betadex has been researched along with plumbagin* in 3 studies
3 other study(ies) available for betadex and plumbagin
| Article | Year |
|---|---|
Molecular Dynamic Simulation Analysis on the Inclusion Complexation of Plumbagin with β-Cyclodextrin Derivatives in Aqueous Solution.
Stable encapsulation of medically active compounds can lead to longer storage life and facilitate the slow-release mechanism. In this work, the dynamic and molecular interactions between plumbagin molecule with β-cyclodextrin (BCD) and its two derivatives, which are dimethyl-β-cyclodextrin (MBCD), and 2- Topics: 2-Hydroxypropyl-beta-cyclodextrin; beta-Cyclodextrins; Computational Biology; Cyclodextrins; Drug Compounding; Molecular Dynamics Simulation; Naphthoquinones; Solubility; Water | 2021 |
Synthesis, characterization, molecular docking and anti-tubercular activity of Plumbagin-Isoniazid Analog and its β-cyclodextrin conjugate.
A novel Plumbagin-Isoniazid Analog (PLIHZ) and its β-cyclodextrin inclusion complex (PLIHZCD) is prepared, characterized and evaluated for antitubercular activity under low and high iron conditions. PLIHZCD inclusion complex was characterized by Fourier Transform Infra-Red (FTIR), Differential Scanning Calorimetry (DSC), Powder X-ray Diffraction Studies (PXRD), (1)H NMR Studies and Scanning Electron Microscopic (SEM) analysis. The orientation and interaction of PLIHZ and CD was studied by molecular docking. PLIHZCD exhibited superior activity (MIC of 4 μg/ml) than PLIHZ and PL under 7H9 medium conditions. The standard anti-tubercular compound INH exhibited MIC values of 0.125 and 32 μg/ml under high and low iron conditions, whereas the conjugate PLIHZ exhibited MIC values of 0.5 and 2.0 μg/ml under high and low iron (corresponding to isoniazid resistant condition) indicating the advantage of combining plumbagin with INH overcoming resistance. The cyclodextrin conjugate offers improved aqueous solubility and thermal stability which are advantages in the treatment protocol. Topics: Antitubercular Agents; beta-Cyclodextrins; Calorimetry, Differential Scanning; Drug Stability; Isoniazid; Microscopy, Electron, Scanning; Molecular Conformation; Molecular Dynamics Simulation; Mycobacterium tuberculosis; Naphthoquinones; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2014 |
Reduced toxicity and enhanced antitumor efficacy of betacyclodextrin plumbagin inclusion complex in mice bearing Ehrlich ascites carcinoma.
Inclusion complex of plumbagin was prepared with betacyclodextrin employing neutralization method. The toxicity of the drug was reduced and the antitumor efficacy was enhanced on complexation with betacyclodextrin. Topics: Absorption; Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; beta-Cyclodextrins; Carcinogens; Carcinoma, Ehrlich Tumor; Cyclodextrins; Dose-Response Relationship, Drug; Drug Carriers; Drug Synergism; Female; Lethal Dose 50; Mice; Mice, Inbred BALB C; Naphthoquinones; Neoplasm Transplantation | 1997 |