betadex and ethyl-carbonate

The carbonate ester derivatives of β-cyclodextrin play a very important role in several fields, such as catalytic reaction and enantiomer separation. In this work, a novel synthesis process of the β-cyclodextrin carbonate ester has been investigated through the reaction between β-cyclodextrin and diethyl carbonate with anhydrous potassium carbonate as catalyst. The compounds were separated by semi-preparative chromatography and characterized by FT-IR, MS, (1)H NMR, and (13)C NMR spectroscopy. The position of the substituent was confirmed by (13)C NMR and this conclusion coincides with the analyses of MS and (1)H NMR in the main. The yield of the mono-6-O-ethoxycarbonyl β-CD is 65.8%.

Topics: beta-Cyclodextrins; Chemistry Techniques, Synthetic; Diethyl Pyrocarbonate; Mass Spectrometry; Spectroscopy, Fourier Transform Infrared