bexarotene has been researched along with tretinoin in 49 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (32.65) | 18.2507 |
| 2000's | 16 (32.65) | 29.6817 |
| 2010's | 16 (32.65) | 24.3611 |
| 2020's | 1 (2.04) | 2.80 |
| Authors | Studies |
|---|---|
| Cameron, JF; Chao, WR; Dawson, MI; Hobbs, PD; Jong, L; Lee, MO; Pfahl, M; Shroot, B | 1 |
| Ebisawa, M; Eisenmann, G; Eyrolles, L; Fukasawa, H; Gronemeyer, H; Hashimoto, Y; Kagechika, H; Kawachi, E; Shudo, K; Umemiya, H | 1 |
| Corey, DR; Doyle, DF; Mangelsdorf, DJ; Peet, DJ | 1 |
| Hibi, S; Hida, T; Kikuchi, K; Nagai, M; Tai, K; Yoshimura, H | 1 |
| Chandraratna, RA; Thacher, SM; Vasudevan, J | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Darwaiz, T; Deans, DG; Grozic, A; Heck, MC; Jurutka, PW; Ma, N; MacNeill, M; Marshall, PA; Robinson, NM; Salama, SH; Shahani, PH; Shimabuku, M; van der Vaart, A; Wagner, CE; Ziller, JW | 1 |
| Gellrich, L; Heering, J; Kaiser, A; Kalinowsky, L; Kilu, W; Merk, D; Ohrndorf, J; Pollinger, J; Proschak, E; Schierle, S; Schmidt, J | 1 |
| Issandou, M; Nicaud, M; Nicodeme, E | 1 |
| Chao, W; Chen, DL; Dawson, MI; Elster, E; Heber, D; Heyman, R; Ikeda, Y; Kizaki, M; Koeffler, HP; Morikawa, M; Morosetti, R; Pakkala, S; Pfahl, M; Ueno, H | 1 |
| Auwerx, J; Dallongeville, J; Heyman, RA; Kosykh, V; Schoonjans, K; Staels, B; Vu-Dac, N | 1 |
| Dawson, MI; Eckert, RL; Fuchs, E; Hong, WK; Kurie, JM; Lee, HY; Lotan, R; Nesbitt, JC; Walsh, GL | 1 |
| Ohkubo, H; Yokota, Y | 1 |
| Commes, T; Defacque, H; Marti, J; Piquemal, D; Rochette-Egly, C; Sévilla, C | 1 |
| Allegretto, EA; Chandraratna, RA; Fitzgerald, P; Heyman, RA; Teng, M | 1 |
| Hendriks, HF; Kaptein, A; Kooistra, T; Neele, DM; Princen, HM; Twisk, J | 1 |
| Howell, SR; Shirley, MA; Ulm, EH | 1 |
| Hewson, QC; Irving, H; Lovat, PE; Malcolm, AJ; Pearson, AD; Redfern, CP | 1 |
| Budel, V; Cahen, P; Chaboteaux, C; Darro, F; Decaestecker, C; Kiss, R; Leblond, B; Nogaret, JM; Pétein, M; Pourrias, B; Ramos, C; Schoofs, A; Vianna, A | 1 |
| Hewson, QC; Lova, PE; Malcolm, AJ; Pearson, AD; Redfern, CP | 1 |
| Anderson, B; Smith, MA | 1 |
| Chu, F; Guo, Z; Huang, N | 1 |
| Li, D; Li, T; Samuels, HH; Tian, H; Wang, F | 1 |
| Foss, F; Gorgun, G | 1 |
| Hewson, QC; Lovat, PE; Pearson, AD; Redfern, CP | 1 |
| Simeone, AM; Tari, AM | 1 |
| Fung, BB; Guitart, J; Kuzel, TM; Posten, W; Querfeld, C; Rademaker, A; Rosen, ST | 1 |
| Elmazar, MM; Nau, H | 1 |
| Mei, JH; Wang, MW | 1 |
| DiPette, D; Guleria, R; Joshi, S; Pan, J; Singh, US | 1 |
