betadex and navitoclax

betadex has been researched along with navitoclax* in 1 studies

Other Studies

1 other study(ies) available for betadex and navitoclax

Article	Year
Targeting cholesterol with β-cyclodextrin sensitizes cancer cells for apoptosis. FEBS letters, 2015, Dec-21, Volume: 589, Issue:24 Pt B We found that targeting cholesterol with beta-cyclodextrin (bCD) and its derivatives disrupted signal transduction between PI3K and AKT, attenuating AKT pro-survival signals. In their absence, 2-deoxyglucose (2DG) caused anti-apoptotic protein Mcll to dissociate from pro-apoptotic Bak at mitochondria. Normally Bak is sequestered by its inhibitory associations with Mcll and Bcl-xL, and only when Bak is released from both, is it free to form oligomers through which cytochrome c can escape into the cytosol. Thus an addition of a bcl-2 antagonist dissociates Bak from Bcl-xL, triggering cytochrome c release and inducing apoptosis. 2DG-bCD can also sensitize type II cancer cells for TRAIL-mediated apoptosis. Topics: 2-Hydroxypropyl-beta-cyclodextrin; Aniline Compounds; Animals; Anticholesteremic Agents; Antimetabolites; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; beta-Cyclodextrins; Cell Line, Tumor; Crosses, Genetic; Deoxyglucose; Drug Synergism; Humans; Mice, Inbred NOD; Mice, SCID; Neoplasms; Specific Pathogen-Free Organisms; Sulfonamides; Tumor Burden; Xenograft Model Antitumor Assays	2015

Article

Year

Targeting cholesterol with β-cyclodextrin sensitizes cancer cells for apoptosis.

FEBS letters, 2015, Dec-21, Volume: 589, Issue:24 Pt B

We found that targeting cholesterol with beta-cyclodextrin (bCD) and its derivatives disrupted signal transduction between PI3K and AKT, attenuating AKT pro-survival signals. In their absence, 2-deoxyglucose (2DG) caused anti-apoptotic protein Mcll to dissociate from pro-apoptotic Bak at mitochondria. Normally Bak is sequestered by its inhibitory associations with Mcll and Bcl-xL, and only when Bak is released from both, is it free to form oligomers through which cytochrome c can escape into the cytosol. Thus an addition of a bcl-2 antagonist dissociates Bak from Bcl-xL, triggering cytochrome c release and inducing apoptosis. 2DG-bCD can also sensitize type II cancer cells for TRAIL-mediated apoptosis.

Topics: 2-Hydroxypropyl-beta-cyclodextrin; Aniline Compounds; Animals; Anticholesteremic Agents; Antimetabolites; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; beta-Cyclodextrins; Cell Line, Tumor; Crosses, Genetic; Deoxyglucose; Drug Synergism; Humans; Mice, Inbred NOD; Mice, SCID; Neoplasms; Specific Pathogen-Free Organisms; Sulfonamides; Tumor Burden; Xenograft Model Antitumor Assays

2015