betadex has been researched along with diloxanide-furoate* in 3 studies
3 other study(ies) available for betadex and diloxanide-furoate
| Article | Year |
|---|---|
Diloxanide furoate binary complexes with β-, methyl-β-, and hydroxypropyl-β-cyclodextrins: inclusion mode, characterization in solution and in solid state and in vitro dissolution studies.
The purpose of this study was to investigate the effect on solubility and dissolution rate of binary complexes of β-(βCD), methyl-(MβCD) and hydroxypropyl-β-cyclodextrin (HPβCD) with diloxanide furoate (DF). The complexation in solution was evaluated by phase solubility studies and Topics: 2-Hydroxypropyl-beta-cyclodextrin; Administration, Oral; Amebicides; beta-Cyclodextrins; Drug Compounding; Excipients; Furans; Humans; Phase Transition; Solubility | 2018 |
Enzymatic hydrolysis of diloxanide furoate in the presence of beta-cyclodextrin and its methylated derivatives.
In this study, we investigated the susceptibility to enzymatic and alkaline hydrolysis of diloxanide furoate (DF) and its cyclodextrin inclusion complexes, in aqueous solution. The cyclodextrins (CDs) utilized were beta-cyclodextrin (beta-CD), (2,6-di-O-methyl)-beta-cyclodextrin (DM-beta-CD) and (2,3,6-tri-O-methyl)-beta-cyclodextrin (TM-beta-CD). All cyclodextrins studied provided a stabilizing effect to diloxanide furoate hydrolysis. In alkaline hydrolysis (pH 10.75), without the enzyme, beta-CD and TM-beta-CD provided similar effect on the stability of DF, with an inhibition factor in the order of 2.0. The DM-beta-CD, on the other hand, provided more pronounced stabilization effect than the other two CDs, with an inhibition factor around of 8. The maximum activity of the enzyme occured around pH 7.0. In the presence of enzyme, all cyclodextrins produced similar effect, with a DF hydrolysis inhibition factor in the order of 10. However, the plot of rate of hydrolysis versus [CD] fit with a equation based in a model that considers the association of the enzyme with the CDs. Therefore, it is concluded that the stabilization of DF is not only due to its cyclodextrin complex but also due to enzyme inhibition by cyclodextrin complexation. Topics: beta-Cyclodextrins; Chemical Phenomena; Chemistry, Physical; Cyclodextrins; Dose-Response Relationship, Drug; Drug Stability; Furans; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Lipase; Methylation; Spectrophotometry, Ultraviolet | 2003 |
Inhibition of Cryptosporidium infection in mice treated with a cyclodextrin inclusion complex with diloxanide furoate.
The efficacies of diloxanide furoate, beta-cyclodextrin and a cyclodextrin inclusion complex against Cryptosporidium parvum were evaluated in a suckling murine model. Efficacy was established by numbers of oocysts recovered from the intestinal tract of mice on day 7 postinfection. The level of infection in treated mice was significantly lower than in control mice and, surprisingly, the most efficacious treatment was beta-cyclodextrin, an excipient used in pharmaceutical technology. Topics: Amebicides; Animals; beta-Cyclodextrins; Cattle; Cryptosporidiosis; Cryptosporidium parvum; Cyclodextrins; Disease Models, Animal; Drug Carriers; Drug Therapy, Combination; Excipients; Furans; Mice; Parasite Egg Count | 2001 |