betaxolol and pindolol

betaxolol has been researched along with pindolol in 43 studies

Research

Studies (43)

Timeframe	Studies, this research(%)	All Research%
pre-1990	16 (37.21)	18.7374
1990's	15 (34.88)	18.2507
2000's	8 (18.60)	29.6817
2010's	4 (9.30)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Baldwin, JJ; Christy, ME; Denny, GH; Freedman, MB; Gross, DM; Habecker, CN; Lyle, PA; Ponticello, GS; Sweet, CS; Varga, SL	1
Carrupt, PA; el Tayar, N; Testa, B; Van de Waterbeemd, H	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Abraham, MH; Acree, WE; Ibrahim, A	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Tran, VT	1
Bonin, H; Bouvier, M; Frielle, T; Nantel, F; Nguyen, CT; Suzuki, T; Valiquette, M	1
Barry, WH; Bristow, MR; Debellis, CC; Klein, J; Peeters, GA; Port, JD	1
Gayet, J; Ginefri-Gayet, M	1
Ahlenius, S; Larsson, K	2
Lesch, KP; Poten, B; Rupprecht, R; Schoellnhammer, G; Schulte, HM; Söhnle, K	1
Lesch, KP; Poten, B; Schulte, HM; Söhnle, K	1
Ahlenius, S; Fernandez-Guasti, A; Larsson, K	1
Kelvie, SL; Sundaresan, PR	1
Brunton, LL; Buxton, IL	1
Amlaiky, N; Leclerc, G	1
Cavero, I; Hicks, PE; Langer, SZ; Lefevre-Borg, F; Manoury, P	1
Baldwin, JJ; Gautheron, P; Grove, J; Mallorga, P; Ponticello, GS; Sugrue, MF; Varga, SL; Viader, MP	1
Forler, C; Fozard, JR; Middlemiss, DN; Tricklebank, MD	1
Healy, DP; Insel, PA; Münzel, PA	1
Lew, R; Summers, RJ	1
Johnston, HG; Summers, RJ	1
Brunswick, DJ; Conway, PG; Tondo, L	1
Engel, G	1
Harvengt, C	1
Chojnacka-Wójcik, E; Filip, M; Przegaliński, E; Tatarczyńska, E	1
Benovic, JL; Higgins, NC; Kelsen, SG; Mardini, IA; Zhou, S	1
Jantos, H; Monti, JM	1
Ahlenius, S; Cortizo, L; Wadenberg, ML	1
Assie, MB; Koek, W	1
Cui, Y; Iwase, M; Kalthof, B; Sato, N; Shen, YT; Uechi, M; Vatner, DE; Vatner, SF	1
Gillin, JC; Seifritz, E; Stahl, SM	1
Gobert, A; Millan, MJ	1
Ahlenius, S; Kaur, P	1

Reviews

2 review(s) available for betaxolol and pindolol

Article	Year
Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists. Journal of medicinal chemistry, 1988, Volume: 31, Issue:11 Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Models, Molecular; Receptors, Adrenergic, beta; Structure-Activity Relationship	1988
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

