Page last updated: 2024-09-04

beta-lactams and sulbactam

beta-lactams has been researched along with sulbactam in 53 studies

Compound Research Comparison

Studies (beta-lactams)	Trials (beta-lactams)	Recent Studies (post-2010) (beta-lactams)	Studies (sulbactam)	Trials (sulbactam)	Recent Studies (post-2010) (sulbactam)
7,579	179	3,395	1,844	297	488

Protein Interaction Comparison

Protein	Taxonomy	sulbactam (IC50)
Beta-lactamase	Escherichia coli	6.2
Beta-lactamase	Shouchella clausii	0.075
Beta-lactamase	Pseudomonas aeruginosa	0.37
Beta-lactamase	Pseudomonas aeruginosa	3
Beta-lactamase	Aeromonas allosaccharophila	4
Beta-lactamase	Staphylococcus aureus	6.5
Beta-lactamase	Enterobacter cloacae	1.4
Beta-lactamase TEM	Escherichia coli	4.3
Beta-lactamase	Acinetobacter pittii	1.12
Beta-lactamase	Acinetobacter pittii	7.758
Beta-lactamase	Pseudomonas aeruginosa	3
Beta-lactamase	Escherichia coli	2.4

Research

Studies (53)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (16.98)	18.7374
1990's	7 (13.21)	18.2507
2000's	14 (26.42)	29.6817
2010's	20 (37.74)	24.3611
2020's	3 (5.66)	2.80

