betadex and naringin

betadex has been researched along with naringin* in 5 studies

Other Studies

5 other study(ies) available for betadex and naringin

ArticleYear
Local delivery of naringin in beta-cyclodextrin modified mesoporous bioactive glass promotes bone regeneration: from anti-inflammatory to synergistic osteogenesis and osteoclastogenesis.
    Biomaterials science, 2022, Mar-29, Volume: 10, Issue:7

    The bone immune response dominated by macrophages plays an indispensable role in the osteogenesis of bone defects. Moreover, moderate polarization of macrophages against inflammatory M2 has been proved to promote osteogenesis. Therefore, the addition of anti-inflammatory agents to bioactive bone repair materials facilitates efficient bone regeneration by regulating the polarization of macrophages. Bioactive glass (BG) has been widely used for bone defect repair. However, BG alone cannot effectively inhibit the inflammatory response caused by

    Topics: Animals; Anti-Inflammatory Agents; beta-Cyclodextrins; Bone Regeneration; Flavanones; Glass; Osteogenesis; Porosity; Rats; Tissue Scaffolds

2022
Binding interactions of naringenin and naringin with calf thymus DNA and the role of β-cyclodextrin in the binding.
    AAPS PharmSciTech, 2013, Volume: 14, Issue:2

    The interaction of naringenin (Nar) and its neohesperidoside, naringin (Narn), with calf thymus deoxyribonucleic acid (ctDNA) in the absence and the presence of β-cyclodextrin (β-CD) was investigated. The interaction of Nar and Narn with β-CD/ctDNA was analyzed by using absorption, fluorescence, and molecular modeling techniques. Docking studies showed the existence of hydrogen bonding, electrostatic and phobic interaction of Nar and Narn with β-CD/DNA. 1:2 stoichiometric inclusion complexes were observed for Nar and Narn with β-CD. With the addition of ctDNA, Nar and Narn resulted into the fluorescence quenching phenomenon in the aqueous solution and β-CD solution. The binding constant K(b) and the number of binding sites were found to be different for Nar and Narn bindings with DNA in aqueous and β-CD solution. The difference is attributed to the structural difference between Nar and Narn with neohesperidoside moiety present in Narn.

    Topics: beta-Cyclodextrins; Binding Sites; Chemistry, Pharmaceutical; DNA; Drug Carriers; Flavanones; Hydrogen Bonding; Molecular Docking Simulation; Molecular Structure; Nucleic Acid Conformation; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Static Electricity; Technology, Pharmaceutical

2013
[Preparation of naringenin by enzymolysis of naringin-HP-beta-CD].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2012, Volume: 37, Issue:3

    To determine the major factors affecting the conversion efficiency of naringin-HP-beta-CD that was enzymed to prepare naringenin were determined and select the process condition with high conversion efficiency, stable and suitable for industrial production.. The dropping method was used to prepare naringin-HP-beta-CD, which was hydrolyzed by snailase to obtain naringenin. With the bioconversion rate as the index, the effects of pH value, temperature, reaction time, dosage of enzyme and concentration of naringin-HP-beta-CD on conversion rate of naringenin were detected for the purpose of optimizing the preparation condition. the conversion efficiency of naringin-HP-beta-CD was verified by scanning calorimetry, and the Hydrolysis product was identified by H-NMR, and 13C-NMR.. The optimum enzymolysis of naringin-HP-beta-CD with snailase was 98.4% under the conditions of 37 degrees C, a pH 5.0 acetic acid- sodium acetate buffer solution for 12 hours. The substrate concentration was 30 g x L(-1) and the weight ratio of enzyme and substrate was 3: 5. Under the optimum enzymolysis condition, the conversion rate of naringin-HP-beta-CD was higher than naringin that was not entrapped with HP-beta-CD, with 272.25 reaction product relative molecules. The structure of naringenin was confirmed by the analysis of 1H-NMR and 13C-NMR.. Naringin which is entrapped with HP-beta-CD to prepare naringenin can significantly improve the conversion efficiency by shortening the reaction time, increasing the concentration of the substrate and reducing the amount of enzyme. Therefore, the process is stable and it was suitable for industrialization.

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; beta-Cyclodextrins; Flavanones; Hydrolysis; Solubility

2012
Effect of β-cyclodextrin complexation on solubility and enzymatic conversion of naringin.
    International journal of molecular sciences, 2012, Nov-05, Volume: 13, Issue:11

    In the present paper, the effect of beta-cyclodextrin (beta-CD) inclusion complexation on the solubility and enzymatic hydrolysis of naringin was investigated. The inclusion complex of naringin/beta-CD at the molar ratio of 1:1 was obtained by the dropping method and was characterized by differential scanning calorimetry. The solubility of naringin complexes in water at 37 ± 0.1 °C was 15 times greater than that of free naringin. Snailase-involved hydrolysis conditions were tested for the bioconversion of naringin into naringenin using the univariate experimental design. Naringin can be transformed into naringenin by snailase-involved hydrolysis. The optimum conditions for enzymatic hydrolysis were determined as follows: pH 5.0, temperature 37 °C, ratio of snailase/substrate 0.8, substrate concentration 20 mg·mL(-1), and reaction time 12 h. Under the optimum conditions, the transforming rate of naringenin from naringin for inclusion complexes and free naringin was 98.7% and 56.2% respectively, suggesting that beta-CD complexation can improve the aqueous solubility and consequently the enzymatic hydrolysis rate of naringin.

    Topics: beta-Cyclodextrins; Calorimetry, Differential Scanning; Flavanones; Hydrolysis; Kinetics; Reproducibility of Results; Solubility; Temperature

2012
A highly sensitive and selective sensing ECL platform for naringin based on β-Cyclodextrin functionalized carbon nanohorns.
    Chemical communications (Cambridge, England), 2011, Nov-21, Volume: 47, Issue:43

    A new electrochemiluminescent sensing platform utilizing β-Cyclodextrin functionalized carbon nanohorns as an electrochemiluminescent amplification and sensing element was developed for sensitive detection of naringin with good specificity and excellent stability.

    Topics: beta-Cyclodextrins; Carbon; Electrochemical Techniques; Ferrocyanides; Flavanones; Luminescent Measurements; Luminol; Nanostructures; Porosity

2011