betulinic acid and betulin

betulinic acid has been researched along with betulin in 108 studies

Research

Studies (108)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	8 (7.41)	18.2507
2000's	31 (28.70)	29.6817
2010's	59 (54.63)	24.3611
2020's	10 (9.26)	2.80

Authors

Authors	Studies
Ballas, LM; Chen, IS; Cosentino, LM; Fujioka, T; Janzen, WP; Jiang, JB; Kashiwada, Y; Kilkuskie, RE; Lee, KH	1
Chen, CH; Cosentino, LM; Kashiwada, Y; Lee, KH; Shen, JK; Sun, IC; Wang, HK; Yang, LM	1
Cosentino, LM; Lee, KH; Shen, JK; Sun, IC; Wang, HK	1
Kim, DS; Pezzuto, JM; Pisha, E	1
Hata, K; Hori, K; Takahashi, S	1
Cuong, NM; Fong, HH; Hoang, VD; Hung, NV; Pezzuto, JM; Soejarto, DD; Tan, GT; Zhang, HJ	1
Ando, M; Fu, L; Hasegawa, T; Hirose, K; Kataoka, T; Kiuchi, M; Li, N; Mitsui, T; Oka, S; Sakai, J; Wang, J; Zhang, S; Zhao, M	1
Hajduch, M; Kvasnica, M; Sarek, J; Tislerova, I; Urban, M	1
Habib-Jiwan, JL; Hoet, S; Muccioli, GG; Opperdoes, FR; Pieters, L; Quetin-Leclercq, J	1
Akhtar, MN; Choudhary, MI; Khan, SN; Zareen, S	1
Alexacou, KM; Cheng, K; Gimisis, T; Hao, J; Hayes, JM; Leonidas, DD; Liu, J; Ni, P; Oikonomakos, NG; Sun, H; Wen, X; Zhang, L; Zhang, P; Zographos, SE	1
Abdel Bar, FM; Ahmad, KF; Bachawal, SV; El Sayed, KA; Sylvester, PW; Zaghloul, AM	1
Gauthier, C; Lavoie, S; Legault, J; Pichette, A; Rondeau, S; Tremblay, S	1
Gauthier, C; Girard-Lalancette, K; Legault, J; Mshvildadze, V; Pichette, A	1
Gauthier, C; Lavoie, S; Legault, J; Pichette, A; Piochon, M; Tremblay, S	1
Drag, M; Drag-Zalesinska, M; Kulbacka, J; Saczko, J; Surowiak, P; Wysocka, T; Zabel, M	1
Ahola, T; Alakurtti, S; Pohjala, L; Tammela, P; Yli-Kauhaluoma, J	1
Auwerx, J; Boudjelal, G; Genet, C; Lobstein, A; Saladin, R; Schmidt, C; Schoonjans, K; Souchet, M; Strehle, A; Wagner, A	1
Chen, J; Chen, L; Cheng, K; Gong, Y; Hao, J; Jiang, H; Li, H; Li, L; Liang, Z; Liu, H; Liu, J; Luo, C; Sun, H; Wen, X; Zhang, L; Zhang, P; Zhang, X; Zheng, M; Zhu, X	1
Dzubak, P; Hajduch, M; Sarek, J; Urban, M; Vlk, M	1
Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P	1
Arumugam, SR; Badri, KR; He, JJ; Visalli, RJ; Zhang, X; Zhao, H; Ziobrowski, H	1
Csuk, R; Heller, L; Kluge, R; Perl, V; Ströhl, D; Wiemann, J	1
Alakurtti, S; Haavikko, R; Hämäläinen, M; Laavola, M; Leppänen, T; Moilanen, E; Moreira, VM; Nieminen, R; Yli-Kauhaluoma, J	1
Brandner, JM; Merfort, I; Schmidt, G; Templin, MF; Thomas, M; Wardecki, T; Werner, P	1
Al-Harrasi, A; Csuk, R; Heller, L; Perl, V; Wiemann, J	1
Fan, P; Li, D; Lou, H; Ye, Y; Yuan, H; Zhang, T	1
Dong, YS; Sun, WL; Wen, C; Xing, Y; Xiu, ZL; Yu, XX; Zhang, BW	1
García-Cámara, I; Moo-Puc, RE; Peraza-Sánchez, SR; Torres-Tapia, LW; Valencia-Chan, LS	1
Baikova, IP; Giniyatullina, GV; Kataev, VE; Kazakova, OB; Lopatina, TV; Medvedeva, NI; Smirnova, IE	1
Anaya-Eugenio, GD; Burdette, JE; Chai, HB; Czarnecki, AA; de Blanco, EJC; Kinghorn, AD; Ninh, TN; Ren, Y; Soejarto, DD; Yuan, C	1
Friedrich, O; Hahn, F; Hampel, F; Kappes, B; Karagöz, AÇ; Leidenberger, M; Marschall, M; Tsogoeva, SB	1
Brandes, B; Csuk, R; Fischer, L; Hoenke, S	1
Awale, S; Dibwe, DF; Kim, MJ; Omar, AM; Sun, S; Tawila, AM; Toyooka, N; Ueda, JY	1
Miao, Z; Wang, C; Wang, Y; Wu, Y; Ye, S; Zhang, H; Zhang, Y; Zhu, Y	1
Giner, RM; Gueho, J; Hostettmann, K; Julien, HR; Máñez, S; Recio, MC; Ríos, JL	1
Li, C; Mu, Q; Sun, H	1
Giner, RM; Máñez, S; Recio, MC; Ríos, JL	1
Alekseeva, SG; Andiia-Pravdivyĭ, IuE; Gribor'ev, VB; Kaplun, AP; Shvets, VI; Son, LB; Spilevskiĭ, AA	1
Chen, G; Kodama, H; Lu, H; Lu, J; Manabe, M; Sagara, Y; Yamashita, K; Yokoyama, T	1
Lu, JC; Sun, QS; Xu, BB; Zhang, XY	1
Boreko, EI; Flekhter, OB; Nikolaeva, SN; Pavlova, NI; Savinova, OV	1
Che, CT; Cheung, FW; Ho, JC; Liu, BP; Liu, WK; Ye, WC	1
Dzubak, P; Hajduch, M; Klinotova, E; Kvasnica, M; Sarek, J	1
Deng, ZW; Fu, HZ; Gao, TX; Lin, WH; Zhang, Y	1
Dufour, P; Gauthier, C; Lebrun, M; Legault, J; Pichette, A	1
Pascoal Neto, C; Pinto, PC; Silvestre, AJ; Sousa, AF	1
Cao, D; Yan, W; Zhao, G	1
Bollinger, L; Förstermann, U; Horke, S; Li, H; Steinkamp-Fenske, K; Xu, H; Yao, Y	1
Cmoch, P; Pakulski, Z; Strnad, M; Swaczynová, J	1
Dzirkale, Z; Klusa, V; Krigere, L; Mezhapuke, R; Muceniece, R; Rumaks, J; Saleniece, K; Zharkova, O	1
Cui, BS; Li, HY; Li, S; Shi, Y; Yuan, Y	1
Durić, K; E Kovac-Besović, E; Kalodera, Z; Sofić, E	1
Dietel, M; Drag, M; Drag-Zalesinska, M; Lage, H; Oleksyszyn, J; Surowiak, P	1
Kessler, JH; Medema, JP; Mullauer, FB	1
Cascante, M; Marín, S; Salvador, JA; Santos, RC	1
Kalbitz, J; Kaluđerović, GN; Kommera, H; Paschke, R	1
Alakurtti, S; Bergström, P; Jaffe, CL; Sacerdoti-Sierra, N; Yli-Kauhaluoma, J	1
Chen, XG; Cui, BS; Li, S; Shang, XY; Shi, JG; Shi, Y; Yang, YC; Yuan, Y	1
Bette, M; Fuchs, P; Fulda, S; Kalbitz, J; Kaluderović, GN; Kommera, H; Mier, W; Paschke, R	1
Dittrich, S; Dräger, B; Kalbitz, J; Kaluderović, GN; Kommera, H; Mueller, T; Paschke, R	1
Cascante, M; Dinis, TC; Marín, S; Moreira, JN; Salvador, JA; Santos, RC	1
Chen, CH; Kashiwada, Y; Lee, KH; Morris-Natschke, SL; Qian, K; Takaishi, Y; Xiong, J	1
Kalbitz, J; Kaluderović, GN; Kommera, H; Paschke, R	1
Chen, QH; Fu, ML; Liu, J	1
Daniluk, J; Kandefer-Szerszeń, M; Plewka, K; Szuster-Ciesielska, A	1
Barthel, A; Csuk, R; Schwarz, S; Sczepek, R; Siewert, B	1
Chen, WM; Lan, P; Ye, WC; Zhang, DM	1
Djachuk, GI; Esaulenko, EV; Kosman, VM; Makarov, VG; Pozharitskaya, ON; Sergeev, DV; Shikov, AN	1
Alexa, E; Aluas, M; Dehelean, CA; Kása, P; Peev, C; Soica, CM; Zupkó, I	1
Kandefer-Szerszeń, M; Plewka, K; Szuster-Ciesielska, A	1
Soica, CM; Wang, HM; Wenz, G	1
He, C; Ma, G; Peng, Y; Wei, H; Xiao, P	1
Chen, QH; Fang, RS; Feng, Y; He, GQ; Li, M; Liu, J; Xu, TY	1
Cho, JA; Cho, JY; Kim, CM; Kim, WS; Lee, HJ; Lee, SH; Moon, JH; Park, KH	1
Kempińska, K; Mituła, P; Niezgoda, N; Tubek, B; Wawrzeńczyk, C; Wietrzyk, J	1
Bai, T; Cui, PH; Jiang, S; Jin, XJ; Lian, LH; Nan, JX; Sun, XT; Wan, Y; Wu, YL	1
Corsello, MA; Jonnalagadda, SC; Sleet, CE	1
Alves, V; Salvador, JA; Santos, RC; Santos-Rosa, M; Sousa, MC; Varandas, R	1
Heidary Navid, M; Laszczyk-Lauer, MN; Reichling, J; Schnitzler, P	1
Gubaidullin, RR; Keiser, J; Khalitova, RR; Nedopekina, DA; Odinokov, VN; Shakurova, ER; Spivak, AY; Vargas, M	1