Authors

Authors	Studies
Kunii, O; Nishiya, H	1
Coleman, K; Griffin, DR; Page, JW; Upshon, PA	1
Easton, CJ; Knowles, JR	1
Belasco, JG; Charnas, RL; Fisher, J; Khosla, S; Knowles, JR	1
Andrews, JM; Bedford, KA; Wise, R	1
Fu, KP; Neu, HC	2
Li, JT; Moosdeen, F; Williams, JD	1
Baumgärtner, M; Wundt, W	1
Fass, RJ	1
Frère, JM; Ghuysen, MF; Matagne, A	1
Inoue, E; Mitsuhashi, S; Muratani, T; Nakane, T; Yokota, E	1
Jin, YF; Piddock, LJ; Turner, HL	1
Kato, H; Kato, N; Tanaka, Y; Tanaka-Bandoh, K; Ueno, K; Watanabe, K	1
Giakkoupi, P; Legakis, NJ; Tzelepi, E; Tzouvelekis, LS	1
Degnan, BA; Farmer, TH; Payne, DJ	1
Karasawa, T; Kuriyama, T; Nakagawa, K; Nakamura, S; Yamamoto, E	1
Lin, YI; Mansour, TS; Prashad, AS; Sandanayaka, VP; Williamson, RT; Yang, Y	1
Singh, GS	1
Higgins, PG; Seifert, H; Stefanik, D; Wisplinghoff, H	1
Chmela, Z; Hejnar, P; Kolár, M	1
Lee, WS; Lin, ML; Liu, CY; Wang, FD	1
Brauers, J; Frank, U; Kresken, M; Rodloff, AC; Seifert, H	1
Barcelona, L; Marín, M; Stamboulian, D	1
Levin, AS; Oliveira, MS	1
Iguchi, A; Kaneda, M; Kobayashi, R; Nakajima, M; Sato, T	1
Kuo, HY; Lin, ML; Liu, CY; Wang, FD; Yen, YF	1
Citron, DM; Elgourt, T; Goldstein, EJ; Lu, S; Meibohm, AR; Peraino, V	1
Arakawa, S; Fujisawa, M; Shigemura, K; Yamashita, M; Yasufuku, T	1
Ishibashi, Y; Kitamura, J; Sakane, T; Sato, H; Sato, M; Shimada, T; Takahashi, N; Tanabe, K; Yoshitomi, H	1
Bonomo, RA; Distler, AM; Endimiani, A; Hornick, JM; Hujer, AM; Hujer, KM; Papp-Wallace, KM; Taracila, M	1
dos Santos, RP; Goldani, LZ; Jacoby, T	1
Ansaloni, L; Catena, F; Coccolini, F; Di Saverio, S; Ercolani, G; Gazzotti, F; Lazzareschi, D; Pinna, AD	1
Chen, CP; Chen, TL; Fung, CP; Huang, LJ; Kuo, SC; Lee, YT; Liang-Yu, C; Liu, CY; Luo, BS	1
Abuzenadah, AM; Alam, Q; Azhar, EI; Damanhouri, GA; Jabir, NR; Kamal, MA; Shakil, S; Tabrez, S	1
Antunes, NT; Frase, H; Toth, M; Vakulenko, SB; Vakulenko, V	1
Bonomo, RA; Buynak, JD; Chai, W; Gatta, J; Han, S; Harris, ME; Lacey, BM; Papp-Wallace, KM; Rice, LB; Senkfor, B; Shanmugasundaram, V; Skalweit, MJ; Taracila, MA; Tomaras, AP; Zaniewski, RP	1
Chen, Y; Du, X; Fu, Y; Ji, J; Wang, H; Yu, Y	1
Chaudhary, M; Kumar, S; Payasi, A	1
Amaduzzi, A; Ansaloni, L; Baiocchi, GL; Catena, F; Coccolini, F; Cucchi, M; Di Saverio, S; Lazzareschi, D; Pasqualini, E; Pinna, AD; Sartelli, M; Schiavina, R; Vallicelli, C	1
Bandettini, R; Buffa, P; Castagnola, E; Caviglia, I; Ciucci, A; Ginocchio, F; Guida, E; Haupt, R; Loy, A; Masa, DL; Mattioli, G; Perotti, M; Pini Prato, A	1
dos Santos, VM; Ferrer, M; Friedrichs, AK; Heinsen, FA; Knecht, C; Knecht, H; Neulinger, SC; Ott, SJ; Rosenstiel, PC; Schilhabel, A; Schmitz, RA; Schreiber, S; Zimmermann, A	1
Altay, MA; Baur, DA; Flores-Hidalgo, A; Ort, Y; Quereshy, FA	1
Gentry, CA; Williams, RJ	1
Badal, RE; Cao, B; Chen, S; Chu, Y; Duan, Q; Feng, X; Gui, B; Hu, B; Hu, Z; Huang, W; Kong, H; Liao, K; Luo, Y; Ni, Y; Shao, H; Su, J; Sun, Z; Wang, Y; Wu, A; Xu, Y; Yang, Q; Yu, Y; Zhang, H; Zhang, S	1
Görür, K; İsmi, O; Özcan, C; Vayisoğlu, Y; Yeşilova, M	1
Andrews, B; Bifulco, N; Carter, NM; Chen, B; Comita-Prevoir, J; de Jonge, B; Durand-Réville, TF; Ehmann, DE; Gao, N; Giacobbe, RA; Guler, S; Huynh, H; Lahiri, S; McLaughlin, R; McLeod, SM; Miller, AA; Moussa, SH; Mueller, JP; Newman, JV; O'Donnell, J; Olivier, NB; Palmer, T; Shapiro, AB; Thresher, J; Tommasi, RA; Velez-Vega, C	1
Baldini, LM; Gold, HS; Snyder, GM; Stack, CM; Wright, SB	1
Guo, Q; Hu, F; Li, Y; Su, J; Wang, M; Wu, S; Xu, S	1
Alshehri, FS; Hakami, AY; Sari, Y	1
Chai, J; Chen, S; Cheng, Q; Wai Chi Chan, E; Xu, C; Zhang, R	1
Bar-David, E; Ben-Shmuel, A; Glinert, I; Kobiler, D; Levy, H; Schlomovitz, J; Sittner, A; Weiss, S	1
Cardoso, MH; Costa, BO; Franco, OL	1

