Page last updated: 2024-09-04

beta-lactams and penicillanic acid

beta-lactams has been researched along with penicillanic acid in 140 studies

Compound Research Comparison

Studies (beta-lactams)	Trials (beta-lactams)	Recent Studies (post-2010) (beta-lactams)	Studies (penicillanic acid)	Trials (penicillanic acid)	Recent Studies (post-2010) (penicillanic acid)
7,579	179	3,395	2,764	327	880

Research

Studies (140)

Timeframe	Studies, this research(%)	All Research%
pre-1990	25 (17.86)	18.7374
1990's	8 (5.71)	18.2507
2000's	55 (39.29)	29.6817
2010's	51 (36.43)	24.3611
2020's	1 (0.71)	2.80

Authors

Authors	Studies
Dewdney, JM; Munro, AC; Smith, H; Wheeler, AW	1
Campbell, MM; Johnson, G	1
Abraham, EP	1
Rolinson, GN	1
Cartwright, SJ; Coulson, AF	1
Livermore, DM; Seetulsingh, P	1
Neu, HC	1
Bellefroid-Bourguignon, C; De Meester, F; Frère, JM; Joris, B; Reckinger, G; Waley, SG	1
Hou, JP; Poole, JW	1
Greenwood, D; O'Grady, F	1
Brumfitt, W; Hamilton-Miller, JM	1
Jonsson, M	1
Nayler, JH	1
Easton, CJ; Knowles, JR	1
Belasco, JG; Charnas, RL; Fisher, J; Khosla, S; Knowles, JR	1
Fukagawa, Y; Ishikura, T; Takei, T	1
Andrews, JM; Bedford, KA; Wise, R	1
Chacko, E; Sheehan, JC; Shibahara, S	1
Fu, KP; Neu, HC	2
Andrews, JM; Patel, N; Wise, R	1
Crast, LB; Gottstein, WJ; Graham, RG; Haynes, UJ; McGregor, DN	1
Frère, JM; Ghuysen, JM; Kelly, JA; Klein, D	1
Li, JT; Moosdeen, F; Williams, JD	1
Baumgärtner, M; Wundt, W	1
Fass, RJ	1
Dryjanski, M; Pratt, RF	1
Inoue, E; Mitsuhashi, S; Muratani, T; Nakane, T; Yokota, E	1
Alarcón, MA; Campos, M; González, H; Sánchez, R	1
Jin, YF; Piddock, LJ; Turner, HL	1
Czajkowski, DP; Hanehara-Kunugita, C; Hyodo, A; Maiti, SN; Micetich, RG; Phillips, OA; Singh, MP; Spevak, P	1
Giakkoupi, P; Legakis, NJ; Tzelepi, E; Tzouvelekis, LS	1
Degnan, BA; Farmer, TH; Payne, DJ	1
Bolsoni, AP; Mendes, RE; Roland, RK; Sader, HS; Silbert, S	1
Ceesay, TP; Gesser, R; Graham, DR; Holtom, P; Lucasti, C; Malafaia, O; McAdams, A; Nichols, RL; Perez, NQ; Woods, GL	1
Citron, DM; Gesser, RM; Goldstein, EJ; Merriam, CV; Tyrrell, KL; Warren, Y	1
Friedland, I; Majumdar, A; Mixson, LA; Motyl, M; Woods, GL	1
Carides, A; Choe, KA; Christou, NV; Dellinger, EP; Fernandez, A; Malafaia, O; Rotstein, OD; Satishchandran, V; Solomkin, JS; Tellado, JM; Teppler, H; Yellin, AE	1
Gesser, R; McCarroll, K; Tellado, J; Teppler, H; Woods, GL	1
Gesser, RM; McCarroll, K; Teppler, H; Woods, GL	2
Zaĭtsev, AA	1
Adeyi, B; Angel-Muller, E; Hague, C; Higareda, I; Ismail, M; Roy, S; Teppler, H; Woods, GL	1
Anderson, VE; Bethel, CR; Bonomo, RA; Helfand, MS; Hujer, AM; Hujer, KM	1
Fosse, T; Giraud-Morin, C; Madinier, I	1
Gesser, RM; McCarroll, KA; Woods, GL	2
Boosten, WH; Bukhanov, AL; Moody, HM; Svedas, VK; Youshko, MI	1
Meibohm, AR; Teppler, H; Woods, GL	1
Higgins, PG; Seifert, H; Stefanik, D; Wisplinghoff, H	1
Bethel, CR; Bonomo, RA; Helfand, MS; Hujer, AM	1
Chmela, Z; Hejnar, P; Kolár, M	1
Burgess, DS; Hall, RG	1
Gesser, RM; Graham, DR; Meibohm, AR; Roy, S; Solomkin, J; Teppler, H; Woods, GL	1
Friedland, IR; Gesser, RM; Herman, G; Isaacs, R; Meibohm, A; Mistry, G; Teppler, H; Woods, GL	1
Gabor, EM; Janssen, DB	1
Baysallar, M; Doğanci, L; Kiliç, A; Küçükkaraaslan, A; Senses, Z	1
Evangelista, AT; Jones, ME; Karlowsky, JA; Sahm, DF; Thornsberry, C; Yee, YC	1
Burgess, DS; Frei, CR	1
Chan, CY; Dinubile, MJ; Friedland, I; Giezek, H; Motyl, MR; Quinn, JP; Shivaprakash, M; Weinstein, RA	1
Abramson, MA; Chow, JW; DiNubile, MJ; Motyl, MR; Polis, A; Satishchandran, V; Teppler, H	1
Kotapati, S; Kuti, JL; Nicolau, DP	1
Abramson, MA; Armstrong, DG; Citron, DM; Lipsky, BA; Morgenstern, DE; Tice, AD	1
Asperger, W; Chan, CY; Dela Pena, AS; DiNubile, MJ; Giezek, H; Kafka, R; Köckerling, F; Raz, R; Shivaprakash, M; Vrijens, F; Warren, B	1
Borbone, S; Cascone, C; Mezzatesta, ML; Santagati, M; Stefani, S	1
Geddes, AM; Rolinson, GN	1
Drusano, GL; Lodise, TP; Lomaestro, B	1
Broide, E; Raveh, D; Rudensky, B; Yinnon, AM	1
Abramson, MA; Jensen, EH; Namias, N; Solomkin, JS; Tomassini, JE	1
Abramson, MA; Armstrong, DG; Lipsky, BA; Polis, AB; Sheehan, P; Tice, AD	1
Abramson, MA; Hoey, CT; Lipsky, BA; Tice, AD; Turpin, RS; Wu, J	1
Cross, SE; Dalley, AJ; Lipman, J; Roberts, MS; Rudd, M; Venkatesh, B	1
Apolônio, ACM; Coutinho, SC; Diniz, CG; Farias, LM; Geralda de Sousa-Gaia, L; Nicoli, JR; Roque de Carvalho, MA; Valéria Dos Santos, K	1
Hall, AJ; Moreno-Bondi, MC; Orellana, G; Sellergren, B; Urraca, JL	1
Kóczián, K; Kökösi, J; Noszál, B; Szakács, Z	1
Bonomo, RA; Buynak, JD; Carey, PR; Helfand, MS; Taracila, MA; Totir, MA; van den Akker, F	1
Medina, M; Palma-Carlos, AG; Palma-Carlos, ML	1
Anuradha, K; Lakshmi, V; Sailaja, VV; Satheesh, T; Umabala, P	1
Apolônio, ACM; Carvalho, MAR; Coutinho, SC; Diniz, CG; Farias, LM; Martins, WA; Nicoli, JR; Santos, KVD	1
Ben Salem, A; Corvis, Y; de Vains, JB; Korchowiec, B; Korchowiec, J; Rogalska, E	1
Chan, HW; Chan, KC; Chan, PH; Chung, WH; Lai, TS; Leung, YC; Ma, DL; Siu, FM; So, PK; Tsang, CW; Wong, KY; Yiu, KF; Zhao, Y	1
Lipman, J; Paratz, JD; Roberts, JA	1
Chen, W; Cooper, WJ; Greaves, J; Miller, GE; Song, W	1
Chang, KT; Ledesma, KR; Quinn, JP; Tam, VH; Wang, TY	1
Iguchi, A; Kaneda, M; Kobayashi, R; Nakajima, M; Sato, T	1
Kuo, HY; Lin, ML; Liu, CY; Wang, FD; Yen, YF	1
Carmeli, Y; Jansen, JP; Kumar, R	1
An, MM; Chen, ML; Jiang, YY; Liu, P; Shen, H; Wang, R; Zhang, JD; Zou, Z	1
Bonomo, RA; Distler, AM; Endimiani, A; Hornick, JM; Hujer, AM; Hujer, KM; Papp-Wallace, KM; Taracila, M	1
De Backer, D; Delattre, I; Dugernier, T; Jacobs, F; Laterre, PF; Layeux, B; Spapen, H; Taccone, FS; Vincent, JL; Wallemacq, P; Wittebole, X	1
Amancio Martins, W; Bahia, JL; Cara, DC; Coutinho, SC; DE Macedo Farias, L; Galuppo Diniz, C; Lopes DE Andrade, JP; Morais Apolonio, AC; Nicoli, JR; Roque DE Carvalho, MA; Valéria Dos Santos, K	1
Buyle, F; Claus, B; Robays, H; Vogelaers, D	1
Bellón, T; Bobolea, ID; Cabañas, R; Fiandor-Román, AM; Jurado-Palomo, J; López-Serrano, MC; Prior, N; Quirce, S	1
Bivas, A; Fraser, A; Leibovici, L; Paul, M; Yahav, D	1
Cabot, G; Juan, C; Mark, BL; Moyá, B; Oliver, A; Reeve, TM; Vocadlo, DJ; Zamorano, L	1
Hawser, SP	1
Cotton, F; De Backer, D; Jacobs, F; Macours, P; Seyler, L; Taccone, FS; Vincent, JL	1
Kurochkina, VB; Satarova, JE; Sklyarenko, AV; Yarotsky, SV	1
Hille, DA; Namias, N; Zakrison, TL	1
Couet, W; Grégoire, N; Marliat, M; Mimoz, O; Nordmann, P; Poirel, L	1
Antunes, NT; Frase, H; Toth, M; Vakulenko, SB; Vakulenko, V	1
Chen, YH; Chen, YS; Chuang, YC; Ho, CM; Hsueh, PR; Huang, CC; Ko, WC; Lee, YL; Liu, CE; Liu, YC; Liu, YM; Lu, PL; Ni, Y; Tang, HJ; Toh, HS; Wang, JH; Xu, Y; Yu, KW	1
Crea, F; Cucinotta, D; De Stefano, C; Milea, D; Sammartano, S; Vianelli, G	1
Beumier, M; Cotton, F; De Backer, D; Hites, M; Jacobs, F; Lorent, S; Roisin, S; Seyler, L; Surin, R; Taccone, FS; Vincent, JL; Wolff, F	1
Arnold, HM; Hampton, NB; Hoban, A; Hoffmann, J; Hollands, JM; Juang, PH; Kollef, MH; McCormick, S; Micek, ST; Reichley, RM; Skrupky, LP; Smith, JR	1
Falagas, ME; Ikawa, K; Tansarli, GS; Vardakas, KZ	1
Gupta, N; Rodrigues, C; Shetty, A; Soman, R	1
Ashar, TK; Bečka, S; Datla, A; Dobišová, M; Grulich, M; Kyslík, P; Marešová, H; Maršálek, J; Palyzová, A; Plačková, M; Plháčková, K; Štěpánek, V; Valešová, R; Vyasarayani, RW	1
Kumar, A; Shahi, SK; Singh, VK	1
Bandettini, R; Buffa, P; Castagnola, E; Caviglia, I; Ciucci, A; Ginocchio, F; Guida, E; Haupt, R; Loy, A; Masa, DL; Mattioli, G; Perotti, M; Pini Prato, A	1
Belghiti, J; Bert, F; Dondero, F; Durand, F; Larroque, B; Moreau, R; Nicolas-Chanoine, MH; Paugam-Burtz, C	1
Singh, HL; Singh, RM	1
Antonucci, E; Beumier, M; Cristallini, S; de Backer, D; Donadello, K; Jacobs, F; Roberts, JA; Rondelet, B; Scolletta, S; Taccone, FS; Vincent, JL	1
Cavanillas, R; Grau, S; Lozano, V; Nocea, G; Valladares, A; Xie, Y	1
D'Agostino, C; Rhodes, NJ; Roberts, JA; Scheetz, MH; Skoglund, E	1
Badal, RE; Cao, B; Chen, S; Chu, Y; Duan, Q; Feng, X; Gui, B; Hu, B; Hu, Z; Huang, W; Kong, H; Liao, K; Luo, Y; Ni, Y; Shao, H; Su, J; Sun, Z; Wang, Y; Wu, A; Xu, Y; Yang, Q; Yu, Y; Zhang, H; Zhang, S	1
Arakawa, Y; Fujita, A; Jin, W; Kimura, K; Mikamo, H; Suematsu, H; Wachino, J; Yamada, K; Yamagishi, Y; Yokoyama, S	1
De Rosa, M; Palma, G; Saturnino, C; Soriente, A; Vigliotta, G	1
Hung, YP; Ko, WC; Lee, JC; Li, CW; Li, MC; Lin, HJ; Liu, HC; Wu, YH	1
Gan, WJ; Mu, SM; Ran, XW; Shen, JF; Wang, J; Xian, Y; Xu, ZR; Yan, XD; Yuan, GY; Zhang, BS	1
Bork, JT; D'Angelo, RG; Heil, EL; Johnson, JK	1
Boelens, J; Catteeuw, J; Claeys, G; De Bus, L; De Waele, JJ; Decruyenaere, J; Denys, W; Depuydt, PO; Gadeyne, B; Vermeulen, K	1
Banerjee, R; Boyce, TG; Cunningham, SA; Hasassri, ME; Jeraldo, PR; Kaye, KS; Norgan, AP; Patel, R; Pogue, JM; Weissman, SJ	1
Dixon, N; Fowler, RC; Geyer, CN; Hanson, ND; Harrison, L; Horiyama, T; Ishii, Y; Moland, ES; Thomson, K; Yoshizumi, A	1
Borgia, G; Gentile, I; Maraolo, AE	1
Abdel-Haq, N; Ang, JY; Nicolau, DP; Satlin, MJ; Thabit, AK; van Duin, D; Zhu, F	1
Carroll, K; Romagnoli, M; Simner, PJ; Wang, F; Workneh, M	1
Hackel, MA; Hoban, DJ; Karlowsky, JA; Lob, SH; Sahm, DF	1
Dizbay, M; Karaşahin, EF; Karaşahin, Ö; Özger, HS	1
Lavigne, JP; Meiller, E; Merens, A; Nicolas-Chanoine, MH; Pantel, A; Robert, J	1
Burgess, DS; Rutter, WC	1
Aslanzadeh, J; Kuti, JL; Nicolau, DP; Stainton, SM; Thabit, AK	1
Kim, JH; Kim, MJ; Sohn, JW; Yang, KS; Yoon, YK	1
Falagas, ME; Kofteridis, DP; Maraki, S; Mavromanolaki, VE; Perdikis, D; Samonis, G; Vardakas, KZ	1
Kim, HS; Kim, HY; Kim, YK; Lee, J; Lee, JA; Lee, SS; Seo, YB; Song, W; Uh, Y	1
Allerberger, F; Jesumirhewe, C; Lepuschitz, S; Ruppitsch, W; Springer, B	1
Cohen-Wolkowiez, M; Greenberg, RG; Rivera-Chaparro, ND	1
Logan, J; Mellor, TE; Mitchell, N	1
Hatti, M; Odenholt, I; Resman, F; Solomonidi, N; Tham, J	1
Lin, FJ; Shao, CH; Tai, CH; Wang, CC; Wang, JT; Wu, CC	1

