betadex and fexofenadine

betadex has been researched along with fexofenadine* in 3 studies

Other Studies

3 other study(ies) available for betadex and fexofenadine

ArticleYear
Carbopol-incorporated thermoreversible gel for intranasal drug delivery.
    Molecules (Basel, Switzerland), 2015, Mar-04, Volume: 20, Issue:3

    The present study describes the preparation and evaluation of a poloxamer 407 (P407)-based thermoreversible gel using Carbopol 934P (C934P) as a mucoadhesive polymer and hydroxypropyl-β-cyclodextrin (HP-β-CD) for enhancing the aqueous solubility and intranasal absorption of fexofenadine hydrochloride (FXD HCl). The prepared gels were characterized by gelation temperature, viscoelasticity, and drug release profile. Thermoreversibility of P407/C934P gel was demonstrated by rheological studies. The incorporation of carbopol into P407 gel also reduced the amounts of drug released from the gel formulations (p < 0.05). In vivo pharmacokinetic results of the prepared gel formulations in rabbits (at 0.5 mg/kg dose) showed that the relative bioavailability of drug from P407/C934P gel was 11.3 and 2.7-fold higher than those of drug solution and P407 gel group, respectively. These findings suggested that developed thermoreversible gels could be used as promising dosage forms to improve intranasal drug absorption.

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Acrylates; Adhesiveness; Administration, Intranasal; Animals; beta-Cyclodextrins; Biological Availability; Drug Delivery Systems; Gels; Histamine H1 Antagonists, Non-Sedating; Poloxamer; Rabbits; Rheology; Terfenadine; Tissue Distribution; Viscosity

2015
Poloxamer/cyclodextrin/chitosan-based thermoreversible gel for intranasal delivery of fexofenadine hydrochloride.
    Journal of pharmaceutical sciences, 2011, Volume: 100, Issue:2

    To enhance permeation and solubility of an intranasal delivery system of fexofenadine hydrochloride (FXD HCl), a new formulation using poloxamer 407 (P407)/hydroxypropyl-β-cyclodextrin (HP-β-CD)-based thermoreversible gels with chitosan, was developed. Prepared gels were characterized by gelation temperature, viscosity, viscoelasticity, and drug release profile. The in vitro permeation study was performed in primary human nasal epithelial cell monolayers cultured by air-liquid interface method. The addition of chitosan caused the slight elevation of gelation temperature and viscosity-enhancing effect. Viscosity enhancement by the incorporation of chitosan caused the retardation of drug release from P407 gels in in vitro release test. The in vitro permeation profile showed that the increase in chitosan content (0.1% and 0.3%, w/v) significantly enhanced the permeation of FXD HCl. After intranasal administration of P407/HP-β-CD-based thermoreversible gels containing 0.1% and 0.3% of chitosan in rabbits at 0.5 mg/kg dose, plasma concentrations of FXD HCl were significantly higher than those of nasal solutions (p < 0.05). In particular, the bioavailability of the optimized thermoreversible gel containing 0.3% chitosan was about 18-fold higher than that of the solution type. These results suggested the feasibility that thermosensitive gels could be used as an effective dosage form to enhance the nasal absorption of FXD HCl.

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Administration, Intranasal; Animals; beta-Cyclodextrins; Cell Membrane Permeability; Cells, Cultured; Chitosan; Gels; Histamine H1 Antagonists, Non-Sedating; Humans; Poloxamer; Rabbits; Temperature; Terfenadine; Viscosity

2011
Determination of fexofenadine in tablets by capillary electrophoresis in free solution and in solution with cyclodextrins as analyte carriers.
    Drug development and industrial pharmacy, 2005, Volume: 31, Issue:8

    Capillary electrophoresis (CE) methods for the determination of fexofenadine (FEX) in commercial pharmaceuticals were developed. It was demonstrated that FEX could be effectively analyzed in free solution cationic CE at low pH. Another analytical approach studied was based on cyclodextrin (CD) modified CE where highly charged CD derivatives served as analyte carriers. In this way, the separation range was spread to physiological pH region and a CE analysis of FEX, present actually in its zwitterionic form, could be accomplished. Several parameters affecting the separations were studied, including the type and concentration of carrier ion, counterion, analyte carrier, and pH of the buffer. The methods based on the free solution CE and CD-modified CE were compared each other, validated, and applied for the determination of FEX in tablets.

    Topics: Anti-Allergic Agents; beta-Cyclodextrins; Chemistry, Pharmaceutical; Drug Carriers; Electrolytes; Electrophoresis, Capillary; Histamine H1 Antagonists; Tablets; Terfenadine

2005