betadex and glycylsarcosine

betadex has been researched along with glycylsarcosine* in 1 studies

Other Studies

1 other study(ies) available for betadex and glycylsarcosine

ArticleYear
Multifunctional nanocomposite eye drops of cyclodextrin complex@layered double hydroxides for relay drug delivery to the posterior segment of the eye.
    Carbohydrate polymers, 2021, May-15, Volume: 260

    Topical drug delivery system to the posterior segment of the eye is facing many challenges, such as rapid drug elimination, low permeability, and low concentration at the targeted sites. To overcome these challenges, Multifunctional nanocomposite eye drops of dexamethasone-carboxymethyl-β-cyclodextrin@layered double hydroxides-glycylsarcosine (DEX-CM-β-CD@LDH-GS) were developed for relay drug delivery. Herein, our studies demonstrated that DEX-CM-β-CD@LDH-GS could penetrate through human conjunctival epithelial cells with an intact structure and exhibited integrity in the sclera of rabbits' eyes with in vivo fluorescence resonance energy transfer imaging. Consequently, tissue distribution indicated that DEX-CM-β-CD@LDH-GS nanocomposite eye drops could maintain the effective therapeutic concentration of DEX in choroid-retina within 3 h. As a relay drug delivery system, drug-CD@LDH nanocomposites offer an efficient strategy for drug delivery from ocular surface to the posterior segment.

    Topics: Animals; beta-Cyclodextrins; Cornea; Dexamethasone; Dipeptides; Drug Carriers; Drug Liberation; Hydroxides; Nanocomposites; Ophthalmic Solutions; Optical Imaging; Rabbits

2021