betadex has been researched along with lomefloxacin* in 2 studies
2 other study(ies) available for betadex and lomefloxacin
| Article | Year |
|---|---|
Enantioseparation of lomefloxacin hydrochloride by high-speed counter-current chromatography using sulfated-β-cyclodextrin as a chiral selector.
Enantiomers of lomefloxacin hydrochloride were separated by high-speed counter-current chromatography (HSCCC) using sulfated-β-cyclodextrin as a chiral selector (CS). The separation was performed with a two-phase solvent system composed of ethyl acetate-methanol-water (10:1:10, v/v) containing CS at 0-60mmol/l in a head-to-tail elution mode, while obtained fractions were identified by polarimeter and spectropolarimeter. The results show that the concentration of the CS in the system strongly affects the peak resolution (Rs). As the concentration of CS increases, the Rs first increases reaching the maximum at 50mmol/l and then decreases. When the CS concentration is kept constant in the solvent systems, the Rs decreases as the concentration of the lomefloxacin hydrochloride increases. The overall results of our studies indicated that sulfated-β-cyclodextrin is very useful for the chiral separation by HSCCC. Topics: beta-Cyclodextrins; Chromatography, High Pressure Liquid; Circular Dichroism; Countercurrent Distribution; Fluoroquinolones; Stereoisomerism; Sulfates | 2010 |
Chiral separation of four fluoroquinolone compounds using capillary electrophoresis with hydroxypropyl-beta-cyclodextrin as chiral selector.
A capillary zone electrophoresis (CZE) investigation on the enantiomeric separation of lomefloxacin, gatifloxacin, pazufloxacin and ofloxacin was undertaken. Resolution of the enantiomers was achieved using hydroxypropyl-beta-cyclodextrin (HP-beta-CD) as the chiral selector. Parameters influencing separation include cyclodextrin concentration, separational potential, pH and organic additive are discussed. A buffer consisting of 70 mM phosphate and 40 mM HP-beta-CD at pH 3.96 was found to be highly efficient for the separation of lomefloxacin, at pH 3.90 for gatifloxacin, at pH 5.04 for pazufloxacin and at pH 2.16 for ofloxacin. To the best of our knowledge, this is the first report on the enantiomeric resolution of lomefloxacin and gatifloxacin applying CE. Topics: 2-Hydroxypropyl-beta-cyclodextrin; beta-Cyclodextrins; Electrophoresis, Capillary; Fluoroquinolones; Gatifloxacin; Hydrogen-Ion Concentration; Molecular Structure; Ofloxacin; Oxazines; Quinolones; Stereoisomerism | 2006 |