beta-nitrostyrene has been researched along with diethyl-malonate* in 1 studies
1 other study(ies) available for beta-nitrostyrene and diethyl-malonate
Article | Year |
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Transition state analysis of an enantioselective Michael addition by a bifunctional thiourea organocatalyst.
The mechanism of the enantioselective Michael addition of diethyl malonate to trans-β-nitrostyrene catalyzed by a tertiary amine thiourea organocatalyst is explored using experimental 13C kinetic isotope effects and density functional theory calculations. Large primary 13C KIEs on the bond-forming carbon atoms of both reactants suggest that carbon-carbon bond formation is the rate-determining step in the catalytic cycle. This work resolves conflicting mechanistic pictures that have emerged from prior experimental and computational studies. Topics: Catalysis; Density Functional Theory; Malonates; Molecular Structure; Stereoisomerism; Styrenes; Thiourea | 2019 |