bibp-3226 and 3-nitrotyrosine

bibp-3226 has been researched along with 3-nitrotyrosine* in 1 studies

Other Studies

1 other study(ies) available for bibp-3226 and 3-nitrotyrosine

ArticleYear
Modulation of methamphetamine-induced nitric oxide production by neuropeptide Y in the murine striatum.
    Brain research, 2012, Nov-05, Volume: 1483

    Methamphetamine (METH) is a potent stimulant that induces both acute and long-lasting neurochemical changes in the brain including neuronal cell loss. Our laboratory demonstrated that the neuropeptide substance P enhances the striatal METH-induced production of nitric oxide (NO). In order to better understand the role of the striatal neuropeptides on the METH-induced production of NO, we used agonists and antagonists of the NPY (Y1R and Y2R) receptors infused via intrastriatal microinjection followed by a bolus of METH (30 mg/kg, ip) and measured 3-NT immunofluorescence, an indirect index of NO production. One striatum received pharmacological agent while the contralateral striatum received aCSF and served as control. NPY receptor agonists dose dependently attenuated the METH-induced production of striatal 3-NT. Conversely, NPY receptor antagonists had the opposite effect. Moreover, METH induced the accumulation of cyclic GMP and activated caspase-3 in approximately 18% of striatal neurons, a phenomenon that was attenuated by pre-treatment with NPY2 receptor agonist. Lastly, METH increased the levels of striatal preproneuropeptide Y mRNA nearly five-fold 16 h after injection as determined by RT-PCR, suggesting increased utilization of the neuropeptide. In conclusion, NPY inhibits the METH-induced production of NO in striatal tissue. Consequently, production of this second messenger induces the accumulation of cyclic GMP and activated caspase-3 in some striatal neurons, an event that may precede the apoptosis of some striatal neurons.

    Topics: Analysis of Variance; Animals; Arginine; Caspase 3; Corpus Striatum; Cyclic GMP; Drug Interactions; Male; Methamphetamine; Mice; Mice, Inbred ICR; Microinjections; Neuropeptide Y; Nitric Oxide Synthase Type II; Peptides; Protein Precursors; Receptors, Neuropeptide Y; RNA, Messenger; Tyrosine

2012
chemdatabank.com