Reviews

12 review(s) available for beta-lactams and penicillanic acid

Article	Year
beta-Lactam antibiotics and related substances. The Japanese journal of antibiotics, 1977, Volume: 30 Suppl Topics: Animals; Anti-Bacterial Agents; Bacteria; Bacterial Infections; beta-Lactams; Carboxypeptidases; Cephalosporinase; Cephalosporins; Drug Synergism; Humans; Hydrolases; Penicillanic Acid; Penicillin Resistance; Penicillinase; Penicillins; Staphylococcus; Streptomyces; Structure-Activity Relationship	1977
The role of beta-lactamase inhibitors in chemotherapy. Pharmacology & therapeutics, 1985, Volume: 30, Issue:1 Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Chemical Phenomena; Chemistry; Clavulanic Acid; Clavulanic Acids; Gram-Negative Bacteria; Humans; Lactams; Penicillanic Acid; Sulfones	1985
-lactam antibiotics: their physicochemical properties and biological activities in relation to structure. Journal of pharmaceutical sciences, 1971, Volume: 60, Issue:4 Topics: Amides; beta-Lactamase Inhibitors; beta-Lactams; Cephalosporins; Drug Stability; Drug Synergism; Infrared Rays; Intestinal Absorption; Kinetics; Microbial Sensitivity Tests; Models, Structural; Penicillanic Acid; Penicillins; Solubility; Spectrum Analysis; Structure-Activity Relationship; Ultraviolet Rays	1971
Newer beta-lactam antibiotics. Infection, 1974, Volume: 2, Issue:2 Topics: Acetamides; Amines; Ampicillin; Azepines; Azides; beta-Lactams; Carbenicillin; Carboxylic Acids; Cephalosporins; Cyclohexanes; In Vitro Techniques; Indenes; Mandelic Acids; Nitriles; Penicillanic Acid; Penicillin G; Penicillins; Pyridines; Sulfonic Acids; Tetrazoles; Thiadiazoles; Thiophenes; Valerates	1974
Advances in penicillin research. Advances in drug research, 1973, Volume: 7 Topics: Acetates; Acylation; Amination; Bacteria; beta-Lactamase Inhibitors; beta-Lactams; Carboxylic Acids; Cell Wall; Chemical Phenomena; Chemistry; Crystallization; Drug Hypersensitivity; Enzyme Inhibitors; Humans; Hydroxylation; Intestinal Absorption; Isomerism; Oxidation-Reduction; Penicillanic Acid; Penicillin Resistance; Penicillins; Pseudomonas; Staphylococcus; Stereoisomerism; Structure-Activity Relationship	1973
[Beta lactamase inhibitors, a new start of antibiotic therapy]. Deutsche medizinische Wochenschrift (1946), 1982, Aug-27, Volume: 107, Issue:34 Topics: beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Drug Resistance, Microbial; Humans; Kinetics; Penicillanic Acid; Sulbactam	1982
Safety and tolerability of ertapenem. The Journal of antimicrobial chemotherapy, 2004, Volume: 53 Suppl 2 Topics: Adult; Aged; Anti-Bacterial Agents; Bacteria, Aerobic; Bacteria, Anaerobic; Bacterial Infections; beta-Lactams; Ceftriaxone; Clinical Trials as Topic; Community-Acquired Infections; Ertapenem; Female; Humans; Lactams; Male; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Randomized Controlled Trials as Topic	2004
The 50th anniversary of the discovery of 6-aminopenicillanic acid (6-APA). International journal of antimicrobial agents, 2007, Volume: 29, Issue:1 Topics: Anti-Bacterial Agents; Bacterial Infections; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Cephalosporins; Humans; Hydrolysis; Penicillanic Acid; Penicillins; Thienamycins	2007
Ertapenem versus piperacillin/tazobactam for the treatment of complicated infections: a meta-analysis of randomized controlled trials. BMC infectious diseases, 2009, Dec-02, Volume: 9 Topics: Anti-Bacterial Agents; Bacterial Infections; beta-Lactams; Ertapenem; Humans; Penicillanic Acid; Piperacillin; Randomized Controlled Trials as Topic; Tazobactam; Treatment Outcome	2009
Anti-pseudomonal beta-lactams for the initial, empirical, treatment of febrile neutropenia: comparison of beta-lactams. The Cochrane database of systematic reviews, 2010, Nov-10, Issue:11 Topics: Anti-Bacterial Agents; beta-Lactams; Cefepime; Ceftazidime; Cephalosporins; Fever; Humans; Imipenem; Meropenem; Neutropenia; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Pseudomonas aeruginosa; Pseudomonas Infections; Randomized Controlled Trials as Topic; Thienamycins	2010
Treatment options for extended-spectrum beta-lactamase (ESBL) and AmpC-producing bacteria. Expert opinion on pharmacotherapy, 2016, Volume: 17, Issue:7 Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Cefepime; Cephalosporins; Drug Resistance, Bacterial; Drug Therapy, Combination; Enterobacteriaceae; Enterobacteriaceae Infections; Gram-Negative Aerobic Bacteria; Gram-Negative Bacterial Infections; Humans; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination	2016
Lemierre's syndrome variant of the gut. BMJ case reports, 2017, Oct-20, Volume: 2017 Topics: Abdominal Pain; Anti-Bacterial Agents; Anticoagulants; beta-Lactams; Endoscopy, Gastrointestinal; Ertapenem; Fever; Fusobacterium Infections; Fusobacterium necrophorum; Heparin; Humans; Lemierre Syndrome; Male; Penicillanic Acid; Phlebitis; Piperacillin; Piperacillin, Tazobactam Drug Combination; Portal Vein; Treatment Outcome	2017

