betadex and 8-nitroguanine
betadex has been researched along with 8-nitroguanine* in 1 studies
Other Studies
1 other study(ies) available for betadex and 8-nitroguanine
Article | Year |
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Nitrative DNA damage in cultured macrophages exposed to indium oxide.
Indium compounds are used in manufacturing displays of mobile phones and televisions. However, these materials cause interstitial pneumonia in exposed workers. Animal experiments demonstrated that indium compounds caused lung cancer. Chronic inflammation is considered to play a role in lung carcinogenesis and fibrosis induced by particulate matters. 8-Nitroguanine (8-nitroG) is a mutagenic DNA lesion formed during inflammation and may participate in carcinogenesis. To clarify the mechanism of carcinogenesis, we examined 8-nitroG formation in indium-exposed cultured cells.. We treated RAW 264.7 mouse macrophages with indium oxide (In. In. These results suggest that endocytosis and NO generation participate in indium-induced 8-nitroG formation. NO released from indium-exposed inflammatory cells may induce DNA damage in adjacent lung epithelial cells and contribute to carcinogenesis. Topics: Amidines; Animals; Benzylamines; beta-Cyclodextrins; Cadaverine; Cells, Cultured; DNA Damage; Dose-Response Relationship, Drug; Guanine; Immunohistochemistry; Indium; Macrophages; Mice; Nanoparticles; Nitric Oxide; Nitric Oxide Synthase Type II; Particle Size | 2018 |