| Nandan, R | 1 |
| Benoit, BM; Newton, SB; Rook, AH; Wysocka, M; Yoon, JS | 1 |
| Gudas, LJ; Su, D | 1 |
| Chai, D; He, B; Pu, J; Shan, P; Shen, L; Yuan, A | 1 |
| Kast, RE | 1 |
| Balitrand, N; Boelle, PY; Cassinat, B; Chomienne, C; Cras, A; Darsin-Bettinger, D; Politis, B; Toubert, ME | 1 |
| Baker, KM; Guleria, RS; Kendall, JA; Nizamutdinova, IT; Pan, J; Singh, AB | 1 |
| Carroll, M; Glantz, ST; Kasner, MT; Sanchez, PV; Scotland, S | 1 |
| Boerma, LJ; Chalmers, MJ; Cox, BD; Griffin, PR; Lobo-Ruppert, S; Muccio, DD; Qui, C; Renfrow, MB; Smith, CD; Xia, G | 1 |
| Bu, G; Dong, Q; Fu, Y; Kanekiyo, T; Liu, CC; Nielsen, HM; Shinohara, M; Zhao, J | 1 |
| Cho, H; Choi, G; Heo, JC; Hwang, D; Jung, D; Jung, M; Jung, TH; Kim, HY; Lee, HK; Lee, JO; Lee, S; Park, JH; Seol, HJ | 1 |
| Af Hällström, TM; Aittokallio, T; Bychkov, D; Eldfors, S; Heckman, C; Horvath, P; Kallioniemi, O; Mirtti, T; Mpindi, JP; Östling, P; Paavolainen, L; Peehl, DM; Rahkama, V; Rannikko, A; Saeed, K; Wennerberg, K; Yadav, B | 1 |
| Achenbach, J; Heitel, P; Merk, D; Moser, D; Proschak, E | 1 |
| Bridges, LC; Chen, J; Crouch, MJ; DeMarco, SS; Maiorana-Boutilier, AL; Peaks, MS; Phillips, CM; Shaikh, SR; Shewchuk, BM; Wang, L | 1 |
| Al-Hayali, M; Ali, J; Bradshaw, TD; Chan, TH; Chiang, M; Cipolla, E; Collins, HM; Feng, W; Fischer, PM; Gao, X; Garces, AE; Gershkovich, P; Heery, DM; Hume, A; Kagan, L; Kim, MG; Kim, TH; Lau, CL; Lee, JB; Malec, J; McIntosh, TM; Qin, C; Shin, BS; Soukarieh, F; Stocks, MJ; Voronin, G; Yoo, SD; Zgair, A | 1 |
| Gudas, LJ; Osei-Sarfo, K | 1 |
| Adamkova, K; Chlapek, P; Dobrotkova, V; Jezova, M; Mazanek, P; Sterba, J; Veselska, R | 1 |
| Atigadda, V; Belyaeva, OV; Berger, WK; Elmets, CA; Halasz, L; Kane, MA; Kedishvili, NY; Klyuyeva, AV; Melo, N; Muccio, DD; Nagy, L; Pilli, N; Renfrow, MB; Yang, Z; Yu, J | 1 |
5 review(s) available for bexarotene and tretinoin
| Article | Year |
|---|---|
Therapeutic applications for ligands of retinoid receptors.
Topics: Animals; Drug Design; Humans; Ligands; Receptors, Retinoic Acid; Retinoids; Structure-Activity Relationship | 2000 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
How retinoids regulate breast cancer cell proliferation and apoptosis.
Topics: Alitretinoin; Anticarcinogenic Agents; Apoptosis; Bexarotene; Breast Neoplasms; Cell Cycle; Cell Division; Female; Fenretinide; Humans; Retinoids; Tetrahydronaphthalenes; Tretinoin | 2004 |
[Advances in studies on selective RXR ligands].