Trials

22 trial(s) available for beta-lactams and penicillanic acid

Article	Year
Is chloramphenicol the drug of choice for the treatment of enteric fever? Comparative studies on the effects of chloramphenicol, trimethoprim-sulphametoxazole and beta-lactam antibiotics. Infection, 1974, Volume: 2, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Ampicillin; Anti-Bacterial Agents; Azepines; beta-Lactams; Carrier State; Chloramphenicol; Drug Evaluation; Extrachromosomal Inheritance; Humans; Middle Aged; Paratyphoid Fever; Penicillanic Acid; Penicillin Resistance; Salmonella; Sulfamethoxazole; Time Factors; Trimethoprim; Typhoid Fever; Valerates	1974
Ertapenem once daily versus piperacillin-tazobactam 4 times per day for treatment of complicated skin and skin-structure infections in adults: results of a prospective, randomized, double-blind multicenter study. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2002, Jun-01, Volume: 34, Issue:11 Topics: Adult; Anti-Bacterial Agents; beta-Lactams; Double-Blind Method; Drug Therapy, Combination; Enzyme Inhibitors; Ertapenem; Female; Humans; Lactams; Male; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Penicillins; Piperacillin; Prospective Studies; Pseudomonas aeruginosa; Skin Diseases; Staphylococcus aureus; Tazobactam; Treatment Outcome	2002
General microbiology and in vitro susceptibility of anaerobes isolated from complicated skin and skin-structure infections in patients enrolled in a comparative trial of ertapenem versus piperacillin-tazobactam. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2002, Sep-01, Volume: 35, Issue:Suppl 1 Topics: Anti-Bacterial Agents; Bacteria, Anaerobic; beta-Lactams; Double-Blind Method; Enzyme Inhibitors; Ertapenem; Humans; Lactams; Microbial Sensitivity Tests; Penicillanic Acid; Penicillins; Piperacillin; Skin Diseases, Bacterial; Tazobactam	2002
Ertapenem versus piperacillin/tazobactam in the treatment of complicated intraabdominal infections: results of a double-blind, randomized comparative phase III trial. Annals of surgery, 2003, Volume: 237, Issue:2 Topics: Abdominal Abscess; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; beta-Lactams; Digestive System Surgical Procedures; Double-Blind Method; Drug Therapy, Combination; Ertapenem; Female; Gram-Negative Bacterial Infections; Gram-Positive Bacterial Infections; Hospitalization; Humans; Lactams; Male; Middle Aged; Penicillanic Acid; Peritonitis; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Research Design; Treatment Outcome	2003
Ertapenem versus piperacillin-tazobactam for treatment of mixed anaerobic complicated intra-abdominal, complicated skin and skin structure, and acute pelvic infections. Surgical infections, 2002,Winter, Volume: 3, Issue:4 Topics: Abdomen; Adult; Aged; Anti-Bacterial Agents; Bacteria, Anaerobic; Bacterial Infections; beta-Lactams; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Ertapenem; Female; Humans; Lactams; Male; Middle Aged; Pelvic Infection; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Skin Diseases, Bacterial; Surgical Wound Infection	2002
Surgical infections with enterococcus: outcome in patients treated with ertapenem versus piperacillin-tazobactam. Surgical infections, 2002,Winter, Volume: 3, Issue:4 Topics: Abdomen; Adolescent; Adult; Aged; Anti-Bacterial Agents; beta-Lactams; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Enterococcus; Ertapenem; Female; Gram-Positive Bacterial Infections; Humans; Lactams; Male; Middle Aged; Pelvic Infection; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Skin Diseases, Bacterial; Surgical Wound Infection; Treatment Outcome	2002
Efficacy of ertapenem in the treatment of serious infections caused by Enterobacteriaceae: analysis of pooled clinical trial data. The Journal of antimicrobial chemotherapy, 2003, Volume: 51, Issue:5 Topics: Adult; Aged; beta-Lactams; Ceftriaxone; Cephalosporins; Community-Acquired Infections; Double-Blind Method; Drug Therapy, Combination; Enterobacteriaceae Infections; Ertapenem; Escherichia coli Infections; Humans; Lactams; Middle Aged; Multicenter Studies as Topic; Penicillanic Acid; Piperacillin; Tazobactam; Treatment Outcome; Urinary Tract Infections	2003
[Carbapenem antibiotic ertapenem in the treatment of extrahospital intraabdominal infections]. Khirurgiia, 2003, Issue:4 Topics: Abdominal Abscess; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; beta-Lactams; Double-Blind Method; Ertapenem; Female; Humans; Lactams; Male; Middle Aged; Penicillanic Acid; Peritonitis; Piperacillin; Prospective Studies; Tazobactam; Treatment Outcome	2003
Ertapenem once a day versus piperacillin-tazobactam every 6 hours for treatment of acute pelvic infections: a prospective, multicenter, randomized, double-blind study. Infectious diseases in obstetrics and gynecology, 2003, Volume: 11, Issue:1 Topics: Acute Disease; Adult; Aged; Anti-Bacterial Agents; beta-Lactams; Confidence Intervals; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Ertapenem; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Lactams; Middle Aged; Pelvic Infection; Penicillanic Acid; Piperacillin; Probability; Prospective Studies; Risk Assessment; Severity of Illness Index; Tazobactam; Treatment Outcome	2003
Evaluation of outpatient treatment with ertapenem in a double blind controlled clinical trial of complicated skin/skin structure infections. The Journal of infection, 2004, Volume: 48, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; beta-Lactams; Chi-Square Distribution; Double-Blind Method; Drug Therapy, Combination; Enzyme Inhibitors; Ertapenem; Female; Humans; Infusions, Intravenous; Lactams; Logistic Models; Male; Middle Aged; Penicillanic Acid; Piperacillin; Prospective Studies; Skin Diseases; Statistics, Nonparametric; Tazobactam; Treatment Outcome	2004
Management of complicated appendicitis and comparison of outcome with other primary sites of intra-abdominal infection: results of a trial comparing ertapenem and piperacillin-tazobactam. Journal of chemotherapy (Florence, Italy), 2004, Volume: 16, Issue:1 Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anti-Bacterial Agents; Appendicitis; Bacterial Infections; beta-Lactams; Colonic Diseases; Demography; Double-Blind Method; Ertapenem; Female; Humans; Lactams; Male; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Risk Factors; Severity of Illness Index	2004
Treatment of polymicrobial infections: post hoc analysis of three trials comparing ertapenem and piperacillin-tazobactam. The Journal of antimicrobial chemotherapy, 2004, Volume: 53 Suppl 2 Topics: Abdomen; Adolescent; Adult; Anti-Bacterial Agents; Bacteria, Aerobic; Bacteria, Anaerobic; Bacterial Infections; beta-Lactams; Double-Blind Method; Ertapenem; Female; Humans; Lactams; Male; Pelvic Infection; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Skin Diseases, Bacterial; Treatment Outcome	2004
Efficacy of ertapenem against methicillin-susceptible Staphylococcus aureus in complicated skin/skin structure infections: results of a double-blind clinical trial versus piperacillin-tazobactam. International journal of antimicrobial agents, 2004, Volume: 23, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; beta-Lactams; Double-Blind Method; Ertapenem; Female; Humans; Lactams; Male; Methicillin Resistance; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Skin Diseases, Bacterial; Staphylococcal Infections; Staphylococcus aureus	2004
Bowel colonization with resistant gram-negative bacilli after antimicrobial therapy of intra-abdominal infections: observations from two randomized comparative clinical trials of ertapenem therapy. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2005, Volume: 24, Issue:7 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; beta-Lactams; Carrier State; Ceftriaxone; Digestive System Surgical Procedures; Drug Resistance, Bacterial; Drug Therapy, Combination; Ertapenem; Female; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Intestines; Lactams; Male; Metronidazole; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination	2005
Acquisition of resistant bowel flora during a double-blind randomized clinical trial of ertapenem versus piperacillin-tazobactam therapy for intraabdominal infections. Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:8 Topics: Abdominal Abscess; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; beta-Lactams; Double-Blind Method; Drug Resistance, Bacterial; Drug Therapy, Combination; Enterobacteriaceae; Ertapenem; Female; Humans; Lactams; Male; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Rectum; Treatment Outcome	2005
Ertapenem versus piperacillin/tazobactam for diabetic foot infections (SIDESTEP): prospective, randomised, controlled, double-blinded, multicentre trial. Lancet (London, England), 2005, Nov-12, Volume: 366, Issue:9498 Topics: Adult; Aged; Anti-Bacterial Agents; beta-Lactams; Diabetic Foot; Double-Blind Method; Drug Administration Schedule; Ertapenem; Female; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Male; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Severity of Illness Index; Treatment Outcome	2005
Efficacy and safety of ertapenem versus piperacillin-tazobactam for the treatment of intra-abdominal infections requiring surgical intervention. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2006, Volume: 10, Issue:4 Topics: Abdomen; Abscess; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Anti-Bacterial Agents; Bacterial Infections; Bacteroides fragilis; Bacteroides Infections; beta-Lactams; Diarrhea; Ertapenem; Escherichia coli Infections; Female; Gastrointestinal Diseases; Humans; Male; Middle Aged; Penicillanic Acid; Peritonitis; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Treatment Outcome	2006
Randomized, multicenter, double-blind study of efficacy, safety, and tolerability of intravenous ertapenem versus piperacillin/tazobactam in treatment of complicated intra-abdominal infections in hospitalized adults. Surgical infections, 2007, Volume: 8, Issue:1 Topics: Abdominal Abscess; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; APACHE; Bacterial Infections; Bacteroides; beta-Lactams; Double-Blind Method; Ertapenem; Escherichia coli; Female; Humans; Male; Middle Aged; Penicillanic Acid; Peritonitis; Piperacillin; Piperacillin, Tazobactam Drug Combination	2007
Piperacillin/tazobactam plus ceftazidime versus sulbactam/ampicillin plus aztreonam as empirical therapy for fever in severely neutropenic pediatric patients. Journal of pediatric hematology/oncology, 2009, Volume: 31, Issue:4 Topics: Adolescent; Ampicillin; Anti-Bacterial Agents; Aztreonam; beta-Lactams; Ceftazidime; Child; Child, Preschool; Drug Therapy, Combination; Female; Fever; Humans; Infant; Infant, Newborn; Male; Neoplasms; Neutropenia; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Severity of Illness Index; Sulbactam	2009
Prolonged infusion antibiotics for suspected gram-negative infections in the ICU: a before-after study. The Annals of pharmacotherapy, 2013, Volume: 47, Issue:2 Topics: Aged; Anti-Bacterial Agents; beta-Lactams; Cefepime; Cephalosporins; Cohort Studies; Cross Infection; Drug Administration Schedule; Female; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Hospitals, Teaching; Hospitals, Urban; Humans; Infusions, Intravenous; Intensive Care Units; Length of Stay; Male; Meropenem; Middle Aged; Missouri; Penicillanic Acid; Pilot Projects; Piperacillin; Piperacillin, Tazobactam Drug Combination; Thienamycins	2013
Ertapenem versus piperacillin/tazobactam for diabetic foot infections in China: a Phase 3, multicentre, randomized, double-blind, active-controlled, non-inferiority trial. The Journal of antimicrobial chemotherapy, 2016, Volume: 71, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Infections; beta-Lactamase Inhibitors; beta-Lactams; China; Diabetic Foot; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Ertapenem; Female; Humans; Male; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Treatment Outcome; Young Adult	2016
Randomized controlled trial of piperacillin-tazobactam, cefepime and ertapenem for the treatment of urinary tract infection caused by extended-spectrum beta-lactamase-producing Escherichia coli. BMC infectious diseases, 2017, 06-07, Volume: 17, Issue:1 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Cefepime; Cephalosporins; Cross Infection; Ertapenem; Escherichia coli; Escherichia coli Infections; Female; Genotype; Humans; Male; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Republic of Korea; Tazobactam; Urinary Tract Infections	2017

