betadex has been researched along with 6-chloro-2-pyridylmethyl-nitrate* in 1 studies
1 other study(ies) available for betadex and 6-chloro-2-pyridylmethyl-nitrate
| Article | Year |
|---|---|
Moisture adsorption-desorption effect on the structure of inclusion complex of 6-chloro-2-pyridylmethyl nitrate and beta-cyclodextrin.
A new anti-anginal drug, 6-chloro-2-pyridylmethyl nitrate (FR46171), was found to form a complex with beta-cyclodextrin (beta-CyD), molecular ratio 1:1. The FR46171/beta-CyD complex thus prepared showed a moisture adsorption-desorption hysteresis characteristic of hydrophilic polymers. The moisture adsorption-desorption isotherm and differential scanning calorimetry indicated that the moisture adsorbed FR46171/beta-CyD complex includes 13-15 mol of water while the moisture desorbed complex includes 5 mol of water. X-ray diffraction patterns of these samples confirmed their different structures. The scanning electron photomicrographs and the surface areas (BET) suggested that the moisture adsorption-desorption hysteresis observed in FR46171/beta-CyD complex can be attributed to reversible hydrogen bonding between water molecules and hydroxyl groups. Topics: Adsorption; beta-Cyclodextrins; Chemical Phenomena; Chemistry, Physical; Cyclodextrins; Differential Thermal Analysis; Humidity; Microscopy, Electron, Scanning; Pyridines; X-Ray Diffraction | 1990 |