betadex and coumarin

betadex has been researched along with coumarin* in 6 studies

Other Studies

6 other study(ies) available for betadex and coumarin

ArticleYear
Robust synthesis of sugar-coumarin based fluorescent 1,4-disubstituted-1,2,3-triazoles using highly efficient recyclable citrate grafted β-cyclodextrin@magnetite nano phase transfer catalyst in aqueous media.
    Carbohydrate research, 2019, Aug-01, Volume: 482

    Green synthesis of 1,4-disubstituted-1,2,3-triazoles via click reaction using nano magnetic Fe

    Topics: beta-Cyclodextrins; Catalysis; Chemistry Techniques, Synthetic; Citric Acid; Coumarins; Fluorescent Dyes; Magnetite Nanoparticles; Recycling; Sugars; Triazoles; Water

2019
Interaction of fluorescently labeled triethyleneglycol and peptide derivatives with β-cyclodextrin.
    Chemphyschem : a European journal of chemical physics and physical chemistry, 2014, Feb-24, Volume: 15, Issue:3

    A triethyleneglycol (TEG) chain, a linear peptide, and a cyclic peptide labeled with 7-methoxycoumarin-3-carboxylic acid (MC) and 7-diethylaminocoumarin-3-carboxylic acid (DAC) were used to thoroughly study Förster resonance energy transfer (FRET) in inclusion complexes. (1) H NMR evidence was given for the formation of a 1:1 inclusion complex between β-cyclodextrin (β-CD) and the fluorophore moieties of model compounds. The binding constant was 20 times higher for DAC than for MC derivatives. Molecular modeling provided additional information. The UV/Vis absorption and fluorescence properties were studied and the energy transfer process was quantified. Fluorescence quenching was particularly strong for the peptide derivatives. The presence of β-CDs reduced the FRET efficiency slightly. Dye-labeled peptide derivatives can thus be used to form inclusion complexes with β-CDs and retain most of their FRET properties. This paves the way for their subsequent use in analytical devices that are designed to measure the activity of matrix metalloproteinases.

    Topics: beta-Cyclodextrins; Coumarins; Ethylene Glycol; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Models, Molecular; Peptides

2014
Versatile fluorescence resonance energy transfer-based mesoporous silica nanoparticles for real-time monitoring of drug release.
    ACS nano, 2013, Mar-26, Volume: 7, Issue:3

    We describe the development of a versatile fluorescence resonance energy transfer (FRET)-based real-time monitoring system, consisting of (a) coumarin-labeled-cysteine tethered mesoporous silica nanoparticles (MSNs) as the drug carrier, (b) a fluorescein isothiocyanate-β-cyclodextrin (FITC-β-CD) as redox-responsive molecular valve blocking the pores, and (c) a FRET donor-acceptor pair of coumarin and FITC integrated within the pore-unlocking event, thereby allowing for monitoring the release of drugs from the pores in real-time. Under nonreducing conditions, when the disulfide bond is intact, the close proximity between coumarin and FITC on the surface of MSNs results in FRET from coumarin to FITC. However, in the presence of the redox stimuli like glutathione (GSH), the disulfide bond is cleaved which leads to the removal of molecular valve (FITC-β-CD), thus triggering drug release and eliminating FRET. By engineering such a FRET-active donor-acceptor structure within the redox-responsive molecular valve, we can monitor the release of the drugs entrapped within the pores of the MSN nanocarrier, following the change in the FRET signal. We have demonstrated that, any exogenous or endogenous change in the GSH concentration will result in a change in the extent of drug release as well as a concurrent change in the FRET signal, allowing us to extend the applications of our FRET-based MSNs for monitoring the release of any type of drug molecule in real-time.