Shi, W; Tang, N; Yan, WD	1
Gray, CA; Johnson, JA; Li, H; Webster, D	1
Chang, FW; Chen, SP; Chen, YH; Fu, CL; Ho, JY; Hsu, RJ; Hsu, YC; Liu, JM; Yu, CP; Yu, JC	1
Csuk, R; Heller, L; Obernauer, A	1
Borska, S; Choromańska, A; Drąg, M; Drąg-Zalesińska, M; Kulbacka, J; Poręba, M; Saczko, J; Wysocka, T	1
Cho, N; Jeon, BJ; Kim, HW; Lee, HK; Sung, SH	1
Chen, NH; Li, YL; Wang, GC; Wu, YZ; Zhang, YB	1
Duarte, MF; Oliveira, PJ; Silva, FS	1
Bag, BG; Majumdar, R	1
Bakur, A; Chen, Q; Li, H; Niu, Y; Wu, J	1
Ajiboye, HO; Ajiboye, TO; Oloyede, HOB; Salawu, MO	1
Chou, CH; Jhan, YL; Tsai, SJ; Wang, CM; Yeh, KL	1
Bache, M; Bruschke, M; Csuk, R; Emmerich, D; Paschke, R; Seifert, F; Vanchanagiri, K; Vordermark, D	1
Borkotoky, S; Busi, S; Mohanty, SK; Murali, A; Rajkumari, J; Suchiang, K	1
Cai, YT; Geng, HW	1
Ahmadian Chashmi, N; Ghasemi Bezdi, K; Jafari Hajati, R; Payamnoor, V	1
Ai-Dhabi, NA; Arasu, MV; Baska, TB; Park, CH; Park, SU; Park, YE; Yeo, HJ; Zhao, S	1
Cheng, Z; Ding, W; Wang, Y; Yao, W; Zhang, T; Zheng, J; Zhou, F; Zhu, L	1
Adamek, J; Grymel, M; Zawojak, M	1
Wang, G; Wang, JJ; Wang, YZ; Xu, K; Yin, PH; Yu, Y	1
Ahmadian Chashmi, N; Jafari Hajati, R; Payamnoor, V	1
Li, Y; Qu, Z; Sun, L; Wang, S; Xiao, J; Yang, J; Yin, J; Zhan, Y	1
Kutkowska, J; Rapak, A; Strzadala, L	1
Alhadrami, HA; Azhar, EI; Rateb, ME; Sayed, AM; Sharif, AM	1
Al-Harrasi, A; Csuk, R; Deigner, HP; Hoenke, S; Kozubek, M; Schmidt, T	1
Adepoju, FO; Duru, KC; Kovaleva, EG; Li, E; Tsurkan, MV	1
Chen, M; Ding, W; Liang, Y; Wang, Y; Xu, T; Zheng, J; Zhu, M	1

Reviews

6 review(s) available for betulinic acid and betulin

Article	Year
[Advances in the study of structural modifications and biological activities of betulinic acids]. Yao xue xue bao = Acta pharmaceutica Sinica, 2010, Volume: 45, Issue:11 Topics: Anti-HIV Agents; Antineoplastic Agents, Phytogenic; Betula; Betulinic Acid; Cell Line, Tumor; HIV; Humans; Pentacyclic Triterpenes; Plant Bark; Plant Leaves; Plants, Medicinal; Triterpenes	2010
Betulin-betulinic acid natural product based analogs as anti-cancer agents. Anti-cancer agents in medicinal chemistry, 2013, Volume: 13, Issue:10 Topics: Amines; Antineoplastic Agents, Phytogenic; Betula; Betulinic Acid; Carbamates; Cell Line, Tumor; Cell Survival; Esters; Humans; Imidazoles; Nitriles; Pentacyclic Triterpenes; Plant Bark; Plant Extracts; Triazoles; Triterpenes	2013
Oleanolic, Ursolic, and Betulinic Acids as Food Supplements or Pharmaceutical Agents for Type 2 Diabetes: Promise or Illusion? Journal of agricultural and food chemistry, 2016, Apr-20, Volume: 64, Issue:15 Topics: Anti-Inflammatory Agents; Betulinic Acid; Body Weight; Diabetes Mellitus, Type 2; Dietary Supplements; Hypoglycemic Agents; Illusions; Insulin Resistance; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Triterpenes	2016
Self-assembly of Renewable Nano-sized Triterpenoids. Chemical record (New York, N.Y.), 2017, Volume: 17, Issue:9 Topics: Betulinic Acid; Cyclization; Gels; Glycyrrhetinic Acid; Microscopy, Electron, Scanning; Nanoparticles; Oleanolic Acid; Pentacyclic Triterpenes; Plants; Terpenes; Triterpenes	2017
Triphenylphosphonium Analogues of Betulin and Betulinic Acid with Biological Activity: A Comprehensive Review. Journal of natural products, 2019, 06-28, Volume: 82, Issue:6 Topics: Antineoplastic Agents; Betulinic Acid; Esters; Molecular Structure; Pentacyclic Triterpenes; Triterpenes	2019
Pharmacological Potential of Betulin as a Multitarget Compound. Biomolecules, 2023, 07-12, Volume: 13, Issue:7 Topics: Betulinic Acid; Cytokines; Humans; Inflammation; NF-kappa B; Triterpenes	2023

Other Studies

102 other study(ies) available for betulinic acid and betulin

Article	Year
Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids. Journal of natural products, 1994, Volume: 57, Issue:2 Topics: Antiviral Agents; Betulinic Acid; Cells, Cultured; HIV-1; Humans; Lymphocytes; Pentacyclic Triterpenes; Plants, Medicinal; Protein Kinase C; Triterpenes; Virus Replication	1994
Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents. Journal of medicinal chemistry, 1998, Nov-05, Volume: 41, Issue:23 Topics: Acquired Immunodeficiency Syndrome; Animals; Anti-HIV Agents; Cell Fusion; Cell Line; Glutarates; HeLa Cells; HIV-1; Humans; Lymphocytes; Mice; Structure-Activity Relationship; Triterpenes; Virus Replication	1998
Anti-AIDS agents. 32. Synthesis and anti-HIV activity of betulin derivatives. Bioorganic & medicinal chemistry letters, 1998, May-19, Volume: 8, Issue:10 Topics: Anti-HIV Agents; Cell Line; Cell Survival; Drug Design; HIV-1; Humans; Lymphocytes; Molecular Structure; Structure-Activity Relationship; Triterpenes	1998
Synthesis of betulinic acid derivatives with activity against human melanoma. Bioorganic & medicinal chemistry letters, 1998, Jul-07, Volume: 8, Issue:13 Topics: Antineoplastic Agents; Betulinic Acid; Carcinoma, Squamous Cell; Drug Screening Assays, Antitumor; Humans; Hydrogen Bonding; Melanoma; Mouth Neoplasms; Pentacyclic Triterpenes; Triterpenes	1998
Differentiation- and apoptosis-inducing activities by pentacyclic triterpenes on a mouse melanoma cell line. Journal of natural products, 2002, Volume: 65, Issue:5 Topics: Animals; Apoptosis; Betulinic Acid; Cell Differentiation; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Melanoma, Experimental; Mice; Molecular Structure; Oxidation-Reduction; Pentacyclic Triterpenes; Pyridinium Compounds; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship; Triterpenes; Tumor Cells, Cultured	2002
Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea. Journal of natural products, 2003, Volume: 66, Issue:2 Topics: Anti-HIV Agents; Chlorophyll; Ericales; Humans; Inhibitory Concentration 50; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Osteosarcoma; Plant Leaves; Plant Stems; Plants, Medicinal; Sesquiterpenes; Stereoisomerism; Triterpenes; Tumor Cells, Cultured; Vietnam	2003
Three new triterpenes from Nerium oleander and biological activity of the isolated compounds. Journal of natural products, 2005, Volume: 68, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Screening Assays, Antitumor; Humans; Intercellular Adhesion Molecule-1; Japan; Models, Biological; Molecular Structure; Nerium; Oleanolic Acid; Plant Leaves; Plants, Medicinal; Triterpenes; Tumor Cells, Cultured	2005