Topics: Alitretinoin; Animals; Antineoplastic Agents; Bexarotene; Humans; Ligands; Neoplasms; Retinoid X Receptors; Retinoids; Structure-Activity Relationship; Tetrahydronaphthalenes; Tretinoin | 2005 |
Potential for all-trans retinoic acid (tretinoin) to enhance interferon-alpha treatment response in chronic myelogenous leukemia, melanoma, myeloma and renal cell carcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bexarotene; Carcinoma, Renal Cell; Drug Screening Assays, Antitumor; Hepacivirus; Humans; Interferon-alpha; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Melanoma; Models, Biological; Multiple Myeloma; Ribavirin; Tetrahydronaphthalenes; Treatment Outcome; Tretinoin | 2008 |
2 trial(s) available for bexarotene and tretinoin
| Article | Year |
|---|---|
Comparison of selective retinoic acid receptor- and retinoic X receptor-mediated efficacy, tolerance, and survival in cutaneous t-cell lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Anticarcinogenic Agents; Antineoplastic Agents; Bexarotene; Female; Follow-Up Studies; Humans; Lymphoma, T-Cell, Cutaneous; Male; Middle Aged; Receptors, Retinoic Acid; Retinoid X Receptors; Retrospective Studies; Survival Analysis; Tetrahydronaphthalenes; Treatment Outcome; Tretinoin | 2004 |
Bexarotene via CBP/p300 induces suppression of NF-κB-dependent cell growth and invasion in thyroid cancer.
Topics: Antigens, Differentiation; Antineoplastic Agents; Bexarotene; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; E1A-Associated p300 Protein; Female; Gene Expression Regulation, Neoplastic; Humans; Isotretinoin; Male; Middle Aged; Neoplasm Invasiveness; NF-kappa B; Receptors, Retinoic Acid; Retinoid X Receptor gamma; Tetrahydronaphthalenes; Thyroid Neoplasms; Transcription, Genetic; Transcriptional Activation; Treatment Outcome; Tretinoin | 2012 |
42 other study(ies) available for bexarotene and tretinoin
| Article | Year |
|---|---|
Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity.
Topics: beta-Galactosidase; Cell Line; Chloramphenicol O-Acetyltransferase; Isotretinoin; Magnetic Resonance Spectroscopy; Protein Conformation; Receptors, Retinoic Acid; Retinoid X Receptors; Transcription Factors; Transcription, Genetic | 1995 |
Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.
Topics: Azepines; Benzoates; Binding, Competitive; Cell Differentiation; Dibenzazepines; Dimerization; Drug Synergism; HL-60 Cells; Humans; Molecular Structure; Protein Binding; Receptors, Retinoic Acid; Retinoid X Receptors; Retinoids; Tetrahydronaphthalenes; Transcription Factors | 1997 |
Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR.
Topics: Amino Acid Sequence; Ligands; Models, Molecular; Molecular Sequence Data; Mutagenesis; Protein Conformation; Protein Engineering; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Sequence Alignment; Sequence Homology, Amino Acid; Transcription Factors; Transcription, Genetic; Transcriptional Activation | 1998 |
Syntheses and structure-activity relationships of novel retinoid X receptor agonists.
Topics: Animals; Cell Line; COS Cells; Cricetinae; Drug Design; Humans; Kinetics; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Quinolones; Receptors, Retinoic Acid; Recombinant Proteins; Retinoid X Receptors; Structure-Activity Relationship; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tretinoin | 1998 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR)-Selective Agonists: Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(5,5,8,8-tetrahydronaphthalen-2-
Topics: Antineoplastic Agents; Bexarotene; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; HEK293 Cells; Histone Deacetylase 1; Humans; Lymphoma, T-Cell, Cutaneous; Models, Molecular; Niacin; Retinoid X Receptors; Sterol Regulatory Element Binding Proteins; Tetrahydronaphthalenes | 2016 |
Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation.