41 other study(ies) available for betaxolol and pindolol

Article	Year
Beta 1-selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted amino)-2-hydroxypropoxy]phenyl]imidazole class. 2. Journal of medicinal chemistry, 1986, Volume: 29, Issue:6 Topics: Adrenergic beta-Antagonists; Animals; Female; Guinea Pigs; Heart Rate; Hydrogen Bonding; Imidazoles; In Vitro Techniques; Receptors, Adrenergic, beta; Solubility; Structure-Activity Relationship	1986
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs. European journal of medicinal chemistry, 2008, Volume: 43, Issue:3 Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Human retinal pigment epithelial cells possess beta 2-adrenergic receptors. Experimental eye research, 1992, Volume: 55, Issue:3 Topics: Adenylyl Cyclases; Betaxolol; Cells, Cultured; Cyclic AMP; Epinephrine; Humans; Isoproterenol; Norepinephrine; Pigment Epithelium of Eye; Pindolol; Propanolamines; Receptors, Adrenergic, beta	1992
Distinct regulation of beta 1- and beta 2-adrenergic receptors in Chinese hamster fibroblasts. Molecular pharmacology, 1992, Volume: 41, Issue:3 Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Alprenolol; Animals; Betaxolol; Binding, Competitive; Cells, Cultured; Cricetinae; Cricetulus; DNA; Down-Regulation; Epinephrine; Fibroblasts; Iodocyanopindolol; Isoproterenol; Norepinephrine; Pindolol; Propanolamines; Radioligand Assay; Receptors, Adrenergic, beta; Transfection	1992
Pharmacological characterization of chick and frog beta adrenergic receptors in primary cultures of myocardial cells. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:1 Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Animals; Betaxolol; Binding, Competitive; Cell Membrane; Chick Embryo; Culture Techniques; Drug Interactions; Iodocyanopindolol; Kinetics; Myocardium; Pindolol; Propanolamines; Receptors, Adrenergic, beta; Xenopus laevis	1992
Involvement of serotonin receptors in methionine sulfoximine-induced hypothermia in the rat. European journal of pharmacology, 1992, Jun-24, Volume: 217, Issue:1 Topics: Adrenergic beta-Antagonists; Animals; Betaxolol; Body Temperature; Central Nervous System; Dose-Response Relationship, Drug; Hypothermia, Induced; Ketanserin; Male; Methionine Sulfoximine; Pindolol; Propanolamines; Propranolol; Rats; Rats, Wistar; Receptors, Serotonin	1992
Opposite effects of 5-methoxy-N,N-di-methyl-tryptamine and 5-hydroxytryptophan on male rat sexual behavior. Pharmacology, biochemistry, and behavior, 1991, Volume: 38, Issue:1 Topics: 5-Hydroxytryptophan; Adrenergic beta-Antagonists; Animals; Benserazide; Betaxolol; Dose-Response Relationship, Drug; Female; Male; Metergoline; Methoxydimethyltryptamines; Pindolol; Piperidines; Rats; Rats, Inbred Strains; Sexual Behavior, Animal; Stimulation, Chemical	1991
Corticotropin and cortisol secretion after central 5-hydroxytryptamine-1A (5-HT1A) receptor activation: effects of 5-HT receptor and beta-adrenoceptor antagonists. The Journal of clinical endocrinology and metabolism, 1990, Volume: 70, Issue:3 Topics: Adrenergic beta-Agonists; Adrenocorticotropic Hormone; Adult; Betaxolol; Biotransformation; Female; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Metergoline; Pindolol; Pituitary-Adrenal System; Pyrimidines; Receptors, Serotonin; Serotonin	1990
Pharmacology of the hypothermic response to 5-HT1A receptor activation in humans. European journal of clinical pharmacology, 1990, Volume: 39, Issue:1 Topics: Adrenergic beta-Antagonists; Adult; Betaxolol; Body Temperature; Dose-Response Relationship, Drug; Female; Humans; Male; Metergoline; Pindolol; Pyrimidines; Receptors, Serotonin; Serotonin Antagonists	1990
Evidence for the involvement of central 5-HT1A receptors in the mediation of lordosis behavior in the female rat. Psychopharmacology, 1989, Volume: 98, Issue:4 Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Betaxolol; Estradiol; Female; Male; Methiothepin; Pindolol; Piperidines; Posture; Propanolamines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Sexual Behavior, Animal; Tetrahydronaphthalenes	1989
Antagonism by pindolol, but not betaxolol, of 8-OH-DPAT-induced facilitation of male rat sexual behavior. Journal of neural transmission, 1989, Volume: 77, Issue:2-3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Betaxolol; Ejaculation; Female; Male; Naphthalenes; Pindolol; Propanolamines; Rats; Rats, Inbred Strains; Sexual Behavior, Animal; Tetrahydronaphthalenes	1989