Triterpenoid pyrazines and benzopyrazines with cytotoxic activity. Journal of natural products, 2007, Volume: 70, Issue:4 Topics: Antineoplastic Agents, Phytogenic; Betulinic Acid; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Leukemia, T-Cell; Molecular Structure; Pentacyclic Triterpenes; Pyrazines; Structure-Activity Relationship; Triterpenes; Tumor Cells, Cultured	2007
Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds. Journal of natural products, 2007, Volume: 70, Issue:8 Topics: Animals; Benin; Cell Line, Tumor; Molecular Structure; Plant Leaves; Plants, Medicinal; Sterols; Stigmasterol; Structure-Activity Relationship; Strychnos; Triterpenes; Trypanocidal Agents; Trypanosoma brucei brucei	2007
alpha-Glucosidase inhibitory activity of triterpenoids from Cichorium intybus. Journal of natural products, 2008, Volume: 71, Issue:5 Topics: alpha-Glucosidases; Cichorium intybus; Glycoside Hydrolase Inhibitors; Molecular Structure; Pentacyclic Triterpenes; Plants, Medicinal; Saccharomyces; Seeds; Triterpenes	2008
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies. Journal of medicinal chemistry, 2008, Jun-26, Volume: 51, Issue:12 Topics: Adenosine Monophosphate; Allosteric Site; Animals; Binding Sites; Crystallography, X-Ray; Glycogen Phosphorylase; Hypoglycemic Agents; Kinetics; Models, Molecular; Muscles; Oleanolic Acid; Pentacyclic Triterpenes; Protein Binding; Protein Conformation; Rabbits; Stereoisomerism; Structure-Activity Relationship; Triterpenes	2008
Antiproliferative triterpenes from Melaleuca ericifolia. Journal of natural products, 2008, Volume: 71, Issue:10 Topics: Animals; Drug Screening Assays, Antitumor; Egypt; Melaleuca; Mice; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Leaves; Plants, Medicinal; Triterpenes	2008
Synthesis and cytotoxicity of bidesmosidic betulin and betulinic acid saponins. Journal of natural products, 2009, Volume: 72, Issue:1 Topics: Antineoplastic Agents, Phytogenic; Betulinic Acid; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Pentacyclic Triterpenes; Saponins; Structure-Activity Relationship; Triterpenes	2009
Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins. Bioorganic & medicinal chemistry, 2009, Mar-01, Volume: 17, Issue:5 Topics: Animals; Cell Line, Tumor; Cell Membrane Permeability; Erythrocytes; Hemolysis; Humans; Oleanolic Acid; Saponins; Sheep; Triterpenes	2009
Synthesis, cytotoxicity, and haemolytic activity of chacotrioside lupane-type neosaponins and their germanicane-type rearrangement products. Bioorganic & medicinal chemistry letters, 2009, Apr-15, Volume: 19, Issue:8 Topics: Animals; Cell Line, Tumor; Cytotoxins; Erythrocytes; Hemolytic Agents; Humans; Saponins; Sheep; Triterpenes; Tropanes	2009
Esters of betulin and betulinic acid with amino acids have improved water solubility and are selectively cytotoxic toward cancer cells. Bioorganic & medicinal chemistry letters, 2009, Aug-15, Volume: 19, Issue:16 Topics: Amino Acids; Antineoplastic Agents; Betulinic Acid; Esters; Humans; Pentacyclic Triterpenes; Solubility; Triterpenes; Tumor Cells, Cultured	2009
Betulin-derived compounds as inhibitors of alphavirus replication. Journal of natural products, 2009, Volume: 72, Issue:11 Topics: Betulinic Acid; Guanosine; Molecular Structure; Pentacyclic Triterpenes; Semliki forest virus; Sindbis Virus; Triterpenes; Virus Replication	2009
Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. Journal of medicinal chemistry, 2010, Jan-14, Volume: 53, Issue:1 Topics: 3T3-L1 Cells; Animals; Betulinic Acid; CHO Cells; Cricetinae; Cricetulus; Male; Mice; Mice, Inbred C57BL; Molecular Conformation; Pentacyclic Triterpenes; Receptors, G-Protein-Coupled; Stereoisomerism; Structure-Activity Relationship; Triterpenes	2010
Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies. European journal of medicinal chemistry, 2011, Volume: 46, Issue:6 Topics: Animals; Enzyme Inhibitors; Glycogen Phosphorylase, Muscle Form; Models, Molecular; Molecular Conformation; Muscle, Skeletal; Pentacyclic Triterpenes; Quantitative Structure-Activity Relationship; Rabbits; Stereoisomerism	2011
Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid. Bioorganic & medicinal chemistry, 2012, Jun-01, Volume: 20, Issue:11 Topics: Antineoplastic Agents, Phytogenic; Betulinic Acid; Cell Line, Tumor; Crystallography, X-Ray; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes	2012
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22 Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship	2012
Ionic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase. Bioorganic & medicinal chemistry letters, 2015, Aug-15, Volume: 25, Issue:16 Topics: Acyclovir; Animals; Antiviral Agents; Betulinic Acid; Chlorocebus aethiops; Herpesvirus 2, Human; HIV Reverse Transcriptase; HIV-1; Humans; Pentacyclic Triterpenes; Triterpenes; Vero Cells; Virus Replication	2015
Betulinic acid derived hydroxamates and betulin derived carbamates are interesting scaffolds for the synthesis of novel cytotoxic compounds. European journal of medicinal chemistry, 2015, Dec-01, Volume: 106 Topics: Animals; Antineoplastic Agents; Betulinic Acid; Carbamates; Cell Line, Tumor; Cell Proliferation; Cytotoxins; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fibroblasts; Humans; Hydroxamic Acids; Mice; Molecular Structure; NIH 3T3 Cells; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes	2015
Betulin Derivatives Effectively Suppress Inflammation in Vitro and in Vivo. Journal of natural products, 2016, Feb-26, Volume: 79, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Betula; Betulinic Acid; Carrageenan; Chemokine CCL2; Cyclooxygenase 2; Cytokines; Dinoprostone; Inflammation; Interleukin-6; Lipopolysaccharides; Macrophages; Male; Mice; Molecular Structure; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Pentacyclic Triterpenes; Triterpenes	2016
Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors. Journal of natural products, 2016, Apr-22, Volume: 79, Issue:4 Topics: Betula; Cytokines; Diabetes Mellitus; Female; Fibroblasts; Humans; Interleukin-6; Interleukin-8; Keratinocytes; p38 Mitogen-Activated Protein Kinases; Pentacyclic Triterpenes; Plant Bark; rho GTP-Binding Proteins; Triterpenes; Wound Healing	2016
Amino(oxo)acetate moiety: A new functional group to improve the cytotoxicity of betulin derived carbamates. Bioorganic & medicinal chemistry letters, 2016, 06-15, Volume: 26, Issue:12 Topics: Acetates; Carbamates; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Molecular Structure; Structure-Activity Relationship; Triterpenes	2016
Mitochondria-Targeted Lupane Triterpenoid Derivatives and Their Selective Apoptosis-Inducing Anticancer Mechanisms. Journal of medicinal chemistry, 2017, 07-27, Volume: 60, Issue:14 Topics: Animals; Antineoplastic Agents; Apoptosis; Betulinic Acid; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Screening Assays, Antitumor; Heterografts; Humans; Membrane Potential, Mitochondrial; Mitochondria; Neoplasm Metastasis; Neoplasm Transplantation; Organophosphorus Compounds; Pentacyclic Triterpenes; Reactive Oxygen Species; Structure-Activity Relationship; Triterpenes; Zebrafish	2017
Pentacyclic triterpenes as α-glucosidase and α-amylase inhibitors: Structure-activity relationships and the synergism with acarbose. Bioorganic & medicinal chemistry letters, 2017, 11-15, Volume: 27, Issue:22 Topics: Acarbose; alpha-Amylases; alpha-Glucosidases; Drug Synergism; Inhibitory Concentration 50; Kinetics; Oleanolic Acid; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes	2017
Lupane-Type Triterpenes of Phoradendron vernicosum. Journal of natural products, 2017, 11-22, Volume: 80, Issue:11 Topics: Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; HeLa Cells; Humans; KB Cells; MCF-7 Cells; Mexico; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phoradendron; Plant Components, Aerial; Plant Extracts; Plant Leaves; Triterpenes	2017
Synthesis and antimycobacterial activity of triterpeni≿ A-ring azepanes. European journal of medicinal chemistry, 2018, Jan-01, Volume: 143 Topics: Antitubercular Agents; Azepines; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Structure-Activity Relationship; Triterpenes	2018
Cytotoxic and NF-κB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives. Bioorganic & medicinal chemistry, 2018, 08-15, Volume: 26, Issue:15 Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; HT29 Cells; Humans; Membrane Potential, Mitochondrial; Molecular Conformation; NF-kappa B; Plant Extracts; Plant Leaves; Structure-Activity Relationship; Syzygium; Triterpenes; Ursolic Acid	2018
Synthesis of new betulinic acid/betulin-derived dimers and hybrids with potent antimalarial and antiviral activities. Bioorganic & medicinal chemistry, 2019, 01-01, Volume: 27, Issue:1 Topics: Antimalarials; Antiviral Agents; Artemisinins; Cytomegalovirus; Ferrous Compounds; Fibroblasts; Humans; Parasitic Sensitivity Tests; Plasmodium falciparum; Triterpenes	2019
Design, synthesis and cytotoxicity of BODIPY FL labelled triterpenoids. European journal of medicinal chemistry, 2020, Jan-01, Volume: 185 Topics: Antineoplastic Agents; Boron Compounds; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Fluorescent Dyes; Humans; MCF-7 Cells; Molecular Structure; Structure-Activity Relationship; Triterpenes	2020
Chemical constituents of Callistemon citrinus from Egypt and their antiausterity activity against PANC-1 human pancreatic cancer cell line. Bioorganic & medicinal chemistry letters, 2020, 08-15, Volume: 30, Issue:16 Topics: Antineoplastic Agents, Phytogenic; Cell Death; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Egypt; Humans; Molecular Structure; Myrtaceae; Pancreatic Neoplasms; Structure-Activity Relationship; Terpenes; Tumor Microenvironment	2020
Discovery and optimization of betulinic acid derivatives as novel potent CD73 inhibitors. Bioorganic & medicinal chemistry, 2022, 04-01, Volume: 59 Topics: 5'-Nucleotidase; Adenosine; Betulinic Acid; Humans; Immunotherapy; Neoplasms; Pentacyclic Triterpenes	2022
Investigations on the steroidal anti-inflammatory activity of triterpenoids from Diospyros leucomelas. Planta medica, 1995, Volume: 61, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Betulinic Acid; Female; Mice; Pentacyclic Triterpenes; Plants, Medicinal; Steroids; Triterpenes; Ursolic Acid	1995
[Chemical constituents of Coleus carnosifolius Dunn]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 1996, Volume: 21, Issue:2 Topics: Betulinic Acid; Drugs, Chinese Herbal; Pentacyclic Triterpenes; Triterpenes	1996
Effect of selected triterpenoids on chronic dermal inflammation. European journal of pharmacology, 1997, Sep-03, Volume: 334, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Betulinic Acid; Dermatitis, Contact; Dexamethasone; Drug Evaluation, Preclinical; Female; Mice; Oleanolic Acid; Pentacyclic Triterpenes; Tetradecanoylphorbol Acetate; Triterpenes; Ursolic Acid	1997
[Synthesis of betulinic acid from betulin and study of its solubilization usingliposomes]. Bioorganicheskaia khimiia, 1998, Volume: 24, Issue:10 Topics: Betulinic Acid; Light; Liposomes; Pentacyclic Triterpenes; Scattering, Radiation; Solubility; Triterpenes	1998
Effect of three triterpenoids, lupeol, betulin, and betulinic acid on the stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophils. Clinica chimica acta; international journal of clinical chemistry, 2002, Volume: 325, Issue:1-2 Topics: Anemone; Arachidonic Acid; Betulinic Acid; Hemolysis; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pentacyclic Triterpenes; Phosphorylation; Proteins; Superoxides; Triterpenes; Tyrosine	2002
[Study on chemical constituents of rhizome of Anemone raddeana]. Yao xue xue bao = Acta pharmaceutica Sinica, 2002, Volume: 37, Issue:9 Topics: Anemone; Betulinic Acid; Eleutherococcus; Molecular Structure; Pentacyclic Triterpenes; Plant Extracts; Plants, Medicinal; Rhizome; Saponins; Triterpenes	2002