Reviews

6 review(s) available for beta-lactams and sulbactam

Article	Year
[Beta lactamase inhibitors, a new start of antibiotic therapy]. Deutsche medizinische Wochenschrift (1946), 1982, Aug-27, Volume: 107, Issue:34 Topics: beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Drug Resistance, Microbial; Humans; Kinetics; Penicillanic Acid; Sulbactam	1982
Beta-lactams in the new millennium. Part-II: cephems, oxacephems, penams and sulbactam. Mini reviews in medicinal chemistry, 2004, Volume: 4, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactams; Structure-Activity Relationship; Sulbactam	2004
[Betalactam antibiotics combined with bectalactamases inhibitors. Amoxicillin-sulbactam]. Medicina, 2008, Volume: 68, Issue:1 Topics: Amoxicillin; Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Community-Acquired Infections; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Enzyme Inhibitors; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Microbial Sensitivity Tests; Penicillin Resistance; Pneumonia, Bacterial; Pulmonary Disease, Chronic Obstructive; Sulbactam	2008
The challenge of multidrug resistance: the treatment of gram-negative rod infections. Shock (Augusta, Ga.), 2008, Volume: 30 Suppl 1 Topics: Acinetobacter; Bacterial Infections; beta-Lactamases; beta-Lactams; Clinical Trials as Topic; Drug Resistance, Multiple; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae; Ertapenem; Gram-Negative Bacteria; Humans; Microbial Sensitivity Tests; Minocycline; Polymyxins; Pseudomonas aeruginosa; Sulbactam; Tigecycline	2008
New Delhi metallo-β-lactamase (NDM-1): an update. Journal of chemotherapy (Florence, Italy), 2011, Volume: 23, Issue:5 Topics: Anti-Bacterial Agents; Azabicyclo Compounds; Aztreonam; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Biotransformation; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Enzyme Inhibitors; Global Health; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Molecular Targeted Therapy; Sulbactam	2011
Development of Peptides that Inhibit Aminoglycoside-Modifying Enzymes and β-Lactamases for Control of Resistant Bacteria. Current protein & peptide science, 2020, Volume: 21, Issue:10 Topics: Aminoglycosides; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Bacterial Infections; beta-Lactamases; beta-Lactams; Clavulanic Acid; Drug Design; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Kanamycin Kinase; Nucleotidyltransferases; Sulbactam; Tazobactam	2020

Trials

3 trial(s) available for beta-lactams and sulbactam

Article	Year
Piperacillin/tazobactam plus ceftazidime versus sulbactam/ampicillin plus aztreonam as empirical therapy for fever in severely neutropenic pediatric patients. Journal of pediatric hematology/oncology, 2009, Volume: 31, Issue:4 Topics: Adolescent; Ampicillin; Anti-Bacterial Agents; Aztreonam; beta-Lactams; Ceftazidime; Child; Child, Preschool; Drug Therapy, Combination; Female; Fever; Humans; Infant; Infant, Newborn; Male; Neoplasms; Neutropenia; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Severity of Illness Index; Sulbactam	2009
A prospective, multi centre, randomized clinical study to compare the efficacy and safety of Ertapenem 3 days versus Ampicillin-Sulbactam 3 days in the treatment of localized community acquired intra-abdominal infection. (T.E.A. Study: Three days Ertapene BMC gastroenterology, 2011, Apr-18, Volume: 11 Topics: Abdomen; Adult; Ampicillin; Anti-Bacterial Agents; Bacterial Infections; beta-Lactams; Clinical Protocols; Community-Acquired Infections; Drug Therapy, Combination; Ertapenem; Humans; Peritonitis; Sulbactam	2011
T.E.A. Study: three-day ertapenem versus three-day Ampicillin-Sulbactam. BMC gastroenterology, 2013, Apr-30, Volume: 13 Topics: Ampicillin; Anti-Bacterial Agents; beta-Lactams; Chi-Square Distribution; Drug Administration Schedule; Ertapenem; Female; Humans; Male; Middle Aged; Peritonitis; Sulbactam; Surgical Wound Infection; Treatment Outcome	2013

