry; Microscopy, Confocal; Microscopy, Fluorescence; Nitriles; Prostatic Neoplasms; Protein Transport; Receptors, Androgen; Subcellular Fractions; Tosyl Compounds; Transfection

2004
5alpha-dihydrotestosterone inhibits 1alpha,25-dihydroxyvitamin D3-induced expression of CYP24 in human prostate cancer cells.
    The Prostate, 2005, May-15, Volume: 63, Issue:3

    Topics: Androgen Receptor Antagonists; Androgens; Anilides; Calcitriol; Cycloheximide; Cytochrome P-450 Enzyme System; Dihydrotestosterone; Drug Interactions; Flutamide; Gene Expression Regulation, Enzymologic; Humans; Male; Nitriles; Prostatic Neoplasms; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Steroid Hydroxylases; Tosyl Compounds; Tumor Cells, Cultured; Vitamin D3 24-Hydroxylase

2005
Antiandrogens prevent stable DNA-binding of the androgen receptor.
    Journal of cell science, 2005, Sep-15, Volume: 118, Issue:Pt 18

    Topics: Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Anilides; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, Cultured; Computer Simulation; DNA; DNA-Binding Proteins; DNA, Neoplasm; Flutamide; Green Fluorescent Proteins; Humans; Liver Neoplasms; Male; Metribolone; Nitriles; Prostatic Neoplasms; Receptors, Androgen; Recombinant Fusion Proteins; Tosyl Compounds

2005
Co-activator and co-repressor interplay on the human androgen receptor.
    Andrologia, 2005, Volume: 37, Issue:6

    Topics: Androgen Antagonists; Androgen-Binding Protein; Androgens; Anilides; Cyproterone Acetate; Flutamide; Humans; Ligands; Male; Nitriles; Protein Binding; Receptors, Androgen; Repressor Proteins; Response Elements; Time Factors; Tosyl Compounds; Trans-Activators; Transcriptional Activation

2005
Ligand-specific dynamics of the androgen receptor at its response element in living cells.
    Molecular and cellular biology, 2007, Volume: 27, Issue:5

    Topics: Adenocarcinoma; Androgen Antagonists; Androgens; Anilides; Animals; Cell Line, Tumor; Chromatin Assembly and Disassembly; Cyproterone Acetate; Dihydrotestosterone; Female; Fluorescence Recovery After Photobleaching; Flutamide; Genes, Reporter; Green Fluorescent Proteins; In Situ Hybridization, Fluorescence; Ligands; Luciferases; Mammary Neoplasms, Animal; Mammary Tumor Virus, Mouse; Metribolone; Mice; Microscopy, Video; Mifepristone; Models, Biological; Nitriles; Plasmids; Promoter Regions, Genetic; Receptors, Androgen; Response Elements; Testosterone; Tosyl Compounds; Transcription, Genetic

2007
The androgen receptor T877A mutant recruits LXXLL and FXXLF peptides differently than wild-type androgen receptor in a time-resolved fluorescence resonance energy transfer assay.
    Biochemistry, 2007, Jan-23, Volume: 46, Issue:3

    Topics: Amino Acid Sequence; Amino Acid Substitution; Androgen Antagonists; Anilides; Animals; Cyproterone Acetate; Dihydrotestosterone; Fluoresceins; Fluorescence Resonance Energy Transfer; Flutamide; Ligands; Mifepristone; Nitriles; Oligopeptides; Rats; Receptors, Androgen; Tosyl Compounds

2007
Non-steroidal antiandrogens act as AF-1 agonists under conditions of high androgen-receptor expression.
    The Prostate, 2007, May-01, Volume: 67, Issue:6

    Topics: Androgens; Anilides; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Flutamide; HeLa Cells; Humans; Male; Nitriles; Prostatic Neoplasms; Receptors, Androgen; Receptors, Interferon; Tosyl Compounds; Transcriptional Activation

2007
Effects of steroidal and non-steroidal antiandrogens on wild-type and mutant androgen receptors.
    The Prostate, 2007, Jun-01, Volume: 67, Issue:8

    Topics: Allylestrenol; Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Anilides; Cyproterone Acetate; Flutamide; Humans; Imidazolidines; Male; Models, Molecular; Mutagenesis, Site-Directed; Neoplasms, Hormone-Dependent; Nitriles; Plasmids; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Testosterone; Tosyl Compounds; Transcription, Genetic; Transfection

2007
Computationally identified novel diphenyl- and phenylpyridine androgen receptor antagonist structures.
    Journal of chemical information and modeling, 2008, Volume: 48, Issue:9

