betadex has been researched along with oxazolidine* in 1 studies
1 other study(ies) available for betadex and oxazolidine
| Article | Year |
|---|---|
Effect of hydroxypropyl-beta-cyclodextrin on the central stimulant activity of (-)-ephedrine and an oxazolidine prodrug in rats.
1. Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) increases the stability of the oxazolidine prodrug toward hydrolysis. 2. The binding constant (Kb) and rate constant (Kc) for the hydrolysis of the prodrug-HP-beta-CD complex were calculated from the kinetic data. 3. Ion-spray mass spectra confirmed prodrug-HP-beta-CD complexation. 4. Mass spectral and kinetic data indicated 1:1 stoichiometry for the complex. 5. A significant elevation of locomotor activity in rats was observed when either (-)-ephedrine or the prodrug was administered by either the intraperitoneal or the oral route. 6. Addition of HP-beta-CD potentiated the central nervous system effect of both (-)-ephedrine and the prodrug when administered intraperitoneally. However, when the drugs were administered orally, HP-beta-CD caused a decrease in activity. Topics: 2-Hydroxypropyl-beta-cyclodextrin; Adrenergic Agents; Animals; beta-Cyclodextrins; Cyclodextrins; Dose-Response Relationship, Drug; Ephedrine; Male; Mass Spectrometry; Oxazoles; Prodrugs; Rats; Rats, Sprague-Dawley | 1998 |