beta-lactams has been researched along with serine in 29 studies
| Studies (beta-lactams) | Trials (beta-lactams) | Recent Studies (post-2010) (beta-lactams) | Studies (serine) | Trials (serine) | Recent Studies (post-2010) (serine) |
|---|---|---|---|---|---|
| 7,579 | 179 | 3,395 | 23,914 | 115 | 6,084 |
| Protein | Taxonomy | beta-lactams (IC50) | serine (IC50) |
|---|---|---|---|
| Acetylcholinesterase | Electrophorus electricus (electric eel) | 0.015 | |
| Cholinesterase | Equus caballus (horse) | 0.016 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (10.34) | 18.7374 |
| 1990's | 7 (24.14) | 18.2507 |
| 2000's | 9 (31.03) | 29.6817 |
| 2010's | 5 (17.24) | 24.3611 |
| 2020's | 5 (17.24) | 2.80 |
| Authors | Studies |
|---|---|
| Frère, JM | 1 |
| Herzberg, O; Moult, J | 1 |
| Aklonis, CA; Gillum, AM; O'Sullivan, J; Souser, ML; Sykes, RB | 1 |
| Dubus, A; Frère, JM; Galleni, M; Knox, JR; Lamotte-Brasseur, J; Monnaie, D; Raquet, X | 1 |
| Nukaga, M; Sawai, T; Tamaki, M | 1 |
| Frère, JM; Ghuysen, MF; Matagne, A | 1 |
| Dubus, A; Frère, JM; Jacobs, C; Monnaie, D; Normark, S | 1 |
| Dalbey, RE; Paetzel, M; Strynadka, NC | 1 |
| Danelon, GO; Laborde, M; Mascaretti, OA; Mata, EG; Setti, EL | 1 |
| Burgess, K; Feng, Y; Pattarawarapan, M; Wang, Z | 1 |
| Meloni, MM; Taddei, M | 1 |
| Cha, JY; Golemi-Kotra, D; Meroueh, SO; Mobashery, S; Vakulenko, SB | 1 |
| Lin, YI; Mansour, TS; Prashad, AS; Sandanayaka, VP; Williamson, RT; Yang, Y | 1 |
| Champelovier, D; Chesnel, L; Croizé, J; Dideberg, O; Lemaire, D; Pernot, L; Vernet, T; Zapun, A | 1 |
| Anderson, VE; Bethel, CR; Bonomo, RA; Helfand, MS; Hujer, AM; Hujer, KM | 1 |
| Avenoza, A; Busto, JH; Jiménez-Osés, G; Peregrina, JM | 1 |
| Bonomo, RA; Buynak, JD; Carey, PR; Helfand, MS; Taracila, MA; Totir, MA; van den Akker, F | 1 |
| Brown, LE; Gerstenberger, BS; Konopelski, JP; Lin, J; Mimieux, YS; Oliver, AG | 1 |
| Fisher, JF; Mobashery, S | 1 |
| McLeish, MJ; Pratt, RF | 1 |
| Andersson, I; Blikstad, C; Demetriades, M; Dubus, A; Généreux, C; Hopkinson, RJ; Iqbal, A; Ivison, D; Kershaw, NJ; Lloyd, AJ; McDonough, MA; Roper, DI; Schofield, CJ; Valegård, K | 1 |
| Gaudelli, NM; Long, DH; Townsend, CA | 1 |
| Ghosh, AS; Mallik, D; Pal, S | 1 |
| Arthur, M; Atze, H; Compain, F; Dubée, V; Dupuis, A; Edoo, Z; Etheve-Quelquejeu, M; Hugonnet, JE; Ourghanlian, C; Sutterlin, L; Triboulet, S | 1 |
| He, Y; Huang, X; Lei, J; Pan, X; Zhao, Y | 1 |
| Aoki, T; Fujiu, M; Kawachi, T; Kohira, N; Komano, K; Kusano, H; Miyagawa, S; Sato, J; Sato, S; Shibuya, S; Yamawaki, K; Yokoo, K | 1 |
| Adapa, SR; Atlas, ZD; Chen, Y; Eswara, PJ; Gatdula, JR; Gelis, I; Gongora, MV; Hammond, LR; Jiang, RHY; Keramisanou, D; Lewandowski, EM; Marty, MT; Morgan, RT; Sacco, MD; Sun, X; Townsend, JA; Wang, J; Wang, S; Zhang, X | 1 |
| Akhtar, F; Ali, A; Farhat, N; Gupta, D; Khan, AU; Khan, F; Kulanthaivel, S; Kumar, Y; Mishra, P | 1 |
| Gyurcsik, B; Hunyadi-Gulyás, É; Nafaee, ZH | 1 |
4 review(s) available for beta-lactams and serine
| Article | Year |
|---|---|
Mechanism of action of beta-lactam antibiotics at the molecular level.