Beta-adrenergic receptor coupled adenylate cyclase in rat kidney. Differential coupling in glomeruli and tubules. Biochemical pharmacology, 1988, Dec-01, Volume: 37, Issue:23 Topics: Adenylyl Cyclases; Animals; Betaxolol; Colforsin; Cyclic AMP; Guanylyl Imidodiphosphate; Iodocyanopindolol; Kidney Glomerulus; Kidney Tubules; Male; Pindolol; Propanolamines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Stereoisomerism	1988
Direct analysis of beta-adrenergic receptor subtypes on intact adult ventricular myocytes of the rat. Circulation research, 1985, Volume: 56, Issue:1 Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Betaxolol; Binding Sites; Cells, Cultured; Ethanolamines; Heart; Iodine Radioisotopes; Iodocyanopindolol; Male; Myocardium; Pindolol; Practolol; Propanolamines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta	1985
Synthesis and irreversible beta-adrenergic blockade with a bromoacetamido derivative of betaxolol. Journal of pharmaceutical sciences, 1985, Volume: 74, Issue:10 Topics: Adrenergic beta-Antagonists; Animals; Betaxolol; Binding, Competitive; Cerebral Cortex; Chemical Phenomena; Chemistry; Guinea Pigs; Heart Rate; In Vitro Techniques; Iodocyanopindolol; Isoproterenol; Muscle Contraction; Muscle, Smooth; Pindolol; Propanolamines; Rats; Rats, Inbred Strains	1985
Comparative analysis of beta-1 adrenoceptor agonist and antagonist potency and selectivity of cicloprolol, xamoterol and pindolol. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:3 Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Betaxolol; Blood Pressure; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Pindolol; Propanolamines; Propranolol; Rats; Receptors, Adrenergic, beta; Trachea; Xamoterol	1987
L-653,328: an ocular hypotensive agent with modest beta receptor blocking activity. Investigative ophthalmology & visual science, 1988, Volume: 29, Issue:5 Topics: Adrenergic beta-Antagonists; Animals; Betaxolol; Ciliary Body; Dose-Response Relationship, Drug; Intraocular Pressure; Iodine Radioisotopes; Iodocyanopindolol; Iris; Ophthalmic Solutions; Pharmacology; Pindolol; Prodrugs; Propanolamines; Rabbits; Radioligand Assay; Receptors, Adrenergic, beta; Timolol	1988
Subtypes of the 5-HT receptor mediating the behavioural responses to 5-methoxy-N,N-dimethyltryptamine in the rat. European journal of pharmacology, 1985, Oct-29, Volume: 117, Issue:1 Topics: Animals; Apomorphine; Behavior, Animal; Betaxolol; Haloperidol; Ketanserin; Male; Pindolol; Piperidines; Prazosin; Propanolamines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Reserpine; Spiperone	1985
Localization of beta 1- and beta 2-adrenergic receptors in rat kidney by autoradiography. Circulation research, 1985, Volume: 57, Issue:2 Topics: Animals; Autoradiography; Betaxolol; Binding, Competitive; Ethanolamines; Iodocyanopindolol; Kidney; Male; Pindolol; Propanolamines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta	1985
Autoradiographic localization of beta-adrenoceptor subtypes in guinea-pig kidney. British journal of pharmacology, 1985, Volume: 85, Issue:2 Topics: Animals; Autoradiography; Betaxolol; Binding, Competitive; Female; Guinea Pigs; Iodocyanopindolol; Kidney; Kidney Cortex; Kidney Glomerulus; Kidney Medulla; Kidney Tubules, Proximal; Male; Pindolol; Propanolamines; Receptors, Adrenergic, beta; Stereoisomerism; Tissue Distribution	1985
Localization of beta-adrenoceptors in the rabbit ear by light microscopic autoradiography. European journal of pharmacology, 1985, Sep-10, Volume: 115, Issue:1 Topics: Animals; Autoradiography; Betaxolol; Cell Nucleus; Ear, External; In Vitro Techniques; Iodine Radioisotopes; Iodocyanopindolol; Microscopy; Pindolol; Propanolamines; Rats; Receptors, Adrenergic, beta	1985
Labeling in vivo of beta adrenergic receptors in the central nervous system of the rat after administration of [125I] iodopindolol. The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:1 Topics: Alprenolol; Animals; Betaxolol; Binding, Competitive; Brain Stem; Central Nervous System; Cerebellum; Cerebral Cortex; Clenbuterol; Isotope Labeling; Male; Mathematics; Pindolol; Propanolamines; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Spinal Cord; Tissue Distribution	1985
Subclasses of beta-adrenoceptors--a quantitative estimation of beta 1- and beta 2- adrenoceptors in guinea pig and human lung. Postgraduate medical journal, 1981, Volume: 57 Suppl 1 Topics: Aged; Animals; Atenolol; Betaxolol; Cell Membrane; Guinea Pigs; Humans; Iodocyanopindolol; Lung; Metoprolol; Middle Aged; Models, Biological; Pindolol; Practolol; Propanolamines; Receptors, Adrenergic; Receptors, Adrenergic, beta	1981
