Page last updated: 2024-09-04

beta-lactams and trimethoprim

beta-lactams has been researched along with trimethoprim in 21 studies

Compound Research Comparison

Studies (beta-lactams)	Trials (beta-lactams)	Recent Studies (post-2010) (beta-lactams)	Studies (trimethoprim)	Trials (trimethoprim)	Recent Studies (post-2010) (trimethoprim)
7,579	179	3,395	6,989	845	894

Protein Interaction Comparison

Protein	Taxonomy	trimethoprim (IC50)
Chain A, Dihydrofolate reductase	Bacillus anthracis	77200
Chain A, dihydrofolate reductase (DHFR)	Bacillus anthracis	77200
Dihydrofolate reductase	Mycobacterium avium	0.2588
Dihydrofolate reductase	Homo sapiens (human)	1.8206
Dihydrofolate reductase	Lacticaseibacillus casei	0.3493
Dihydrofolate reductase type 1	Escherichia coli	0.25
Dihydrofolate reductase	Neisseria gonorrhoeae	0.45
Thymidylate synthase	Homo sapiens (human)	3.405
Dihydrofolate reductase	Staphylococcus aureus	0.0875
Thymidylate synthase	Escherichia coli K-12	3.405
Dihydrofolate reductase	Escherichia coli K-12	0.6064
Bifunctional dihydrofolate reductase-thymidylate synthase	Plasmodium falciparum K1	0.01
Dihydrofolate reductase type 1 from Tn4003	Staphylococcus aureus	0.023
Dipeptidyl peptidase 4	Rattus norvegicus (Norway rat)	2.7
Dihydrofolate reductase	Pneumocystis carinii	0.7061
Dihydrofolate reductase	Candida albicans	0.1361
Dipeptidyl peptidase 4	Homo sapiens (human)	2.7
5-hydroxytryptamine receptor 2B	Rattus norvegicus (Norway rat)	0.45
Metabotropic glutamate receptor 5	Rattus norvegicus (Norway rat)	2.73
Mu-type opioid receptor	Cavia porcellus (domestic guinea pig)	2.8
Bifunctional dihydrofolate reductase-thymidylate synthase	Toxoplasma gondii	3.2206
Bifunctional dihydrofolate reductase-thymidylate synthase	Plasmodium berghei ANKA	0.12
Dihydrofolate reductase	Streptococcus pneumoniae TIGR4	0.0297
Dihydrofolate reductase	Lactococcus lactis subsp. lactis Il1403	0.45
Dihydrofolate reductase	Bacillus anthracis	4.77
Dihydrofolate reductase	Rattus norvegicus (Norway rat)	1.244
Dihydrofolate reductase	Pneumocystis jirovecii	0.092

Research

Studies (21)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (28.57)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (4.76)	29.6817
2010's	12 (57.14)	24.3611
2020's	2 (9.52)	2.80

Authors

Authors	Studies
Jonsson, M	1
Labthavikul, P; Neu, HC	1
Chin, NX; Neu, HC	1
Grimm, H	1
Garau, J; Liñares, J; Martín, R; Murgui, L; Perez, JL	1
Gombert, ME	1
Harigae, H; Ishikawa, S; Kaku, M; Kanemitsu, K; Kunishima, H; Saga, T; Takemura, H	1
Brown, JR; Huang, J; Ingraham, K; Kumar, V; Li, Y; Palmer, L; Sun, P; Vamathevan, J	1
Blazquez, J; Briales, A; Díaz de Alba, P; Machuca, J; Pascual, A; Rodriguez-Martinez, JM; Velasco, C	1
Burian, A; Erdogan, Z; Jandrisits, C; Zeitlinger, M	1
Amyes, SG; Duffy, B; Walsh, F	1
Cadieux, PA; Denstedt, JD; Li, H; Wang, K; Yang, L	1
Hartmann, M; Honscha, W; Käsbohrer, A; Kreienbrock, L; Merle, R; Ottilie, H; van Rennings, L; von Münchhausen, C	1
Amer, AM; Badr, JM; Osman, KM; Saad, AS	1
Angelin, M; Bengtsson-Palme, J; Huss, M; Johansson, A; Kjellqvist, S; Kristiansson, E; Larsson, DG; Palmgren, H	1
Bakour, R; Bonnet, R; Hamidi, M; Messai, Y; Robin, F; Yahiaoui, M	1
Beljantseva, J; Cava, F; Del Peso Santos, T; Dzhygyr, I; Hauryliuk, V; Kudrin, P; Oliveira, SR; Rejman, D; Tenson, T; Varik, V	1
Becker, K; Idelevich, EA; Kriegeskorte, A; Peters, G; Schleimer, N; von Eiff, C	1
Andersson, R; Birindwa, AM; Cibicabene, D; Emgård, M; Geravandi, S; Gonzales-Siles, L; Kabeza, N; Kashosi, T; Lindh, M; Manegabe, JT; Mirindi, J; Morisho, L; Muhigirwa, B; Munguakonkwa, E; Mwambanyi, B; Nordén, R; Samuelsson, E; Skovbjerg, S	1
Emami, S; Lerno, LA; Taha, AY	1
Jantharadej, K; Kongprajug, A; Limpiyakorn, T; Mhuantong, W; Mongkolsuk, S; Sirikanchana, K; Suwannasilp, BB	1

