betadex and pyrazolo(3-4-d)pyrimidine

betadex has been researched along with pyrazolo(3-4-d)pyrimidine* in 1 studies

Other Studies

1 other study(ies) available for betadex and pyrazolo(3-4-d)pyrimidine

Article	Year
2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:12 The main aim of this study was to enhance the solubility of pyrazolo[3,4-d]pyrimidines 1-8 able to strongly inhibit Src and Abl tyrosine kinase phosphorylation in cell-free assays and to significantly reduce leukemic and osteosarcoma cell lines growth, but characterized by very low solubility in aqueous media. Their water solubility was improved between 100 and 1000 folds by solubilization with 2-hydroxypropyl-β-cyclodextrin (HPβCD) and ratio of inclusion complex were determined by phase solubility method. Finally, some complexed compounds were tested on different leukemic (K-652, KU-812 and HL-60) and osteosarcoma (SaOS-2) cell lines showing a good enhancement of biological response in comparison with the not complexed compounds. Topics: 2-Hydroxypropyl-beta-cyclodextrin; Antineoplastic Agents; beta-Cyclodextrins; Cell Proliferation; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Molecular Structure; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Solubility; src-Family Kinases; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured; Water	2010

Article

Year

2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors.

European journal of medicinal chemistry, 2010, Volume: 45, Issue:12

The main aim of this study was to enhance the solubility of pyrazolo[3,4-d]pyrimidines 1-8 able to strongly inhibit Src and Abl tyrosine kinase phosphorylation in cell-free assays and to significantly reduce leukemic and osteosarcoma cell lines growth, but characterized by very low solubility in aqueous media. Their water solubility was improved between 100 and 1000 folds by solubilization with 2-hydroxypropyl-β-cyclodextrin (HPβCD) and ratio of inclusion complex were determined by phase solubility method. Finally, some complexed compounds were tested on different leukemic (K-652, KU-812 and HL-60) and osteosarcoma (SaOS-2) cell lines showing a good enhancement of biological response in comparison with the not complexed compounds.

Topics: 2-Hydroxypropyl-beta-cyclodextrin; Antineoplastic Agents; beta-Cyclodextrins; Cell Proliferation; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Molecular Structure; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Solubility; src-Family Kinases; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured; Water

2010