Drugs recently released in Belgium. Acta clinica Belgica, 1984, Volume: 39, Issue:2 Topics: Belgium; Betaxolol; Humans; Pindolol; Propanolamines	1984
The role of 5-hydroxytryptamine1A (5-HT1A) receptors in the anticonflict activity of beta-adrenoceptor antagonists. Pharmacology, biochemistry, and behavior, 1994, Volume: 47, Issue:4 Topics: Adrenergic beta-Antagonists; Animals; Anxiety; Betaxolol; Conflict, Psychological; Disease Models, Animal; Drug Interactions; Male; p-Chloroamphetamine; Pindolol; Piperazines; Prazosin; Propanolamines; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists	1994
Functional behavior of the beta-adrenergic receptor-adenylyl cyclase system in rabbit airway epithelium. American journal of respiratory cell and molecular biology, 1994, Volume: 11, Issue:3 Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Animals; Betaxolol; Binding, Competitive; Bradykinin; Colforsin; Cyclic AMP; Dinoprostone; Epithelial Cells; Epithelium; Glycerol; Isoproterenol; Kinetics; Pindolol; Propanolamines; Rabbits; Receptors, Adrenergic, beta; Tetradecanoylphorbol Acetate; Trachea	1994
Stereoselective antagonism by the pindolol enantiomers of 8-OH-DPAT-induced changes of sleep and wakefulness. Neuropharmacology, 1994, Volume: 33, Issue:5 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Betaxolol; Electroencephalography; Electromyography; Male; Pindolol; Rats; Rats, Wistar; Sleep; Sleep, REM; Stereoisomerism; Wakefulness	1994
Evidence for specific interactions between 5-HT1A and dopamine D2 receptor mechanisms in the mediation of extrapyramidal motor functions in the rat. Pharmacology, biochemistry, and behavior, 1994, Volume: 47, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Betaxolol; Catalepsy; Dopamine D2 Receptor Antagonists; Extrapyramidal Tracts; Male; Pindolol; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Serotonin; Salicylamides; Serotonin Antagonists	1994
(-)-pindolol and (+/-)-tertatolol affect rat hippocampal 5-HT levels through mechanisms involving not only 5-HT1A, but also 5-HT1B receptors. Neuropharmacology, 1996, Volume: 35, Issue:2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Betaxolol; Hippocampus; Male; Microdialysis; Pindolol; Propanolamines; Rats; Receptors, Serotonin; Serotonin; Thiophenes	1996
Identification and functional role of beta-adrenergic receptor subtypes in primate and rodent: in vivo versus isolated myocytes. Journal of molecular and cellular cardiology, 1996, Volume: 28, Issue:6 Topics: Adrenergic beta-Antagonists; Animals; Betaxolol; Blood Pressure; Cells, Cultured; Coronary Vessels; Heart; Heart Rate; In Vitro Techniques; Isoproterenol; Kinetics; Male; Myocardium; Papio; Pindolol; Propanolamines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Vascular Resistance; Ventricular Function, Left; Ventricular Function, Right	1996
Human sleep EEG following the 5-HT1A antagonist pindolol: possible disinhibition of raphe neuron activity. Brain research, 1997, Jun-06, Volume: 759, Issue:1 Topics: Adrenergic beta-Antagonists; Adult; Betaxolol; Dose-Response Relationship, Drug; Electroencephalography; Humans; Male; Middle Aged; Neural Inhibition; Neurons; Pindolol; Raphe Nuclei; Serotonin Antagonists; Sleep; Sleep Stages	1997
Modulation of dialysate levels of dopamine, noradrenaline, and serotonin (5-HT) in the frontal cortex of freely-moving rats by (-)-pindolol alone and in association with 5-HT reuptake inhibitors: comparative roles of beta-adrenergic, 5-HT1A, and 5-HT1B re Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1999, Volume: 21, Issue:2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Betaxolol; Dopamine; Fluoxetine; Frontal Lobe; Guinea Pigs; Humans; Male; Microdialysis; Norepinephrine; Pindolol; Piperazines; Propanolamines; Pyridines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Adrenergic, beta; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists	1999
Non-serotonergic potentiation by (-)-pindolol of DOI-induced forward locomotion in rats: possible involvement of beta-adrenoceptors?. Journal of neural transmission (Vienna, Austria : 1996), 2000, Volume: 107, Issue:8-9 Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Animals; Betaxolol; Biogenic Monoamines; Dihydroxyphenylalanine; Drug Synergism; Indophenol; Male; Motor Activity; Pindolol; Piperazines; Piperidines; Propanolamines; Prosencephalon; Pyridines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Adrenergic, beta; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reserpine; Serotonin Antagonists; Serotonin Receptor Agonists	2000