Other Studies

106 other study(ies) available for beta-lactams and penicillanic acid

Article	Year
Antigenic properties of polymers formed by beta-lactam antibiotics. International archives of allergy and applied immunology, 1976, Volume: 50, Issue:2 Topics: Ampicillin; Animals; Antigens; beta-Lactams; Cephalosporins; Epitopes; Guinea Pigs; Haplorhini; Papio; Passive Cutaneous Anaphylaxis; Penicillanic Acid; Penicillin G; Polymers; Rabbits; Skin Tests	1976
Conversion of secopenicillanic acid derivatives into beta-lactam sulphimides and oxazolines. Journal of the Chemical Society. Perkin transactions 1, 1975, Issue:12 Topics: beta-Lactams; Chemical Phenomena; Chemistry; Imides; Methods; Oxazoles; Penicillanic Acid	1975
6-APA and the development of the beta-lactam antibiotics. The Journal of antimicrobial chemotherapy, 1979, Volume: 5, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Cephalosporins; Chemistry; Drug Stability; History, 20th Century; Penicillanic Acid; Penicillin Resistance; Penicillins	1979
A semi-synthetic penicillinase inactivator. Nature, 1979, Mar-22, Volume: 278, Issue:5702 Topics: beta-Lactamase Inhibitors; beta-Lactams; Binding Sites; Dose-Response Relationship, Drug; Penicillanic Acid; Staphylococcus aureus; Structure-Activity Relationship; Sulfones	1979
Susceptibility of Escherichia coli isolates with TEM-1 beta-lactamase to combinations of BRL42715, tazobactam or clavulanate with piperacillin or amoxycillin . The Journal of antimicrobial chemotherapy, 1991, Volume: 27, Issue:6 Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Clavulanic Acids; Drug Synergism; Drug Therapy, Combination; Escherichia coli; Lactams; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Tazobactam	1991
Automated analysis of enzyme inactivation phenomena. Application to beta-lactamases and DD-peptidases. Biochemical pharmacology, 1987, Jul-15, Volume: 36, Issue:14 Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactams; Cephaloridine; Enzyme Activation; Hot Temperature; Kinetics; Lactams; Microcomputers; Muramoylpentapeptide Carboxypeptidase; Penicillanic Acid; Signal Processing, Computer-Assisted; Software; Spectrophotometry, Ultraviolet; Zinc	1987
FL 1060: a new beta-lactam antibiotic with novel properties. Journal of clinical pathology, 1973, Volume: 26, Issue:1 Topics: Anti-Bacterial Agents; Azepines; beta-Lactams; Culture Media; Drug Resistance, Microbial; Escherichia coli; Microscopy, Electron, Scanning; Osmolar Concentration; Penicillanic Acid; Phenotype; Time Factors	1973
Correlation of the effect of beta-lactamase inhibitors on the beta-lactamase in growing cultures of gram-negative bacteria with their effect on the isolated beta-lactamase. Antimicrobial agents and chemotherapy, 1984, Volume: 26, Issue:3 Topics: Ampicillin; Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acids; Lactams; Penicillanic Acid; Penicillins; Sulbactam	1984
Beta-lactamase inactivation by mechanism-based reagents. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 1980, May-16, Volume: 289, Issue:1036 Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Lactams; Penicillanic Acid; Sulbactam	1980
Inhibition of beta-lactamase of Bacillus licheniformis 749/C by compound PS-5, a new beta-lactam antibiotic. The Biochemical journal, 1980, Jan-01, Volume: 185, Issue:1 Topics: Ampicillin; Anti-Bacterial Agents; Bacillus; beta-Lactamase Inhibitors; beta-Lactams; Cephaloridine; Computers; Hydrolysis; Kinetics; Models, Chemical; Penicillanic Acid; Penicillin G; Spectrophotometry, Ultraviolet; Thienamycins	1980
Clavulanic acid and CP-45,899: a comparison of their in vitro activity in combination with penicillins. The Journal of antimicrobial chemotherapy, 1980, Volume: 6, Issue:2 Topics: Bacteria; Bacteroides fragilis; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Enterobacteriaceae; Haemophilus influenzae; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Penicillanic Acid; Penicillins; Pseudomonas aeruginosa; Staphylococcus aureus; Sulbactam	1980
Simple beta-lactam compounds derived from 6-aminopenicillanic acid. Journal of medicinal chemistry, 1980, Volume: 23, Issue:7 Topics: Bacteria; beta-Lactams; Drug Synergism; Microbial Sensitivity Tests; Penicillanic Acid; Penicillins	1980
Synergistic activity of piperacillin in combination with beta-lactamase inhibitors. Antimicrobial agents and chemotherapy, 1980, Volume: 18, Issue:4 Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Drug Synergism; Penicillanic Acid; Penicillins; Piperacillin; Sulbactam	1980
6-beta-bromo- and 6-beta-iodo penicillanic acid, two novel beta-lactamase inhibitors. The Journal of antimicrobial chemotherapy, 1981, Volume: 7, Issue:5 Topics: Ampicillin; Bacteria; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Penicillanic Acid	1981
Synergistic activity of cefoperazone in combination with beta-lactamase inhibitors. The Journal of antimicrobial chemotherapy, 1981, Volume: 7, Issue:3 Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactams; Cefoperazone; Cefotaxime; Cephalosporins; Clavulanic Acid; Drug Synergism; Penicillanic Acid; Sulbactam	1981
Synthesis and beta-lactamase inhibitory properties of 2 beta-(chloromethyl)-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide. Journal of medicinal chemistry, 1981, Volume: 24, Issue:12 Topics: Amoxicillin; Animals; beta-Lactamase Inhibitors; beta-Lactams; Chemical Phenomena; Chemistry; Clavulanic Acid; Escherichia coli Infections; Mice; Mice, Inbred ICR; Penicillanic Acid; Staphylococcal Infections; Staphylococcus aureus	1981
Interaction between non-classical beta-lactam compounds and the Zn2+-containing G and serine R61 and R39 D-alanyl-D-alanine peptidases. The Biochemical journal, 1981, Oct-01, Volume: 199, Issue:1 Topics: Actinomycetaceae; Amdinocillin; beta-Lactams; Carboxypeptidases; Cefoxitin; Cephalosporins; Clavulanic Acid; Drug Interactions; Endopeptidases; Enzyme Inhibitors; Imipenem; Kinetics; Penicillanic Acid; Penicillins; Quinoxalines; Serine-Type D-Ala-D-Ala Carboxypeptidase; Streptomyces; Zinc	1981
The effect of inhibitors of beta-lactamases on beta-lactamase extracts and on intact cells. The Journal of antimicrobial chemotherapy, 1982, Volume: 9, Issue:4 Topics: Ampicillin; Bacteria; beta-Lactamase Inhibitors; beta-Lactams; Cephaloridine; Clavulanic Acid; Hydrolysis; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam	1982
Inconsistency of synergy between the beta-lactamase inhibitor CP-45,899 and beta-lactam antibiotics against multiply drug-resistant Enterobacteriaceae and pseudomonas species. Antimicrobial agents and chemotherapy, 1981, Volume: 19, Issue:2 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Drug Resistance, Microbial; Drug Synergism; Enterobacteriaceae; Microbial Sensitivity Tests; Penicillanic Acid; Pseudomonas; Sulbactam	1981
Steady-state kinetics of the binding of beta-lactams and penicilloates to the second binding site of the Enterobacter cloacae P99 beta-lactamase. Biochemistry, 1995, Mar-21, Volume: 34, Issue:11 Topics: beta-Lactamases; beta-Lactams; Binding Sites; Enterobacter cloacae; Kinetics; Penicillanic Acid	1995
In-vitro evaluation of the four beta-lactamase inhibitors: BRL42715, clavulanic acid, sulbactam, and tazobactam. The Journal of antimicrobial chemotherapy, 1993, Volume: 32, Issue:3 Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Clavulanic Acids; Drug Resistance, Microbial; Escherichia coli; Lactams; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	1993
Effect of five irreversible inhibitors on beta-lactamase from Shigella flexneri UCSF-129. Microbios, 1993, Volume: 76, Issue:308 Topics: Ampicillin; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Clavulanic Acids; Drug Synergism; Lactams; Microbial Sensitivity Tests; Penicillanic Acid; Shigella flexneri	1993
Activity of 13 beta-lactam agents combined with BRL 42715 against beta-lactamase producing gram-negative bacteria compared to combinations with clavulanic acid, tazobactam and sulbactam. The Journal of antimicrobial chemotherapy, 1993, Volume: 31, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Clavulanic Acids; Drug Therapy, Combination; Enzyme Inhibitors; Gram-Negative Bacteria; Lactams; Penicillanic Acid; Sulbactam; Tazobactam	1993
SYN-1012: a new beta-lactamase inhibitor of penem skeleton. The Journal of antibiotics, 1997, Volume: 50, Issue:4 Topics: Animals; Anti-Bacterial Agents; beta-Lactams; Drug Synergism; Enzyme Inhibitors; Humans; Lactams; Male; Mice; Microbial Sensitivity Tests; Penicillanic Acid; Rabbits; Tazobactam	1997
Aspartic acid for asparagine substitution at position 276 reduces susceptibility to mechanism-based inhibitors in SHV-1 and SHV-5 beta-lactamases. The Journal of antimicrobial chemotherapy, 1999, Volume: 43, Issue:1 Topics: Amino Acid Substitution; Anti-Bacterial Agents; Asparagine; Aspartic Acid; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Enzyme Inhibitors; Escherichia coli; Inhibitory Concentration 50; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	1999
Penetration of beta-lactamase inhibitors into the periplasm of gram-negative bacteria. FEMS microbiology letters, 1999, Jul-01, Volume: 176, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Cell Membrane Permeability; Clavulanic Acid; Enterobacter cloacae; Enzyme Inhibitors; Escherichia coli; Gram-Negative Bacteria; Klebsiella pneumoniae; Lactams; Penicillanic Acid; Periplasm; Sulbactam; Tazobactam	1999
In vitro antimicrobial activity of piperacillin/tazobactam in comparison with other broad-spectrum beta-lactams. The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, 2000, Volume: 4, Issue:5 Topics: Bacteria; Bacterial Infections; beta-Lactams; Brazil; Cross Infection; Drug Resistance, Microbial; Drug Resistance, Multiple; Drug Therapy, Combination; Hospitals, University; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination	2000