Antiviral activity of betulin, betulinic and betulonic acids against some enveloped and non-enveloped viruses. Fitoterapia, 2003, Volume: 74, Issue:5 Topics: Antiviral Agents; Betulinic Acid; Dose-Response Relationship, Drug; Echovirus 6, Human; Herpesvirus 1, Human; Humans; Influenza A virus; Microbial Sensitivity Tests; Oleanolic Acid; Pentacyclic Triterpenes; Phytotherapy; Plant Bark; Plant Extracts; Triterpenes; Tumor Cells, Cultured; Viral Envelope Proteins	2003
Apoptotic activity of betulinic acid derivatives on murine melanoma B16 cell line. European journal of pharmacology, 2004, Sep-13, Volume: 498, Issue:1-3 Topics: Animals; Apoptosis; Betulinic Acid; Cell Cycle; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Intracellular Membranes; Melanoma, Experimental; Membrane Potentials; Mice; Mitochondria; NADPH Oxidases; Pentacyclic Triterpenes; Piperidines; Propionates; Reactive Oxygen Species; Structure-Activity Relationship; Triterpenes	2004
Synthesis of phthalates of betulinic acid and betulin with cytotoxic activity. Bioorganic & medicinal chemistry, 2005, May-16, Volume: 13, Issue:10 Topics: Acylation; Antineoplastic Agents; Betulinic Acid; Cell Survival; Drug Screening Assays, Antitumor; Esters; Humans; Neoplasms; Pentacyclic Triterpenes; Phthalic Acids; Triterpenes; Tumor Cells, Cultured	2005
[Chemical constituents from the mangrove plant Ceriops tagal]. Yao xue xue bao = Acta pharmaceutica Sinica, 2005, Volume: 40, Issue:10 Topics: Betulinic Acid; Diterpenes; Molecular Conformation; Molecular Structure; Pentacyclic Triterpenes; Plant Stems; Plants, Medicinal; Rhizophoraceae; Squalene; Triterpenes	2005
Glycosidation of lupane-type triterpenoids as potent in vitro cytotoxic agents. Bioorganic & medicinal chemistry, 2006, Oct-01, Volume: 14, Issue:19 Topics: Animals; Antineoplastic Agents, Phytogenic; Betula; Betulinic Acid; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Fibroblasts; Glycosides; Humans; Mice; Pentacyclic Triterpenes; Triterpenes	2006
Triterpenic and other lipophilic components from industrial cork byproducts. Journal of agricultural and food chemistry, 2006, Sep-06, Volume: 54, Issue:18 Topics: Betulinic Acid; Gas Chromatography-Mass Spectrometry; Pentacyclic Triterpenes; Plant Bark; Quercus; Triterpenes	2006
Simultaneous determination of betulin and betulinic acid in white birch bark using RP-HPLC. Journal of pharmaceutical and biomedical analysis, 2007, Feb-19, Volume: 43, Issue:3 Topics: Betula; Betulinic Acid; Chromatography, High Pressure Liquid; Drug Stability; Indicators and Reagents; Pentacyclic Triterpenes; Plant Bark; Reference Standards; Reproducibility of Results; Solutions; Solvents; Spectrophotometry, Ultraviolet; Triterpenes	2007
Reciprocal regulation of endothelial nitric-oxide synthase and NADPH oxidase by betulinic acid in human endothelial cells. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:2 Topics: Acetophenones; Betulinic Acid; Blotting, Western; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Endothelial Cells; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; NADPH Oxidase 4; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Pentacyclic Triterpenes; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Saponins; Spermine; Triterpenes; Ziziphus	2007
Synthesis of lupane-type saponins bearing mannosyl and 3,6-branched trimannosyl residues and their evaluation as anticancer agents. Carbohydrate research, 2008, May-05, Volume: 343, Issue:6 Topics: Antineoplastic Agents; Betulinic Acid; Cell Survival; Cells, Cultured; Fibroblasts; Humans; Mannose; Mannosides; Molecular Structure; Neoplasms; Pentacyclic Triterpenes; Saponins; Triterpenes	2008
Betulin binds to gamma-aminobutyric acid receptors and exerts anticonvulsant action in mice. Pharmacology, biochemistry, and behavior, 2008, Volume: 90, Issue:4 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antineoplastic Agents; Betulinic Acid; Bicuculline; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred ICR; Muscle Tonus; Pentacyclic Triterpenes; Postural Balance; Receptors, GABA; Seizures; Triterpenes	2008
[Studies on chemical constituents from roots of Pterospermum heterophyllum]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2008, Volume: 33, Issue:16 Topics: Betulinic Acid; Chromatography; Malvaceae; Naphthoquinones; Oleanolic Acid; Palmitic Acid; Pentacyclic Triterpenes; Plant Roots; Sitosterols; Triterpenes	2008
Identification and isolation of pharmacologically active triterpenes in Betuale cortex, Betula pendula Roth., Betulaceae. Bosnian journal of basic medical sciences, 2009, Volume: 9, Issue:1 Topics: Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Antiviral Agents; Betula; Betulinic Acid; Chromatography, Thin Layer; Oleanolic Acid; Pentacyclic Triterpenes; Plant Bark; Spectrophotometry, Infrared; Triterpenes	2009
Comparision of the cytotoxic effects of birch bark extract, betulin and betulinic acid towards human gastric carcinoma and pancreatic carcinoma drug-sensitive and drug-resistant cell lines. Molecules (Basel, Switzerland), 2009, Apr-24, Volume: 14, Issue:4 Topics: Antineoplastic Agents, Phytogenic; Betula; Betulinic Acid; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Molecular Structure; Pancreatic Neoplasms; Pentacyclic Triterpenes; Plant Bark; Plant Extracts; Stomach Neoplasms; Triterpenes	2009
Betulin is a potent anti-tumor agent that is enhanced by cholesterol. PloS one, 2009, Volume: 4, Issue:4 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Betulinic Acid; Cell Line; Cells, Cultured; Cholesterol; Cyclosporine; Drug Synergism; Fas-Associated Death Domain Protein; Gene Expression; Genes, bcl-2; HeLa Cells; Humans; Jurkat Cells; Mice; Mice, Knockout; Pentacyclic Triterpenes; Reactive Oxygen Species; Triterpenes	2009
Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity. Bioorganic & medicinal chemistry, 2009, Sep-01, Volume: 17, Issue:17 Topics: Antineoplastic Agents; Betulinic Acid; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes	2009
Lupane triterpenoids--betulin and betulinic acid derivatives induce apoptosis in tumor cells. Investigational new drugs, 2011, Volume: 29, Issue:2 Topics: Antineoplastic Agents; Apoptosis; Betulinic Acid; Caspases; Cell Line, Tumor; Cell Survival; DNA Fragmentation; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Kinetics; Pentacyclic Triterpenes; Triterpenes	2011