Topics: Actinomycetales; Anti-Bacterial Agents; beta-Lactams; Binding Sites; Carboxypeptidases; Penicillins; Peptidyl Transferases; Protein Binding; Serine | 1977 |
The enigmatic catalytic mechanism of active-site serine beta-lactamases.
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacteria; beta-Lactamases; beta-Lactams; Binding Sites; Carboxypeptidases; Catalysis; Drug Resistance, Microbial; Molecular Sequence Data; Molecular Structure; Serine; Serine-Type D-Ala-D-Ala Carboxypeptidase; Structure-Activity Relationship | 1995 |
Recent advances in the chemistry of beta-lactam compounds as selected active-site serine beta-lactamase inhibitors.
Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Binding Sites; Enzyme Inhibitors; Gram-Negative Bacteria; Hydrolysis; Serine; Stereoisomerism | 1999 |
Three decades of the class A beta-lactamase acyl-enzyme.
Topics: Bacterial Infections; beta-Lactamases; beta-Lactams; Binding Sites; Catalysis; Catalytic Domain; Chemistry, Pharmaceutical; Crystallography, X-Ray; Humans; Hydrolysis; Models, Chemical; Penicillins; Protein Conformation; Serine; Spectrophotometry, Infrared | 2009 |
25 other study(ies) available for beta-lactams and serine
| Article | Year |
|---|---|
Bacterial resistance to beta-lactam antibiotics: crystal structure of beta-lactamase from Staphylococcus aureus PC1 at 2.5 A resolution.
Topics: Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Binding Sites; Biological Evolution; Catalysis; Crystallization; Drug Resistance, Microbial; Endopeptidases; Models, Molecular; Polyethylene Glycols; Protein Conformation; Serine; Serine Endopeptidases; Solvents; Staphylococcus aureus | 1987 |
Biosynthesis of monobactam compounds: origin of the carbon atoms in the beta-lactam ring.
Topics: Aztreonam; Bacteria; beta-Lactams; Cell-Free System; Chemical Phenomena; Chemistry; Culture Media; Cystine; Serine | 1982 |
Replacement of serine 237 in class A beta-lactamase of Proteus vulgaris modifies its unique substrate specificity.
Topics: Alanine; Amino Acid Sequence; Anti-Bacterial Agents; Base Sequence; beta-Lactamases; beta-Lactams; Escherichia coli; Glutamine; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Proteus vulgaris; Sequence Analysis, DNA; Serine; Structure-Activity Relationship; Substrate Specificity | 1994 |
Interactions between active-site-serine beta-lactamases and mechanism-based inactivators: a kinetic study and an overview.
Topics: Actinomycetales; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Binding Sites; Clavulanic Acid; Clavulanic Acids; Hydrolysis; Kinetics; Lactams; Serine; Streptomyces; Sulbactam | 1993 |
A dramatic change in the rate-limiting step of beta-lactam hydrolysis results from the substitution of the active-site serine residue by a cysteine in the class-C beta-lactamase of Enterobacter cloacae 908R.