In vitro activity of ertapenem against common clinical isolates in relation to human pharmacokinetics. Journal of chemotherapy (Florence, Italy), 2002, Volume: 14, Issue:5 Topics: Anti-Bacterial Agents; Bacterial Infections; beta-Lactams; Ceftriaxone; Community-Acquired Infections; Drug Resistance, Microbial; Drug Therapy, Combination; Enterobacteriaceae; Ertapenem; Haemophilus influenzae; Humans; Lactams; Microbial Sensitivity Tests; Moraxella catarrhalis; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Staphylococcus aureus; Streptococcus agalactiae; Streptococcus pyogenes	2002
Understanding resistance to beta-lactams and beta-lactamase inhibitors in the SHV beta-lactamase: lessons from the mutagenesis of SER-130. The Journal of biological chemistry, 2003, Dec-26, Volume: 278, Issue:52 Topics: Ampicillin; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Binding, Competitive; Clavulanic Acid; Drug Resistance, Microbial; Enzyme Inhibitors; Escherichia coli; Kinetics; Models, Chemical; Mutagenesis; Mutagenesis, Site-Directed; Penicillanic Acid; Plasmids; Serine; Tazobactam; Thermodynamics; Time Factors	2003
[Phenotypes of beta-lactam resistance in the genus Aeromonas]. Pathologie-biologie, 2003, Volume: 51, Issue:5 Topics: Aeromonas; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Enzyme Inhibitors; Isoelectric Focusing; Isoelectric Point; Lactams; Microbial Sensitivity Tests; Penicillanic Acid; Phenotype; Tazobactam	2003
Penicillin acylase-catalyzed synthesis of beta-lactam antibiotics in highly condensed aqueous systems: beneficial impact of kinetic substrate supersaturation. Biotechnology and bioengineering, 2004, Feb-05, Volume: 85, Issue:3 Topics: Amoxicillin; Ampicillin; Anti-Bacterial Agents; beta-Lactams; Catalysis; Cephalexin; Cephalosporins; Enzyme Activation; Escherichia coli; Kinetics; Penicillanic Acid; Penicillin Amidase; Solutions; Substrate Specificity; Water	2004
In vitro activities of the beta-lactamase inhibitors clavulanic acid, sulbactam, and tazobactam alone or in combination with beta-lactams against epidemiologically characterized multidrug-resistant Acinetobacter baumannii strains. Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:5 Topics: Acinetobacter baumannii; Acinetobacter Infections; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; DNA; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Electrophoresis, Gel, Pulsed-Field; Enzyme Inhibitors; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	2004
Exploring the effectiveness of tazobactam against ceftazidime resistant Escherichia coli: insights from the comparison between susceptibility testing and beta-lactamase inhibition. FEMS microbiology letters, 2004, May-01, Volume: 234, Issue:1 Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Cefepime; Ceftazidime; Cephalosporins; Drug Resistance, Bacterial; Drug Therapy, Combination; Enzyme Inhibitors; Ertapenem; Escherichia coli; Escherichia coli Infections; Lactams; Microbial Sensitivity Tests; Penicillanic Acid; Tazobactam	2004
Double-disk synergy test positivity in Stenotrophomonas maltophilia clinical strains. Folia microbiologica, 2004, Volume: 49, Issue:1 Topics: Amoxicillin-Potassium Clavulanate Combination; Ampicillin; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Drug Resistance, Bacterial; Drug Synergism; Enzyme Inhibitors; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Stenotrophomonas maltophilia; Sulbactam	2004
In vitro killing of parenteral beta-lactams against standard and high inocula of extended-spectrum beta-lactamase and non-ESBL producing Klebsiella pneumoniae. Diagnostic microbiology and infectious disease, 2004, Volume: 49, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Cefepime; Cephalosporins; Culture Media, Conditioned; Drug Resistance, Bacterial; Humans; In Vitro Techniques; Klebsiella pneumoniae; Meropenem; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Sensitivity and Specificity; Tazobactam; Thienamycins	2004
Increasing the synthetic performance of penicillin acylase PAS2 by structure-inspired semi-random mutagenesis. Protein engineering, design & selection : PEDS, 2004, Volume: 17, Issue:7 Topics: beta-Lactams; Catalysis; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Escherichia coli; Genetic Techniques; Glycine; Hydrolysis; Kinetics; Models, Chemical; Mutagenesis; Mutation; Penicillanic Acid; Penicillin Amidase; Plasmids; Protein Conformation; Protein Engineering; Time Factors	2004
[Investigation of the in-vitro effectiveness of ertapenem against Pseudomonas aeruginosa strains isolated from intensive care unit patients]. Mikrobiyoloji bulteni, 2004, Volume: 38, Issue:4 Topics: Anti-Bacterial Agents; beta-Lactams; Drug Resistance, Multiple, Bacterial; Ertapenem; Humans; Imipenem; Intensive Care Units; Lactams; Meropenem; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Pseudomonas aeruginosa; Pseudomonas Infections; Thienamycins	2004
Stable antimicrobial susceptibility rates for clinical isolates of Pseudomonas aeruginosa from the 2001-2003 tracking resistance in the United States today surveillance studies. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2005, Feb-15, Volume: 40 Suppl 2 Topics: beta-Lactams; Ceftazidime; Ciprofloxacin; Drug Resistance, Multiple, Bacterial; Fluoroquinolones; Gatifloxacin; Gentamicins; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Pseudomonas aeruginosa; Pseudomonas Infections; United States	2005
Continuous infusion beta-lactams for intensive care unit pulmonary infections. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2005, Volume: 11, Issue:5 Topics: Anti-Bacterial Agents; Aztreonam; beta-Lactams; Cefepime; Ceftazidime; Cephalosporins; Computer Simulation; Drug Combinations; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Infusions, Intravenous; Intensive Care Units; Microbial Sensitivity Tests; Monte Carlo Method; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Pneumonia, Bacterial; United States	2005
Pharmacodynamic modeling of beta-lactam antibiotics for the empiric treatment of secondary peritonitis: a report from the OPTAMA program. Surgical infections, 2005,Fall, Volume: 6, Issue:3 Topics: Anti-Bacterial Agents; beta-Lactams; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug Combinations; Humans; Imipenem; Meropenem; Microbial Sensitivity Tests; Models, Biological; Monte Carlo Method; Penicillanic Acid; Peritonitis; Piperacillin; Piperacillin, Tazobactam Drug Combination; Pseudomonas aeruginosa; Pseudomonas Infections; Thienamycins	2005
Bactericidal activity of ertapenem against major intra-abdominal pathogens. International journal of antimicrobial agents, 2006, Volume: 28, Issue:5 Topics: Abdomen; Anti-Bacterial Agents; Bacterial Infections; Bacteroides fragilis; beta-Lactams; Ceftazidime; Ceftriaxone; Digestive System Diseases; Enterobacter cloacae; Enterococcus faecalis; Ertapenem; Escherichia coli; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Klebsiella; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Proteus mirabilis; Staphylococcus aureus; Time Factors	2006
Piperacillin-tazobactam for Pseudomonas aeruginosa infection: clinical implications of an extended-infusion dosing strategy. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2007, Feb-01, Volume: 44, Issue:3 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; APACHE; beta-Lactams; Cohort Studies; Critical Illness; Cross Infection; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Microbial Sensitivity Tests; Middle Aged; Models, Biological; Monte Carlo Method; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Pseudomonas Infections; Retrospective Studies	2007
Susceptibilities of ESBL-producing Enterobacteriaceae to ertapenem, meropenem and piperacillin-tazobactam with and without clavulanic acid. Chemotherapy, 2007, Volume: 53, Issue:3 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Drug Interactions; Ertapenem; Escherichia coli; Klebsiella pneumoniae; Meropenem; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Thienamycins	2007
Clinical predictors of treatment failure for diabetic foot infections: data from a prospective trial. International wound journal, 2007, Volume: 4, Issue:1 Topics: Adult; Aged; Anti-Bacterial Agents; Bacterial Infections; beta-Lactams; Diabetic Foot; Ertapenem; Female; Humans; Leukocyte Count; Male; Middle Aged; Multivariate Analysis; Outcome Assessment, Health Care; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Randomized Controlled Trials as Topic; Risk Factors; Severity of Illness Index; Treatment Failure	2007
Comparative costs of ertapenem and piperacillin-tazobactam in the treatment of diabetic foot infections. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2007, May-15, Volume: 64, Issue:10 Topics: Anti-Bacterial Agents; Bacterial Infections; beta-Lactams; Diabetic Foot; Drug Administration Schedule; Drug Combinations; Ertapenem; Female; Health Care Costs; Humans; Male; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination	2007
Inadequate antimicrobial prophylaxis during surgery: a study of beta-lactam levels during burn debridement. The Journal of antimicrobial chemotherapy, 2007, Volume: 60, Issue:1 Topics: Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Bacterial Infections; beta-Lactams; Burns; Cephalothin; Debridement; Drug Administration Schedule; Drug Therapy, Combination; Humans; Penicillanic Acid; Piperacillin; Pseudomonas aeruginosa; Staphylococcus aureus; Tazobactam	2007