Topics: Animals; HEK293 Cells; Hep G2 Cells; Humans; Male; Mice, Inbred C57BL; Microsomes, Liver; Molecular Structure; Peroxisome Proliferator-Activated Receptors; Pyrimidines; Rats; Retinoid X Receptors; Structure-Activity Relationship | 2019 |
Retinoids stimulate fibrinogen production both in vitro (hepatocytes) and in vivo. Induction requires activation of the retinoid X receptor.
Topics: Animals; Bexarotene; Cells, Cultured; Fibrinogen; Humans; Liver; Male; Rats; Rats, Sprague-Dawley; Receptors, Retinoic Acid; Retinoid X Receptors; Tetrahydronaphthalenes; Transcription Factors; Tretinoin | 1995 |
Effects of novel retinoid X receptor-selective ligands on myeloid leukemia differentiation and proliferation in vitro.
Topics: Bexarotene; Biomarkers; Cell Differentiation; Cell Division; Drug Synergism; Gene Expression Regulation, Leukemic; HL-60 Cells; Humans; Ligands; Macrophage-1 Antigen; Molecular Structure; Neoplasm Proteins; Neoplastic Stem Cells; Protein Multimerization; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Retinoid X Receptors; Retinoids; Signal Transduction; Tetrahydronaphthalenes; Transcription Factor AP-1; Transcription Factors; Tretinoin; Tumor Cells, Cultured | 1996 |
Retinoids increase human apolipoprotein A-11 expression through activation of the retinoid X receptor but not the retinoic acid receptor.
Topics: Apolipoprotein A-II; Apolipoproteins E; Base Sequence; Benzoates; Bexarotene; Carcinoma, Hepatocellular; Cloning, Molecular; DNA-Binding Proteins; Female; Gene Expression Regulation; Genomic Library; HeLa Cells; Humans; Kinetics; Liver Neoplasms; Molecular Sequence Data; Nicotinic Acids; Oligodeoxyribonucleotides; Placenta; Pregnancy; Receptors, Retinoic Acid; Regulatory Sequences, Nucleic Acid; Retinoid X Receptors; Retinoids; RNA, Messenger; Tetrahydronaphthalenes; Transcription Factors; Transcription, Genetic; Transfection; Tretinoin; Tumor Cells, Cultured | 1996 |
Retinoic acid receptor- and retinoid X receptor-selective retinoids activate signaling pathways that converge on AP-1 and inhibit squamous differentiation in human bronchial epithelial cells.
Topics: Alitretinoin; Benzoates; Bexarotene; Blotting, Northern; Bronchi; Cell Differentiation; Epithelium; Humans; Isomerism; Luciferases; Receptors, Retinoic Acid; Retinoid X Receptors; Retinoids; Signal Transduction; Tetrahydronaphthalenes; Transcription Factor AP-1; Transcription Factors; Transfection; Tretinoin | 1996 |
9-cis-retinoic acid induces neuronal differentiation of retinoic acid-nonresponsive embryonal carcinoma cells.
Topics: Animals; Bexarotene; Carcinoma, Embryonal; Cell Differentiation; Dose-Response Relationship, Drug; Down-Regulation; Mice; Neurons; Receptors, Retinoic Acid; Retinoid X Receptors; Retinoids; RNA, Messenger; Stereoisomerism; Tetrahydronaphthalenes; Transcription Factors; Tretinoin; Tumor Cells, Cultured | 1996 |
Potentiation of VD-induced monocytic leukemia cell differentiation by retinoids involves both RAR and RXR signaling pathways.
