Page last updated: 2024-09-03

bibn 99 and afdx 116

bibn 99 has been researched along with afdx 116 in 3 studies

Compound Research Comparison

Studies (bibn 99)	Trials (bibn 99)	Recent Studies (post-2010) (bibn 99)	Studies (afdx 116)	Trials (afdx 116)	Recent Studies (post-2010) (afdx 116)
11	0	0	367	1	24

Protein Interaction Comparison

Protein	Taxonomy	afdx 116 (IC50)
Muscarinic acetylcholine receptor M2	Homo sapiens (human)	1.8
Muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	2.927
Muscarinic acetylcholine receptor M3	Rattus norvegicus (Norway rat)	3.4558
Muscarinic acetylcholine receptor M4	Rattus norvegicus (Norway rat)	2.927
Muscarinic acetylcholine receptor M5	Rattus norvegicus (Norway rat)	2.927
Muscarinic acetylcholine receptor M2	Rattus norvegicus (Norway rat)	2.5994
Muscarinic acetylcholine receptor M2	Mus musculus (house mouse)	6.2

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Doods, H; Eberlein, W; Engel, W; Entzeroth, M; Mihm, G; Rudolf, K; Schiavi, G; Ziegler, H	1
Bechtel, WD; Doods, HN; Engel, W; Ensinger, HA; Entzeroth, M; Ladinsky, H; Mihm, G; Quirion, R; Rudolf, K; Schiavi, GB	1
Hirano, S; Kakefuda, A; Shibata, H; Takizawa, K; Tanaka, A; Watanabe, T; Yamagiwa, Y; Yanagisawa, I	1

Reviews

1 review(s) available for bibn 99 and afdx 116

Article	Year
Therapeutic potential of CNS-active M2 antagonists: novel structures and pharmacology. Life sciences, 1993, Volume: 52, Issue:5-6 Topics: Animals; Benzodiazepinones; Brain; CHO Cells; Cognition Disorders; Cricetinae; Dibenzazepines; Drug Design; Motor Activity; Parasympatholytics; Piperidines; Pirenzepine; Pyridines; Rats; Receptors, Muscarinic; Structure-Activity Relationship	1993

Other Studies

2 other study(ies) available for bibn 99 and afdx 116

Article	Year
Characterization of BIBN 99: a lipophilic and selective muscarinic M2 receptor antagonist. European journal of pharmacology, 1993, Sep-21, Volume: 242, Issue:1 Topics: Animals; Binding Sites; Dibenzazepines; Guinea Pigs; Heart; Hemodynamics; Male; Muscarinic Antagonists; Muscle, Smooth; Myocardium; Parasympatholytics; Pirenzepine; Pyridines; Rabbits; Rats; Rats, Wistar; Receptors, Muscarinic	1993
Synthesis and biological evaluation of phenylacetyl derivatives having low central nervous system permeability as potent and selective M2 muscarinic receptor antagonists. Chemical & pharmaceutical bulletin, 1998, Volume: 46, Issue:1 Topics: Animals; Bradycardia; Cerebral Cortex; Dibenzazepines; Dogs; Heart; Male; Mice; Muscarinic Antagonists; Parasympatholytics; Phenylacetates; Pirenzepine; Pyridines; Rats; Rats, Wistar; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Salivation; Structure-Activity Relationship; Submandibular Gland; Tremor	1998

Article

Year

Characterization of BIBN 99: a lipophilic and selective muscarinic M2 receptor antagonist.

European journal of pharmacology, 1993, Sep-21, Volume: 242, Issue:1

Topics: Animals; Binding Sites; Dibenzazepines; Guinea Pigs; Heart; Hemodynamics; Male; Muscarinic Antagonists; Muscle, Smooth; Myocardium; Parasympatholytics; Pirenzepine; Pyridines; Rabbits; Rats; Rats, Wistar; Receptors, Muscarinic

1993

Synthesis and biological evaluation of phenylacetyl derivatives having low central nervous system permeability as potent and selective M2 muscarinic receptor antagonists.

Chemical & pharmaceutical bulletin, 1998, Volume: 46, Issue:1

Topics: Animals; Bradycardia; Cerebral Cortex; Dibenzazepines; Dogs; Heart; Male; Mice; Muscarinic Antagonists; Parasympatholytics; Phenylacetates; Pirenzepine; Pyridines; Rats; Rats, Wistar; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Salivation; Structure-Activity Relationship; Submandibular Gland; Tremor

1998