In vitro activity of piperacillin/tazobactam and ertapenem against Bacteroides fragilis and Escherichia coli in pure and mixed cultures. Journal of medical microbiology, 2007, Volume: 56, Issue:Pt 6 Topics: Anti-Bacterial Agents; Bacteroides fragilis; beta-Lactams; Colony Count, Microbial; Ertapenem; Escherichia coli; Microbial Sensitivity Tests; Microbial Viability; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Time Factors	2007
Molecularly imprinted polymers as antibody mimics in automated on-line fluorescent competitive assays. Analytical chemistry, 2007, Jul-01, Volume: 79, Issue:13 Topics: Amoxicillin; Ampicillin; Anti-Bacterial Agents; Antibody Specificity; Automation; beta-Lactams; Binding, Competitive; Chromatography; Fluoroimmunoassay; Molecular Mimicry; Nafcillin; Oxacillin; Penicillanic Acid; Penicillin G; Penicillin V; Polymers; Sensitivity and Specificity	2007
Site-specific protonation microequilibria of penicillin and cephalosporin beta-lactam core molecules. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2007, Volume: 32, Issue:1 Topics: beta-Lactams; Cephalosporins; Hydrogen-Ion Concentration; Ions; Magnetic Resonance Spectroscopy; Osmolar Concentration; Penicillanic Acid; Penicillins; Potentiometry; Protons	2007
Raman crystallographic studies of the intermediates formed by Ser130Gly SHV, a beta-lactamase that confers resistance to clinical inhibitors. Biochemistry, 2007, Jul-24, Volume: 46, Issue:29 Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Crystallography, X-Ray; Enzyme Inhibitors; Glycine; Penicillanic Acid; Serine; Spectrum Analysis, Raman; Stereoisomerism; Tazobactam	2007
"In vivo" and "in vitro" tests in the diagnosis of Beta-lactams allergy. European annals of allergy and clinical immunology, 2007, Volume: 39, Issue:5 Topics: Allergens; Benzeneacetamides; beta-Lactams; Drug Hypersensitivity; Humans; Immunoglobulin E; Penicillanic Acid; Polylysine; Sensitivity and Specificity; Serologic Tests; Skin Tests	2007
Sensitivity pattern of gram negative bacilli to three beta-lactam/beta-lactamase inhibitor combinations using the automated API system. Indian journal of medical microbiology, 2007, Volume: 25, Issue:3 Topics: Acinetobacter; Amoxicillin; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Enterobacteriaceae; Enzyme Inhibitors; Gram-Negative Bacteria; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Pseudomonas; Stenotrophomonas; Tazobactam; Ticarcillin	2007
Comparative activity of ertapenem and piperacillin tazobactam in a murine systemic infection model with Bacteroides fragilis and Escherichia coli. Journal of medical microbiology, 2007, Volume: 56, Issue:Pt 11 Topics: Animals; Anti-Bacterial Agents; Ascitic Fluid; Bacteroides fragilis; Bacteroides Infections; beta-Lactams; Blood; Colony Count, Microbial; Ertapenem; Escherichia coli; Escherichia coli Infections; Female; Mice; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Sepsis	2007
Calixarenes in a membrane environment: a monolayer study on the miscibility of three p-tert-butylcalix[4]arene beta-lactam derivatives with 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine. The journal of physical chemistry. B, 2007, Nov-22, Volume: 111, Issue:46 Topics: beta-Lactams; Calixarenes; Chemical Phenomena; Chemistry, Physical; Magnetic Resonance Spectroscopy; Membranes, Artificial; Models, Molecular; Penicillanic Acid; Phosphatidylethanolamines; Spectrophotometry, Ultraviolet	2007
Fluorophore-labeled beta-lactamase as a biosensor for beta-lactam antibiotics: a study of the biosensing process. Journal of the American Chemical Society, 2008, May-21, Volume: 130, Issue:20 Topics: Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Biosensing Techniques; Cefuroxime; Circular Dichroism; Computer Simulation; Fluoresceins; Fluorescent Dyes; Kinetics; Mass Spectrometry; Models, Molecular; Penicillanic Acid; Penicillin G; Protein Denaturation; Spectrometry, Fluorescence	2008
Continuous infusion of beta-lactams in the intensive care unit--best way to hit the target? Critical care medicine, 2008, Volume: 36, Issue:5 Topics: Anti-Bacterial Agents; beta-Lactams; Body Fluids; Epithelium; Humans; Infusions, Intravenous; Intensive Care Units; Penicillanic Acid; Piperacillin; Pneumonia, Ventilator-Associated; Tazobactam	2008
Free-radical destruction of beta-lactam antibiotics in aqueous solution. The journal of physical chemistry. A, 2008, Aug-14, Volume: 112, Issue:32 Topics: Anti-Bacterial Agents; beta-Lactams; Free Radicals; Hydroxyl Radical; Kinetics; Penicillanic Acid; Solutions; Time Factors; Water	2008
Killing of Escherichia coli by beta-lactams at different inocula. Diagnostic microbiology and infectious disease, 2009, Volume: 64, Issue:2 Topics: Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Ceftriaxone; Colony Count, Microbial; Ertapenem; Escherichia coli; Humans; Microbial Viability; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Time Factors	2009
In vitro activities of piperacillin or cefoperazone alone and in combination with beta-lactamase inhibitors against gram-negative bacilli. The new microbiologica, 2009, Volume: 32, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Cefoperazone; Drug Therapy, Combination; Enzyme Inhibitors; Gram-Negative Bacteria; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Sulbactam; Tazobactam	2009
Accounting for the development of antibacterial resistance in the cost effectiveness of ertapenem versus piperacillin/tazobactam in the treatment of diabetic foot infections in the UK. PharmacoEconomics, 2009, Volume: 27, Issue:12 Topics: Anti-Bacterial Agents; Bacterial Infections; beta-Lactams; Cost-Benefit Analysis; Decision Trees; Diabetic Foot; Direct Service Costs; Drug Costs; Drug Resistance, Bacterial; Ertapenem; Humans; Models, Biological; Models, Econometric; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Quality-Adjusted Life Years; Treatment Outcome; United Kingdom	2009
Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:7 Topics: Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Cephalosporinase; Clavulanic Acid; Computer Simulation; Enzyme Inhibitors; Hydrogen Bonding; Kinetics; Microbial Sensitivity Tests; Molecular Structure; Mutagenesis, Site-Directed; Penicillanic Acid; Protein Structure, Secondary; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Sulbactam; Tazobactam	2010
Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock. Critical care (London, England), 2010, Volume: 14, Issue:4 Topics: Anti-Bacterial Agents; beta-Lactams; Cefepime; Ceftazidime; Cephalosporins; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Female; Humans; Male; Meropenem; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Piperacillin; Prospective Studies; Sepsis; Shock, Septic; Tazobactam; Thienamycins	2010
In vitro selection of ertapenem and piperacillin/tazobactam-resistant strains of Bacteroides fragilis and analysis of their virulence in gnotobiotic mice. Journal of chemotherapy (Florence, Italy), 2010, Volume: 22, Issue:4 Topics: Animals; Anti-Bacterial Agents; Bacteroides fragilis; Bacteroides Infections; beta-Lactam Resistance; beta-Lactams; Ertapenem; Germ-Free Life; In Vitro Techniques; Mice; Microbial Sensitivity Tests; Penicillanic Acid; Phenotype; Piperacillin; Tazobactam; Virulence	2010
Importance of infusion volume and pump characteristics in extended administration of ß-lactam antibiotics. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:11 Topics: Anti-Bacterial Agents; beta-Lactams; Drug Administration Routes; Humans; Meropenem; Penicillanic Acid; Piperacillin; Tazobactam; Thienamycins	2010
Use of the lymphocyte transformation test in the diagnosis of DRESS syndrome induced by ceftriaxone and piperacillin-tazobactam: two case reports. Journal of investigational allergology & clinical immunology, 2010, Volume: 20, Issue:5 Topics: Adrenal Cortex Hormones; Adult; Anticonvulsants; beta-Lactams; Ceftriaxone; Cell Proliferation; Cells, Cultured; Colitis, Ulcerative; Drug Hypersensitivity; Eosinophilia; Epilepsy; Exanthema; Female; Histamine Antagonists; Humans; Lymphocyte Activation; Male; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination	2010
AmpG inactivation restores susceptibility of pan-beta-lactam-resistant Pseudomonas aeruginosa clinical strains. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:5 Topics: Aztreonam; Bacterial Proteins; beta-Lactams; Cefepime; Ceftazidime; Cephalosporins; Drug Resistance, Bacterial; Membrane Transport Proteins; Meropenem; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Pseudomonas aeruginosa; Thienamycins	2011
Superior in vitro activity of ertapenem and piperacillin/tazobactam against recent clinical isolates of Proteus mirabilis from intra-abdominal infections (SMART 2009-2010). International journal of antimicrobial agents, 2011, Volume: 38, Issue:2 Topics: Abdominal Abscess; Anti-Bacterial Agents; beta-Lactams; Ertapenem; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Proteus Infections; Proteus mirabilis	2011
Recommended β-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy. Critical care (London, England), 2011, Volume: 15, Issue:3 Topics: Aged; Anti-Bacterial Agents; beta-Lactams; Cefepime; Ceftazidime; Cephalosporins; Dose-Response Relationship, Drug; Female; Humans; Intensive Care Units; Male; Meropenem; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Practice Guidelines as Topic; Prospective Studies; Pseudomonas aeruginosa; Renal Replacement Therapy; Shock, Septic; Thienamycins	2011