Trials

1 trial(s) available for beta-lactams and trimethoprim

Article	Year
Is chloramphenicol the drug of choice for the treatment of enteric fever? Comparative studies on the effects of chloramphenicol, trimethoprim-sulphametoxazole and beta-lactam antibiotics. Infection, 1974, Volume: 2, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Ampicillin; Anti-Bacterial Agents; Azepines; beta-Lactams; Carrier State; Chloramphenicol; Drug Evaluation; Extrachromosomal Inheritance; Humans; Middle Aged; Paratyphoid Fever; Penicillanic Acid; Penicillin Resistance; Salmonella; Sulfamethoxazole; Time Factors; Trimethoprim; Typhoid Fever; Valerates	1974

Article

Year

Is chloramphenicol the drug of choice for the treatment of enteric fever? Comparative studies on the effects of chloramphenicol, trimethoprim-sulphametoxazole and beta-lactam antibiotics.

Infection, 1974, Volume: 2, Issue:3

Topics: Administration, Oral; Adolescent; Adult; Ampicillin; Anti-Bacterial Agents; Azepines; beta-Lactams; Carrier State; Chloramphenicol; Drug Evaluation; Extrachromosomal Inheritance; Humans; Middle Aged; Paratyphoid Fever; Penicillanic Acid; Penicillin Resistance; Salmonella; Sulfamethoxazole; Time Factors; Trimethoprim; Typhoid Fever; Valerates