Anti-leishmanial activity of betulin derivatives. The Journal of antibiotics, 2010, Volume: 63, Issue:3 Topics: Animals; Antiprotozoal Agents; Betulinic Acid; Cell Line; Cell Survival; Humans; Leishmania donovani; Macrophages; Mice; Oleanolic Acid; Oxidation-Reduction; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes	2010
Triterpenoids from the roots of Pterospermum heterophyllum Hance. Journal of Asian natural products research, 2009, Volume: 11, Issue:7 Topics: Antineoplastic Agents, Phytogenic; Betulinic Acid; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Female; Humans; Malvaceae; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Palmitic Acid; Pentacyclic Triterpenes; Plant Roots; Sitosterols; Stereoisomerism; Terpenes; Triterpenes	2009
In vitro anticancer studies of alpha- and beta-D-glucopyranose betulin anomers. Chemico-biological interactions, 2010, Apr-29, Volume: 185, Issue:2 Topics: Antineoplastic Agents; Apoptosis; Betulinic Acid; Caspase 3; Cell Cycle; Cell Line, Tumor; DNA Fragmentation; Drug Screening Assays, Antitumor; Glucose; HCT116 Cells; Humans; Isomerism; Magnetic Resonance Spectroscopy; Mass Spectrometry; Pentacyclic Triterpenes; Time Factors; Triterpenes; X-Ray Diffraction	2010
Carbamate derivatives of betulinic acid and betulin with selective cytotoxic activity. Bioorganic & medicinal chemistry letters, 2010, Jun-01, Volume: 20, Issue:11 Topics: Betulinic Acid; Carbamates; Cell Line, Tumor; Cell Proliferation; Humans; Pentacyclic Triterpenes; Triterpenes	2010
Synthesis and structure-activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid. Bioorganic & medicinal chemistry, 2010, Jun-15, Volume: 18, Issue:12 Topics: Antineoplastic Agents; Betulinic Acid; Carbamates; Cell Line, Tumor; DNA Topoisomerases, Type I; Drug Screening Assays, Antitumor; Heterocyclic Compounds; Humans; Pentacyclic Triterpenes; Structure-Activity Relationship; Topoisomerase I Inhibitors; Triazoles; Triterpenes	2010
Conjugates of betulin derivatives with AZT as potent anti-HIV agents. Bioorganic & medicinal chemistry, 2010, Sep-01, Volume: 18, Issue:17 Topics: Anti-HIV Agents; Betulinic Acid; CD4-Positive T-Lymphocytes; Cell Line; HIV-1; Humans; Pentacyclic Triterpenes; Triterpenes; Zidovudine	2010
Synthesis and anticancer activity of novel betulinic acid and betulin derivatives. Archiv der Pharmazie, 2010, Volume: 343, Issue:8 Topics: Antineoplastic Agents; Betulinic Acid; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Mass Spectrometry; Pentacyclic Triterpenes; Structure-Activity Relationship; Thyroid Neoplasms; Triterpenes	2010
Biotransformation optimization of betulin into betulinic acid production catalysed by cultured Armillaria luteo-virens Sacc ZJUQH100-6 cells. Journal of applied microbiology, 2011, Volume: 110, Issue:1 Topics: Antineoplastic Agents, Phytogenic; Armillaria; Betulinic Acid; Biocatalysis; Biotransformation; Pentacyclic Triterpenes; Triterpenes	2011
Betulin and betulinic acid attenuate ethanol-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS), cytokine (TNF-α, TGF-β) production and by influencing intracellular signaling. Toxicology, 2011, Feb-27, Volume: 280, Issue:3 Topics: Animals; Betulinic Acid; Cell Line; Ethanol; Hepatic Stellate Cells; Intracellular Fluid; Pentacyclic Triterpenes; Rats; Reactive Oxygen Species; Signal Transduction; Transforming Growth Factor beta; Triterpenes; Tumor Necrosis Factor-alpha	2011
Synthesis, encapsulation and antitumor activity of new betulin derivatives. Archiv der Pharmazie, 2011, Volume: 344, Issue:1 Topics: Antineoplastic Agents; Betulinic Acid; Cell Line, Tumor; Colorimetry; Drug Screening Assays, Antitumor; Fluorescent Dyes; Humans; Liposomes; Neoplasms; Pentacyclic Triterpenes; Pyrazoles; Rhodamines; Structure-Activity Relationship; Triazoles; Triterpenes	2011
Birch bark extract as therapy for chronic hepatitis C--a pilot study. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2011, Jul-15, Volume: 18, Issue:10 Topics: Adult; Aged; Analysis of Variance; Antiviral Agents; Betula; Betulinic Acid; Body Mass Index; Dyspepsia; Fatigue; Female; Hepatitis C, Chronic; Humans; Male; Middle Aged; Pentacyclic Triterpenes; Phytotherapy; Pilot Projects; Plant Bark; Plant Extracts; RNA, Viral; Triterpenes; Young Adult	2011
Physico-chemical comparison of betulinic acid, betulin and birch bark extract and in vitro investigation of their cytotoxic effects towards skin epidermoid carcinoma (A431), breast carcinoma (MCF7) and cervix adenocarcinoma (HeLa) cell lines. Natural product research, 2012, Volume: 26, Issue:10 Topics: Adenocarcinoma; Betula; Betulinic Acid; Breast Neoplasms; Cell Line, Tumor; Female; HeLa Cells; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Pentacyclic Triterpenes; Plant Extracts; Skin Neoplasms; Triterpenes; Uterine Cervical Neoplasms	2012
Betulin, betulinic acid and butein are inhibitors of acetaldehyde-induced activation of liver stellate cells. Pharmacological reports : PR, 2011, Volume: 63, Issue:5 Topics: Acetaldehyde; Animals; Antioxidants; Betulinic Acid; Chalcones; Cytokines; Down-Regulation; Hepatic Stellate Cells; Liver Cirrhosis; Matrix Metalloproteinase 2; Pentacyclic Triterpenes; Rats; Reactive Oxygen Species; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta; Triterpenes	2011
A comparison investigation on the solubilization of betulin and betulinic acid in cyclodextrin derivatives. Natural product communications, 2012, Volume: 7, Issue:3 Topics: Betulinic Acid; Cyclodextrins; Pentacyclic Triterpenes; Solubility; Triterpenes	2012
[Chemical constituents of Dolomiaea souliei]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2012, Volume: 37, Issue:9 Topics: 4-Butyrolactone; Asteraceae; Betulinic Acid; Emodin; Lactones; Pentacyclic Triterpenes; Sesquiterpenes; Triterpenes; Ursolic Acid	2012
A novel one-step microbial transformation of betulin to betulinic acid catalysed by Cunninghamella blakesleeana. Food chemistry, 2013, Jan-01, Volume: 136, Issue:1 Topics: Betulinic Acid; Biotransformation; Cunninghamella; Industrial Microbiology; Pentacyclic Triterpenes; Triterpenes	2013