Topics: Alitretinoin; Animals; Benzoates; Bexarotene; Cell Differentiation; Chromans; COS Cells; HL-60 Cells; Humans; Leukemia, Monocytic, Acute; Lymphoma, Large B-Cell, Diffuse; Molecular Structure; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Retinoid X Receptors; Retinoids; Signal Transduction; Tetrahydronaphthalenes; Transcription Factors; Transfection; Tretinoin; Tumor Cells, Cultured; Vitamin D | 1997 |
Retinoic acid receptor alpha expression correlates with retinoid-induced growth inhibition of human breast cancer cells regardless of estrogen receptor status.
Topics: Alitretinoin; Aminobenzoates; Antineoplastic Agents; Benzoates; Bexarotene; Breast Neoplasms; Cell Division; Chromans; Female; Humans; Nicotinic Acids; Nuclear Proteins; Receptors, Estrogen; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Retinoid X Receptors; Retinoids; Tetrahydronaphthalenes; Transcription Factors; Tretinoin; Tumor Cells, Cultured | 1997 |
Mechanism of the slow induction of apolipoprotein A-I synthesis by retinoids in cynomolgus hepatocytes: involvement of retinoic acid and retinoid X receptors.
Topics: Alitretinoin; Animals; Apolipoprotein A-I; Benzoates; Bexarotene; Blotting, Northern; Cells, Cultured; Female; Gene Expression Regulation; Liver; Macaca fascicularis; Male; Receptors, Retinoic Acid; Retinoid X Receptors; Retinoids; RNA, Messenger; Tetrahydronaphthalenes; Time Factors; Transcription Factors; Transcriptional Activation; Tretinoin | 1997 |
Effects of retinoid treatment of rats on hepatic microsomal metabolism and cytochromes P450. Correlation between retinoic acid receptor/retinoid x receptor selectivity and effects on metabolic enzymes.
Topics: Animals; Bexarotene; Cytochrome P-450 Enzyme System; Isoenzymes; Male; Microsomes, Liver; Molecular Structure; Nicotinic Acids; Rats; Rats, Sprague-Dawley; Receptors, Retinoic Acid; Retinoid X Receptors; Retinoids; Tetrahydronaphthalenes; Transcription Factors; Tretinoin | 1998 |
Retinoid-induced differentiation of neuroblastoma: comparison between LG69, an RXR-selective analogue and 9-cis retinoic acid.
Topics: Antineoplastic Agents; Bexarotene; Blotting, Northern; Cell Differentiation; Cell Division; Dose-Response Relationship, Drug; Gene Expression; Humans; Neuroblastoma; Tetrahydronaphthalenes; Tretinoin | 1998 |
Growth inhibition of human in vitro and mouse in vitro and in vivo mammary tumor models by retinoids in comparison with tamoxifen and the RU-486 anti-progestagen.
Topics: Alitretinoin; Animals; Anticarcinogenic Agents; Apoptosis; Benzoates; Bexarotene; Breast Neoplasms; Cell Division; Disease Models, Animal; Female; Fenretinide; Hormone Antagonists; Humans; Mammary Neoplasms, Animal; Mice; Mice, Inbred C57BL; Mifepristone; Retinoids; Tamoxifen; Tetrahydronaphthalenes; Tretinoin; Tumor Cells, Cultured | 1998 |
Receptor mechanisms mediating differentiation and proliferation effects of retinoids on neuroblastoma cells.
Topics: Alitretinoin; Bexarotene; Cell Differentiation; Cell Division; Dimerization; Humans; Neuroblastoma; Receptors, Retinoic Acid; Retinoid X Receptors; Retinoids; Tetrahydronaphthalenes; Transcription Factors; Tretinoin; Tumor Cells, Cultured | 2000 |
Where to next with retinoids for cancer therapy?
Topics: Alitretinoin; Antineoplastic Agents; Bexarotene; Humans; Isotretinoin; Neoplasms; Retinoids; Tetrahydronaphthalenes; Tretinoin | 2001 |
[Studies on the structure-activity relationship of retinoids--Hansch analysis and 3D-OSAR studies on specific ligands of retinoid x receptor].
