betadex and raltitrexed

betadex has been researched along with raltitrexed* in 1 studies

Other Studies

1 other study(ies) available for betadex and raltitrexed

ArticleYear
Chiral separation of raltitrexed by cyclodextrin-modified micellar electrokinetic chromatography.
    Analytical and bioanalytical chemistry, 2009, Volume: 393, Issue:1

    A rapid and effective method was developed for the chiral separation of raltitrexed (RD) enantiomers by carboxymethyl-beta-cyclodextrin (CM-beta-CD)-modified micellar electrokinetic chromatography (MEKC). Optimization of conditions including the type and concentration of the chiral selector, concentration of sodium dodecyl sulfate (SDS), pH and concentration of the background electrolyte (BGE), capillary temperature, and applied voltage was investigated. The enantiomers of raltitrexed could be separated with satisfactory resolution and linear response by using 75 mM Tris-phosphate at pH 8.0 containing 30 mM SDS and 8 mM CM-beta-CD as buffer system. Furthermore, the usefulness of this method was demonstrated in a purity test of a real synthetic drug sample.

    Topics: beta-Cyclodextrins; Chromatography, Micellar Electrokinetic Capillary; Electrochemistry; Electrolytes; Hydrogen-Ion Concentration; Molecular Conformation; Quinazolines; Sodium Dodecyl Sulfate; Stereoisomerism; Temperature; Thiophenes; Time Factors

2009