betadex and 4-hydroxybenzoic-acid

betadex has been researched along with 4-hydroxybenzoic-acid* in 2 studies

Other Studies

2 other study(ies) available for betadex and 4-hydroxybenzoic-acid

Article	Year
A method of detecting two tumor markers (p-hydroxybenzoic acid and p-cresol) in human urine using a porous magnetic -cyclodextrine polymer as solid phase extractant, an alternative for early gastric cancer diagnosis. Talanta, 2019, Jan-01, Volume: 191 Analyzing of tumor markers has become an important means for cancer diagnosis and prevention. In this study, a novel solid phase extraction based on porous magnetic cyclodextrin polymer (MA-CD) was developed and used for detection of trace small molecule gastric tumor markers in urine samples. The adsorption properties of the magnetic cyclodextrin polymer were tested. Through experiments of the solid phase extraction (SPE) at the different condition, the optimal condition was selected to test the two tumor markers by High-performance-liquid chromatography -Diode array detector (HPLC-DAD). The analytical performance of the method showed good accuracy (88.82%-104.34%) and precision (< 3.55%), appropriated detection limits (1.016 and 5.714 μg L Topics: Adsorption; beta-Cyclodextrins; Biomarkers, Tumor; Cresols; Early Detection of Cancer; Humans; Hydrogen-Ion Concentration; Kinetics; Limit of Detection; Magnets; Parabens; Porosity; Solid Phase Extraction; Stomach Neoplasms; Urinalysis	2019
Do cyclodextrins bound to dextran microspheres act as sustained delivery systems of drugs? International journal of pharmaceutics, 2014, Jul-20, Volume: 469, Issue:1 The use of cyclodextrins (CDs) for controlled delivery of drugs is largely presented in the literature. However, the question of whether CDs themselves linked to a polymeric network are able to sustain the release of drugs still persists. Here, CD immobilization within dextran microspheres is reported, and CD-dextran complexes were packed in a glass column and then, the retention time of different drugs and drug model compounds was determined by liquid chromatography. The release profiles of drugs and of drug model compounds (indole, 3-nitrophenol, p-hydroxybenzoic acid, diclofenac), characterized by different values of the retention time (high, moderate or low), were investigated. The release rates were quite high even for drugs that exhibit very high retention time (high association equilibrium constant). Moreover, the volume of the release fluid strongly influences the rate of drug release. As a whole, "the sink conditions" must be continuously maintained, since at each drug concentration in the release medium, equilibrium occurs between the free and the CD-bound drug. Topics: alpha-Cyclodextrins; beta-Cyclodextrins; Chemistry, Pharmaceutical; Chromatography, Liquid; Cyclodextrins; Delayed-Action Preparations; Dextrans; Diclofenac; Drug Carriers; gamma-Cyclodextrins; Indoles; Kinetics; Microspheres; Models, Chemical; Nitrophenols; Parabens; Solubility; Technology, Pharmaceutical	2014

Article

Year

A method of detecting two tumor markers (p-hydroxybenzoic acid and p-cresol) in human urine using a porous magnetic -cyclodextrine polymer as solid phase extractant, an alternative for early gastric cancer diagnosis.

Talanta, 2019, Jan-01, Volume: 191

Analyzing of tumor markers has become an important means for cancer diagnosis and prevention. In this study, a novel solid phase extraction based on porous magnetic cyclodextrin polymer (MA-CD) was developed and used for detection of trace small molecule gastric tumor markers in urine samples. The adsorption properties of the magnetic cyclodextrin polymer were tested. Through experiments of the solid phase extraction (SPE) at the different condition, the optimal condition was selected to test the two tumor markers by High-performance-liquid chromatography -Diode array detector (HPLC-DAD). The analytical performance of the method showed good accuracy (88.82%-104.34%) and precision (< 3.55%), appropriated detection limits (1.016 and 5.714 μg L

Topics: Adsorption; beta-Cyclodextrins; Biomarkers, Tumor; Cresols; Early Detection of Cancer; Humans; Hydrogen-Ion Concentration; Kinetics; Limit of Detection; Magnets; Parabens; Porosity; Solid Phase Extraction; Stomach Neoplasms; Urinalysis

2019

Do cyclodextrins bound to dextran microspheres act as sustained delivery systems of drugs?

International journal of pharmaceutics, 2014, Jul-20, Volume: 469, Issue:1

The use of cyclodextrins (CDs) for controlled delivery of drugs is largely presented in the literature. However, the question of whether CDs themselves linked to a polymeric network are able to sustain the release of drugs still persists. Here, CD immobilization within dextran microspheres is reported, and CD-dextran complexes were packed in a glass column and then, the retention time of different drugs and drug model compounds was determined by liquid chromatography. The release profiles of drugs and of drug model compounds (indole, 3-nitrophenol, p-hydroxybenzoic acid, diclofenac), characterized by different values of the retention time (high, moderate or low), were investigated. The release rates were quite high even for drugs that exhibit very high retention time (high association equilibrium constant). Moreover, the volume of the release fluid strongly influences the rate of drug release. As a whole, "the sink conditions" must be continuously maintained, since at each drug concentration in the release medium, equilibrium occurs between the free and the CD-bound drug.

Topics: alpha-Cyclodextrins; beta-Cyclodextrins; Chemistry, Pharmaceutical; Chromatography, Liquid; Cyclodextrins; Delayed-Action Preparations; Dextrans; Diclofenac; Drug Carriers; gamma-Cyclodextrins; Indoles; Kinetics; Microspheres; Models, Chemical; Nitrophenols; Parabens; Solubility; Technology, Pharmaceutical

2014