betadex and benzidine

betadex has been researched along with benzidine* in 2 studies

Other Studies

2 other study(ies) available for betadex and benzidine

ArticleYear
pH-operated nanopistons on the surfaces of mesoporous silica nanoparticles.
    Journal of the American Chemical Society, 2010, Sep-22, Volume: 132, Issue:37

    The development of drug delivery systems for the targeted and on-demand release of pharmaceutical products has risen rapidly to become a contemporary challenge in the field of nanobiotechnology. Biocompatible mechanized phosphonate-clothed silica nanoparticles have been designed and fabricated in which the supramolecular machinery, which covers the surfaces of the nanoparticles, behaves like nanopistons, releasing encapsulated guest molecules in a controlled fashion under acidic conditions. The mechanized nanoparticles consist of a monolayer of β-cyclodextrin (β-CD) rings positioned selectively around the orifices of the nanopores of the mesoporous nanoparticles. A rhodamine B/benzidine conjugate was prepared for use as the nanopistons for movement in and out of the cylindrical cavities provided by the β-CD rings on the surfaces of the nanoparticles. Luminescence experiments indicated that the mechanized nanoparticles were able to store small cargo molecules (e.g., 2,6-naphthalenedisulfonic acid disodium) within their nanopores at neutral pH and then release them by passage through the cavities of the β-CD rings as soon as the pH was lowered to ∼5. In further investigations, the phosphonate-covered silica nanoparticles were functionalized selectively with the β-CD rings, but on this occasion, the seven linkers attaching the rings to the orifices surrounding the nanopores contained cleavable imine double bonds. The β-CD rings on the surface of the nanoparticles served as gates for the storage of large cargo molecules (e.g., rhodamine B) inside the nanopores of the nanoparticles under neutral conditions. Since imine bonds can be hydrolyzed under acidic conditions, the β-CD rings could be severed from the surface of the nanoparticles when the pH was decreased to 6, releasing the large cargo molecules. The results described here present a significant step toward the development of pH-responsive nanoparticle-based dual drug delivery vehicles that are potentially capable of being interfaced with biological systems.

    Topics: Benzidines; beta-Cyclodextrins; Drug Carriers; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Nanoparticles; Nanotechnology; Porosity; Rhodamines; Silicon Dioxide; Surface Properties

2010
Studies of a disposable biosensor based on the beta-cyclodextrin inclusion complex as mediator.
    Analytical biochemistry, 2001, Dec-01, Volume: 299, Issue:1

    This paper reports the use of a disposable voltammetric biosensor based on a screen-printed basal electrode and highly efficient mediators, the beta-cyclodextrin inclusion complexes tetramethylbenzidine and ferrocene. The polyphenol oxidase, contained in the crude extract of mushroom, was immobilized in the membrane of the cross-linked beta-cyclodextrin polymer. The resulting biosensor gave excellent analytical performance due to the supramolecular complexation for mediators. It responded to the concentration of dopamine with high selectively in the range from 1.0 x 10(-9) to 1.0 x 10(-6) M with a detection limit as low as 5 x 10(-10) M. The response time for reaching 90% of its steady-state value was less than 60 s, and the activity was retained for at least 15 days.

    Topics: Agaricales; Benzidines; beta-Cyclodextrins; Biosensing Techniques; Catechol Oxidase; Cyclodextrins; Disposable Equipment; Dopamine; Electrodes; Enzymes, Immobilized; Equipment Design; Ferrous Compounds; Macromolecular Substances; Magnetic Resonance Spectroscopy; Metallocenes; Oxidation-Reduction; Patch-Clamp Techniques

2001