beta-lapachone has been researched along with dicumarol in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 10 (62.50) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Bomfim, IS; Boothman, DA; Botteselle, GV; Braga, AL; Cavalcanti, BC; da Cruz, EHG; da Silva Júnior, EN; de Simone, CA; Jardim, GAM; Nair, DK; Namboothiri, INN; Pessoa, C; Resende, JM; Silvers, MA | 1 |
| Chen, D; Hao, H; Jiang, S; Ma, K; Wu, X; Zhang, K | 1 |
| Liu, ZP; Ma, X; Wu, LQ; Zhang, C | 1 |
| Boothman, DA; Pink, JJ; Planchon, SM; Siegel, D; Tagliarino, C; Varnes, ME | 1 |
| Boothman, DA; Bornmann, WG; Pink, JJ; Planchon, SM; Tagliarino, C; Varnes, ME | 1 |
| Ahn, KJ; Ahn, SD; Bey, EA; Boothman, DA; Bornmann, WG; Choi, E; Gao, J; Griffin, R; Kim, EJ; Lee, SW; Park, HJ; Song, CW; Williams, B | 1 |
| Ahn, KJ; Ahn, SD; Boothman, DA; Choi, EK; Choi, J; Griffin, R; Ji, IM; Kim, EJ; Kook, YH; Lee, CK; Park, HJ; Song, CW; Williams, B | 1 |
| Bey, EA; Boothman, DA; Dong, Y; Gao, J; Hsieh, JT; Kabbani, W; Li, LS; Xie, XJ; Yan, J | 1 |
| Chen, YH; Cheng, CM; Huang, CJ; Hwang, SP; Lin, CY; Lu, YF; Tsai, MY; Wu, YT | 1 |
| Boothman, DA; Gao, J; Huang, G; Huang, X; Li, L; Luo, X; Ma, X; Wang, Y | 1 |
| Belandia, B; Gadea, J; Menacho-Márquez, M; Murguía, JR; Pérez-Valle, J; Rodríguez-Hernández, CJ; Villaronga, MÁ | 1 |
| Anderson, G; Boothman, DA; Burma, S; Chakrabarti, G; DeBerardinis, RJ; Gao, J; Gerber, DE; Gerson, SL; Ilcheva, M; Liu, L; Liu, Y; Luo, X; Moore, ZR; Sarode, V; Silvers, MA | 1 |
| Beaudoin, JN; Gaskins, HR; Kenis, PJ; Kolossov, VL; Leslie, MT; Ponnuraj, N | 1 |
| Dringen, R; Ehrke, E; Karger, G; Kube, S; Steinmeier, J | 1 |
1 review(s) available for beta-lapachone and dicumarol
| Article | Year |
|---|---|
NAD(P)H:Quinone Oxidoreductase 1 (NQO1) as a Therapeutic and Diagnostic Target in Cancer.
Topics: Antineoplastic Agents; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; NAD(P)H Dehydrogenase (Quinone); Neoplasms; Quinones | 2018 |
15 other study(ies) available for beta-lapachone and dicumarol
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
Synthesis and antitumor activity of selenium-containing quinone-based triazoles possessing two redox centres, and their mechanistic insights.
Topics: Antineoplastic Agents; Benzoquinones; Cell Death; Cell Line, Tumor; Chemistry Techniques, Synthetic; Drug Design; Humans; Leukocytes, Mononuclear; Oxidation-Reduction; Selenium; Structure-Activity Relationship; Triazoles | 2016 |
Design, synthesis, and biological evaluation of 4-substituted-3,4-dihydrobenzo[h]quinoline-2,5,6(1H)-triones as NQO1-directed antitumor agents.
Topics: Animals; Antineoplastic Agents; Apoptosis; Body Weight; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Heterografts; Humans; Mice; Models, Molecular; Molecular Targeted Therapy; NAD(P)H Dehydrogenase (Quinone); Naphthoquinones; Neoplasms, Experimental; Oxidative Stress; Quinolines; Reactive Oxygen Species; Structure-Activity Relationship | 2020 |
NAD(P)H:Quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity.
Topics: Antibiotics, Antineoplastic; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Division; Cytochrome Reductases; Cytochrome-B(5) Reductase; Dicumarol; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Flow Cytometry; Humans; Models, Biological; NAD; NADH, NADPH Oxidoreductases; NADPH-Ferrihemoprotein Reductase; Naphthoquinones; Proteins; Quinone Reductases; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Vitamin K | 2000 |
beta-Lapachone-induced apoptosis in human prostate cancer cells: involvement of NQO1/xip3.