Other Studies

44 other study(ies) available for beta-lactams and sulbactam

Article	Year
[Beta-lactamase inhibitors]. Nihon rinsho. Japanese journal of clinical medicine, 1991, Volume: 49, Issue:9 Topics: Anti-Bacterial Agents; Bacteria; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Binding Sites; Binding, Competitive; Clavulanic Acids; Drug Resistance, Microbial; Hydrolysis; Lactams; Sulbactam	1991
In vitro evaluation of BRL 42715, a novel beta-lactamase inhibitor. Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:9 Topics: Amoxicillin; Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acids; Drug Synergism; Lactams; Microbial Sensitivity Tests; Sulbactam	1989
Correlation of the effect of beta-lactamase inhibitors on the beta-lactamase in growing cultures of gram-negative bacteria with their effect on the isolated beta-lactamase. Antimicrobial agents and chemotherapy, 1984, Volume: 26, Issue:3 Topics: Ampicillin; Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acids; Lactams; Penicillanic Acid; Penicillins; Sulbactam	1984
Beta-lactamase inactivation by mechanism-based reagents. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 1980, May-16, Volume: 289, Issue:1036 Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Lactams; Penicillanic Acid; Sulbactam	1980
Clavulanic acid and CP-45,899: a comparison of their in vitro activity in combination with penicillins. The Journal of antimicrobial chemotherapy, 1980, Volume: 6, Issue:2 Topics: Bacteria; Bacteroides fragilis; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Enterobacteriaceae; Haemophilus influenzae; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Penicillanic Acid; Penicillins; Pseudomonas aeruginosa; Staphylococcus aureus; Sulbactam	1980
Synergistic activity of piperacillin in combination with beta-lactamase inhibitors. Antimicrobial agents and chemotherapy, 1980, Volume: 18, Issue:4 Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Drug Synergism; Penicillanic Acid; Penicillins; Piperacillin; Sulbactam	1980
Synergistic activity of cefoperazone in combination with beta-lactamase inhibitors. The Journal of antimicrobial chemotherapy, 1981, Volume: 7, Issue:3 Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactams; Cefoperazone; Cefotaxime; Cephalosporins; Clavulanic Acid; Drug Synergism; Penicillanic Acid; Sulbactam	1981
The effect of inhibitors of beta-lactamases on beta-lactamase extracts and on intact cells. The Journal of antimicrobial chemotherapy, 1982, Volume: 9, Issue:4 Topics: Ampicillin; Bacteria; beta-Lactamase Inhibitors; beta-Lactams; Cephaloridine; Clavulanic Acid; Hydrolysis; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam	1982
Inconsistency of synergy between the beta-lactamase inhibitor CP-45,899 and beta-lactam antibiotics against multiply drug-resistant Enterobacteriaceae and pseudomonas species. Antimicrobial agents and chemotherapy, 1981, Volume: 19, Issue:2 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Drug Resistance, Microbial; Drug Synergism; Enterobacteriaceae; Microbial Sensitivity Tests; Penicillanic Acid; Pseudomonas; Sulbactam	1981
Interactions between active-site-serine beta-lactamases and mechanism-based inactivators: a kinetic study and an overview. The Biochemical journal, 1993, Nov-01, Volume: 295 ( Pt 3) Topics: Actinomycetales; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Binding Sites; Clavulanic Acid; Clavulanic Acids; Hydrolysis; Kinetics; Lactams; Serine; Streptomyces; Sulbactam	1993
In-vitro evaluation of the four beta-lactamase inhibitors: BRL42715, clavulanic acid, sulbactam, and tazobactam. The Journal of antimicrobial chemotherapy, 1993, Volume: 32, Issue:3 Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Clavulanic Acids; Drug Resistance, Microbial; Escherichia coli; Lactams; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	1993