Ionization constants and solubility of compounds involved in enzymatic synthesis of aminopenicillins and aminocephalosporins. Bioprocess and biosystems engineering, 2011, Volume: 34, Issue:9 Topics: Amino Acids; beta-Lactams; Cephalosporins; Chemistry, Pharmaceutical; Drug Design; Electrolytes; Hydrogen-Ion Concentration; Ions; Models, Chemical; Models, Theoretical; Penicillanic Acid; Penicillins; Solubility; Temperature; Thermodynamics	2011
Effect of body mass index on treatment of complicated intra-abdominal infections in hospitalized adults: comparison of ertapenem with piperacillin-tazobactam. Surgical infections, 2012, Volume: 13, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; beta-Lactams; Body Mass Index; Ertapenem; Female; Humans; Intraabdominal Infections; Male; Middle Aged; Multicenter Studies as Topic; Obesity, Morbid; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Randomized Controlled Trials as Topic; Young Adult	2012
Broad-spectrum β-lactam antibiotics for treating experimental peritonitis in mice due to Klebsiella pneumoniae producing the carbapenemase OXA-48. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:5 Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Cefotaxime; Ceftazidime; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug Combinations; Ertapenem; Imipenem; Klebsiella Infections; Klebsiella pneumoniae; Lethal Dose 50; Mice; Penicillanic Acid; Peritonitis; Piperacillin; Piperacillin, Tazobactam Drug Combination; Plasmids; Survival Rate	2012
Class A carbapenemase FPH-1 from Francisella philomiragia. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:6 Topics: Bacterial Proteins; beta-Lactamases; beta-Lactams; Carbapenems; Clavulanic Acid; Doripenem; Ertapenem; Escherichia coli; Francisella; Imipenem; Meropenem; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam; Thienamycins	2012
Epidemiology and antimicrobial susceptibility profiles of Gram-negative bacteria causing urinary tract infections in the Asia-Pacific region: 2009-2010 results from the Study for Monitoring Antimicrobial Resistance Trends (SMART). International journal of antimicrobial agents, 2012, Volume: 40 Suppl Topics: Amikacin; Anti-Bacterial Agents; Asia; Australasia; beta-Lactamases; beta-Lactams; Carbapenems; Ceftazidime; Drug Resistance, Bacterial; Ertapenem; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prevalence; Prospective Studies; Urinary Tract Infections	2012
Modeling solubility, acid-base properties and activity coefficients of amoxicillin, ampicillin and (+)6-aminopenicillanic acid, in NaCl(aq) at different ionic strengths and temperatures. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2012, Nov-20, Volume: 47, Issue:4 Topics: Amoxicillin; Ampicillin; beta-Lactams; Hydrogen-Ion Concentration; Hydrolysis; Osmolar Concentration; Penicillanic Acid; Potentiometry; Sodium Chloride; Solubility; Solutions; Temperature; Water	2012
Case-control study of drug monitoring of β-lactams in obese critically ill patients. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Infections; beta-Lactams; Case-Control Studies; Cefepime; Ceftazidime; Cephalosporins; Drug Monitoring; Enzyme Inhibitors; Female; Humans; Male; Meropenem; Middle Aged; Obesity; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Renal Replacement Therapy; Sepsis; Shock, Septic; Tazobactam; Thienamycins; Young Adult	2013
Reply to Soman et al and Frippiat et al. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2013, Volume: 57, Issue:2 Topics: Anti-Bacterial Agents; Bacterial Infections; beta-Lactams; Carbapenems; Female; Humans; Male; Penicillanic Acid; Piperacillin; Sepsis	2013
Are prolonged/continuous infusions of β-lactams for all? Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2013, Volume: 57, Issue:2 Topics: Anti-Bacterial Agents; Bacterial Infections; beta-Lactams; Carbapenems; Female; Humans; Male; Penicillanic Acid; Piperacillin; Sepsis	2013
Penicillin G acylase from Achromobacter sp. CCM 4824 : an efficient biocatalyst for syntheses of beta-lactam antibiotics under conditions employed in large-scale processes. Applied microbiology and biotechnology, 2014, Volume: 98, Issue:3 Topics: Achromobacter; Amoxicillin; Ampicillin; Anti-Bacterial Agents; beta-Lactams; Biotransformation; Enzyme Stability; Enzymes, Immobilized; Hydrogen-Ion Concentration; Penicillanic Acid; Penicillin Amidase; Temperature	2014
Detection of Escherichia coli and associated β-lactamases genes from diabetic foot ulcers by multiplex PCR and molecular modeling and docking of SHV-1, TEM-1, and OXA-1 β-lactamases with clindamycin and piperacillin-tazobactam. PloS one, 2013, Volume: 8, Issue:7 Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clindamycin; Diabetic Foot; Escherichia coli; Escherichia coli Infections; Gene Expression; Humans; Microbial Sensitivity Tests; Molecular Docking Simulation; Multiplex Polymerase Chain Reaction; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Structural Homology, Protein; Structure-Activity Relationship	2013
Susceptibility to antibiotics of aerobic bacteria isolated from community acquired secondary peritonitis in children: therapeutic guidelines might not always fit with and everyday experience. Journal of chemotherapy (Florence, Italy), 2013, Volume: 25, Issue:4 Topics: Ampicillin; Anti-Bacterial Agents; Bacterial Infections; beta-Lactams; Child; Community-Acquired Infections; Drug Resistance, Bacterial; Drug Therapy, Combination; Ertapenem; Gentamicins; Hospitals, Pediatric; Humans; Italy; Meropenem; Microbial Sensitivity Tests; Penicillanic Acid; Peritonitis; Piperacillin; Piperacillin, Tazobactam Drug Combination; Practice Guidelines as Topic; Sulbactam; Thienamycins	2013
Risk factors associated with preoperative fecal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae in liver transplant recipients. Transplant infectious disease : an official journal of the Transplantation Society, 2014, Volume: 16, Issue:1 Topics: Adult; Amikacin; beta-Lactamases; beta-Lactams; Cefoxitin; Ciprofloxacin; Drug Resistance, Bacterial; End Stage Liver Disease; Enterobacter cloacae; Enterobacteriaceae; Enterobacteriaceae Infections; Escherichia coli; Escherichia coli Infections; Feces; Female; Humans; Imipenem; Klebsiella; Klebsiella Infections; Klebsiella pneumoniae; Liver Transplantation; Logistic Models; Male; Microbial Sensitivity Tests; Middle Aged; Multivariate Analysis; Penicillanic Acid; Peritonitis; Piperacillin; Piperacillin, Tazobactam Drug Combination; Preoperative Period; Risk Factors; Severity of Illness Index	2014
Comparative evaluation of six phenotypic methods for detecting extended-spectrum beta-lactamase-producing Enterobacteriaceae. Journal of infection in developing countries, 2014, Apr-15, Volume: 8, Issue:4 Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bacterial Typing Techniques; beta-Lactamases; beta-Lactams; Cefepime; Cefotaxime; Ceftazidime; Cephalosporins; Enterobacteriaceae; False Negative Reactions; False Positive Reactions; Female; Humans; India; Male; Microbial Sensitivity Tests; Penicillanic Acid; Phenotype; Piperacillin; Piperacillin, Tazobactam Drug Combination; Predictive Value of Tests	2014
β-Lactam pharmacokinetics during extracorporeal membrane oxygenation therapy: A case-control study. International journal of antimicrobial agents, 2015, Volume: 45, Issue:3 Topics: Adult; Anti-Bacterial Agents; beta-Lactams; Case-Control Studies; Extracorporeal Membrane Oxygenation; Female; Humans; Male; Meropenem; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Pseudomonas Infections; Sepsis; Serum; Thienamycins; Treatment Outcome	2015
Impact of a Dynamic Microbiological Environment on the Clinical Efficacy of Ertapenem and Piperacillin/Tazobactam in the Treatment of Complicated Community-Acquired Intra-Abdominal Infection in Spain: A Cost-Consequence Analysis. Applied health economics and health policy, 2015, Volume: 13, Issue:4 Topics: Anti-Bacterial Agents; APACHE; beta-Lactams; Clinical Trials, Phase III as Topic; Community-Acquired Infections; Cost-Benefit Analysis; Decision Trees; Double-Blind Method; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Ertapenem; Humans; Intraabdominal Infections; Length of Stay; Models, Economic; Monte Carlo Method; Multicenter Studies as Topic; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Spain	2015
Microbiologic clearance following transition from standard infusion piperacillin-tazobactam to extended-infusion for persistent Gram-negative bacteremia and possible endocarditis: A case report and review of the literature. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2015, Volume: 21, Issue:10 Topics: Aged; Anti-Bacterial Agents; Bacteremia; beta-Lactamases; beta-Lactams; Endocarditis; Gram-Negative Bacterial Infections; Humans; Infusions, Intravenous; Male; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination	2015
Antimicrobial Susceptibilities of Aerobic and Facultative Gram-Negative Bacilli from Intra-abdominal Infections in Patients from Seven Regions in China in 2012 and 2013. Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:1 Topics: Amikacin; Ampicillin; Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Cefoxitin; China; Ciprofloxacin; Community-Acquired Infections; Cross Infection; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae; Enterobacteriaceae Infections; Ertapenem; Gene Expression; Humans; Imipenem; Intraabdominal Infections; Levofloxacin; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Sulbactam	2016
Characterization of Piperacillin/Tazobactam-Resistant Klebsiella oxytoca Recovered from a Nosocomial Outbreak. PloS one, 2015, Volume: 10, Issue:11 Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Cross Infection; Disease Outbreaks; Drug Resistance, Multiple, Bacterial; Escherichia coli; Escherichia coli Infections; Female; Humans; Japan; Klebsiella Infections; Klebsiella oxytoca; Male; Microbial Sensitivity Tests; Middle Aged; Multilocus Sequence Typing; Penicillanic Acid; Piperacillin; Tazobactam	2015
