betadex and cetyl-alcohol

betadex has been researched along with cetyl-alcohol* in 2 studies

Other Studies

2 other study(ies) available for betadex and cetyl-alcohol

Article	Year
Cholesterol displacement from membrane phospholipids by hexadecanol. Biophysical journal, 2007, Sep-15, Volume: 93, Issue:6 Adding cholesterol to monolayers of certain phospholipids drives the separation of liquid-ordered from liquid-disordered domains. The ordered phases appear to contain stoichiometric complexes of cholesterol and phospholipid. Furthermore, it has been suggested that the cholesterol in these complexes has a low chemical activity compared to that of the free sterol; i.e., that in excess of the phospholipid binding capacity. We have now tested the hypothesis that the membrane intercalator 1-hexadecanol (HD) similarly associates with phospholipids and thereby displaces the complexed cholesterol. HD introduced into monolayers of pure dimyristoylphosphatidylcholine generated highly condensed (stable and solid) domains. In contrast, the phase behavior of mixed monolayers of the phospholipid, sterol, and alcohol suggested that HD could substitute for cholesterol mole for mole in promoting liquid-ordered domains. We also found that the transfer of cholesterol from mixed monolayers to aqueous cyclodextrin was greatly stimulated by the presence of HD, but only at levels sufficient to competitively displace the sterol from the phospholipid. This enhanced efflux was interpreted to reflect an increase in uncomplexed cholesterol. We conclude that HD forms complexes with dimyristoylphosphatidylcholine that are surprisingly similar to those of cholesterol. HD competitively displaces cholesterol from the phospholipid and thereby increases its chemical activity. Topics: beta-Cyclodextrins; Biophysical Phenomena; Biophysics; Cholestanol; Cholesterol; Dimyristoylphosphatidylcholine; Fatty Alcohols; Hydrostatic Pressure; Kinetics; Membrane Lipids; Membranes, Artificial; Phospholipids; Thermodynamics	2007
1H NMR investigations of inclusion complexes between beta-cyclodextrin and 1-hexadecanol. Current drug discovery technologies, 2007, Volume: 4, Issue:4 The inclusion complex between beta-CD and 1-hexadecanol is synthesized and identified via (1)H NMR spectrum. The possible conformation of the inclusion complex is figured out. Via MM2 calculations, the possibility of complexation is verified. Topics: beta-Cyclodextrins; Carbohydrate Conformation; Fatty Alcohols; Indicators and Reagents; Magnetic Resonance Spectroscopy; Solvents	2007

Article

Year

Cholesterol displacement from membrane phospholipids by hexadecanol.

Biophysical journal, 2007, Sep-15, Volume: 93, Issue:6

Adding cholesterol to monolayers of certain phospholipids drives the separation of liquid-ordered from liquid-disordered domains. The ordered phases appear to contain stoichiometric complexes of cholesterol and phospholipid. Furthermore, it has been suggested that the cholesterol in these complexes has a low chemical activity compared to that of the free sterol; i.e., that in excess of the phospholipid binding capacity. We have now tested the hypothesis that the membrane intercalator 1-hexadecanol (HD) similarly associates with phospholipids and thereby displaces the complexed cholesterol. HD introduced into monolayers of pure dimyristoylphosphatidylcholine generated highly condensed (stable and solid) domains. In contrast, the phase behavior of mixed monolayers of the phospholipid, sterol, and alcohol suggested that HD could substitute for cholesterol mole for mole in promoting liquid-ordered domains. We also found that the transfer of cholesterol from mixed monolayers to aqueous cyclodextrin was greatly stimulated by the presence of HD, but only at levels sufficient to competitively displace the sterol from the phospholipid. This enhanced efflux was interpreted to reflect an increase in uncomplexed cholesterol. We conclude that HD forms complexes with dimyristoylphosphatidylcholine that are surprisingly similar to those of cholesterol. HD competitively displaces cholesterol from the phospholipid and thereby increases its chemical activity.

Topics: beta-Cyclodextrins; Biophysical Phenomena; Biophysics; Cholestanol; Cholesterol; Dimyristoylphosphatidylcholine; Fatty Alcohols; Hydrostatic Pressure; Kinetics; Membrane Lipids; Membranes, Artificial; Phospholipids; Thermodynamics

2007

1H NMR investigations of inclusion complexes between beta-cyclodextrin and 1-hexadecanol.

Current drug discovery technologies, 2007, Volume: 4, Issue:4

The inclusion complex between beta-CD and 1-hexadecanol is synthesized and identified via (1)H NMR spectrum. The possible conformation of the inclusion complex is figured out. Via MM2 calculations, the possibility of complexation is verified.

Topics: beta-Cyclodextrins; Carbohydrate Conformation; Fatty Alcohols; Indicators and Reagents; Magnetic Resonance Spectroscopy; Solvents

2007