Caffeoyl triterpenes from pear (Pyrus pyrifolia Nakai) fruit peels and their antioxidative activities against oxidation of rat blood plasma. Journal of agricultural and food chemistry, 2013, May-15, Volume: 61, Issue:19 Topics: Animals; Antioxidants; Betulinic Acid; Biphenyl Compounds; Caffeic Acids; Cholesterol Esters; Fruit; Lipid Peroxidation; Oxidation-Reduction; Pentacyclic Triterpenes; Picrates; Pyrus; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Triterpenes	2013
Synthesis and cytotoxic activity of new betulin and betulinic acid esters with conjugated linoleic acid (CLA). Natural product communications, 2013, Volume: 8, Issue:4 Topics: Animals; Antineoplastic Agents; Betulinic Acid; Cell Line, Tumor; Humans; Linoleic Acids, Conjugated; Mice; Pentacyclic Triterpenes; Triterpenes	2013
Betulinic acid and betulin ameliorate acute ethanol-induced fatty liver via TLR4 and STAT3 in vivo and in vitro. International immunopharmacology, 2013, Volume: 17, Issue:2 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Betulinic Acid; Cell Line; Cytochrome P-450 CYP2E1; Fatty Liver, Alcoholic; Hepatic Stellate Cells; Humans; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Pentacyclic Triterpenes; Phosphorylation; STAT3 Transcription Factor; Sterol Regulatory Element Binding Protein 1; Toll-Like Receptor 4; Triglycerides; Triterpenes	2013
Antileishmanial activity of semisynthetic lupane triterpenoids betulin and betulinic acid derivatives: synergistic effects with miltefosine. PloS one, 2014, Volume: 9, Issue:3 Topics: Animals; Antiprotozoal Agents; Betulinic Acid; Cell Line; Cell Survival; Drug Synergism; Imidazoles; Inhibitory Concentration 50; Leishmania infantum; Life Cycle Stages; Macrophages; Mice; Pentacyclic Triterpenes; Phosphorylcholine; Structure-Activity Relationship; Triterpenes	2014
Pentacyclic triterpenes in birch bark extract inhibit early step of herpes simplex virus type 1 replication. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2014, Sep-25, Volume: 21, Issue:11 Topics: Animals; Antiviral Agents; Betula; Betulinic Acid; Cell Line; Chlorocebus aethiops; Herpesvirus 1, Human; Pentacyclic Triterpenes; Plant Bark; Plant Extracts; Triterpenes; Virus Replication	2014
Synthesis and activity of new triphenylphosphonium derivatives of betulin and betulinic acid against Schistosoma mansoni in vitro and in vivo. Bioorganic & medicinal chemistry, 2014, Nov-01, Volume: 22, Issue:21 Topics: Animals; Anthelmintics; Betulinic Acid; Female; Humans; Mice; Organophosphorus Compounds; Pentacyclic Triterpenes; Schistosoma mansoni; Schistosomiasis mansoni; Triterpenes	2014
Synthesis and cytotoxicity of triterpenoids derived from betulin and betulinic acid via click chemistry. Journal of Asian natural products research, 2015, Volume: 17, Issue:2 Topics: Antineoplastic Agents; Betulinic Acid; Click Chemistry; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Molecular Structure; Pentacyclic Triterpenes; Structure-Activity Relationship; Triazoles; Triterpenes	2015
Anti-mycobacterial triterpenes from the Canadian medicinal plant Alnus incana. Journal of ethnopharmacology, 2015, May-13, Volume: 165 Topics: Alnus; Anti-Bacterial Agents; Betulinic Acid; HEK293 Cells; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mycobacterium tuberculosis; Pentacyclic Triterpenes; Phytotherapy; Plant Bark; Plant Extracts; Triterpenes	2015
The triterpenoids of Hibiscus syriacus induce apoptosis and inhibit cell migration in breast cancer cells. BMC complementary and alternative medicine, 2015, Mar-14, Volume: 15 Topics: Antineoplastic Agents; Apoptosis; Betulinic Acid; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Survival; Female; Hibiscus; Humans; Pentacyclic Triterpenes; Phytotherapy; Plant Extracts; Triterpenes	2015
Simple structural modifications confer cytotoxicity to allobetulin. Bioorganic & medicinal chemistry, 2015, Jul-01, Volume: 23, Issue:13 Topics: Animals; Antineoplastic Agents; Betulinic Acid; Cell Line; Cell Line, Tumor; Cytotoxins; Drug Screening Assays, Antitumor; Fibroblasts; Humans; Inhibitory Concentration 50; Mice; Molecular Structure; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes	2015
The new esters derivatives of betulin and betulinic acid in epidermoid squamous carcinoma treatment - In vitro studies. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2015, Volume: 72 Topics: Aged, 80 and over; Betulinic Acid; Carcinoma, Squamous Cell; Caspase 3; Cell Death; Cell Line, Tumor; Comet Assay; Drug Screening Assays, Antitumor; Esters; Female; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Inhibitory Concentration 50; Keratinocytes; Pentacyclic Triterpenes; Poly(ADP-ribose) Polymerases; Skin Neoplasms; Triterpenes	2015
Ameliorative effect of betulin from Betula platyphylla bark on scopolamine-induced amnesic mice. Bioscience, biotechnology, and biochemistry, 2016, Volume: 80, Issue:1 Topics: Administration, Oral; Alzheimer Disease; Amnesia; Animals; Avoidance Learning; Betula; Betulinic Acid; Cognition; Disease Models, Animal; Glutathione; Hippocampus; Humans; Male; Maze Learning; Memory; Mice; Neuroprotective Agents; Nootropic Agents; Pentacyclic Triterpenes; Plant Bark; Plant Extracts; Scopolamine; Triterpenes	2016
[Chemical Constituents from Syzygium samarangense Branches and Leaves]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2015, Volume: 38, Issue:4 Topics: Betulinic Acid; Pentacyclic Triterpenes; Phytochemicals; Plant Extracts; Plant Leaves; Sitosterols; Syzygium; Triterpenes	2015
Cell-Free Production of Pentacyclic Triterpenoid Compound Betulinic Acid from Betulin by the Engineered Saccharomyces cerevisiae. Molecules (Basel, Switzerland), 2017, Jun-27, Volume: 22, Issue:7 Topics: Arabidopsis Proteins; Betulinic Acid; Bioengineering; Pentacyclic Triterpenes; Saccharomyces cerevisiae; Triterpenes	2017
