betadex has been researched along with furnidipine* in 1 studies
1 other study(ies) available for betadex and furnidipine
Article | Year |
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Spectrophotometric and electrochemical study of the inclusion complex between beta-cyclodextrin and furnidipine.
Inclusion complexation between furnidipine (2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-tetrahydrofurfuryl 5-methyl diester), a calcium-channel antagonist, and beta-cyclodextrin (beta-CyD) was studied in aqueous solution by using both spectrophotometric and electrochemical measurements. The phase solubility profile was classified as A(L)-type, indicating the formation of 1:1 stoichiometric inclusion complex of furnidipine with beta-CyD. Based on the spectrophotometric absorbance's variations, a formation constant value, K(f), of 156 M(-1) was determined. Electrochemical measurements using chronocoulometric experiments were used for the determination of the diffusion coefficients. In absence of beta-CyD, a diffusion coefficient value of 4.32 x 10(-6) cm2 s(-1) was obtained for furnidipine. The addition of beta-CyD produced a decrease of 30% for the diffusion coefficient. Formation of inclusion complexes of furnidipine with beta-CyD was proved to increase more than three times the solubility of furnidipine. Topics: beta-Cyclodextrins; Calcium Channel Blockers; Cyclodextrins; Dihydropyridines; Electrochemistry; Molecular Structure; Solubility; Spectrophotometry, Ultraviolet | 2004 |