Topics: Alitretinoin; Anticarcinogenic Agents; Antineoplastic Agents; Bexarotene; Molecular Conformation; Quantitative Structure-Activity Relationship; Receptors, Retinoic Acid; Retinoid X Receptors; Retinoids; Structure-Activity Relationship; Tetrahydronaphthalenes; Transcription Factors; Tretinoin | 1998 |
Functional evidence for retinoid X receptor (RXR) as a nonsilent partner in the thyroid hormone receptor/RXR heterodimer.
Topics: Alitretinoin; Anticarcinogenic Agents; Bexarotene; Dimerization; DNA-Binding Proteins; Gene Expression Regulation; Genes, Reporter; HeLa Cells; Herpes Simplex Virus Protein Vmw65; Humans; Ligands; Nuclear Proteins; Receptors, Retinoic Acid; Receptors, Thyroid Hormone; Recombinant Fusion Proteins; Retinoid X Receptors; Tetrahydronaphthalenes; Transcription Factors; Tretinoin; Triiodothyronine | 2002 |
Immunomodulatory effects of RXR rexinoids: modulation of high-affinity IL-2R expression enhances susceptibility to denileukin diftitox.
Topics: Adjuvants, Immunologic; Alitretinoin; Antineoplastic Agents; B-Lymphocytes; Bexarotene; Diphtheria Toxin; Gene Expression Regulation; Humans; Interleukin-2; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Interleukin-2; Receptors, Retinoic Acid; Recombinant Fusion Proteins; Retinoid X Receptors; Retinoids; T-Lymphocytes; Tetrahydronaphthalenes; Transcription Factors; Tretinoin; Tumor Cells, Cultured | 2002 |
Retinoid signalling and gene expression in neuroblastoma cells: RXR agonist and antagonist effects on CRABP-II and RARbeta expression.
Topics: Alitretinoin; Bexarotene; Dose-Response Relationship, Drug; Gene Expression; Humans; Neuroblastoma; Receptors, Retinoic Acid; Retinoid X Receptors; Retinoids; RNA, Messenger; Signal Transduction; Tetrahydronaphthalenes; Transcription Factors; Tretinoin; Tumor Cells, Cultured | 2002 |
Potentiation of the teratogenic effects induced by coadministration of retinoic acid or phytanic acid/phytol with synthetic retinoid receptor ligands.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Benzoates; Bexarotene; Dose-Response Relationship, Drug; Drug Synergism; Female; Gestational Age; Ligands; Mice; Mice, Inbred Strains; Phytanic Acid; Phytol; Pregnancy; Prenatal Exposure Delayed Effects; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Retinoid X Receptors; Teratogens; Tetrahydronaphthalenes; Tretinoin; Vitamin A | 2004 |
Retinoic acid receptors and tissue-transglutaminase mediate short-term effect of retinoic acid on migration and invasion of neuroblastoma SH-SY5Y cells.
Topics: Alitretinoin; Antineoplastic Agents; Bexarotene; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Gene Expression Regulation, Neoplastic; GTP-Binding Proteins; Humans; Kidney; Neoplasm Invasiveness; Neuroblastoma; Protein Glutamine gamma Glutamyltransferase 2; Receptors, Retinoic Acid; Retinoid X Receptors; Signal Transduction; Tetrahydronaphthalenes; Transglutaminases; Tretinoin | 2006 |
Promising results achieved with a combination of chemotherapy and two retinoids in patients with advanced non-small-cell lung cancer.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bexarotene; Biological Availability; Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung Neoplasms; Male; Middle Aged; Survival Rate; Tetrahydronaphthalenes; Treatment Outcome; Tretinoin | 2006 |
Apoptotic responses to all-trans retinoic acid of targretin-resistant, malignant, CD4+ peripheral blood T cells from patients with Sezary syndrome.