Influence of oxidative stress on the antibacterial activity of betulin, betulinic acid and ursolic acid. Microbial pathogenesis, 2017, Volume: 111 Topics: Anti-Bacterial Agents; Betulinic Acid; DNA Fragmentation; Escherichia coli; Glutathione; Malondialdehyde; Microbial Sensitivity Tests; Oxidative Stress; Pentacyclic Triterpenes; Pseudomonas aeruginosa; Reactive Oxygen Species; Staphylococcus aureus; Triterpenes; Ursolic Acid	2017
Anti-Proliferative Activity of Triterpenoids and Sterols Isolated from Alstonia scholaris against Non-Small-Cell Lung Carcinoma Cells. Molecules (Basel, Switzerland), 2017, Dec-01, Volume: 22, Issue:12 Topics: A549 Cells; Alstonia; Antineoplastic Agents; Betulinic Acid; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Humans; Lung Neoplasms; Pentacyclic Triterpenes; Phytosterols; Plant Extracts; Plant Leaves; Sterols; Tetrazolium Salts; Thiazoles; Triterpenes; Ursolic Acid	2017
Synthesis and biological investigation of new carbonic anhydrase IX (CAIX) inhibitors. Chemico-biological interactions, 2018, Mar-25, Volume: 284 Topics: A549 Cells; Apoptosis; Betulinic Acid; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Cell Cycle Checkpoints; Cell Line; Humans; MCF-7 Cells; Pentacyclic Triterpenes; Triterpenes	2018
Attenuation of quorum sensing controlled virulence factors and biofilm formation in Pseudomonas aeruginosa by pentacyclic triterpenes, betulin and betulinic acid. Microbial pathogenesis, 2018, Volume: 118 Topics: Alginates; Animals; Anti-Bacterial Agents; Bacterial Adhesion; Bacterial Proteins; Betulinic Acid; Biofilms; Caenorhabditis elegans; Chitinases; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Multiple, Bacterial; Genes, Bacterial; Glucuronic Acid; Glycolipids; Hexuronic Acids; Hydrophobic and Hydrophilic Interactions; Indoles; Metalloendopeptidases; Metalloproteases; Microbial Sensitivity Tests; Microbial Viability; Molecular Docking Simulation; Molecular Dynamics Simulation; Pentacyclic Triterpenes; Polysaccharides, Bacterial; Pseudomonas aeruginosa; Pseudomonas Infections; Pyocyanine; Quorum Sensing; Survival Analysis; Trans-Activators; Triterpenes; Virulence; Virulence Factors	2018
[Chemical Constituents from the Roots of Rhodomyrtus tomentosa]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2016, Volume: 39, Issue:6 Topics: Betulinic Acid; Magnoliaceae; Pentacyclic Triterpenes; Plant Roots; Sitosterols; Triterpenes	2016
Improved accumulation of betulin and betulinic acid in cell suspension culture of Betula pendula roth by abiotic and biotic elicitors. Preparative biochemistry & biotechnology, 2018, Volume: 48, Issue:9 Topics: Acetates; Anti-HIV Agents; Antineoplastic Agents, Phytogenic; Betula; Betulinic Acid; Cell Culture Techniques; Cell Survival; Chlormequat; Cyclopentanes; Oxylipins; Pentacyclic Triterpenes; Plant Growth Regulators; Salicylic Acid; Triterpenes	2018
Comparison of Different Strains of Agrobacterium rhizogenes for Hairy Root Induction and Betulin and Betulinic Acid Production in Morus alba. Natural product communications, 2017, Volume: 12, Issue:4 Topics: Agrobacterium; Betulinic Acid; Morus; Pentacyclic Triterpenes; Plant Roots; Triterpenes	2017
A derivative of betulinic acid protects human Retinal Pigment Epithelial (RPE) cells from cobalt chloride-induced acute hypoxic stress. Experimental eye research, 2019, Volume: 180 Topics: Acute Disease; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antimutagenic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; Blotting, Western; Cell Line; Cobalt; Cytoprotection; Humans; Hypoxia; Middle Aged; Oxidative Stress; Pentacyclic Triterpenes; Reactive Oxygen Species; Retinal Pigment Epithelium; Triterpenes	2019
Triterpenoids Extracted from Nutrition and cancer, 2020, Volume: 72, Issue:2 Topics: Animals; Apoptosis; Betulinic Acid; Cell Line, Tumor; Cell Proliferation; Chromatography, Liquid; Colorectal Neoplasms; Flavonoids; Gene Regulatory Networks; Glutamine; Glycolysis; Humans; Male; Metabolome; Mice; Mice, Inbred BALB C; Mice, Nude; Pentacyclic Triterpenes; Plant Extracts; Rhus; Tandem Mass Spectrometry; Triterpenes; Validation Studies as Topic; Xenograft Model Antitumor Assays	2020
Effect of biotic and abiotic elicitors on production of betulin and betulinic acid in the hairy root culture of Preparative biochemistry & biotechnology, 2019, Volume: 49, Issue:10 Topics: Betula; Betulinic Acid; Pentacyclic Triterpenes; Plant Roots; Triterpenes	2019
Functional identification of BpMYB21 and BpMYB61 transcription factors responding to MeJA and SA in birch triterpenoid synthesis. BMC plant biology, 2020, Aug-12, Volume: 20, Issue:1 Topics: Acetates; Betula; Betulinic Acid; Conserved Sequence; Cyclopentanes; Gene Expression Profiling; Gene Expression Regulation, Plant; Oleanolic Acid; Oxylipins; Pentacyclic Triterpenes; Plants, Genetically Modified; Promoter Regions, Genetic; Protein Domains; Salicylates; Squalene; Transcription Factors; Triterpenes	2020
Hypoxia increases the apoptotic response to betulinic acid and betulin in human non-small cell lung cancer cells. Chemico-biological interactions, 2021, Jan-05, Volume: 333 Topics: Antineoplastic Agents; Apoptosis; Betulinic Acid; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Pentacyclic Triterpenes; Triterpenes; Tumor Hypoxia	2021
Olive-Derived Triterpenes Suppress SARS COV-2 Main Protease: A Promising Scaffold for Future Therapeutics. Molecules (Basel, Switzerland), 2021, May-01, Volume: 26, Issue:9 Topics: Antiviral Agents; Betulinic Acid; Coronavirus 3C Proteases; COVID-19; COVID-19 Drug Treatment; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Olea; Pentacyclic Triterpenes; Protease Inhibitors; SARS-CoV-2; Triterpenes; Ursolic Acid	2021
Synthesis and cytotoxicity of betulin and betulinic acid derived 30-oxo-amides. Steroids, 2022, Volume: 182 Topics: Amides; Antineoplastic Agents; Betulinic Acid; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes	2022
A Novel Betulinic Acid Analogue: Synthesis, Solubility, Antitumor Activity and Pharmacokinetic Study in Rats. Molecules (Basel, Switzerland), 2023, Jul-28, Volume: 28, Issue:15 Topics: Animals; Betulinic Acid; Cell Line, Tumor; HeLa Cells; Humans; Pentacyclic Triterpenes; Rats; Solubility; Triterpenes	2023