bezafibrate has been researched along with pirinixic acid in 36 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.78) | 18.7374 |
| 1990's | 9 (25.00) | 18.2507 |
| 2000's | 20 (55.56) | 29.6817 |
| 2010's | 6 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brown, PJ; Henke, BR; Sternbach, DD; Willson, TM | 1 |
| Andersen, AS; Brand, CL; Bury, PS; Fleckner, J; Jeppesen, L; Lehmann, SV; Mogensen, JP; Mortensen, SB; Panajotova, V; Pettersson, I; Polivka, Z; Rasmussen, HB; Sauerberg, P; Sindelar, K; Sturis, J; Svensson, LA; Wassermann, K; Wöldike, HF; Wulff, EM; Ynddal, L | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Bahekar, R; Giri, S; Jain, M; Makadia, P; Patel, D; Patel, P; Pingali, H; Pola, S; Priyadarshini, P; Shah, M; Shah, SR; Suthar, D; Thube, B; Trivedi, C; Zaware, P | 1 |
| Doddareddy, MR; Gavande, N; Groundwater, PW; Hibbs, DE; Matin, A; Nammi, S; Roubin, RH | 1 |
| Imanaka, T; Itoga, H; Okawa, S; Suga, T; Watanabe, T | 1 |
| Cannon, JR; Eacho, PI | 1 |
| Bar-Tana, J; Hertz, R | 1 |
| Gibson, GG; Howes, D; Kass, GE; Orrenius, S; Shackleton, GL; Sharma, RK | 1 |
| Galloway, SM; Johnson, TE; Ledwith, BJ; Manam, S; Nichols, WW; Pauley, CJ; Wagner, LK | 1 |
| Belury, MA; Moya-Camarena, SY; Van den Heuvel, JP | 1 |
| Börchers, T; Buhlmann, C; Rolf, B; Spener, F; Wolfrum, C | 1 |
| Wallace, KB; Zhou, S | 1 |
| Brun, S; Carmona, MC; Giralt, M; Iglesias, R; Mampel, T; Villarroya, F; Viñas, O | 1 |
| Eriksson, P; Hamsten, A; Nilsson, L; Takemura, T | 1 |
| Börchers, T; Sacchettini, JC; Spener, F; Wolfrum, C | 1 |
| Carmona, MC; Giralt, M; Iglesias, R; Mampel, T; Pedraza, N; Solanes, G; Vazquez, M; Villarroya, F; Viñas, O | 1 |
| Adzet, T; Alegret, M; Cabrero, A; Laguna, JC; Sánchez, R; Vázquez, M | 1 |
| Adzet, T; Alegret, M; Cabrero, A; Laguna, JC; Sánchez, RM; Vázquez, M | 1 |
| Anchiraico, GJ; Belury, MA; Fischer, SM; Gimenez-Conti, I; Liu, KL; Maldve, RE; Muga, SJ; Nickel, KP; Thuillier, P | 1 |
| Giralt, M; Iglesias, R; Pedraza, N; Solanes, G; Vázquez, M; Villarroya, F | 1 |
| Hashimoto, T; Nawata, H; Sako, Y; Tajiri, Y; Umeda, F; Yoshikawa, H | 1 |
| Fernando, R; Moorhead, JF; Powis, SH; Ruan, XZ; Varghese, Z; Wheeler, DC | 1 |
| Goya, K; Kasayama, S; Kawase, I; Kitamura, T; Kouhara, H; Kurebayashi, S; Saito, H; Sumitani, S; Xu, X; Yamamoto, H | 1 |
| Agellon, LB; Gbaguidi, GF | 1 |
| Baldwin, GS; Ford, J; Lachal, S; Shulkes, A | 1 |
| Lee, LE; Liu, G; Metcalfe, CD; Moon, TW; Trudeau, VL | 1 |
| Beck, KF; Huwiler, A; Mathieson, P; Pavenstädt, H; Pfeilschifter, J; Ren, S; Saleem, MA; Xin, C | 1 |
| Asai, T; Cao, X; Hirai, T; Kambe, F; Murakami, H; Murakami, R; Murohara, T; Numaguchi, Y; Okumura, K; Seo, H; Takahashi, R | 1 |
| Caguyong, MJ; Cornwell, PD; Dai, X; De Souza, AT; Ulrich, RG | 1 |
| Blann, E; Collins, J; Dial, S; Dragan, YP; Fan, XH; Fang, H; Guo, L; Mehta, K; Shi, L; Tong, W; Wong, A | 1 |
