betadex and oleylamine

The global threat of antimicrobial resistant strains calls for innovative strategies to utilize nano drug delivery systems to enhance the delivery of antibiotics, thus reducing the development of resistance. Supramolecular amphiphiles that can self-assemble into nanostructures are one such nano delivery system, that are showing potential for effective drug delivery. The aim of this study was to synthesize and formulate a novel sugar-based cationic amphiphile (BCD-OLA) derivative from a Beta-cyclodextrin (BCD) head and long C18 carbon chain with a terminal amine; oleylamine (OLA), using inclusion complexation for application in antibiotic delivery. A suspension method was used for preparing the BCD-OLA amphiphile, which was then utilized for the formulation of nanovesicles. The complexation of BCD-OLA was confirmed by FTIR,

Topics: A549 Cells; Amines; Anti-Bacterial Agents; beta-Cyclodextrins; Cell Line; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Drug Delivery Systems; HEK293 Cells; HeLa Cells; Humans; Macrophages; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Nanoparticles; Nanostructures; Particle Size; Staphylococcal Infections; Th1 Cells; Vancomycin