betadex and tricalcium-phosphate

betadex has been researched along with tricalcium-phosphate* in 1 studies

Other Studies

1 other study(ies) available for betadex and tricalcium-phosphate

ArticleYear
Compaction, compression and drug release characteristics of xanthan gum pellets of different compositions.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2004, Volume: 21, Issue:2-3

    Compaction and compression of xanthan gum (XG) pellets were evaluated and drug release from tablets made of pellets was characterised. Three formulations were prepared by extrusion-spheronisation and included, among other excipients, diclofenac sodium (Dic Na), at 10% (w/w); xanthan gum, at 16% (w/w); and one of three different fillers (lactose monohydrated (LAC), tribasic calcium phosphate (TCP) and beta-cyclodextrin (beta-CD)), at 16% (w/w). Five hundred milligrams of pellets (fraction 1000-1400microm) were compacted in a single punch press at maximum punch pressure of 125MPa using flat-faced punches (diameter of 1.00cm). Physical properties of pellets and tablets were analysed. Dissolution was performed according to the USP paddle method. Pellets showed close compressibility degrees (49.27% LAC; 51.32% TCP; and 50.48% beta-CD) but densified differently (3.57% LAC; 14.84% TCP; 3.26% beta-CD). Permanent deformation and densification were the relevant mechanisms of compression. Fragmentation was regarded as non-existent. The release behaviour of tablets made of pellets comprising LAC or beta-CD was anomalous having diffusional exponent (n) values of 0.706 and 0.625, respectively. Drug diffusion and erosion were competing mechanisms of drug release from those tablets.

    Topics: beta-Cyclodextrins; Calcium Phosphates; Chemistry, Pharmaceutical; Compressive Strength; Diclofenac; Drug Compounding; Excipients; Particle Size; Polysaccharides, Bacterial; Porosity; Powders; Surface Properties; Tablets; Time Factors

2004