| Giralt, M; Hondares, E; Iglesias, R; Pineda-Torra, I; Staels, B; Villarroya, F | 1 |
| Aso, Y; Bruemmer, D; Fuentes, L; Gizard, F; Heywood, EB; Inukai, T; Jones, KL; Nakamachi, T; Nomiyama, T; Staels, B; Takebayashi, K; Zhao, Y | 1 |
| He, JG; Lu, XH; Lv, GP; Si, SY; Zhang, H; Zhao, BH; Zheng, ZH | 1 |
| Capdevila, JH; Chen, X; Falck, JR; Gangadhariah, M; Hu, W; Jat, JL; Mont, S; Pozzi, A; Skrypnyk, N; Su, Y; Wei, S; Yang, S; Zent, R | 1 |
| Chen, C; Dai, M; Li, H; Wang, D; Wang, W; Wu, L | 1 |
1 review(s) available for bezafibrate and pirinixic acid
| Article | Year |
|---|---|
The PPARs: from orphan receptors to drug discovery.
Topics: Animals; Diabetes Mellitus; Drug Design; Humans; Hyperlipidemias; Hypertension; Inflammation; Ligands; Models, Molecular; Neoplasms; Nuclear Proteins; Obesity; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2000 |
35 other study(ies) available for bezafibrate and pirinixic acid
| Article | Year |
|---|---|
Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity.
Topics: Animals; Blood Glucose; Carbazoles; Cholesterol; Cholesterol, Dietary; Crystallography, X-Ray; Drug Evaluation, Preclinical; Glucose Tolerance Test; Hypoglycemic Agents; Hypolipidemic Agents; Male; Mice; Models, Molecular; Nuclear Proteins; Phenylpropionates; Pioglitazone; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Thiazolidinediones; Transcription Factors; Triglycerides | 2002 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Effect of structurally constrained oxime-ether linker on PPAR subtype selectivity: Discovery of a novel and potent series of PPAR-pan agonists.
Topics: Animals; Cricetinae; Disease Models, Animal; Ether; Hep G2 Cells; Humans; Hypoglycemic Agents; Male; Mice; Mice, Obese; Oximes; Peroxisome Proliferator-Activated Receptors; PPAR alpha; PPAR delta; PPAR gamma; Structure-Activity Relationship; Thiazoles | 2011 |
The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists.
Topics: Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; HEK293 Cells; Humans; Isoflavones; Models, Molecular; Molecular Structure; Peroxisome Proliferator-Activated Receptors; Structure-Activity Relationship | 2013 |
Involvement of calmodulin- and protein kinase C-related mechanism in an induction process of peroxisomal fatty acid oxidation-related enzymes by hypolipidemic peroxisome proliferators.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bezafibrate; Body Weight; Calmodulin; Catalase; Cells, Cultured; Clofibrate; Diethylhexyl Phthalate; Electrophoresis, Polyacrylamide Gel; Isoquinolines; Kinetics; Liver; Male; Membrane Proteins; Microbodies; Molecular Weight; Organ Size; Oxidation-Reduction; Piperazines; Protein Kinase C; Pyrimidines; Rats; Rats, Inbred Strains; Reference Values; Trifluoperazine | 1992 |
Interaction of LY171883 and other peroxisome proliferators with fatty-acid-binding protein isolated from rat liver.
