betadex has been researched along with rhein* in 4 studies
4 other study(ies) available for betadex and rhein
Article | Year |
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A novel β-cyclodextrin-rhein conjugate for improving the water solubility and bioavailability of rhein.
Topics: Anthraquinones; Antineoplastic Agents; beta-Cyclodextrins; Biological Availability; Cell Proliferation; Cell Survival; HeLa Cells; Humans; Molecular Structure; Proton Magnetic Resonance Spectroscopy; Solubility; Spectroscopy, Fourier Transform Infrared; Water | 2020 |
Self-Assembled Herbal Medicine Encapsulated by an Oxidation-Sensitive Supramolecular Hydrogel for Chronic Wound Treatment.
Inflammation has been assumed to affect the pathology of wound healing and is associated with many nonhealing chronic wounds. Naturally derived herbal medicines with anti-inflammatory properties are of interest because of their effectiveness and affordability in clinical treatment. Herein, we report a supramolecular hydrogel comprising self-assembled natural herb rhein and an oxidative responsive cross-linked network based on ferrocene and β-cyclodextrin host-guest recognitions. Rhein can directly self-assemble into fibrils, exerting better anti-inflammation efficiency than its free drug form. The adaption of the supramolecular network can greatly improve the stability and retain the structural integrity of encapsulated self-assembled rhein. In addition, host-guest recognition confers dissolution of the hydrogel under oxidative stress, thereby delivering self-assembled rhein to the wound site and exerting better therapeutic efficiency. Evaluations in diabetic mice indicate that the resultant hydrogel promoted chronic wound healing by suppressing excess reactive oxygen species, facilitating the transition of the wound healing process, and restoring the normal wound-repair process. Therefore, the proposed hydrogel has a potential value as an herbal-based dressing for future clinical chronic wound management. Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; beta-Cyclodextrins; Diabetes Mellitus, Experimental; Drug Carriers; Ferrous Compounds; Herbal Medicine; Hyaluronic Acid; Hydrogels; Metallocenes; Mice; Mice, Inbred C57BL; RAW 264.7 Cells; Wound Healing | 2020 |
Host-guest inclusion system of rhein with polyamine-modified β-cyclodextrins: characterization and cytotoxicity.
We report the preparation of inclusion complexes between rhein and four polyamine-modified β-cyclodextrins, namely amino-β-cyclodextrins (NH Topics: Anthraquinones; beta-Cyclodextrins; Enzyme Inhibitors; Polyamines; Solubility | 2017 |
Solubility, spectroscopic properties and photostability of Rhein/cyclodextrin inclusion complex.
The host-guest interaction between Rhein (Rh)--an anthraquinonic drug characterized by low water solubility and recently considered for its potential antidiabetic and antitumoral activities other than for the well-established anti-inflammatory properties--with cyclodextrins (CDs) was investigated using phase-solubility diagrams. The typical A(L) phase-solubility profiles suggest the formation of the 1:1 inclusion complexes between Rh and the two CDs investigated, namely beta-cyclodextrin and 2-hydroxypropyl-beta-cyclodextrin and the resulting constant values of complex formation, K(c), were estimated. Due to the higher K(c) value, complex of Rhein with 2-hydroxypropyl-beta-cyclodextrin was chosen for further investigation. Characterization in solution of 2-hydroxypropyl-beta-cyclodextrin/Rhein complex was achieved both by fluorescence and visible spectroscopic techniques. These results confirm the formation of inclusion complexes in solution and the 1:1 stoichiometry of the binary system. With respect to Rhein aqueous solution behavior, the inclusion complex appears to be able: (i) to enhance Rhein solubility; (ii) to control its neutral/anionic equilibrium; (iii) to affect both its electronic absorption and fluorescence spectra. Finally, the photostability of Rhein in the presence of cyclodextrins was evaluated. Topics: 2-Hydroxypropyl-beta-cyclodextrin; Absorption; Anthraquinones; beta-Cyclodextrins; Buffers; Hydrogen-Ion Concentration; Light; Solubility; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Time Factors | 2009 |