Activity of 13 beta-lactam agents combined with BRL 42715 against beta-lactamase producing gram-negative bacteria compared to combinations with clavulanic acid, tazobactam and sulbactam. The Journal of antimicrobial chemotherapy, 1993, Volume: 31, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Clavulanic Acids; Drug Therapy, Combination; Enzyme Inhibitors; Gram-Negative Bacteria; Lactams; Penicillanic Acid; Sulbactam; Tazobactam	1993
[In vitro activities of sulopenem, a new parenteral penem, against anaerobes]. The Japanese journal of antibiotics, 1996, Volume: 49, Issue:4 Topics: Ampicillin; Animals; Anti-Bacterial Agents; Bacteria, Anaerobic; beta-Lactamases; beta-Lactams; Cecum; Cefoperazone; Ceftizoxime; Cephalosporins; Clostridioides difficile; Drug Stability; Drug Therapy, Combination; Imipenem; Lactams; Male; Mice; Mice, Inbred ICR; Sulbactam; Thienamycins	1996
Aspartic acid for asparagine substitution at position 276 reduces susceptibility to mechanism-based inhibitors in SHV-1 and SHV-5 beta-lactamases. The Journal of antimicrobial chemotherapy, 1999, Volume: 43, Issue:1 Topics: Amino Acid Substitution; Anti-Bacterial Agents; Asparagine; Aspartic Acid; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Enzyme Inhibitors; Escherichia coli; Inhibitory Concentration 50; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	1999
Penetration of beta-lactamase inhibitors into the periplasm of gram-negative bacteria. FEMS microbiology letters, 1999, Jul-01, Volume: 176, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Cell Membrane Permeability; Clavulanic Acid; Enterobacter cloacae; Enzyme Inhibitors; Escherichia coli; Gram-Negative Bacteria; Klebsiella pneumoniae; Lactams; Penicillanic Acid; Periplasm; Sulbactam; Tazobactam	1999
Antimicrobial susceptibility of major pathogens of orofacial odontogenic infections to 11 beta-lactam antibiotics. Oral microbiology and immunology, 2002, Volume: 17, Issue:5 Topics: Anti-Bacterial Agents; Bacteria; Bacterial Infections; Bacteroidaceae Infections; beta-Lactams; Cefepime; Cefmetazole; Cefoperazone; Cefpirome; Ceftazidime; Ceftizoxime; Cephalosporins; Drug Resistance, Bacterial; Drug Therapy, Combination; Fusobacterium; Fusobacterium Infections; Gram-Positive Bacterial Infections; Humans; Imipenem; Lactams; Microbial Sensitivity Tests; Mouth Diseases; Penicillin G; Penicillins; Peptostreptococcus; Porphyromonas gingivalis; Prevotella; Streptococcal Infections; Streptococcus; Sulbactam	2002
Spirocyclopropyl beta-lactams as mechanism-based inhibitors of serine beta-lactamases. Synthesis by rhodium-catalyzed cyclopropanation of 6-diazopenicillanate sulfone. Journal of medicinal chemistry, 2003, Jun-19, Volume: 46, Issue:13 Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Catalysis; Crystallography, X-Ray; Cyclopropanes; Diazonium Compounds; Enzyme Inhibitors; Escherichia coli; Microbial Sensitivity Tests; Models, Molecular; Pseudomonas aeruginosa; Rhodium; Serine; Serratia marcescens; Spiro Compounds; Structure-Activity Relationship; Sulbactam	2003
In vitro activities of the beta-lactamase inhibitors clavulanic acid, sulbactam, and tazobactam alone or in combination with beta-lactams against epidemiologically characterized multidrug-resistant Acinetobacter baumannii strains. Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:5 Topics: Acinetobacter baumannii; Acinetobacter Infections; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; DNA; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Electrophoresis, Gel, Pulsed-Field; Enzyme Inhibitors; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	2004
Double-disk synergy test positivity in Stenotrophomonas maltophilia clinical strains. Folia microbiologica, 2004, Volume: 49, Issue:1 Topics: Amoxicillin-Potassium Clavulanate Combination; Ampicillin; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Drug Resistance, Bacterial; Drug Synergism; Enzyme Inhibitors; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Stenotrophomonas maltophilia; Sulbactam	2004