Topics: Anti-Bacterial Agents; Base Sequence; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Binding Sites; Cysteine; Enterobacter cloacae; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Serine | 1993 |
Crystal structure of a bacterial signal peptidase in complex with a beta-lactam inhibitor.
Topics: Bacterial Proteins; beta-Lactams; Binding Sites; Carboxylic Acids; Crystallography, X-Ray; Escherichia coli; Lactams; Membrane Proteins; Models, Molecular; Peptide Fragments; Protein Conformation; Serine; Serine Endopeptidases; Serine Proteinase Inhibitors | 1998 |
Solid-phase SN2 macrocyclization reactions to form beta-turn mimics.
Topics: beta-Lactams; Chromatography, High Pressure Liquid; Circular Dichroism; Cyclization; Molecular Mimicry; Peptides; Protein Conformation; Proteins; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 1999 |
Solid-phase synthesis of beta-lactams via the Miller hydroxamate approach.
Topics: Anti-Bacterial Agents; beta-Lactams; Hydroxamic Acids; Hydroxylamines; Polystyrenes; Serine; Threonine | 2001 |
Resistance to beta-lactam antibiotics and its mediation by the sensor domain of the transmembrane BlaR signaling pathway in Staphylococcus aureus.
Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Binding Sites; Carbon; Carbon Dioxide; Carrier Proteins; Circular Dichroism; Cloning, Molecular; Cytoplasm; DNA Mutational Analysis; Drug Resistance, Microbial; Escherichia coli; Gene Expression Regulation; Hexosyltransferases; Hydrogen-Ion Concentration; Kinetics; Lysine; Magnetic Resonance Spectroscopy; Models, Biological; Models, Molecular; Muramoylpentapeptide Carboxypeptidase; Penicillin-Binding Proteins; Peptidyl Transferases; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Serine; Signal Transduction; Staphylococcus aureus | 2003 |
Spirocyclopropyl beta-lactams as mechanism-based inhibitors of serine beta-lactamases. Synthesis by rhodium-catalyzed cyclopropanation of 6-diazopenicillanate sulfone.
Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Catalysis; Crystallography, X-Ray; Cyclopropanes; Diazonium Compounds; Enzyme Inhibitors; Escherichia coli; Microbial Sensitivity Tests; Models, Molecular; Pseudomonas aeruginosa; Rhodium; Serine; Serratia marcescens; Spiro Compounds; Structure-Activity Relationship; Sulbactam | 2003 |
The structural modifications induced by the M339F substitution in PBP2x from Streptococcus pneumoniae further decreases the susceptibility to beta-lactams of resistant strains.
Topics: Acylation; beta-Lactam Resistance; beta-Lactams; Binding Sites; Carrier Proteins; Cefotaxime; Crystallization; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Penicillin G; Penicillin-Binding Proteins; Phenotype; Point Mutation; Serine; Streptococcus pneumoniae | 2003 |
Understanding resistance to beta-lactams and beta-lactamase inhibitors in the SHV beta-lactamase: lessons from the mutagenesis of SER-130.
Topics: Ampicillin; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Binding, Competitive; Clavulanic Acid; Drug Resistance, Microbial; Enzyme Inhibitors; Escherichia coli; Kinetics; Models, Chemical; Mutagenesis; Mutagenesis, Site-Directed; Penicillanic Acid; Plasmids; Serine; Tazobactam; Thermodynamics; Time Factors | 2003 |
A convenient enantioselective synthesis of (S)-alpha-trifluoromethylisoserine.
Topics: beta-Lactams; Catalysis; Fatty Acids, Unsaturated; Models, Chemical; Serine; Stereoisomerism; Sulfinic Acids; Sulfonamides; Taxoids | 2005 |
Raman crystallographic studies of the intermediates formed by Ser130Gly SHV, a beta-lactamase that confers resistance to clinical inhibitors.
Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Crystallography, X-Ray; Enzyme Inhibitors; Glycine; Penicillanic Acid; Serine; Spectrum Analysis, Raman; Stereoisomerism; Tazobactam | 2007 |
Structural characterization of an enantiomerically pure amino acid imidazolide and direct formation of the beta-lactam nucleus from an alpha-amino acid.
Topics: Acetanilides; Amino Acids; beta-Lactams; Imidazoles; Indoles; Molecular Structure; Serine; Stereoisomerism | 2008 |
Structural relationship between the active sites of β-lactam-recognizing and amidase signature enzymes: convergent evolution?
Topics: Amidohydrolases; Amino Acid Sequence; Bacteria; beta-Lactams; Catalytic Domain; Chymotrypsin; Escherichia coli; Evolution, Molecular; Models, Molecular; Peptide Hydrolases; Protein Folding; Serine; Serine Proteases; Staphylococcus aureus; Streptococcus pneumoniae; Streptomyces; Substrate Specificity | 2010 |
Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway.
Topics: Amino Acid Motifs; Bacterial Proteins; beta-Lactamases; beta-Lactams; Carboxypeptidases; Catalytic Domain; Cephalosporins; Clavulanic Acid; Crystallography, X-Ray; Hydrolysis; Models, Molecular; Penicillins; Protein Conformation; Protein Structure, Tertiary; Serine; Streptomyces | 2013 |
β-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis.
Topics: Anti-Bacterial Agents; beta-Lactams; Biocatalysis; Biosynthetic Pathways; Cyclization; Histidine; Lactams; Peptide Synthases; Serine | 2015 |
Involvement of AmpG in mediating a dynamic relationship between serine beta-lactamase induction and biofilm-forming ability of Escherichia coli.
Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; beta-Lactams; Biofilms; Escherichia coli; Membrane Transport Proteins; Microbial Sensitivity Tests; Serine | 2018 |
Tryptophan Fluorescence Quenching in β-Lactam-Interacting Proteins Is Modulated by the Structure of Intermediates and Final Products of the Acylation Reaction.
Topics: Acylation; beta-Lactamases; beta-Lactams; Catalytic Domain; Mycobacterium tuberculosis; Peptidyl Transferases; Serine; Spectrometry, Fluorescence; Tryptophan | 2019 |
The hydrolytic water molecule of Class A β-lactamase relies on the acyl-enzyme intermediate ES* for proper coordination and catalysis.
Topics: Acylation; Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Binding Sites; Catalysis; Catalytic Domain; Crystallography, X-Ray; Hydrogen Bonding; Hydrolysis; Kinetics; Serine; Water | 2020 |
Introduction of a Thio Functional Group to Diazabicyclooctane: An Effective Modification to Potentiate the Activity of β-Lactams against Gram-Negative Bacteria Producing Class A, C, and D Serine β-Lactamases.
Topics: Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Gram-Negative Bacteria; Microbial Sensitivity Tests; Serine | 2020 |
A unique class of Zn
Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Cephalosporin Resistance; Cephalosporins; Clostridioides; Clostridioides difficile; Humans; Serine; Zinc | 2022 |
Broad-Spectrum Inhibitors against Class A, B, and C Type β-Lactamases to Block the Hydrolysis against Antibiotics: Kinetics and Structural Characterization.
Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Colistin; Hydrolysis; Microbial Sensitivity Tests; Molecular Docking Simulation; Serine | 2022 |
Temoneira-1 β-lactamase is not a metalloenzyme, but its native metal ion binding sites allow for purification by immobilized metal ion affinity chromatography.
Topics: Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Binding Sites; Chromatography, Affinity; Histidine; Imidazoles; Ions; Isopropyl Thiogalactoside; Metalloproteins; Penicillinase; Protein Sorting Signals; Serine | 2023 |