Novel Penicillin-Type Analogues Bearing a Variable Substituted 2-Azetidinone Ring at Position 6: Synthesis and Biological Evaluation. Molecules (Basel, Switzerland), 2015, Dec-10, Volume: 20, Issue:12 Topics: Animals; Anti-Bacterial Agents; Azetidines; Bacillus; beta-Lactams; Cell Survival; Escherichia coli; Mice; Microbial Sensitivity Tests; NIH 3T3 Cells; Penicillanic Acid; Pseudomonas; Salmonella typhimurium; Staphylococcus; Structure-Activity Relationship	2015
Antimicrobial susceptibility of clinical Enterobacteriaceae isolates at the emergency department in a regional hospital: A threat of extended spectrum beta-lactamase-producers among nursing home residents. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 2016, Volume: 49, Issue:4 Topics: Amikacin; Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Blood; Drug Resistance, Multiple, Bacterial; Emergency Service, Hospital; Ertapenem; Escherichia coli; Escherichia coli Infections; Female; Humans; Imipenem; Klebsiella Infections; Klebsiella pneumoniae; Male; Meropenem; Microbial Sensitivity Tests; Nursing Homes; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Proteus Infections; Proteus mirabilis; Retrospective Studies; Sputum; Taiwan; Thienamycins; Urine	2016
Impact of de-escalation of beta-lactam antibiotics on the emergence of antibiotic resistance in ICU patients: a retrospective observational study. Intensive care medicine, 2016, Volume: 42, Issue:6 Topics: Aged; Anti-Bacterial Agents; beta-Lactams; Ceftazidime; Drug Resistance, Microbial; Female; Humans; Intensive Care Units; Male; Meropenem; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Retrospective Studies; Thienamycins	2016
An Immunocompromised Child with Bloodstream Infection Caused by Two Escherichia coli Strains, One Harboring NDM-5 and the Other Harboring OXA-48-Like Carbapenemase. Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:6 Topics: Adolescent; Amikacin; Anti-Bacterial Agents; Aztreonam; Bacterial Proteins; beta-Lactamases; beta-Lactams; Ciprofloxacin; Ertapenem; Escherichia coli; Female; Gentamicins; Humans; Immunocompromised Host; Meropenem; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Tazobactam; Thienamycins; Tobramycin	2016
IMP-27, a Unique Metallo-β-Lactamase Identified in Geographically Distinct Isolates of Proteus mirabilis. Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:10 Topics: Aztreonam; beta-Lactamases; beta-Lactams; Ceftazidime; Drug Resistance, Bacterial; Ertapenem; Hydrolysis; Integrons; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Proteus Infections; Proteus mirabilis; United States	2016
What is the role of the new β-lactam/β-lactamase inhibitors ceftolozane/tazobactam and ceftazidime/avibactam? Expert review of anti-infective therapy, 2016, Volume: 14, Issue:10 Topics: Anti-Bacterial Agents; Azabicyclo Compounds; beta-Lactamase Inhibitors; beta-Lactams; Ceftazidime; Cephalosporins; Drug Combinations; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae Infections; Humans; Intraabdominal Infections; Penicillanic Acid; Pseudomonas Infections; Tazobactam; Urinary Tract Infections	2016
Multidrug-Resistant Pseudomonas aeruginosa Infection in a Child with Cystic Fibrosis. Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:10 Topics: Adolescent; Amikacin; Anti-Bacterial Agents; beta-Lactams; Ciprofloxacin; Cystic Fibrosis; Drug Hypersensitivity; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Female; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Pseudomonas aeruginosa; Pseudomonas Infections; Tazobactam	2016
Bypass graft infection and bacteremia caused by Anaerostipes caccae: First report of human infection caused by a recently described gut anaerobe. Anaerobe, 2016, Volume: 42 Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anastomosis, Surgical; Anti-Bacterial Agents; beta-Lactams; Blood Culture; Clostridiales; Ertapenem; Female; Gram-Positive Bacterial Infections; Humans; Metronidazole; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Surgical Wound Infection; Vancomycin	2016
Antimicrobial susceptibility of Gram-negative ESKAPE pathogens isolated from hospitalized patients with intra-abdominal and urinary tract infections in Asia-Pacific countries: SMART 2013-2015. Journal of medical microbiology, 2017, Volume: 66, Issue:1 Topics: Acinetobacter baumannii; Amikacin; Anti-Infective Agents; Asia; beta-Lactamases; beta-Lactams; Carbapenems; Cephalosporins; Drug Resistance, Multiple, Bacterial; Enterobacter; Ertapenem; Gram-Negative Bacteria; Hospitalization; Humans; Imipenem; Intraabdominal Infections; Klebsiella pneumoniae; Levofloxacin; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Pseudomonas aeruginosa; Urinary Tract Infections	2017
Treatment efficacy and superinfection rates in complicated urinarytract infections treated with ertapenem or piperacillin tazobactam. Turkish journal of medical sciences, 2016, Dec-20, Volume: 46, Issue:6 Topics: Anti-Bacterial Agents; beta-Lactams; Ertapenem; Humans; Penicillanic Acid; Piperacillin; Retrospective Studies; Superinfection; Tazobactam; Treatment Outcome	2016
Development of an algorithm for phenotypic screening of carbapenemase-producing Enterobacteriaceae in the routine laboratory. BMC infectious diseases, 2017, 01-17, Volume: 17, Issue:1 Topics: Algorithms; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; beta-Lactams; Carbapenems; Cefepime; Cephalosporins; Clavulanic Acids; Drug Resistance, Bacterial; Enterobacteriaceae; Ertapenem; Humans; Imipenem; Meropenem; Microbial Sensitivity Tests; Penicillanic Acid; Penicillins; Tazobactam; Thienamycins; Ticarcillin	2017
Acute Kidney Injury in Patients Treated with IV Beta-Lactam/Beta-Lactamase Inhibitor Combinations. Pharmacotherapy, 2017, Volume: 37, Issue:5 Topics: Acute Kidney Injury; Adult; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Cohort Studies; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Retrospective Studies; Treatment Outcome; Vancomycin	2017
Prevalence, patient characteristics and outcomes of a novel piperacillin/tazobactam-resistant, pan-β-lactam-susceptible phenotype in Enterobacteriaceae: implications for selective reporting. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2017, Volume: 23, Issue:8 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; beta-Lactams; Connecticut; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Enterobacteriaceae; Enterobacteriaceae Infections; Escherichia coli; Female; Humans; Klebsiella pneumoniae; Male; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Phenotype; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prevalence; Retrospective Studies; Risk Factors; Treatment Outcome	2017
Role of piperacillin/tazobactam as a carbapenem-sparing antibiotic for treatment of acute pyelonephritis due to extended-spectrum β-lactamase-producing Escherichia coli. International journal of antimicrobial agents, 2017, Volume: 49, Issue:4 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Ertapenem; Escherichia coli; Escherichia coli Infections; Female; Hospitals, University; Humans; Male; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Pyelonephritis; Republic of Korea; Retrospective Studies; Survival Analysis; Treatment Failure; Young Adult	2017
In vitro susceptibility and resistance phenotypes in contemporary Enterobacter isolates in a university hospital in Crete, Greece. Future microbiology, 2017, Volume: 12 Topics: Aminoglycosides; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; beta-Lactams; Carbapenems; Cefepime; Cephalosporins; Child; Colistin; Drug Resistance, Multiple, Bacterial; Enterobacter; Enterobacteriaceae Infections; Greece; Hospitals, University; Humans; Microbial Sensitivity Tests; Minocycline; Penicillanic Acid; Phenotype; Piperacillin; Piperacillin, Tazobactam Drug Combination; Tigecycline	2017
Carbapenemase-Producing Enterobacteriaceae Isolates from Edo State, Nigeria. Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:8 Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Carbapenem-Resistant Enterobacteriaceae; Cefotaxime; Ceftazidime; Disk Diffusion Antimicrobial Tests; Enterobacteriaceae Infections; Ertapenem; Fluoroquinolones; Humans; Nigeria; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination	2017
Dosing antibiotics in neonates: review of the pharmacokinetic data. Future microbiology, 2017, Volume: 12 Topics: Adult; Aminoglycosides; Anti-Bacterial Agents; beta-Lactams; Birth Weight; Body Size; Cephalosporins; Child; Clindamycin; Glycopeptides; Humans; Infant; Infant, Newborn; Medication Reconciliation; Meropenem; Metronidazole; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Thienamycins	2017
Considerable variation of trough β-lactam concentrations in older adults hospitalized with infection-a prospective observational study. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2018, Volume: 37, Issue:3 Topics: Aged; Aged, 80 and over; Analysis of Variance; Bacterial Infections; beta-Lactams; Cefotaxime; Drug Monitoring; Female; Humans; Length of Stay; Male; Meropenem; Patient Readmission; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Sepsis; Sweden; Thienamycins	2018
Nephrotoxicity of teicoplanin-based combination therapy: focus on piperacillin/tazobactam and other anti-pseudomonal β-lactams. The Journal of antimicrobial chemotherapy, 2021, 01-19, Volume: 76, Issue:2 Topics: Acute Kidney Injury; Adult; Aged; Anti-Bacterial Agents; beta-Lactams; Cohort Studies; Drug Therapy, Combination; Humans; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Retrospective Studies; Teicoplanin	2021