In vitro activities of beta-lactam antibiotics alone and in combination with sulbactam against Gram-negative bacteria. International journal of antimicrobial agents, 2004, Volume: 23, Issue:6 Topics: Acinetobacter baumannii; Ampicillin; Anti-Bacterial Agents; Aztreonam; beta-Lactams; Cefepime; Cefoperazone; Cefotaxime; Ceftazidime; Cephalosporins; Drug Combinations; Drug Resistance, Bacterial; Enterobacter cloacae; Enzyme Inhibitors; Gram-Negative Bacteria; Humans; Imipenem; Klebsiella pneumoniae; Microbial Sensitivity Tests; Serratia marcescens; Sulbactam	2004
Activities of various beta-lactams and beta-lactam/beta-lactamase inhibitor combinations against Acinetobacter baumannii and Acinetobacter DNA group 3 strains. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2005, Volume: 11, Issue:1 Topics: Acinetobacter; Acinetobacter baumannii; Acinetobacter calcoaceticus; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Drug Resistance, Bacterial; Drug Therapy, Combination; Enzyme Inhibitors; Humans; Microbial Sensitivity Tests; Sulbactam	2005
In vitro activities of piperacillin or cefoperazone alone and in combination with beta-lactamase inhibitors against gram-negative bacilli. The new microbiologica, 2009, Volume: 32, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Cefoperazone; Drug Therapy, Combination; Enzyme Inhibitors; Gram-Negative Bacteria; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Sulbactam; Tazobactam	2009
Introduction of ertapenem into a hospital formulary: effect on antimicrobial usage and improved in vitro susceptibility of Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:12 Topics: Ampicillin; Anti-Bacterial Agents; beta-Lactams; Ertapenem; Formularies, Hospital as Topic; Humans; Imipenem; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Pseudomonas Infections; Retrospective Studies; Sulbactam	2009
Surgical site infections may be reduced by shorter duration of prophylactic antibiotic medication in urological surgeries. Japanese journal of infectious diseases, 2009, Volume: 62, Issue:6 Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Antibiotic Prophylaxis; beta-Lactams; Female; Humans; Male; Middle Aged; Sulbactam; Surgical Wound Infection; Time Factors; Urologic Surgical Procedures; Young Adult	2009
A case of unforeseen intractable severe bacteremia due to Acinetobacter baumannii--an efficacy of sulbactam--. Japanese journal of infectious diseases, 2009, Volume: 62, Issue:6 Topics: Acinetobacter baumannii; Acinetobacter Infections; Anti-Bacterial Agents; Bacteremia; beta-Lactams; Blood; Female; Humans; Middle Aged; Sulbactam; Treatment Outcome	2009
Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:7 Topics: Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Cephalosporinase; Clavulanic Acid; Computer Simulation; Enzyme Inhibitors; Hydrogen Bonding; Kinetics; Microbial Sensitivity Tests; Molecular Structure; Mutagenesis, Site-Directed; Penicillanic Acid; Protein Structure, Secondary; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Sulbactam; Tazobactam	2010
Antimicrobial stewardship lessons: do Pseudomonas-sparing agents, such as ertapenem, effectively improve bacterial resistance? Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:7 Topics: Ampicillin; Anti-Bacterial Agents; beta-Lactams; Carbapenems; Ertapenem; Humans; Imipenem; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Pseudomonas Infections; Sulbactam	2010
Difference in imipenem, meropenem, sulbactam, and colistin nonsusceptibility trends among three phenotypically undifferentiated Acinetobacter baumannii complex in a medical center in Taiwan, 1997-2007. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 2011, Volume: 44, Issue:5 Topics: Acinetobacter baumannii; Acinetobacter Infections; Anti-Bacterial Agents; Bacteremia; beta-Lactams; Cluster Analysis; Colistin; Drug Resistance, Bacterial; Enzyme Inhibitors; Genotype; Hospitals, Veterans; Humans; Microbial Sensitivity Tests; Multiplex Polymerase Chain Reaction; Sequence Analysis, DNA; Sulbactam; Taiwan	2011
