betadex and sodium-arsenite

betadex has been researched along with sodium-arsenite* in 2 studies

Other Studies

2 other study(ies) available for betadex and sodium-arsenite

Article	Year
Thermal decomposition behavior of sodium arsenite in the presence of carbonized beta-cyclodextrin. The journal of physical chemistry. B, 2009, Apr-16, Volume: 113, Issue:15 The thermal decomposition behavior of sodium arsenite (SA) was greatly affected by carbonized beta-cyclodextrin (CD), possessing the releases of four forms of gaseous arsenic molecules according to gas chromatography coupled to time-of-flight mass spectrometry with programmed temperature operation. Also, the decomposition temperature of beta-CD was lowered in the presence of SA. Topics: Arsenites; beta-Cyclodextrins; Gas Chromatography-Mass Spectrometry; Sodium Compounds; Temperature; Time Factors	2009
Caspase activation is accelerated by the inhibition of arsenite-induced, membrane rafts-dependent Akt activation. Free radical biology & medicine, 2003, Mar-01, Volume: 34, Issue:5 Renewed interest in arsenic has been shown recently due to its dual nature of being a potent toxin and a drug for treatment of acute promyelocytic leukemia (APL) because of its ability to trigger caspase activation. Here, we found that sodium arsenite (NaAsO(2)) also triggers the signal for activation of Akt and downstream glycogen synthase 3beta (GSK3beta). Such Akt/GSK3beta activation was abrogated completely by wortmannin, an inhibitor of PI-3 kinase, and greatly by pertussis toxin, a G-protein inhibitor. Arsenite-induced Akt phosphorylation also was inhibited by sequestrating membrane cholesterol with beta cyclodextrin. Reducing reagents/reactive oxygen species (ROS) scavengers reduced arsenite-induced Akt phosphorylation and beta cyclodextrin reduced arsenite-mediated ROS production, suggesting that arsenite-induced G-protein/Akt/GSK3beta pathway is membrane raft dependent and redox linked. We also found that a combination of a low concentration (1 microM) of arsenite and wortmannin triggers the signal for caspase activation, whereas neither of these elements alone did so. These results suggested that selective blockade of the arsenite-provoked PI-3 kinase/Akt pathway can promote the arsenite-triggered pathway for caspase activation, and this may open a new study area for wider applications of arsenic as a drug for treating various kinds of leukemia. Topics: Androstadienes; Apoptosis; Arsenites; beta-Cyclodextrins; Carcinogens; Caspases; Cholesterol; Cyclodextrins; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Glycogen Synthase Kinases; GTP-Binding Proteins; Humans; Immunoblotting; Jurkat Cells; Membrane Microdomains; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Poly(ADP-ribose) Polymerases; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Sodium Compounds; Sulfhydryl Reagents; Wortmannin	2003

Article

Year

Thermal decomposition behavior of sodium arsenite in the presence of carbonized beta-cyclodextrin.

The journal of physical chemistry. B, 2009, Apr-16, Volume: 113, Issue:15

The thermal decomposition behavior of sodium arsenite (SA) was greatly affected by carbonized beta-cyclodextrin (CD), possessing the releases of four forms of gaseous arsenic molecules according to gas chromatography coupled to time-of-flight mass spectrometry with programmed temperature operation. Also, the decomposition temperature of beta-CD was lowered in the presence of SA.

Topics: Arsenites; beta-Cyclodextrins; Gas Chromatography-Mass Spectrometry; Sodium Compounds; Temperature; Time Factors

2009

Caspase activation is accelerated by the inhibition of arsenite-induced, membrane rafts-dependent Akt activation.

Free radical biology & medicine, 2003, Mar-01, Volume: 34, Issue:5

Renewed interest in arsenic has been shown recently due to its dual nature of being a potent toxin and a drug for treatment of acute promyelocytic leukemia (APL) because of its ability to trigger caspase activation. Here, we found that sodium arsenite (NaAsO(2)) also triggers the signal for activation of Akt and downstream glycogen synthase 3beta (GSK3beta). Such Akt/GSK3beta activation was abrogated completely by wortmannin, an inhibitor of PI-3 kinase, and greatly by pertussis toxin, a G-protein inhibitor. Arsenite-induced Akt phosphorylation also was inhibited by sequestrating membrane cholesterol with beta cyclodextrin. Reducing reagents/reactive oxygen species (ROS) scavengers reduced arsenite-induced Akt phosphorylation and beta cyclodextrin reduced arsenite-mediated ROS production, suggesting that arsenite-induced G-protein/Akt/GSK3beta pathway is membrane raft dependent and redox linked. We also found that a combination of a low concentration (1 microM) of arsenite and wortmannin triggers the signal for caspase activation, whereas neither of these elements alone did so. These results suggested that selective blockade of the arsenite-provoked PI-3 kinase/Akt pathway can promote the arsenite-triggered pathway for caspase activation, and this may open a new study area for wider applications of arsenic as a drug for treating various kinds of leukemia.

Topics: Androstadienes; Apoptosis; Arsenites; beta-Cyclodextrins; Carcinogens; Caspases; Cholesterol; Cyclodextrins; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Glycogen Synthase Kinases; GTP-Binding Proteins; Humans; Immunoblotting; Jurkat Cells; Membrane Microdomains; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Poly(ADP-ribose) Polymerases; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Sodium Compounds; Sulfhydryl Reagents; Wortmannin

2003