Topics: Acetophenones; Animals; Bezafibrate; Carrier Proteins; Clofibric Acid; Electrophoresis, Polyacrylamide Gel; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Fibric Acids; Male; Microbodies; Neoplasm Proteins; Nerve Tissue Proteins; Oleic Acid; Oleic Acids; Pyrimidines; Rats; Rats, Inbred F344; SRS-A; Tetrazoles | 1991 |
Increased response to peroxisomal proliferators in starved rats.
Topics: Acyl Coenzyme A; Animals; Anticholesteremic Agents; Bezafibrate; Enoyl-CoA Hydratase; Hydro-Lyases; Liver; Male; Microbodies; Oxidation-Reduction; Palmitoyl Coenzyme A; Pyrimidines; Rats; Rats, Inbred Strains; Starvation | 1987 |
Diverse mechanisms of calcium mobilization by peroxisome proliferators in rat hepatocytes.
Topics: Animals; Anticholesteremic Agents; Antifungal Agents; Bezafibrate; Calcium; Clofibrate; Homeostasis; Imidazoles; In Vitro Techniques; Liver; Male; Microbodies; Pyrimidines; Rats; Rats, Wistar | 1995 |
Growth regulation by peroxisome proliferators: opposing activities in early and late G1.
Topics: Animals; Bezafibrate; Carcinogens; Cell Cycle; Cell Line; Clofibrate; Clofibric Acid; DNA; Fibric Acids; Gene Expression Regulation; Genes, Immediate-Early; Growth Substances; Mice; Microbodies; Pyrimidines; Signal Transduction; Time Factors; Transcriptional Activation | 1996 |
Conjugated linoleic acid activates peroxisome proliferator-activated receptor alpha and beta subtypes but does not induce hepatic peroxisome proliferation in Sprague-Dawley rats.
Topics: Acyl-CoA Oxidase; Animals; Bezafibrate; Carrier Proteins; Cell Line; Diet; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Female; Gene Expression; Genes, Reporter; Hypolipidemic Agents; Linoleic Acids; Liver; Male; Microbodies; Microscopy, Electron; Myelin P2 Protein; Neoplasm Proteins; Nerve Tissue Proteins; Oxidoreductases; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Transcription Factors; Transfection | 1999 |
Variation of liver-type fatty acid binding protein content in the human hepatoma cell line HepG2 by peroxisome proliferators and antisense RNA affects the rate of fatty acid uptake.
Topics: Bezafibrate; Carcinoma, Hepatocellular; Carrier Proteins; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Fatty Acids; Humans; Myelin P2 Protein; Neoplasm Proteins; Peroxisome Proliferators; Pyrimidines; RNA, Antisense; Transfection; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1999 |
The effect of peroxisome proliferators on mitochondrial bioenergetics.
Topics: Animals; Bezafibrate; Calcium; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Energy Metabolism; Fenofibrate; Fibric Acids; Gemfibrozil; Intracellular Membranes; Male; Membrane Potentials; Mitochondria, Liver; Mitochondrial Swelling; Oxygen; Permeability; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Sprague-Dawley; Trichloroethylene | 1999 |
Activators of peroxisome proliferator-activated receptor-alpha induce the expression of the uncoupling protein-3 gene in skeletal muscle: a potential mechanism for the lipid intake-dependent activation of uncoupling protein-3 gene expression at birth.
Topics: Animals; Bezafibrate; Carrier Proteins; Clofibrate; DNA-Binding Proteins; Eating; Fatty Acids, Nonesterified; Female; Gene Expression Regulation, Developmental; Hypolipidemic Agents; Ion Channels; Leptin; Male; Mice; Mitochondria, Muscle; Mitochondrial Proteins; Muscle Development; Muscle, Skeletal; Peroxisome Proliferators; Proteins; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Uncoupling Protein 3 | 1999 |
Effects of fibrate compounds on expression of plasminogen activator inhibitor-1 by cultured endothelial cells.
