betadex has been researched along with eprosartan* in 1 studies
1 other study(ies) available for betadex and eprosartan
| Article | Year |
|---|---|
Formulation and characterization of eprosartan mesylate and β-cyclodextrin inclusion complex prepared by microwave technology.
The goal of this work was to improve the aqueous solubility and dissolution rate of eprosartan mesylate by preparing inclusion complex of drug with β-cyclodextrin (β-CD) by microwave technique. In order to determine the solubility of eprosartan, phase solubility was determined and dissolution study was also conducted. Further, analytical techniques for instance, particle size distribution, differential scanning calorimetry, powder X-ray diffraction, scanning electron microscopy, Fourier-transform infrared spectroscopy, and nuclear magnetic resonance spectroscopy were used for the characterization of inclusion complex. In addition, the binding pattern of eprosartan with the β-CD was investigated by molecular modeling study. Phase solubility study revealed that approximately 4.48 folds improvement in the solubility of drug was noted with β-CD (10 mM). The estimated stability constant ( Topics: Acrylates; beta-Cyclodextrins; Calorimetry, Differential Scanning; Imidazoles; Mesylates; Microwaves; Solubility; Spectroscopy, Fourier Transform Infrared; Technology; Thiophenes; X-Ray Diffraction | 2022 |