betadex and proxymetacaine

betadex has been researched along with proxymetacaine* in 2 studies

Other Studies

2 other study(ies) available for betadex and proxymetacaine

Article	Year
Proparacaine complexation with beta-cyclodextrin and p-sulfonic acid calix[6]arene, as evaluated by varied (1)H-NMR approaches. Magnetic resonance in chemistry : MRC, 2009, Volume: 47, Issue:9 This study focused on the use of NMR techniques as a tool for the investigation of complex formation between proparacaine and cyclodextrins (CDs) or p-sulfonic acid calix[6]arene. The pH dependence of the complexation of proparacaine with beta-CD and p-sulfonic acid calix[6]arene was studied and binding constants were determined by (1)H NMR spectroscopy [diffusion-ordered spectroscopy (DOSY)] for the charged and uncharged forms of the local anesthetic in beta-CD and p-sulfonic acid calix[6]arene. The stoichiometries of the complexes was determined and rotating frame Overhauser enhancement spectroscopy (ROESY) 1D experiments revealed details of the molecular insertion of proparacaine into the beta-CD and p-sulfonic acid calix[6]arene cavities. The results unambiguously demonstrate that pH is an important factor for the development of supramolecular architectures based on beta-CD and p-sulfonic acid calix[6]arene as the host molecules. Such host-guest complexes were investigated in view of their potential use as new therapeutic formulations, designed to increase the bioavailability and/or to decrease the systemic toxicity of proparacaine in anesthesia procedures. Topics: Anesthetics, Local; beta-Cyclodextrins; Binding Sites; Calixarenes; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Phenols; Propoxycaine; Sulfonic Acids	2009
Topology of a ternary complex (proparacaine-beta-cyclodextrin-liposome) by STD NMR. Magnetic resonance in chemistry : MRC, 2008, Volume: 46, Issue:9 The topologies of proparacaine (PPC) in beta-cyclodextrin (beta-CD), PPC in egg phosphatidylcholine (EPC) liposomes and PPC in beta-CD in EPC were investigated using NMR experiments (1D ROESY and saturation transfer difference (STD)). This is the first description of the STD technique applied to PPC-EPC-beta-CD system, revealing that not only PPC was imbedded in EPC bilayer, but beta-CD was also interacting with liposome vesicles. These results are novel and were rationalized as the spontaneous formation of a ternary complex with some beta-CD molecules bound to external liposome vesicles surfaces. Topics: beta-Cyclodextrins; Binding Sites; Diffusion; Liposomes; Magnetic Resonance Spectroscopy; Molecular Structure; Propoxycaine; Reference Standards	2008

Article

Year

Proparacaine complexation with beta-cyclodextrin and p-sulfonic acid calix[6]arene, as evaluated by varied (1)H-NMR approaches.

Magnetic resonance in chemistry : MRC, 2009, Volume: 47, Issue:9

This study focused on the use of NMR techniques as a tool for the investigation of complex formation between proparacaine and cyclodextrins (CDs) or p-sulfonic acid calix[6]arene. The pH dependence of the complexation of proparacaine with beta-CD and p-sulfonic acid calix[6]arene was studied and binding constants were determined by (1)H NMR spectroscopy [diffusion-ordered spectroscopy (DOSY)] for the charged and uncharged forms of the local anesthetic in beta-CD and p-sulfonic acid calix[6]arene. The stoichiometries of the complexes was determined and rotating frame Overhauser enhancement spectroscopy (ROESY) 1D experiments revealed details of the molecular insertion of proparacaine into the beta-CD and p-sulfonic acid calix[6]arene cavities. The results unambiguously demonstrate that pH is an important factor for the development of supramolecular architectures based on beta-CD and p-sulfonic acid calix[6]arene as the host molecules. Such host-guest complexes were investigated in view of their potential use as new therapeutic formulations, designed to increase the bioavailability and/or to decrease the systemic toxicity of proparacaine in anesthesia procedures.

Topics: Anesthetics, Local; beta-Cyclodextrins; Binding Sites; Calixarenes; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Phenols; Propoxycaine; Sulfonic Acids

2009

Topology of a ternary complex (proparacaine-beta-cyclodextrin-liposome) by STD NMR.

Magnetic resonance in chemistry : MRC, 2008, Volume: 46, Issue:9

The topologies of proparacaine (PPC) in beta-cyclodextrin (beta-CD), PPC in egg phosphatidylcholine (EPC) liposomes and PPC in beta-CD in EPC were investigated using NMR experiments (1D ROESY and saturation transfer difference (STD)). This is the first description of the STD technique applied to PPC-EPC-beta-CD system, revealing that not only PPC was imbedded in EPC bilayer, but beta-CD was also interacting with liposome vesicles. These results are novel and were rationalized as the spontaneous formation of a ternary complex with some beta-CD molecules bound to external liposome vesicles surfaces.

Topics: beta-Cyclodextrins; Binding Sites; Diffusion; Liposomes; Magnetic Resonance Spectroscopy; Molecular Structure; Propoxycaine; Reference Standards

2008