betadex and sodium-metabisulfite

betadex has been researched along with sodium-metabisulfite* in 2 studies

Other Studies

2 other study(ies) available for betadex and sodium-metabisulfite

ArticleYear
Approaches to improve the stability of the antiviral agent UC781 in aqueous solutions.
    International journal of pharmaceutics, 2010, Aug-30, Volume: 396, Issue:1-2

    In this work, we evaluated the chemical stability profiles of UC781 based solutions to identify excipients that stabilize the microbicidal agent UC781. When different antioxidants were added to UC781 in sulfobutylether-beta-cyclodextrin (SBE-beta-CD) solutions and subjected to a 50 degrees C stability study, it was observed that EDTA was a better stabilizing agent than sodium metabisulfite, glutathione or ascorbic acid. Some antioxidants accelerated the degradation of UC781, suggesting metal-catalyzed degradation of UC781. Furthermore, we observed substantial degradation of UC781 when stored in 1% Tween 80 and 1% DMSO solutions alone or in those with 10mM EDTA. On the other hand, improved stability of UC781 in the presence of 100 and 200mM of EDTA was observed in these solutions. The addition of both EDTA and citric acid in the stock solutions resulted in recovery of more than 60% of UC781 after 12 weeks. Generally, 10% SBE-beta-CD in the presence of EDTA and citric acid stabilized UC781 solutions: the amount of UC781 recovered approaching 95% after 12 weeks of storage at 40 degrees C. We also showed that the desulfuration reaction of the UC781 thioamide involves oxygen by running solution stability studies in deoxygenated media. Improved stability of UC781 in the present study indicates that the incorporation of EDTA, citric acid and SBE-beta-CD and the removal of oxygen in formulations of this drug will aid in increasing the stability of UC781 where solutions of the drug are required.

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Anilides; Antioxidants; Antiviral Agents; Ascorbic Acid; beta-Cyclodextrins; Chemistry, Pharmaceutical; Dimethyl Sulfoxide; Drug Compounding; Drug Stability; Edetic Acid; Excipients; Fumarates; Furans; Glutathione; Hot Temperature; Models, Chemical; Oxidation-Reduction; Polyethylene Glycols; Polysorbates; Solubility; Sulfites; Technology, Pharmaceutical; Thioamides; Time Factors; Vitamin E

2010
Solubilization and quantification of lycopene in aqueous media in the form of cyclodextrin binary systems.
    International journal of pharmaceutics, 2006, Feb-17, Volume: 309, Issue:1-2

    An optimized kneading method for the preparation of lycopene-cyclodextrin binary systems was developed leading to solubilization of lycopene in water and 5% (w/v) dextrose solution. Lycopene quantification in the prepared binary systems was performed by a developed spectrometric method that followed a successful single-step extraction with dichloromethane. Storage stability characteristics of the binary systems were studied at 4 degrees C in solution and at -20 degrees C in the lyophilized products. Lycopene content was monitored at lambda(max)=482 nm, the limit of detection was 0.41 microg/ml and relative standard deviation was less than 3.1%. The results obtained with the spectrometric method were confirmed by a HPLC method. In the presence of cyclodextrins, lycopene concentration in water was 8.0+/-1.0, 27.1+/-3.2 and 16.0+/-2.2 microg/ml for beta-CD, HP-beta-CD and Me-beta-CD, respectively. In 5% (w/v) aqueous dextrose solutions the corresponding values were 16.0+/-1.8, 48.0+/-5.1 and 4.0+/-0.5 microg/ml, respectively. At 4 degrees C, storage stability of lycopene-cyclodextrin binary systems in water or 5% (w/v) aqueous dextrose solutions, was limited (t(1/2)=1-4 days). Addition of the antioxidant sodium metabisulfite increased the stability of lycopene-HP-beta-CD binary system in water. At -20 degrees C, the lyophilized lycopene-cyclodextrin binary systems were stable for at least 2 weeks.

    Topics: Antioxidants; beta-Cyclodextrins; Calorimetry, Differential Scanning; Carotenoids; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Stability; Freeze Drying; Glucose; Lycopene; Solubility; Spectrophotometry; Sulfites; Technology, Pharmaceutical; Time Factors; Water

2006