beta-methyltryptophan and 2-amino-3-phenylbutanoic-acid

beta-methyltryptophan has been researched along with 2-amino-3-phenylbutanoic-acid* in 1 studies

Other Studies

1 other study(ies) available for beta-methyltryptophan and 2-amino-3-phenylbutanoic-acid

ArticleYear
Enantioseparation of beta-methyl-substituted amino acids with cyclodextrins by capillary zone electrophoresis.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008, Nov-01, Volume: 875, Issue:1

    Direct capillary zone electrophoretic methods were developed for the separation of the enantiomers of unnatural beta-methyl-amino acids such as erythro- and threo-beta-methylphenylalanine, beta-methyltyrosine, beta-methyltryptophan and beta-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid. Capillary zone electrophoresis was carried out using sulfopropylated-alpha-CD (SP2-alpha-CD), sulfopropylated-beta-CD (SP2-beta-CD) both with a degree of substitution of 2 moles/mole cyclodextrin, and sulfopropylated-beta-CD (SP4-beta-CD) with a degree of substitution of 4moles/mole beta-cyclodextrin. The effects of selector and buffer concentrations, electrolyte pH and applied voltage were studied on the separation efficiency. Varying the electrophoretic conditions with application of 20 kV, hydrodynamic injection, unmodified silica capillary, three different buffers (borate, phosphate and acetate) and modified cyclodextrins as chiral selectors all compounds investigated are nearly baseline resolved. The elution sequence was determined in most cases.

    Topics: Amino Acids; Aminobutyrates; Cyclodextrins; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Stereoisomerism; Tryptophan; Tyrosine

2008