1974

Other Studies

20 other study(ies) available for beta-lactams and trimethoprim

Article	Year
In vitro activity of norfloxacin, a quinolinecarboxylic acid, compared with that of beta-lactams, aminoglycosides, and trimethoprim. Antimicrobial agents and chemotherapy, 1982, Volume: 22, Issue:1 Topics: Aminoglycosides; Anti-Bacterial Agents; Bacteria; Bacterial Infections; beta-Lactams; Microbial Sensitivity Tests; Nalidixic Acid; Norfloxacin; Trimethoprim	1982
In vitro activity of enoxacin, a quinolone carboxylic acid, compared with those of norfloxacin, new beta-lactams, aminoglycosides, and trimethoprim. Antimicrobial agents and chemotherapy, 1983, Volume: 24, Issue:5 Topics: Aminoglycosides; Anti-Bacterial Agents; beta-Lactams; Colony-Forming Units Assay; Drug Resistance, Microbial; Drug Synergism; Enoxacin; Microbial Sensitivity Tests; Mutagens; Nalidixic Acid; Naphthyridines; Norfloxacin; Pseudomonas aeruginosa; Trimethoprim	1983
Sensitivity of enterococci to beta-lactam antibiotics, co-trimoxazole, nitrofurantoin, tetracycline and doxycycline. Arzneimittel-Forschung, 1983, Volume: 33, Issue:3 Topics: Anti-Bacterial Agents; beta-Lactams; Diffusion; Doxycycline; Drug Combinations; Enterobacteriaceae; Nitrofurantoin; Sulfamethoxazole; Tetracycline; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination	1983
Comparative susceptibilities of penicillin-resistant pneumococci to co-trimoxazole, vancomycin, rifampicin and fourteen beta-lactam antibiotics. The Journal of antimicrobial chemotherapy, 1984, Volume: 13, Issue:4 Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents, Urinary; beta-Lactams; Carrier State; Child; Drug Combinations; Drug Resistance, Microbial; Humans; Microbial Sensitivity Tests; Penicillin Resistance; Pneumococcal Infections; Rifampin; Streptococcus pneumoniae; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Vancomycin	1984
Susceptibility of Nocardia asteroides to various antibiotics, including newer beta-lactams, trimethoprim-sulfamethoxazole, amikacin, and N-formimidoyl thienamycin. Antimicrobial agents and chemotherapy, 1982, Volume: 21, Issue:6 Topics: Amikacin; Anti-Bacterial Agents; beta-Lactams; Drug Combinations; Imipenem; Microbial Sensitivity Tests; Nocardia asteroides; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination	1982
Efficacy of amikacin combinations for nocardiosis. The Tohoku journal of experimental medicine, 2003, Volume: 201, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Amikacin; Anti-Bacterial Agents; beta-Lactams; Cefotaxime; Ciprofloxacin; DNA, Ribosomal; Drug Therapy, Combination; Erythromycin; Female; Fluoroquinolones; Gram-Positive Bacteria; Humans; Imipenem; Lactams; Male; Middle Aged; Minocycline; Nocardia; Nocardia Infections; RNA, Ribosomal, 16S; Streptomyces; Sulfamethoxazole; Trimethoprim	2003
Comparative genomics of Klebsiella pneumoniae strains with different antibiotic resistance profiles. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:9 Topics: Aminoglycosides; beta-Lactams; Drug Resistance, Multiple, Bacterial; Fluoroquinolones; Genome, Bacterial; Genomics; Klebsiella pneumoniae; Sulfamethoxazole; Trimethoprim	2011
Exposure to diverse antimicrobials induces the expression of qnrB1, qnrD and smaqnr genes by SOS-dependent regulation. The Journal of antimicrobial chemotherapy, 2012, Volume: 67, Issue:12 Topics: Anti-Bacterial Agents; Artificial Gene Fusion; Bacterial Proteins; beta-Lactams; Escherichia coli; Fluoroquinolones; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Genes, Reporter; Green Fluorescent Proteins; Microbial Sensitivity Tests; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Serratia marcescens; SOS Response, Genetics; Trimethoprim	2012
Impact of pH on activity of trimethoprim, fosfomycin, amikacin, colistin and ertapenem in human urine. Pharmacology, 2012, Volume: 90, Issue:5-6 Topics: Amikacin; Anti-Bacterial Agents; Bacteria; beta-Lactams; Colistin; Ertapenem; Fosfomycin; Humans; Hydrogen-Ion Concentration; Microbial Sensitivity Tests; Trimethoprim; Urine	2012
Challenging the concept of bacteria subsisting on antibiotics. International journal of antimicrobial agents, 2013, Volume: 41, Issue:6 Topics: Anti-Bacterial Agents; Bacteria; beta-Lactams; Biotransformation; Chromatography, High Pressure Liquid; Drug Resistance, Bacterial; Energy Metabolism; Soil Microbiology; Streptomycin; Trimethoprim	2013