Topics: Bezafibrate; Cells, Cultured; Clofibric Acid; Endothelium, Vascular; Fenofibrate; Gemfibrozil; Humans; Hypolipidemic Agents; Plasminogen Activator Inhibitor 1; Pyrimidines; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription, Genetic | 1999 |
Binding of fatty acids and peroxisome proliferators to orthologous fatty acid binding proteins from human, murine, and bovine liver.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Amino Acid Sequence; Animals; Bezafibrate; Calorimetry; Carrier Proteins; Cattle; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Fatty Acids; Humans; Ligands; Liver; Mice; Molecular Sequence Data; Myelin P2 Protein; Neoplasm Proteins; Nerve Tissue Proteins; Peroxisome Proliferators; Protein Binding; Pyrimidines; Tumor Suppressor Proteins | 2000 |
Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactation: fibrates and troglitazone reverse lactation-induced downregulation of the uncoupling protein-3 gene.
Topics: Animals; Anticholesteremic Agents; Bezafibrate; Carrier Proteins; Chromans; Female; Gene Expression Regulation; Hypoglycemic Agents; Hypolipidemic Agents; Ion Channels; Lactation; Litter Size; Mice; Microbodies; Mitochondria, Muscle; Mitochondrial Proteins; Muscle, Skeletal; Pyrimidines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone; Uncoupling Agents; Uncoupling Protein 3; Weaning | 2000 |
Peroxisome proliferator-activated receptor alpha (PPARalpha) activators, bezafibrate and Wy-14,643, increase uncoupling protein-3 mRNA levels without modifying the mitochondrial membrane potential in primary culture of rat preadipocytes.
Topics: Adipocytes; Animals; Base Sequence; Bezafibrate; Carrier Proteins; Cells, Cultured; DNA Primers; Ion Channels; Membrane Potentials; Mitochondria; Mitochondrial Proteins; Peroxisome Proliferators; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Stem Cells; Transcription Factors; Uncoupling Protein 3 | 2000 |
Down-regulation of uncoupling protein-3 and -2 by thiazolidinediones in C2C12 myotubes.
Topics: Acyl-CoA Dehydrogenase; Animals; Atorvastatin; Bezafibrate; Carnitine O-Palmitoyltransferase; Carrier Proteins; Cell Line; Cholesterol; Chromans; Down-Regulation; Fatty Acid Desaturases; Heptanoic Acids; Hypoglycemic Agents; Ion Channels; Ligands; Membrane Transport Proteins; Mice; Mitochondrial Proteins; Muscles; Oleic Acid; Peroxisome Proliferators; Proteins; Pyrimidines; Pyrroles; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Triazenes; Troglitazone; Uncoupling Protein 2; Uncoupling Protein 3 | 2000 |
Activators of peroxisome proliferator-activated receptor-alpha partially inhibit mouse skin tumor promotion.
Topics: Animals; Anticarcinogenic Agents; Bezafibrate; Blotting, Western; Cell Differentiation; Cell Line; Chromans; Female; Keratinocytes; Linoleic Acid; Mice; Mice, Inbred SENCAR; Papilloma; Peroxisome Proliferators; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Skin; Skin Neoplasms; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Up-Regulation | 2000 |
Differential regulation of expression of genes encoding uncoupling proteins 2 and 3 in brown adipose tissue during lactation in mice.
Topics: Adipose Tissue, Brown; Animals; Bezafibrate; Carrier Proteins; Chromans; Dietary Fats; Female; Gene Expression Regulation; Ion Channels; Lactation; Litter Size; Membrane Transport Proteins; Mice; Mitochondrial Proteins; Pregnancy; Proteins; Pyrimidines; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone; Uncoupling Protein 2; Uncoupling Protein 3 | 2001 |
Effects of bezafibrate on beta-cell function of rat pancreatic islets.
