betadex and gibberellic-acid
betadex has been researched along with gibberellic-acid* in 1 studies
Other Studies
1 other study(ies) available for betadex and gibberellic-acid
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Inclusion complex of GA-13316 with β-cyclodextrin: preparation, characterization, molecular modeling, and in vitro evaluation.
The inclusion complex of GA-13316 with β-cyclodextrin (β-CD) is one of a unique series of gibberellin derivatives possessed of potential anticancer activities. The complex with β-CD was characterized by means of UV, XRD, DSC, TG, (1)H, and 2D NMR spectroscopy. In addition, we investigated the main aspects of the interaction between GA-13316 and β-CD using both experimental and molecular modeling approaches. The complex still maintained its anticancer activity, as shown by in vitro cell survival assay on the human colon carcinoma cell line (HCT116) and the human lung cancer cell line (H460). The results showed that the use of β-CD could be obviously improved the water solubility and stability of GA-13316, implying that the inclusion complex could be a promising future therapeutic agent. Topics: Antineoplastic Agents; beta-Cyclodextrins; Cell Line, Tumor; Colonic Neoplasms; Gibberellins; Humans; Lung Neoplasms; Magnetic Resonance Spectroscopy; Molecular Docking Simulation; Solubility | 2014 |