betadex has been researched along with cabazitaxel* in 1 studies
1 other study(ies) available for betadex and cabazitaxel
| Article | Year |
|---|---|
Discovery of a Novel Cabazitaxel Nanoparticle-Drug Conjugate (CRLX522) with Improved Pharmacokinetic Properties and Anticancer Effects Using a β-Cyclodextrin-PEG Copolymer Based Delivery Platform.
Novel nanoparticle-drug conjugates (NDCs) containing diverse, clinically relevant anticancer drug payloads (docetaxel, cabazitaxel, and gemcitabine) were successfully generated and tested in drug discovery studies. The NDCs utilized structurally varied linkers that attached the drug payloads to a β-cyclodextrin-PEG copolymer to form self-assembled nanoparticles. In vitro release studies revealed a diversity of release rates driven by linker structure-activity relationships (SARs). Improved in vivo pharmacokinetics (PK) for the cabazitaxel (CBTX) NDCs with glycinate-containing ( Topics: Animals; Antineoplastic Agents; beta-Cyclodextrins; Drug Carriers; Drug Design; Male; Melanoma, Experimental; Mice; Nanoparticles; Polyethylene Glycols; Taxoids; Tissue Distribution | 2019 |