Topics: Animals; Bezafibrate; Carnitine O-Palmitoyltransferase; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Oxidoreductases; Pyrimidines; Pyruvate Carboxylase; Pyruvate Dehydrogenase (Lipoamide); Pyruvate Dehydrogenase Complex; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Time Factors; Transcription Factors | 2001 |
PPAR agonists protect mesangial cells from interleukin 1beta-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathway.
Topics: Anticholesteremic Agents; Antineoplastic Agents; ATP-Binding Cassette Transporters; Bezafibrate; Biological Transport; Cell Line, Transformed; Cholesterol; DNA-Binding Proteins; Glomerular Mesangium; Humans; Hydroxycholesterols; Hypolipidemic Agents; Interleukin-1; Liver X Receptors; Orphan Nuclear Receptors; Prostaglandin D2; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2003 |
Peroxisome proliferator-activated receptor alpha agonists increase nitric oxide synthase expression in vascular endothelial cells.
Topics: Animals; Aorta; Bezafibrate; Cattle; Cells, Cultured; Dactinomycin; Endothelial Cells; Endothelium, Vascular; Enzyme Induction; Fenofibrate; Gene Expression Regulation, Enzymologic; Half-Life; Mifepristone; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pyrimidines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Transfection | 2004 |
The inhibition of the human cholesterol 7alpha-hydroxylase gene (CYP7A1) promoter by fibrates in cultured cells is mediated via the liver x receptor alpha and peroxisome proliferator-activated receptor alpha heterodimer.
Topics: Acids, Acyclic; Animals; Bezafibrate; Binding Sites; Cell Line, Tumor; Cells, Cultured; Cholesterol 7-alpha-Hydroxylase; Clofibrate; Dimerization; DNA-Binding Proteins; Gemfibrozil; Gene Expression Regulation; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 1-beta; Humans; Hydroxycholesterols; Ligands; Liver X Receptors; Nuclear Proteins; Orphan Nuclear Receptors; Promoter Regions, Genetic; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; Repetitive Sequences, Nucleic Acid; Response Elements; Transcription Factors | 2004 |
PPARalpha agonists stimulate progastrin production in human colorectal carcinoma cells.
Topics: Bezafibrate; Cell Proliferation; Clofibrate; Clofibric Acid; Colorectal Neoplasms; Fenofibrate; Fibric Acids; Gastrins; Gemfibrozil; Humans; Hypolipidemic Agents; Ligands; Peroxisome Proliferator-Activated Receptors; Protein Precursors; Pyrimidines; Radioimmunoassay; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Vasodilator Agents | 2004 |
A teleost in vitro reporter gene assay to screen for agonists of the peroxisome proliferator-activated receptors.
Topics: Acetyl-CoA C-Acyltransferase; Alitretinoin; Angiogenesis Inhibitors; Animals; Bezafibrate; Cloning, Molecular; DNA; DNA, Complementary; Dose-Response Relationship, Drug; Environmental Monitoring; Gemfibrozil; Genes, Reporter; Humans; Hypolipidemic Agents; In Vitro Techniques; Liver; Luciferases; Oncorhynchus mykiss; Peroxisome Proliferator-Activated Receptors; Peroxisome Proliferators; Plasmids; PPAR alpha; PPAR-beta; Promoter Regions, Genetic; Pyrimidines; Rats; Retinoid X Receptors; Transcription, Genetic; Transfection; Tretinoin; Water Pollutants, Chemical | 2005 |
PPARalpha activation upregulates nephrin expression in human embryonic kidney epithelial cells and podocytes by a dual mechanism.