Class A carbapenemase FPH-1 from Francisella philomiragia. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:6 Topics: Bacterial Proteins; beta-Lactamases; beta-Lactams; Carbapenems; Clavulanic Acid; Doripenem; Ertapenem; Escherichia coli; Francisella; Imipenem; Meropenem; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam; Thienamycins	2012
Early insights into the interactions of different β-lactam antibiotics and β-lactamase inhibitors against soluble forms of Acinetobacter baumannii PBP1a and Acinetobacter sp. PBP3. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:11 Topics: Acinetobacter; Acinetobacter baumannii; Ampicillin; Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Biological Assay; Boron Compounds; Enzyme Inhibitors; Humans; Kinetics; Molecular Docking Simulation; Penicillin-Binding Proteins; Penicillins; Solubility; Substrate Specificity; Sulbactam	2012
In vitro activity of sulbactam in combination with imipenem, meropenem, panipenem or cefoperazone against clinical isolates of Acinetobacter baumannii. International journal of antimicrobial agents, 2013, Volume: 41, Issue:4 Topics: Acinetobacter baumannii; Acinetobacter Infections; beta-Lactams; Cefoperazone; Drug Resistance, Bacterial; Drug Therapy, Combination; Humans; Imipenem; Meropenem; Microbial Sensitivity Tests; Sulbactam; Thienamycins	2013
In vitro susceptibilities of clinical isolates of Escherichia coli and Klebsiella species to CSE1034 and other β-lactams. The Journal of antibiotics, 2013, Volume: 66, Issue:8 Topics: Anti-Bacterial Agents; beta-Lactams; Drug Combinations; Drug Resistance, Bacterial; Edetic Acid; Escherichia coli; Escherichia coli Infections; Humans; Klebsiella; Klebsiella Infections; Microbial Sensitivity Tests; Sulbactam	2013
Susceptibility to antibiotics of aerobic bacteria isolated from community acquired secondary peritonitis in children: therapeutic guidelines might not always fit with and everyday experience. Journal of chemotherapy (Florence, Italy), 2013, Volume: 25, Issue:4 Topics: Ampicillin; Anti-Bacterial Agents; Bacterial Infections; beta-Lactams; Child; Community-Acquired Infections; Drug Resistance, Bacterial; Drug Therapy, Combination; Ertapenem; Gentamicins; Hospitals, Pediatric; Humans; Italy; Meropenem; Microbial Sensitivity Tests; Penicillanic Acid; Peritonitis; Piperacillin; Piperacillin, Tazobactam Drug Combination; Practice Guidelines as Topic; Sulbactam; Thienamycins	2013
Effects of β-lactam antibiotics and fluoroquinolones on human gut microbiota in relation to Clostridium difficile associated diarrhea. PloS one, 2014, Volume: 9, Issue:2 Topics: Ampicillin; beta-Lactams; Cephalosporins; Clostridioides difficile; Clostridium Infections; Diarrhea; Fluoroquinolones; Gastrointestinal Tract; Humans; Microbiota; RNA, Ribosomal, 16S; Sulbactam	2014
Chronic osteomyelitis of the mandible: diagnosis and management--an institution's experience over 7 years. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2015, Volume: 73, Issue:4 Topics: Administration, Intravenous; Adult; Age Factors; Aged; Aged, 80 and over; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Ampicillin; Anti-Bacterial Agents; beta-Lactams; Chronic Disease; Clindamycin; Doxycycline; Ertapenem; Female; Follow-Up Studies; Fractures, Spontaneous; Humans; Male; Mandibular Diseases; Mandibular Fractures; Middle Aged; Osteomyelitis; Osteosclerosis; Retrospective Studies; Sulbactam; Treatment Outcome; Vancomycin; Young Adult	2015
Trends in Susceptibility Rates and Extended-Spectrum β-Lactamase Production of Klebsiella pneumoniae in Bloodstream Infections Across the United States Veterans Affairs Healthcare System. Microbial drug resistance (Larchmont, N.Y.), 2015, Volume: 21, Issue:6 Topics: Amikacin; Ampicillin; Anti-Bacterial Agents; Bacteremia; beta-Lactamases; beta-Lactams; Cefepime; Cefoxitin; Ceftazidime; Cephalosporins; Drug Resistance, Multiple, Bacterial; Ertapenem; Fluoroquinolones; Gene Expression Regulation, Bacterial; Humans; Imipenem; Klebsiella Infections; Klebsiella pneumoniae; Microbial Sensitivity Tests; Sulbactam; United States; United States Department of Veterans Affairs	2015