Topics: Antineoplastic Agents; Apoptosis; Bexarotene; CD4-Positive T-Lymphocytes; Cell Culture Techniques; Drug Resistance, Neoplasm; Humans; Sezary Syndrome; Skin Neoplasms; Tetrahydronaphthalenes; Tretinoin | 2007 |
Retinoic acid receptor gamma activates receptor tyrosine kinase Tie1 gene transcription through transcription factor GATA4 in F9 stem cells.
Topics: Animals; Bexarotene; Embryonal Carcinoma Stem Cells; GATA4 Transcription Factor; Gene Expression Profiling; Mice; Promoter Regions, Genetic; Receptor, TIE-1; Receptors, Retinoic Acid; Retinoic Acid Receptor gamma; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrahydronaphthalenes; Transcription, Genetic; Tretinoin; Tumor Cells, Cultured | 2008 |
RXR agonists inhibit oxidative stress-induced apoptosis in H9c2 rat ventricular cells.
Topics: Alitretinoin; Animals; Apoptosis; Bexarotene; Caspase 3; Cell Survival; Cytochromes c; Heart Ventricles; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Mitochondria; Myocytes, Cardiac; Oxidative Stress; Rats; Reactive Oxygen Species; Retinoid X Receptors; Tetrahydronaphthalenes; Tretinoin | 2008 |
Retinoic acid protects cardiomyocytes from high glucose-induced apoptosis through inhibition of NF-κB signaling pathway.
Topics: Animals; Apoptosis; Bexarotene; Cytokines; Cytoprotection; Gene Expression Regulation; Hyperglycemia; I-kappa B Kinase; Male; Myocytes, Cardiac; NF-kappa B; Phosphorylation; Protein Phosphatase 2; Rats; Rats, Zucker; Signal Transduction; Tetrahydronaphthalenes; Tretinoin | 2013 |
Induced differentiation of acute myeloid leukemia cells by activation of retinoid X and liver X receptors.
Topics: Bexarotene; CCAAT-Enhancer-Binding Protein-alpha; CCAAT-Enhancer-Binding Proteins; Cell Differentiation; Cell Line, Tumor; Humans; Hydrocarbons, Fluorinated; Leukemia, Myeloid, Acute; Liver X Receptors; Nicotinic Acids; Orphan Nuclear Receptors; Proto-Oncogene Proteins; Retinoid X Receptors; Sulfonamides; Tetrahydronaphthalenes; Trans-Activators; Tretinoin | 2014 |
Defining the communication between agonist and coactivator binding in the retinoid X receptor α ligand binding domain.
Topics: Alitretinoin; Amino Acid Sequence; Bexarotene; Binding Sites; Crystallography, X-Ray; Fatty Acids, Unsaturated; Humans; Ligands; Models, Molecular; Molecular Sequence Data; Molecular Structure; Naphthalenes; Nuclear Receptor Coactivator 2; Protein Binding; Protein Conformation; Protein Multimerization; Protein Structure, Secondary; Protein Structure, Tertiary; Retinoid X Receptor alpha; Tetrahydronaphthalenes; Tretinoin | 2014 |
Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway.
Topics: Alleles; Alzheimer Disease; Animals; Anticarcinogenic Agents; Apolipoproteins E; Astrocytes; ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP-Binding Cassette Transporters; Bexarotene; Brain; Cell Line, Transformed; Humans; Lipoproteins; Lipoylation; Mice; Mice, Transgenic; Nerve Tissue Proteins; Receptors, Retinoic Acid; Retinoid X Receptors; Tetrahydronaphthalenes; Tretinoin | 2014 |
Effect of bexarotene on differentiation of glioblastoma multiforme compared with ATRA.
