betadex and isoquercitrin

In this study, a sensitive electrochemical method based on thio-β-cyclodextrin functionalized graphene/palladium nanoparticles (SH-β-CD-Gr/PdNPs) was developed to detect rutin and isoquercitrin, respectively. The obtained SH-β-CD-Gr/PdNPs were characterized by UV-vis spectroscopy, Fourier transform infrared spectroscopy, transmission electron microscopy and X-ray photoelectron spectroscopy. The results confirm that SH-β-CD and PdNPs were successfully deposited on the surface of graphene nanosheets (GNs). The peak currents of rutin and isoquercitrin on the SH-β-CD-Gr/PdNPs modified glassy carbon electrode (GCE) are dramatically increased compared with that on the bare GCE and SH-β-CD-Gr/GCE. It indicated that the nanocomposite integrated the excellent electric conductivity and electrocatalytic activity of graphene and PdNPs, as well as the host-guest recognition and enrichment ability of SH-β-CD. Under optimum conditions, differential pulse voltammetry (DPV) was used to measure the peak currents of the two drugs. The linear response ranges for rutin and isoquercitrin are 1.0×10

Topics: beta-Cyclodextrins; Electrochemical Techniques; Graphite; Limit of Detection; Nanoparticles; Palladium; Quercetin; Rutin; Sulfhydryl Compounds

In this study, 2,6-dimethyl-β-cyclodextrin (DM-β-CD) functionalized graphene nanosheets (DM-β-CD-GNs) were successfully synthesized by a simple wet-chemical strategy. The as obtained DM-β-CD-GNs were characterized by UV-vis spectroscopy, Fourier transform Infrared (FT-IR) spectroscopy, atomic force microscopy (AFM) and transmission electron microscopy (TEM). The new nanocomposite possesses the unique properties of graphene (large surface area and high conductivity) and DM-β-CD (high supramolecular recognition and enrichment capability). Based on the above properties, a highly sensitive electrochemical sensor was developed to detect two flavonoid drugs (isoquercitrin and baicalin). At the DM-β-CD-GNs modified glassy carbon electrode (DM-β-CD-GNs/GCE), the peak currents of the two drugs increased dramatically compared with that on the bare GCE and GNs/GCE which due to the synergetic effects of GNs and DM-β-CD molecules. The linear response ranges for isoquercitrin and baicalin are 10nM-3.0μM and 0.04μM -3.0μM, with the detection limits of 4nM and 10nM, respectively. The method might open up a new possibility for the widespread use of electrochemical sensors for monitoring of ultra-trace flavonoid drugs owing to its advantages of simple preparation, low cost, high sensitivity, good stability and reproducibility.

Topics: beta-Cyclodextrins; Biosensing Techniques; Conductometry; Electrodes; Equipment Design; Equipment Failure Analysis; Flavonoids; Graphite; Nanoparticles; Quercetin; Surface Properties