Antimicrobial Susceptibilities of Aerobic and Facultative Gram-Negative Bacilli from Intra-abdominal Infections in Patients from Seven Regions in China in 2012 and 2013. Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:1 Topics: Amikacin; Ampicillin; Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Cefoxitin; China; Ciprofloxacin; Community-Acquired Infections; Cross Infection; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae; Enterobacteriaceae Infections; Ertapenem; Gene Expression; Humans; Imipenem; Intraabdominal Infections; Levofloxacin; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Sulbactam	2016
Difficult Cases of Odontogenic Deep Neck Infections: A Report of Three Patients. Balkan medical journal, 2017, Apr-05, Volume: 34, Issue:2 Topics: Adult; Ampicillin; beta-Lactams; Clindamycin; Drainage; Ertapenem; Focal Infection, Dental; Gentamicins; Humans; Infections; Klebsiella Infections; Male; Middle Aged; Neck; Periodontal Abscess; Streptococcal Infections; Sulbactam	2017
ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii. Nature microbiology, 2017, Jun-30, Volume: 2 Topics: Acinetobacter baumannii; Acinetobacter Infections; Animals; Azabicyclo Compounds; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Carbapenems; Dogs; Drug Design; Drug Evaluation, Preclinical; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Mice; Models, Molecular; Penicillin-Binding Proteins; Rats; Sulbactam	2017
Perioperative antimicrobial prophylaxis and prevention of hepatobiliary surgical site infections. Infection control and hospital epidemiology, 2018, Volume: 39, Issue:9 Topics: Aged; Ampicillin; Anti-Infective Agents; Antibiotic Prophylaxis; beta-Lactams; Boston; Case-Control Studies; Cefazolin; Digestive System Surgical Procedures; Drug Combinations; Female; Humans; Logistic Models; Male; Metronidazole; Middle Aged; Multivariate Analysis; Perioperative Care; Retrospective Studies; Risk Factors; Sulbactam; Surgical Wound Infection	2018
Comparison of empirical therapy with cefoperazone/sulbactam or a carbapenem for bloodstream infections due to ESBL-producing Enterobacteriaceae. The Journal of antimicrobial chemotherapy, 2018, 11-01, Volume: 73, Issue:11 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Carbapenems; Case-Control Studies; Cefoperazone; China; Enterobacteriaceae; Enterobacteriaceae Infections; Female; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Retrospective Studies; Sulbactam	2018
β-lactams modulate astroglial glutamate transporters and attenuate dependence to CP 55,940, a CB1 receptor agonist, in rat model. Behavioural brain research, 2019, 02-01, Volume: 359 Topics: Amino Acid Transport System X-AG; Ampicillin; Animals; Astrocytes; beta-Lactams; Brain; Cannabinoid Receptor Agonists; Central Nervous System Agents; Cyclohexanols; Disease Models, Animal; Drug-Seeking Behavior; Gene Expression; Male; Rats; Receptor, Cannabinoid, CB1; Substance-Related Disorders; Sulbactam	2019
Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S ACS infectious diseases, 2020, 04-10, Volume: 6, Issue:4 Topics: Amino Acid Substitution; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Binding Sites; Catalytic Domain; Clavulanic Acid; Crystallography; Drug Resistance, Multiple, Bacterial; Hydrolysis; Mass Spectrometry; Models, Molecular; Sulbactam	2020
Using old antibiotics to treat ancient bacterium-β-lactams for Bacillus anthracis meningitis. PloS one, 2020, Volume: 15, Issue:2 Topics: Amoxicillin-Potassium Clavulanate Combination; Ampicillin; Animals; Anthrax; Anti-Bacterial Agents; Bacillus anthracis; Bacteria; beta-Lactamase Inhibitors; beta-Lactams; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Meropenem; Microbial Sensitivity Tests; Piperacillin, Tazobactam Drug Combination; Rabbits; Sulbactam	2020