Topics: Angiopoietin-Like Protein 4; Angiopoietins; Animals; Bexarotene; Cell Differentiation; Cell Line, Tumor; Cell Movement; Gene Expression Regulation, Neoplastic; Glioblastoma; Growth Differentiation Factor 15; GTP-Binding Proteins; Humans; Kruppel-Like Transcription Factors; Mice; Protein Glutamine gamma Glutamyltransferase 2; Receptors, CXCR4; Retinoid X Receptors; RGS Proteins; Signal Transduction; Tetrahydronaphthalenes; Transglutaminases; Tretinoin; Xenograft Model Antitumor Assays | 2016 |
Comprehensive Drug Testing of Patient-derived Conditionally Reprogrammed Cells from Castration-resistant Prostate Cancer.
Topics: Aniline Compounds; Antineoplastic Agents; Bexarotene; Cellular Reprogramming Techniques; Drug Screening Assays, Antitumor; High-Throughput Screening Assays; Humans; Kallikreins; Keratin-18; Keratin-5; Male; Organoplatinum Compounds; Oxaliplatin; Precision Medicine; Prostate-Specific Antigen; Prostatic Neoplasms, Castration-Resistant; Quinacrine; Receptors, Androgen; Sulfonamides; Tetrahydronaphthalenes; Tretinoin; Tumor Cells, Cultured | 2017 |
DrugBank screening revealed alitretinoin and bexarotene as liver X receptor modulators.
Topics: Alitretinoin; Animals; Bexarotene; Drug Evaluation, Preclinical; HEK293 Cells; Humans; Liver X Receptors; Mice; Tetrahydronaphthalenes; Tretinoin | 2017 |
RARα/RXR synergism potentiates retinoid responsiveness in cutaneous T-cell lymphoma cell lines.
Topics: Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Benzoates; Bexarotene; Cell Adhesion; Cell Line; Cell Movement; Cell Proliferation; Gene Expression; Humans; Integrin beta Chains; Lymphoma, T-Cell, Cutaneous; Retinoic Acid Receptor alpha; Retinoid X Receptors; RNA, Messenger; Tetrahydronaphthalenes; Tretinoin | 2017 |
Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system.
Topics: Animals; Antineoplastic Agents; Bexarotene; Drug Delivery Systems; Esterification; Intestinal Mucosa; Lymph Nodes; Lymphatic System; Lymphatic Vessels; Male; Prodrugs; Rats, Sprague-Dawley; Tissue Distribution; Tretinoin | 2018 |
Retinoids induce antagonism between FOXO3A and FOXM1 transcription factors in human oral squamous cell carcinoma (OSCC) cells.
Topics: Antineoplastic Agents; Bexarotene; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Forkhead Box Protein M1; Forkhead Box Protein O3; Gene Expression; Gene Knockdown Techniques; Histone Deacetylases; Humans; Mouth Neoplasms; Promoter Regions, Genetic; Retinoids; RNA, Messenger; Tretinoin | 2019 |
Prediction of neuroblastoma cell response to treatment with natural or synthetic retinoids using selected protein biomarkers.
Topics: Adolescent; Antineoplastic Agents; Bexarotene; Biomarkers, Pharmacological; Cell Line, Tumor; Cell Proliferation; Child; Child, Preschool; DEAD-box RNA Helicases; Drug Resistance, Neoplasm; Female; Fenretinide; HMGA1a Protein; HMGA2 Protein; Homeodomain Proteins; Humans; Infant; Infant, Newborn; Isotretinoin; Male; Nervous System Neoplasms; Neuroblastoma; Paraffin Embedding; Pre-B-Cell Leukemia Transcription Factor 1; Tissue Fixation; Tretinoin; Young Adult | 2019 |
Next-generation retinoid X receptor agonists increase ATRA signaling in organotypic epithelium cultures and have distinct effects on receptor dynamics.
Topics: Bexarotene; Epidermis; Humans; Ligands; Retinoid X Receptors; Tetrahydronaphthalenes; Tretinoin | 2023 |