Topics: Bezafibrate; Cells, Cultured; Embryo, Mammalian; Epithelial Cells; Humans; Interleukin-1; Kidney; Membrane Proteins; Mifepristone; Podocytes; PPAR alpha; Promoter Regions, Genetic; Pyrimidines; RNA, Messenger; Transcriptional Activation; Tumor Necrosis Factor-alpha; Up-Regulation | 2005 |
Fenofibrate activates AMPK and increases eNOS phosphorylation in HUVEC.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Bezafibrate; Endothelial Cells; Enzyme Activation; Fenofibrate; Humans; Multienzyme Complexes; Nitric Oxide Synthase Type III; Phosphorylation; PPAR alpha; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidines; Umbilical Veins; Up-Regulation | 2006 |
Agonists of the peroxisome proliferator-activated receptor alpha induce a fiber-type-selective transcriptional response in rat skeletal muscle.
Topics: Animals; Bezafibrate; Fatty Acids; Female; Fenofibrate; Gene Expression Profiling; Glucose; Hypolipidemic Agents; Liver; Muscle Fibers, Slow-Twitch; Muscle, Skeletal; PPAR alpha; Pyrimidines; Rats; Rats, Inbred Strains; Rosiglitazone; Thiazolidinediones; Tretinoin | 2006 |
Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonists.
Topics: Animals; Bezafibrate; Cells, Cultured; Fenofibrate; Gene Expression Profiling; Gene Expression Regulation; Hepatocytes; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; PPAR alpha; Pyrimidines | 2006 |
PPARdelta, but not PPARalpha, activates PGC-1alpha gene transcription in muscle.
Topics: Animals; Bezafibrate; Drug Synergism; Fatty Acids; Female; Gene Expression Regulation; Heart; Mice; Muscle, Skeletal; Muscles; Myocardium; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR alpha; PPAR delta; Pyrimidines; Trans-Activators; Transcription Factors; Transcription, Genetic | 2007 |
PPARalpha agonists suppress osteopontin expression in macrophages and decrease plasma levels in patients with type 2 diabetes.
Topics: Animals; Bezafibrate; Cell Line; Diabetes Mellitus, Type 2; Gene Expression Regulation; Humans; Hypolipidemic Agents; Ligands; Macrophages; Mice; Monocytes; Osteopontin; Plasmids; Polymerase Chain Reaction; PPAR alpha; Pyrimidines; Transfection | 2007 |
Impacts of different promoters on the mammalian one-hybrid assay for detecting nuclear receptor agonists.
Topics: Animals; Bezafibrate; Cells, Cultured; Chenodeoxycholic Acid; Drug Discovery; Genetic Vectors; HeLa Cells; High-Throughput Screening Assays; Humans; Hydrocarbons, Fluorinated; Ligands; Mice; NIH 3T3 Cells; Peroxisome Proliferator-Activated Receptors; Pioglitazone; Promoter Regions, Genetic; Pyrimidines; Rosiglitazone; Sensitivity and Specificity; Structure-Activity Relationship; Sulfonamides; Thiazolidinediones; Two-Hybrid System Techniques | 2010 |
PPARα activation can help prevent and treat non-small cell lung cancer.
Topics: Animals; Arachidonic Acids; Bezafibrate; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Disease Models, Animal; Endothelial Cells; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; Mice; Neoplasm Metastasis; Neoplasm Transplantation; Neovascularization, Pathologic; PPAR alpha; Pyrimidines | 2014 |
PPARα ligand, AVE8134, and cyclooxygenase inhibitor therapy synergistically suppress lung cancer growth and metastasis.
Topics: Animals; Antineoplastic Agents; Benzoates; Bezafibrate; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclooxygenase Inhibitors; Cytochrome P450 Family 2; Drug Evaluation, Preclinical; Drug Therapy, Combination; Eicosanoids; Indomethacin; Lung Neoplasms; Mice; Mice, Inbred C57BL; Mice, Knockout; Neoplasm Metastasis; Neovascularization, Pathologic; Oxazoles; PPAR alpha; Pyrimidines; Treatment Outcome; Xenograft Model Antitumor Assays | 2019 |