Topics: Antibiotics, Antineoplastic; Apoptosis; Camptothecin; Caspases; Dicumarol; Enzyme Inhibitors; Humans; Male; NAD(P)H Dehydrogenase (Quinone); Naphthoquinones; Poly(ADP-ribose) Polymerases; Prostatic Neoplasms; Transformation, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2001 |
Susceptibility of cancer cells to beta-lapachone is enhanced by ionizing radiation.
Topics: Animals; Cell Line, Tumor; Dicumarol; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Mice; Mice, Inbred C3H; NAD(P)H Dehydrogenase (Quinone); Naphthoquinones; Neoplasm Proteins; Radiation-Sensitizing Agents; Radiation, Ionizing | 2005 |
Heat-induced up-regulation of NAD(P)H:quinone oxidoreductase potentiates anticancer effects of beta-lapachone.
Topics: Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Combined Modality Therapy; Dicumarol; Enzyme Inhibitors; Humans; Hyperthermia, Induced; Mice; NAD(P)H Dehydrogenase (Quinone); Naphthoquinones; Neoplasms; Up-Regulation | 2005 |
Prostate cancer radiosensitization through poly(ADP-Ribose) polymerase-1 hyperactivation.
Topics: Animals; Apoptosis; Cell Death; Colony-Forming Units Assay; Comet Assay; Dicumarol; DNA Damage; DNA, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Glutathione; Humans; In Situ Nick-End Labeling; Male; Mice; Mice, Nude; Naphthoquinones; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Prostatic Neoplasms; Radiation-Sensitizing Agents; Regression Analysis | 2010 |
β-Lapachone induces heart morphogenetic and functional defects by promoting the death of erythrocytes and the endocardium in zebrafish embryos.
Topics: Animals; Apoptosis; Dicumarol; Dimethyl Sulfoxide; Embryonic Development; Endocardium; Erythrocyte Count; Erythrocytes; Gene Expression Regulation, Developmental; Heart; Heart Defects, Congenital; Microscopy, Fluorescence; Morphogenesis; NAD(P)H Dehydrogenase (Quinone); Naphthoquinones; Reactive Oxygen Species; Time-Lapse Imaging; Zebrafish | 2011 |
Prodrug strategy to achieve lyophilizable, high drug loading micelle formulations through diester derivatives of β-Lapachone.
Topics: Cell Line, Tumor; Cell Survival; Dicumarol; Esters; Freeze Drying; Humans; Micelles; NAD(P)H Dehydrogenase (Quinone); Naphthoquinones; Polyethylene Glycols; Polylysine; Prodrugs | 2014 |
eIF2 kinases mediate β-lapachone toxicity in yeast and human cancer cells.
Topics: Antineoplastic Agents; Dicumarol; eIF-2 Kinase; Enzyme Activation; Humans; Immunoblotting; NAD(P)H Dehydrogenase (Quinone); Naphthoquinones; Oligonucleotide Array Sequence Analysis; Protein Serine-Threonine Kinases; Reactive Oxygen Species; RNA, Small Interfering; Saccharomyces cerevisiae Proteins; Saccharomycetales; Tetrazolium Salts; Thiazoles; Transcriptome | 2015 |
Tumor-selective use of DNA base excision repair inhibition in pancreatic cancer using the NQO1 bioactivatable drug, β-lapachone.
Topics: Animals; Autophagy; Catalase; Cell Line, Tumor; Cell Survival; Dicumarol; DNA Breaks, Double-Stranded; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; Female; Humans; Hydroxylamines; Mice; Mice, Nude; NAD(P)H Dehydrogenase (Quinone); Naphthoquinones; Pancreatic Neoplasms; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Transplantation, Heterologous; X-ray Repair Cross Complementing Protein 1 | 2015 |
Distinct responses of compartmentalized glutathione redox potentials to pharmacologic quinones targeting NQO1.
Topics: Antineoplastic Agents; Biosensing Techniques; Cell Line, Tumor; Cytosol; Dicumarol; Fluorescent Dyes; Glutaredoxins; Glutathione; Green Fluorescent Proteins; Humans; Indolequinones; Mitochondria; Molecular Imaging; Molecular Probes; Molecular Targeted Therapy; NAD(P)H Dehydrogenase (Quinone); Naphthoquinones; Oxidation-Reduction; Oxidative Stress; Quinones; Reactive Oxygen Species; Substrate Specificity | 2017 |
β-Lapachone Induces Acute Oxidative Stress in Rat Primary Astrocyte Cultures that is Terminated by the NQO1-Inhibitor Dicoumarol.
Topics: Animals; Astrocytes; Cell Survival; Dicumarol; Enzyme Inhibitors; Glutathione; NAD(P)H Dehydrogenase (Quinone); Naphthoquinones; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Rats, Wistar; Reactive Oxygen Species | 2020 |