betadex and furan

betadex has been researched along with furan* in 1 studies

Other Studies

1 other study(ies) available for betadex and furan

ArticleYear
Anticryptosporidial activity of furan derivative G1 and its inclusion complex with beta-cyclodextrin.
    Journal of pharmaceutical sciences, 2004, Volume: 93, Issue:1

    The capacity of beta-cyclodextrin (betaCD) to form a complex with a new furanic derivative, G1, was investigated. Interactions of the drug and betaCD in solution and in the solid state were studied using phase solubility techniques, thermal methods, X-ray, and IR spectroscopy. Preparation of a kneaded mix of G1/betaCD increased both the aqueous solubility and the dissolution rate of the furan derivative. The anticryptosporidial efficacies of the drug and of the inclusion complex were evaluated using a suckling murine model. Oral administration of G1 considerably decreased the intensity of the infection, but betaCD showed similar anticryptosporidial activity to that of the betaCD-G1 complex and higher activity than G1 alone.

    Topics: Animals; beta-Cyclodextrins; Cattle; Chemistry, Pharmaceutical; Cryptosporidiosis; Cryptosporidium parvum; Cyclodextrins; Female; Furans; Mice; Nitro Compounds; Oocysts; Solubility

2004