The influence of urinary pH on antibiotic efficacy against bacterial uropathogens. Urology, 2014, Volume: 84, Issue:3 Topics: Aminoglycosides; Anti-Bacterial Agents; Bacteria; beta-Lactams; Diffusion; Drug Resistance, Bacterial; Humans; Hydrogen-Ion Concentration; Macrolides; Microbial Sensitivity Tests; Nitrofurantoin; Quinolines; Sulfonamides; Tetracyclines; Trimethoprim; Urine	2014
Cross-sectional study on antibiotic usage in pigs in Germany. PloS one, 2015, Volume: 10, Issue:3 Topics: Age Factors; Animal Husbandry; Animals; Anti-Bacterial Agents; beta-Lactams; Cross-Sectional Studies; Drug Administration Schedule; Drug Combinations; Drug Resistance, Bacterial; Female; Germany; Macrolides; Male; Reproductive Tract Infections; Respiratory Tract Infections; Retrospective Studies; Sulfadoxine; Swine; Tetracyclines; Trimethoprim	2015
Prevalence and antimicrobial resistance profile of Staphylococcus species in chicken and beef raw meat in Egypt. Foodborne pathogens and disease, 2015, Volume: 12, Issue:5 Topics: Animals; Anti-Bacterial Agents; beta-Lactams; Cattle; Chickens; Drug Resistance, Multiple, Bacterial; Egypt; Food Contamination; Food Microbiology; Meat; Microbial Sensitivity Tests; Penicillins; Red Meat; Staphylococcus; Staphylococcus aureus; Sulfamethoxazole; Trimethoprim; Vancomycin; Vancomycin Resistance	2015
The Human Gut Microbiome as a Transporter of Antibiotic Resistance Genes between Continents. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:10 Topics: Adult; Anti-Bacterial Agents; beta-Lactams; Drug Resistance, Microbial; Escherichia coli; Feces; Female; Gastrointestinal Microbiome; Humans; Male; Metagenomics; Microbial Sensitivity Tests; Proteobacteria; Sulfonamides; Trimethoprim; Young Adult	2015
Antibiotic Resistance, Virulence, and Genetic Background of Community-Acquired Uropathogenic Escherichia coli from Algeria. Microbial drug resistance (Larchmont, N.Y.), 2015, Volume: 21, Issue:5 Topics: Adult; Aged; Algeria; Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Community-Acquired Infections; DNA Gyrase; DNA Topoisomerase IV; Drug Resistance, Multiple, Bacterial; Escherichia coli Infections; Female; Fluoroquinolones; Gene Expression; Genotype; Humans; Integrons; Male; Microbial Sensitivity Tests; Middle Aged; Multilocus Sequence Typing; Mutation; Phylogeny; Polymerase Chain Reaction; Sulfonamides; Trimethoprim; Uropathogenic Escherichia coli; Virulence	2015
Subinhibitory Concentrations of Bacteriostatic Antibiotics Induce Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:4 Topics: Anti-Bacterial Agents; beta-Lactams; Chloramphenicol; Drug Interactions; Drug Tolerance; Escherichia coli; Guanosine Tetraphosphate; Isoleucine-tRNA Ligase; Ligases; Mupirocin; Protein Biosynthesis; Ribosomes; RNA, Transfer; Subcellular Fractions; Tetracycline; Tetrahydrofolate Dehydrogenase; Thiostrepton; Trimethoprim	2017
Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:4 Topics: Anti-Bacterial Agents; beta-Lactams; Daptomycin; Lincosamides; Linezolid; Microbial Sensitivity Tests; Staphylococcus aureus; Trimethoprim	2018
High rate of antibiotic resistance among pneumococci carried by healthy children in the eastern part of the Democratic Republic of the Congo. BMC pediatrics, 2018, 11-19, Volume: 18, Issue:1 Topics: beta-Lactams; Child, Preschool; Democratic Republic of the Congo; Drug Combinations; Drug Resistance, Bacterial; Female; Humans; Immunodiffusion; Infant; Male; Microbial Sensitivity Tests; Nasopharynx; Pneumococcal Vaccines; Serotyping; Streptococcus pneumoniae; Sulfadoxine; Trimethoprim; Vaccines, Conjugate	2018
Antibiotic standards stored as a mixture in water: methanol are unstable at various temperatures irrespective of pH and glass container silanization. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 2022, Volume: 39, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactams; Chromatography, High Pressure Liquid; Fluoroquinolones; Hydrogen-Ion Concentration; Macrolides; Methanol; Sulfadiazine; Tandem Mass Spectrometry; Temperature; Tetracyclines; Trimethoprim; Water	2022
Comparative genomic analyses of pathogenic bacteria and viruses and antimicrobial resistance genes in an urban transportation canal. The Science of the total environment, 2022, Nov-20, Volume: 848 Topics: Aminoglycosides; Anti-Bacterial Agents; Bacteria; Bacteriophages; beta-Lactams; Drug Resistance, Bacterial; Humans; Macrolides; Metagenomics; RNA, Ribosomal, 16S; Sulfonamides; Tetracycline; Transportation; Trimethoprim; Water	2022