betadex and bufalin

betadex has been researched along with bufalin* in 2 studies

Other Studies

2 other study(ies) available for betadex and bufalin

Article	Year
Folate receptor targeted bufalin/β-cyclodextrin supramolecular inclusion complex for enhanced solubility and anti-tumor efficiency of bufalin. Materials science & engineering. C, Materials for biological applications, 2017, Sep-01, Volume: 78 Topics: Antineoplastic Agents; beta-Cyclodextrins; Bufanolides; Calorimetry, Differential Scanning; Folic Acid; Solubility; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction	2017
Bufalin enhances TRAIL-induced apoptosis by redistributing death receptors in lipid rafts in breast cancer cells. Anti-cancer drugs, 2014, Volume: 25, Issue:6 Studies have shown that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in cancer cells. However, breast cancer cells are generally resistant to TRAIL. In the present study, we explored the effect of bufalin on TRAIL-induced breast cancer cell apoptosis. The results showed that bufalin enhanced TRAIL-induced apoptosis in MCF-7 and MDA-MB-231 breast cancer cells by activating the extrinsic apoptotic pathway. Bufalin also promoted the clustering of death receptor 4 (DR4) and DR5 in aggregated lipid rafts. The cholesterol-sequestering agent methyl-β-cyclodextrin reversed the DR4 and DR5 clustering and reduced bufalin+TRAIL-induced apoptosis. Overall, these results indicate that bufalin enhanced TRAIL-induced apoptosis in breast cancer cells by the partial redistribution of DRs in lipid rafts. Topics: Antineoplastic Agents; Apoptosis; beta-Cyclodextrins; Breast Neoplasms; Bufanolides; Cell Line, Tumor; Cholesterol; Female; Humans; Membrane Microdomains; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand	2014

Article

Year

Folate receptor targeted bufalin/β-cyclodextrin supramolecular inclusion complex for enhanced solubility and anti-tumor efficiency of bufalin.

Materials science & engineering. C, Materials for biological applications, 2017, Sep-01, Volume: 78

Topics: Antineoplastic Agents; beta-Cyclodextrins; Bufanolides; Calorimetry, Differential Scanning; Folic Acid; Solubility; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction

2017

Bufalin enhances TRAIL-induced apoptosis by redistributing death receptors in lipid rafts in breast cancer cells.

Anti-cancer drugs, 2014, Volume: 25, Issue:6

Studies have shown that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in cancer cells. However, breast cancer cells are generally resistant to TRAIL. In the present study, we explored the effect of bufalin on TRAIL-induced breast cancer cell apoptosis. The results showed that bufalin enhanced TRAIL-induced apoptosis in MCF-7 and MDA-MB-231 breast cancer cells by activating the extrinsic apoptotic pathway. Bufalin also promoted the clustering of death receptor 4 (DR4) and DR5 in aggregated lipid rafts. The cholesterol-sequestering agent methyl-β-cyclodextrin reversed the DR4 and DR5 clustering and reduced bufalin+TRAIL-induced apoptosis. Overall, these results indicate that bufalin enhanced TRAIL-induced apoptosis in breast cancer cells by the partial redistribution of DRs in lipid rafts.

Topics: Antineoplastic Agents; Apoptosis; beta-Cyclodextrins; Breast Neoplasms; Bufanolides; Cell Line, Tumor; Cholesterol; Female; Humans; Membrane Microdomains; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand

2014