betadex and dapoxetine
betadex has been researched along with dapoxetine* in 1 studies
Other Studies
1 other study(ies) available for betadex and dapoxetine
Article | Year |
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Ploxomer and β-cyclodextrin; promising tools to improve solubility of dapoxetine through binary and ternary solid dispersion techniques.
Present study was aimed to formulate solid dispersions (SD) of Dapoxetine (DAPO), a drug with low water solubility with the help of PVP-30, Ploxomer-180 (P-180) and β-cyclodextrin (CD) by physical mixing to enhance the water solubility and dissolution of drug. Binary and Ternary solid dispersions were prepared with different ratios of drug and polymer and were further evaluated the effects of polymer at individual level as well as when used in combination. The solid dispersions were whitish in color, irregular in shape and have some rough surface when illustrated under SEM. Percentage yield of SDs ranged from 81-95% described the method was structured and significant. Solubility studies were carried out in 0.1N Hcl solution and was observed a remarkable increase in solubility of BSD 8, BSD 12 and TSD 6. Furthermore, the formulations were characterized by FTIR and PXRD. P-180 found an exceptional solubility promoter when used alone and in combination with CD as well. A remarkable enhance in Solubility and dissolution of DAPO was investigated in formulation prepared with ternary SD of Pol-180 and CD. Topics: Benzylamines; beta-Cyclodextrins; Drug Carriers; Microscopy, Electron, Scanning; Naphthalenes; Polymers; Selective Serotonin Reuptake Inhibitors; Solubility; Spectroscopy, Fourier Transform Infrared | 2022 |