    Topics: Antineoplastic Agents; beta-Cyclodextrins; Computer Systems; Coumarins; Doxorubicin; Drug Carriers; Drug Delivery Systems; Drug Monitoring; Fluorescein-5-isothiocyanate; Fluorescence Resonance Energy Transfer; Glutathione; HeLa Cells; Humans; Nanoparticles; Nanotechnology; Oxidation-Reduction; Silicon Dioxide

2013
Fluorescence anisotropy decay and solvation dynamics in a nanocavity: coumarin 153 in methyl beta-cyclodextrins.
    The journal of physical chemistry. A, 2005, Nov-03, Volume: 109, Issue:43

    Fluorescence anisotropy decay and solvation dynamics of coumarin 153 (C153) are studied in dimethyl beta-cyclodextrin (DIMEB) and trimethyl beta-cyclodextrin (TRIMEB) nanocavity in water. C153 binds to DIMEB and TRIMEB to form both 1:1 and 1:2 (C153:cyclodextrin) complexes. The anisotropy decays of C153 in DIMEB and TRIMEB are found to be biexponential. The fast component of anisotropy decay (approximately 1000 ps) is attributed to the 1:1 complex and the slower one (approximately 2500 ps) to the 1:2 complex. From the components of the anisotropy decay, the length of the 1:1 and 1:2 complexes are estimated. Solvation dynamics of C153 in DIMEB exhibits a very fast (2.4 ps) component (41%) and two slower components of 50 ps (29%) and 1450 ps (30%). Solvation dynamics in TRIMEB is described by three slow components of 10.3 ps (24%), 240 ps (45%), and 2450 ps (31%). Possible origins of the ultraslow components are discussed.

    Topics: beta-Cyclodextrins; Coumarins; Fluorescence Polarization; Fluorescent Dyes; Nanotechnology; Solubility

2005
Novel peptides bearing pyrene and coumarin units with or without beta-cyclodextrin in their side chains exhibit intramolecular fluorescence resonance energy transfer.
    Journal of the American Chemical Society, 2003, Sep-17, Volume: 125, Issue:37

    Novel peptides bearing the pyrene/coumarin FRET pair in their side chains have been designed and synthesized. Peptide 1 having endogenous beta-cyclodextrin (beta-CD) in the side chain exhibits FRET in aqueous solution, indicating that coumarin, being accommodated into the CD cavity, is separated from pyrene. Guest-induced quenching of the fluorophores in 1 indicates that coumarin, being excluded from the CD cavity, comes into close contact with pyrene. Peptide 2 shows FRET only after addition of external beta-CD that again reflects the idea that beta-CD surely caps the coumarin unit in its hydrophobic cavity, and, therefore, quenching of the fluorophores can be prevented in FRET peptide probes. With this strategy, various peptide-based FRET probes can be developed that would be useful for studying biological phenomena in living cells.

    Topics: beta-Cyclodextrins; Circular Dichroism; Coumarins; Fluorescence Resonance Energy Transfer; Peptides; Pyrenes

2003
Intramolecular fluorescence resonance energy transfer system with coumarin donor included in beta-cyclodextrin.
    Analytical chemistry, 2001, Mar-01, Volume: 73, Issue:5

    In aqueous solutions, the fluorescence of the intramolecular fluorescence resonance energy-transfer (FRET) system 1 was strongly quenched, because of close contact between the donor and acceptor moieties. FRET occurred, and the acceptor fluorescence was increased, by adding beta-cyclodextrin (beta-CD) to aqueous solutions of 1. Spectral analysis supported the idea that the FRET enhancement was due to the formation of an inclusion complex of the coumarin moiety in beta-CD, resulting in separation of the fluorophores. On the basis of this result, we propose that covalent binding of coumarin to beta-CD will provide a FRET cassette molecule. So, compound 2 bearing beta-CD covalently was designed and synthesized. Fluorescence intensity of 2 was enhanced markedly compared to the intensity of 3. Applying this FRET system, various FRET probes that will be useful for ratio imaging and also the high-throughput screening will be provided.

    Topics: beta-Cyclodextrins; Chemical Phenomena; Chemistry, Physical; Circular Dichroism; Coumarins; Cyclodextrins; Fluorescent Dyes; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet

2001