    Topics: Androgen Antagonists; Androgen Receptor Antagonists; Anilides; Animals; Antineoplastic Agents; Binding, Competitive; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Chlorocebus aethiops; Computer Simulation; Drug Design; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Flutamide; Humans; Male; Models, Molecular; Molecular Structure; Nitriles; Prostatic Neoplasms; Pyridines; Tosyl Compounds

2008
Functional AR signaling is evident in an in vitro mouse follicle culture bioassay that encompasses most stages of folliculogenesis.
    Biology of reproduction, 2009, Volume: 80, Issue:4

    Topics: Androgen Antagonists; Androgen Receptor Antagonists; Anilides; Animals; Biological Assay; Cell Culture Techniques; Cells, Cultured; Female; Flutamide; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Nitriles; Ovarian Follicle; Receptors, Androgen; Signal Transduction; Tosyl Compounds

2009
Systematic structure-function analysis of androgen receptor Leu701 mutants explains the properties of the prostate cancer mutant L701H.
    The Journal of biological chemistry, 2010, Feb-12, Volume: 285, Issue:7

    Topics: Androgen Antagonists; Anilides; Blotting, Western; Cell Line, Tumor; Cyproterone Acetate; Dihydrotestosterone; Flutamide; Humans; Hydrocortisone; Hydrophobic and Hydrophilic Interactions; Male; Mutation; Nitriles; Progesterone; Prostatic Neoplasms; Protein Structure, Secondary; Receptors, Androgen; Steroids; Structure-Activity Relationship; Tosyl Compounds

2010
Hydroxyflutamide enhances cellular sensitivity to 5-fluorouracil by suppressing thymidylate synthase expression in bicalutamide-resistant human prostate cancer cells.
    International journal of oncology, 2011, Volume: 38, Issue:3

    Topics: Androgen Antagonists; Anilides; Antimetabolites, Antineoplastic; Carcinoma; Cell Line, Tumor; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Drug Synergism; Fluorouracil; Flutamide; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Male; Models, Biological; Neoplasms, Hormone-Dependent; Nitriles; Prostatic Neoplasms; Thymidylate Synthase; Tosyl Compounds

2011
Antiandrogens act as selective androgen receptor modulators at the proteome level in prostate cancer cells.
    Molecular & cellular proteomics : MCP, 2015, Volume: 14, Issue:5

    Topics: Amino Acid Sequence; Androgen Antagonists; Anilides; Cell Line, Tumor; Cyproterone Acetate; Flutamide; Gene Expression Regulation, Neoplastic; Humans; Male; Molecular Sequence Annotation; Molecular Sequence Data; Mutation; Nandrolone; Neoplasm Proteins; Nitriles; Prostate; Proteome; Receptors, Androgen; Signal Transduction; Tosyl Compounds

2015
Functional analysis of androgen receptor mutations that confer anti-androgen resistance identified in circulating cell-free DNA from prostate cancer patients.
    Genome biology, 2016, Jan-26, Volume: 17

    Topics: Androgen Receptor Antagonists; Anilides; Benzamides; DNA; Drug Resistance, Neoplasm; Flutamide; High-Throughput Nucleotide Sequencing; Humans; Male; Mutation; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; Tosyl Compounds

2016
Corepressive function of nuclear receptor coactivator 2 in androgen receptor of prostate cancer cells treated with antiandrogen.
    BMC cancer, 2016, 05-25, Volume: 16

    Topics: Androgen Antagonists; Anilides; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Flutamide; Gene Expression Regulation, Neoplastic; Humans; Male; Mutation; Nitriles; Nuclear Receptor Coactivators; Prostatic Neoplasms; Receptors, Androgen; Tosyl Compounds

2016
Enzalutamide inhibits androgen receptor-positive bladder cancer cell growth.
    Urologic oncology, 2016, Volume: 34, Issue:10

    Topics: Androgen Antagonists; Anilides; Animals; Antineoplastic Agents; Apoptosis; Benzamides; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dihydrotestosterone; Down-Regulation; Flutamide; Humans; Interleukin-6; Male; Matrix Metalloproteinase 2; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; Nitriles; Phenylthiohydantoin; Receptors, Androgen; RNA; Tosyl Compounds; Transcription, Genetic; Urinary Bladder Neoplasms

2016
Structural Dynamics of Agonist and Antagonist Binding to the Androgen Receptor.
    The journal of physical chemistry. B, 2019, 09-12, Volume: 123, Issue:36

    Topics: Androgen Receptor Antagonists; Androgens; Anilides; Binding Sites; Dihydrotestosterone; Flutamide; Humans; Molecular Dynamics Simulation; Nitriles; Receptors, Androgen; Testosterone; Tosyl Compounds

2019