betadex and sulconazole

betadex has been researched along with sulconazole* in 2 studies

Other Studies

2 other study(ies) available for betadex and sulconazole

ArticleYear
Study of the enantioseparation capability of chiral dual system based on chondroitin sulfate C in CE.
    Electrophoresis, 2015, Volume: 36, Issue:4

    It has been reported that chiral dual system is able to improve the enantioseparation of enantiomers in many cases. Currently, the dual systems involved in CE chiral separation are mostly dual CDs systems, and the polysaccharides-based chiral dual system was reported in only one paper. To the best of our knowledge, the use of chondroitin sulfate C (CSC)-based dual system for enantiomeric separation has not been reported previously. Herein, four CSC-based chiral dual systems, namely CSC/glycogen, CSC/chondroitin sulfate A (CSA), CSC/hydroxypropyl-β-CD (HP-β-CD), as well as CSC/β-CD (β-CD), were evaluated for the first time for their enantioseparation capability by CE in this paper. During the course of the work, the influences of chiral selector concentration and buffer pH values on enantioseparation in dual systems were systematically investigated. Under the optimized conditions, the dual system consisting of CSC and glycogen exhibited better separations toward nefopam, duloxetine, sulconazole, atenolol, laudanosine, and cetirizine enantiomers compared to the single CSC or glycogen system. The combination of CSC and HP-β-CD improved the separation of amlodipine and chlorphenamine enantiomers. However, no synergistic effect was observed in the CSC/CSA and CSC/β-CD systems.

    Topics: Atenolol; beta-Cyclodextrins; Buffers; Cetirizine; Chlorpheniramine; Chondroitin Sulfates; Duloxetine Hydrochloride; Electrophoresis, Capillary; Glycogen; Hydrogen-Ion Concentration; Imidazoles; Isoquinolines; Nefopam; Stereoisomerism; Thiophenes

2015
Enantioselective separation of azole compounds by EKC. Reversal of migration order of enantiomers with CD concentration.
    Electrophoresis, 2007, Volume: 28, Issue:15

    The enantioselective separation of a group of six weak base azole compounds was achieved in this work using EKC with three neutral beta-CDs as chiral selectors. The native beta-CD and two other beta-CD derivatives with different types and positions of the substituents on the CD rim ((2-hydroxy)propyl-beta-CD (HP-beta-CD) and heptakis-2,3,6-tri-O-methyl-beta-CD (TM-beta-CD)) were employed. Apparent binding constants for each pair compound-CD were determined in order to study analyte-CD interactions. The best enantiomeric resolutions for miconazole, econazole, and sulconazole were observed with HP-beta-CD whereas for the separation of the enantiomers of ketoconazole, terconazole, and bifonazole, TM-beta-CD was the best chiral selector. The enantioseparations obtained were discussed on the basis of the structure of the compounds taking into account that inclusion into the hydrophobic CD cavity occurred through the phenyl ring closer to the azole group. In addition, a change in the migration order for the enantiomers of two of the compounds studied (ketoconazole and terconazole) with the concentration of HP-beta-CD was observed for the first time.

    Topics: Azoles; beta-Cyclodextrins; Chromatography, Micellar Electrokinetic Capillary; Econazole; Imidazoles; Miconazole; Stereoisomerism

2007